Activities in Sub Family	Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (10); Uniprot accession (37); PDB accession (10); 3D entries (6); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
CGL27_05725		Streptomyces sp. 11-1-2	ASQ92711.1			8
P8T65_41190		Streptomyces sp. 11x1	WNZ13355.1			8
SAMN05428941_6359		Streptomyces sp. 2114.2	SDT78278.1			8
SAMN05428941_0608		Streptomyces sp. 2114.2	SDS50526.1			8
SAMN05444521_8314		Streptomyces sp. 3214.6	SHI71357.1			8
K5X85_33025		Streptomyces sp. A144	UAX57504.1			8
IOD14_28430		Streptomyces sp. A2-16	QUC60361.1			8
P8A21_14060		Streptomyces sp. Alt1	WLQ48549.1			8
P8A19_26570		Streptomyces sp. Alt2	WLQ58773.1			8
P8A20_22585		Streptomyces sp. Alt3	WLQ66191.1			8
PZB77_28770		Streptomyces sp. AM 2-1-1	WEH43174.1			8
CVT30_41935		Streptomyces sp. AMCC400023	UJV45543.1			8
CVT30_40110		Streptomyces sp. AMCC400023	UJV45229.1			8
RI578_02180		Streptomyces sp. BB1-1-1	WND33161.1			8
JIX56_40030		Streptomyces sp. CA-210063	UUU35556.1			8
N7925_33480		Streptomyces sp. CA-278952	WDG32897.1			8
HYC88_02305		Streptomyces sp. CB00271	QNQ32617.1			8
NI25_01330		Streptomyces sp. CCM_MD2014	AIV32327.1			8
AS200_38935		Streptomyces sp. CdTB01	ALV37404.1			8
RJD14_35240		Streptomyces sp. CGMCC 4.1456	WNF67487.1			8
VJ737_37915		Streptomyces sp. CGMCC 4.1772	WRU03120.1			8
SJH97_03435		Streptomyces sp. CL7	WPP28424.1			8
CXR04_00690		Streptomyces sp. CMB-StM0423	AUH38961.1			8
AA958_33630		Streptomyces sp. CNQ-509	AKH86353.1			8
NNW99_35720		Streptomyces sp. CRCS-T-1	UUA18212.1			8
NNW98_35835		Streptomyces sp. CRLD-Y-1	UUA10605.1			8
V8690_03705		Streptomyces sp. DG1A-41	WWT93694.1			8
JIX55_08600		Streptomyces sp. DSM 40750	UUU20361.1			8
JIX55_07160		Streptomyces sp. DSM 40750	UUU20104.1			8
HB370_02920		Streptomyces sp. DSM 40868	QIS75621.1			8
HB370_30245		Streptomyces sp. DSM 40868	QIS73744.1			8
EASAB2608_05424		Streptomyces sp. EAS-AB2608 NBRC 114648	BCM70090.1			8
SAM9427_05470		Streptomyces sp. ETH9427	AXI85415.1			8
Q7C01_22725		Streptomyces sp. FXY-T5	WMD07011.1			8
C1703_02515 (Mana1)		Streptomyces sp. Go-475	AXE83855.1			8
C1703_03070 (Mana2)		Streptomyces sp. Go-475	AXE83966.1			8
LUX31_26880		Streptomyces sp. GQFP	UIX33341.1			8
LUV23_06445		Streptomyces sp. HNM0561	UHH16002.1			8
MQE23_39175		Streptomyces sp. HP-A2021	UOB14726.1			8
PGH47_03660		Streptomyces sp. HUAS 31	WCD94790.1			8
Q3Y68_06965		Streptomyces sp. HUAS CX7	WKX17773.1			8
Q3Y68_01165		Streptomyces sp. HUAS CX7	WKX16709.1			8
RLT58_22950		Streptomyces sp. ITFR-16	WNI24578.1			8
G7Z13_26720		Streptomyces sp. JB150	QIJ66767.1			8
G7Z13_26655		Streptomyces sp. JB150	QIJ65213.1			8
KJK32_04150		Streptomyces sp. JCM17656	QWA20802.1			8
R9806_35360		Streptomyces sp. KN37	WPO75505.1			8
D1J63_01305		Streptomyces sp. KPB2	AZM73732.1			8
D1J63_06320		Streptomyces sp. KPB2	AZM74610.1			8
F3K22_03955		Streptomyces sp. LBUM 1475	QTU60282.1			8
F3K22_05495		Streptomyces sp. LBUM 1475	QTU60523.1			8
F3K21_06010		Streptomyces sp. LBUM 1480	QTU52497.1			8
F3K21_04470		Streptomyces sp. LBUM 1480	QTU52260.1			8
F3K20_03990		Streptomyces sp. LBUM 1482	QTU44140.1			8
F3K20_05545		Streptomyces sp. LBUM 1482	QTU44379.1			8
MUK60_04835		Streptomyces sp. LRE541	UPZ27196.1			8
CFP59_08013 (Mana_2)		Streptomyces sp. M56	AUA15823.1			8
M6G08_23535		Streptomyces sp. M92	WCN04853.1			8
K4G22_08110		Streptomyces sp. MA3_2.13	UED84177.1			8
P8A18_11455		Streptomyces sp. Mut1	WLQ34019.1			8
HUT14_04030		Streptomyces sp. NA02536	QKV99071.1			8
HUT15_06090		Streptomyces sp. NA03103	QKW60116.1			8
HUT15_01135		Streptomyces sp. NA03103	QKW59224.1			8
QFW82_40145		Streptomyces sp. NA07423	WHX22801.1			8
OG428_12790		Streptomyces sp. NBC_01422	WUY01551.1			8
OG290_29325		Streptomyces sp. NBC_01423	WUX94764.1			8
OG290_12030		Streptomyces sp. NBC_01423	WUX90439.1			8
OG627_02450		Streptomyces sp. NBC_01429	WUX65885.1			8
HZZ00_19635		Streptomyces sp. NEAU-sy36	QLJ02980.1			8
C6376_38335		Streptomyces sp. P3	AVV46344.1			8
QTO28_12400		Streptomyces sp. P9-2B-1	WJY31759.1			8
F750_2698		Streptomyces sp. PAMC 26508	AGJ55179.1			8
QR97_21190		Streptomyces sp. PBH53	AKN71965.1			8
GPZ77_33785		Streptomyces sp. QHH-9511	QGZ52610.1			8
HYQ63_03720		Streptomyces sp. Rer75	QLH19869.1			8
β-1,4-mannanase (Man5S27)	3.2.1.78	Streptomyces sp. S27	ADK91085.1	E2F4D4		8
N6H00_34355		Streptomyces sp. S465	WAP59622.1			8
D7Y56_12315		Streptomyces sp. S501	QBR06642.1			8
β-1,4-mannanase		Streptomyces sp. s6-204	ABY90130.1			8
SBE_002227		Streptomyces sp. SBE_14.2	WBO78606.1			8
PS467_35215		Streptomyces sp. SCA4-21	WNF00196.1			8
CAG99_02395		Streptomyces sp. SCSIO 03032	ARQ67834.1			8
C1N79_33720		Streptomyces sp. SGAir0924	QCR51144.1			8
β-mannanase (SACTE_2347)	3.2.1.78	Streptomyces sp. SirexAA-E	AEN10237.1 WP_014046222.1	G2NHM6	4FK9[A]	8
B9S64_11350		Streptomyces sp. SM18	AWL38642.1			8
HBB06_18000		Streptomyces sp. SNU607	WKV79888.1			8
U5072_01645		Streptomyces sp. SS162	WVS76425.1			8
E5N77_34085		Streptomyces sp. SS52	QCB26303.1			8
E5N77_28635		Streptomyces sp. SS52	QCB25360.1			8
U5640_41070		Streptomyces sp. SS7	WYV92502.1			8
A7X85_07100		Streptomyces sp. ST1015	QZZ26035.1			8
A7X85_01765		Streptomyces sp. ST1015	QZZ25189.1			8
GEV49_01305		Streptomyces sp. SYP-A7193	QFX79702.1			8
PBV52_46835		Streptomyces sp. T12	WDF43772.1			8
WBG99_31475		Streptomyces sp. TG1A-60	WXC24333.1			8
GLX30_04140		Streptomyces sp. Tu 2975	QIP83389.1			8
KE639_07100 (Mana_5)		Streptomyces sp. V17-9	QUW95830.1			8
KE639_05990 (Mana_3)		Streptomyces sp. V17-9	QUW94727.1			8
OH133_35740		Streptomyces sp. VB1	UZI33893.1			8
PYR72_41875		Streptomyces sp. VNUA24	WEH19876.1			8
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