Glycoside Hydrolase Family 5 / Subf 8

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (373); Uniprot accession (76); PDB accession (10); 3D entries (6); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 β-mannanase (TM1) 3.2.1.78 Bacillus circulans AAT39478.1 Q6IUP2   8
 β-mannanase (Man1;ManB48) 3.2.1.78 Bacillus circulans CGMCC 1416 AAX87002.1 Q49HI4   8
 β-mannanase (Man5A) 3.2.1.78 Bacillus circulans CGMCC1554 AAX87003.1 Q0IJR6   8
 β-mannanase (G) 3.2.1.78 Bacillus circulans K-1 BAA25878.1 O66185   8
 β-mannanase (MANPN11) (fragment) 3.2.1.78 Bacillus nealsonii PN-11 AGU71466.2
AGU71466.1
AGU71466.3
    8
 β-mannanase (Amn5) (Man5A) 3.2.1.78 Bacillus sp. JAMB-602 BAD99527.1 Q4W8M3 1WKY[A] 8
 β-mannanase (ManA;MAN330) (Man5A) 3.2.1.78 Bacillus sp. N16-5 AAT06599.1
AML27065.1
Q5YEX6 3JUG[A] 8
 Balac_1450 3.2.1.78 Bifidobacterium animalis subsp. lactis Bl-04 ACS46797.1 C6A9J9   8
 β-1,4-mannanase (ManA) 3.2.1.78 Caldibacillus cellulovorans AAF22274.1 Q9RFX5   8
 bifunctional mannanase / endoglucanase (CbMan5A/Cel44A;Athe_1859;Cbes_1859;ORF1946) (Man5A-Cel44A) 3.2.1.4
3.2.1.78
Caldicellulosiruptor bescii DSM 6725 ACM60947.1 B9MKT9   8
 bifunctional cellulase / β-mannanase (CelC-ManB;CbCel9B/Man5A;Athe_1865;Cbes_1865;Orf1952) (Cel9B-Man5A) 3.2.1.4
3.2.1.78
Caldicellulosiruptor bescii DSM 6725 ACM60953.1 B9MKU5   8
 Athe_1866 (CelB;CbMan5C/Cel5A) (Man5C-Cel5A) 3.2.1.4 Caldicellulosiruptor bescii DSM 6725 ACM60954.1 B9MKU6   8
 bifunctional β-mannanase / endo-β-1,4-glucanase (ManA) 3.2.1.4
3.2.1.78
Caldicellulosiruptor saccharolyticus AAA71887.1
AAA72861.1
P22533   8
 β-1,4-mannanase (ManH) 3.2.1.78 Cellulosimicrobium sp. HY-13 AEE43708.1     8
 endo-β-1,4-mannanase 5A (CjMan5A;CJA_3338) (Man5A) 3.2.1.78 Cellvibrio japonicus Ueda107 ACE84673.1
AAO31759.1
B3PF24
Q840C2
  8
 endo-β-1,4-mannanase 5B (CJA_2475) (Man5B) 3.2.1.78 Cellvibrio japonicus Ueda107 AAO31760.1
ACE84941.1
B3PKK7
Q840C1
  8
 β-mannanase (GH5C;RUM_21650) (Man5A) 3.2.1.78 Ruminococcus champanellensis 18P13 = JCM 17042 CBL18180.1 D4LEY5   8
 β-mannanase (Man5A) 3.2.1.78 Salipaludibacillus agaradhaerens AAN27517.1
AAN27518.1
AAQ31837.1
AAQ79152.1
AAQ79153.1
ABC13790.1
ABC13791.1
  2WHJ[A]
2WHL[A]
8
 β-mannanase (ManA;SlMan) 3.2.1.78 Streptomyces lividans 1326 AAA26710.2 P51529   8
 β-1,4-mannanase (Man5S27) 3.2.1.78 Streptomyces sp. S27 ADK91085.1 E2F4D4   8
 β-mannanase (SACTE_2347) 3.2.1.78 Streptomyces sp. SirexAA-E AEN10237.1   4FK9[A] 8
 β-mannanase (Man;StMan) 3.2.1.78 Streptomyces thermolilacinus NBRC14274 BAK26781.1   3WSU[A,B]
4Y7E[A,B]
8
 β-mannanase (ManII;StManII) 3.2.1.78 Streptomyces thermoluteus NBRC 14269 BAM62868.1     8
 endomannanase (Man5A) 3.2.1.78 Thermobifida cellulosilytica TB100 AHB89703.1     8
 β-mannanase (Man) (partial) 3.2.1.78 Thermobifida fusca KW3 CAA06924.1 Q9ZF13 2MAN[A]
3MAN[A]
1BQC[A]
8
 endomannanase (TM51_04883) (Man5A) 3.2.1.78 Thermobifida fusca TM51 AHB89702.1     8
 β-mannanase (Man;TfMan;Tfu-man;Tfu_0900) 3.2.1.78 Thermobifida fusca YX AAZ54938.1 Q47RH9   8
 β-mannanase (ManA) 3.2.1.78 Vibrio sp. MA-138 BAA25188.1 O69347   8
 endo-β-1,4-mannosidase (ManA;XCC1778) 3.2.1.78 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM41068.1
NP_637144.1
Q8P9S0   8
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 β-mannanase (Man1;HhMAN1) 3.2.1.78 Hypothenemus hampei ACU52526.1
ACU52527.1
C8CAP6   8
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