Activities in Family	Trans-sialidase (EC 2.4.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-); Kdo hydrolase (EC 3.2.1.124); Exo-α-sialidase (EC 3.2.1.18); Anhydrosialidase (EC 4.2.2.15);
Mechanism	Retaining e
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	CAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)	MEGAZYME;
Statistics	GenBank accession (11188); Uniprot accession (128); PDB accession (186); 3D entries (29); cryst (0)

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Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
glycoprotein 82 kDa (gp82 subfamily C4) (fragment)		Trypanosoma cruzi PERU2	BAF74655.1
trans-sialidase, partial (Tsα-1) (fragment)		Trypanosoma cruzi Silvio X10 cl1 TSA-1	AID66714.1
TcC2-ORF6		Trypanosoma cruzi SYLVIO	AAP80764.1
TcC2-ORF3		Trypanosoma cruzi SYLVIO	AAP80761.1
unknown (fragment)		Trypanosoma cruzi SYLVIO	AAP80760.1
surface protein-2		Trypanosoma cruzi SYLVIO X10/4	ABQ53590.1
trans-sialidase, partial		Trypanosoma cruzi TCC793	AHI17181.1
trans-sialidase, partial		Trypanosoma cruzi TCC793	AHI17182.1
surface antigen PHGST#5 (fragment)		Trypanosoma cruzi TULAHUEN	AAC98688.2
amastigote surface protein 2 (Asp-2)		Trypanosoma cruzi Tulahuen	ADB82626.1
trans-sialidase	2.4.1.-	Trypanosoma cruzi TULAHUEN	AAA99444.1	Q26969
surface protein-2		Trypanosoma cruzi TULAHUEN	ABQ53591.1
FL-160-CRP (fragment)		Trypanosoma cruzi Y CL7	CAO78608.1 CAO78611.1 CAO78616.1
FL-160-CRP (fragment)		Trypanosoma cruzi Y CL7	CAO78609.1 CAO78613.1
FL-160-CRP (fragment)		Trypanosoma cruzi Y CL7	CAO78610.1
FL-160-CRP (fragment)		Trypanosoma cruzi Y CL7	CAO78612.1
FL-160-CRP (fragment)		Trypanosoma cruzi Y CL7	CAO78614.1
FL-160-CRP (fragment)		Trypanosoma cruzi Y CL7	CAO78615.1
trans-sialidase (TCTS)	2.4.1.-	Trypanosoma cruzi Y-STRAIN	CAC34453.1 ABH92692.1	Q9BHJ5
trans-sialidase, partial (fragment)		Trypanosoma dionisii TCC211	AHI17188.1
trans-sialidase, partial		Trypanosoma dionisii TCC211	AHI17189.1
sialidase (TeSA)	3.2.1.18	Trypanosoma evansi	ACM43506.1	B9VS11
trans-sialidase, partial		Trypanosoma evansi	AHB33196.1
surface glycoprotein (Gp-1)		Trypanosoma rangeli	AAY46228.1
sialidase (TrSA)	3.2.1.18	Trypanosoma rangeli	AAC95493.1 AAC95494.1 AAC95495.1	O44049 Q7JNE5 Q7JNE6	1MZ5[A] 1MZ6[A] 1N1S[A] 1N1T[A] 1N1V[A] 1N1Y[A] 1WCS[A] 2A75[A] 2AGS[A] 2FHR[A]
sialidase		Trypanosoma rangeli	AAA18835.1
sialidase (fragment)		Trypanosoma rangeli	AAC47213.1
sialidase		Trypanosoma rangeli	AAC47214.1
4G07		Trypanosoma rangeli	AFX73249.1
ORF		Trypanosoma rangeli	AGN32966.1
ORF		Trypanosoma rangeli	AGN32969.1
ORF		Trypanosoma rangeli	AGN32984.1
ORF (fragment)		Trypanosoma rangeli	AGN33000.1
ORF (fragment)		Trypanosoma rangeli	AGN32995.1
ORF (fragment)		Trypanosoma rangeli	AGN32996.1
ORF (fragment)		Trypanosoma rangeli	AGN33002.1
ORF (fragment)		Trypanosoma rangeli	AGN33003.1
ORF (fragment)		Trypanosoma rangeli	AGN33008.1 AGN33008.2
ORF (fragment)		Trypanosoma rangeli	AGN33013.1
ORF (fragment)		Trypanosoma rangeli	AGN33014.1
ORF (fragment)		Trypanosoma rangeli	AGN33015.1
ORF (fragment)		Trypanosoma rangeli	AGN33016.1
ORF (fragment)		Trypanosoma rangeli	AGN33018.1
ORF (fragment)		Trypanosoma rangeli M/CAN/VE/82/DOG82	ACO87648.1
ORF (fragment)		Trypanosoma rangeli M/CAN/VE/82/DOG82	ACO87649.1
TrGP		Trypanosoma rangeli M/CAN/VE/82/DOG82	ACO87650.1
TrGP		Trypanosoma rangeli M/CAN/VE/82/DOG82	ACO87651.1
ORF (fragment)		Trypanosoma rangeli MHOM/Ve/99/CH-99	ACO87640.1
ORF (fragment)		Trypanosoma rangeli MHOM/Ve/99/CH-99	ACO87641.1
ORF (fragment)		Trypanosoma rangeli MHOM/Ve/99/CH-99	ACO87642.1
ORF (fragment)		Trypanosoma rangeli MHOM/Ve/99/CH-99	ACO87643.1
ORF (fragment)		Trypanosoma rangeli MHOM/Ve/99/CH-99	ACO87653.1
ORF (fragment)		Trypanosoma rangeli MHOM/Ve/99/CH-99	ACO87654.1
ORF (fragment)		Trypanosoma rangeli MHOM/Ve/99/CH-99	ACO87655.1
ORF (fragment)		Trypanosoma rangeli MHOM/Ve/99/CH-99	ACO87656.1
ORF (fragment)		Trypanosoma rangeli MHOM/Ve/99/CH-99	ACO87657.1
trans-sialidase, partial		Trypanosoma rangeli TCC012	AHI17190.1
TVY486_0706570 (fragment)		Trypanosoma vivax Y486	CCC49342.1
TVY486_0806830		Trypanosoma vivax Y486	CCC50076.1
4448		Ustilaginoidea virens (Ustvir1)
UV8b_00974		Ustilaginoidea virens UV-8b	QUC16733.1
121743		Verruconis gallopava (Verga1)
3166		Verticillium alfalfae VaMs.102 (Veral1)
433226		Verticillium dahliae MPI-CAGE-AT-0001 v1.0 (Verdah1)
2776		Verticillium dahliae VdLs.17 (Verda1)
VFH_IV221000		Vicia faba	CAI8611261.1
VFH_IV221040		Vicia faba	CAI8611262.1
VIGAN_02083000 (Vigan.02g083000) (fragment)		Vigna angularis var. angularis	BAT78183.1
VIGAN_01471600 (Vigan.01g471600)		Vigna angularis var. angularis	BAT76676.1
VIGAN_01471500 (Vigan.01g471500)		Vigna angularis var. angularis	BAT76675.1
V8G54_015883		Vigna mungo isolate Urdbean	WVZ11353.1
V8G54_015886		Vigna mungo isolate Urdbean	WVZ11356.1
DEO72_LG2g758		Vigna unguiculata	QCD80437.1
DEO72_LG2g758		Vigna unguiculata	QCD80437.1
VitviT2T_010526		Vitis vinifera	WJZ91459.1
577492		Whalleya microplaca YMJ1829 v1.0 (Whamic1)
Unknown (protein for MGC:81958)		Xenopus laevis	AAH74168.1
Unknown (MGC:181090 IMAGE:8886027)		Xenopus tropicalis PopA	AAI60978.1
sialidase 4 (Neu4)		Xiphophorus maculatus	BBH51368.1
22631		Xylariaceae sp. FL0016 v1.0 (XylFL0016)
423967		Xylariaceae sp. FL0255 v1.0 (XylFL0255)
569510		Xylariaceae sp. 357 FL0662B v1.0 (XylFL0662B)
XNOV1_A013527		Xyrichtys novacula	CAJ1083231.1
XNOV1_A021050		Xyrichtys novacula	CAJ1064057.1
XNOV1_A038785		Xyrichtys novacula	CAJ1065370.1
XNOV1_A038105		Xyrichtys novacula	CAJ1053519.1
XNOV1_A030423 (fragment)		Xyrichtys novacula	CAJ1053518.1
XNOV1_A006651		Xyrichtys novacula	CAJ1053520.1
573250		Zalerion varium MPI-CAGE-AT-0135 v1.0 (Zalva1)
unknown (fragment)		Zea mays	ACG41080.1
unknown		Zea mays	ACG24666.1 ACN25581.1
unknown (ZM_BFb0001J07) (fragment)		Zea mays B73	ACF79583.1
742601		Zopfia rhizophila CBS 207.26 (Zoprh1)
714803		Zopfia rhizophila CBS 207.26 (Zoprh1)
805325		Zymoseptoria pseudotritici STIR04_2.2.1 (Zymps1)
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