Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.124); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (8857); Uniprot accession (133); PDB accession (172); 3D entries (25); cryst (0)
Bacteria
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 sialidase (NanH) 3.2.1.18 pubmed
Actinomyces viscosus T14V AAA21932.1 Q44562  
 sialidase (Hz136) 3.2.1.18 pubmed
Alistipes sp.     6MNJ[B]
6MNJ[A]
 sialidase (NanH; BF1806) 3.2.1.18 pubmed
Bacteroides fragilis NCTC 9343 CAH07505.1
WP_010992682.1
   
 sialidase (BF1729) 3.2.1.18   Bacteroides fragilis YCH46 BAA05853.1
AAA22912.1
BAC56895.1
BAC56895.2
BAD48476.1
P31206
P31206
 
 bimodular α-1,5-rhamnosidase / α-2,3-KDO-hydrolase (BT1013) 3.2.1.124 pubmed
Bacteroides thetaiotaomicron VPI-5482 AAO76120.1
NP_809926.1
Q8A904  
 sialidase (BtsA;BTSA;BT0455) 3.2.1.18 pubmed
Bacteroides thetaiotaomicron VPI-5482 AAO75562.1
NP_809368.1
WP_008766031.1
Q8AAK9 4BBW[A]
 exo-α-sialidase (SiaBb2;BBP_0054) 3.2.1.18 pubmed
Bifidobacterium bifidum JCM 1254 BAK26854.1 F5HN10  
 α-2,6- / α-2,3-sialidase (NanH1;Blon_0646) 3.2.1.18 pubmed
Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ51753.1 B7GPM3  
 α-2,6- / α-2,3-sialidase (NanH2;Blon_2348) 3.2.1.18 pubmed
Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ53406.1 B7GNQ0  
 sialidase (SiaC;CAPCAMM2a;Ccan_04790) 3.2.1.18 pubmed
Capnocytophaga canimorsus Cc5 AEK22601.1
ACA13563.1
B5SV83
F9YS48
 
 sialidase (NanA) (fragment) 3.2.1.18 pubmed
Clostridium chauvoei JF4135 CAR82361.1 E1UGY4  
 sialidase 1 'small' 3.2.1.18 pubmed
Clostridium perfringens A99 CAA68780.1 P10481  
 exo-α-sialidase 'large' (NanH) 3.2.1.18 pubmed
Clostridium perfringens A99 CAA60796.1 Q59310  
 sialidase 2 (NanH) 3.2.1.18 pubmed
Clostridium perfringens ATCC 10543 CAA50436.1 Q59311  
 sialidase (CpNanI;CPF_0721) 3.2.1.18 pubmed
Clostridium perfringens ATCC 13124 ABG83208.1 A0A0H2YQR1
Q0TT67
4L2E[A]
5TSP[A,B]
 exo-α-sialidase (NanI;CPSA;CPE0725) 3.2.1.18 pubmed
Clostridium perfringens str. 13 BAB80431.1
NP_561641.1
Q59310
Q8XMG4
2BF6[A]
2VK5[A]
2VK6[A]
2VK7[A,B]
 sialidase 3.2.1.18   Clostridium septicum NC0054714 CAA44916.1 P29767  
 sialidase (NanH;SiaH) 3.2.1.18 pubmed
Clostridium tertium CAA69951.1 P77848  
 trans-sialidase (NanH;NanA) 2.4.1.- pubmed
Corynebacterium diphtheriae KCTC 3075 ACS34893.1 C6JSW6  
 sialidase (PPA1560) 3.2.1.18 pubmed
Cutibacterium acnes KPA171202 AAT83304.1   7LBU[A]
7LBV[A]
 sialidase (NanA) 3.2.1.18 pubmed
Edwardsiella tarda TX01 AFP73415.1 J7GU76  
 lipid A Kdo hydrolase (KdhA;FTL_0465) 3.2.1.124 pubmed
Francisella tularensis subsp. holarctica LVS CAJ78905.1
AJI59416.1
Q2A4W5  
 lipid A Kdo hydrolase (KdoH1) (sialidase-like subunit) 3.2.1.124 pubmed
Francisella tularensis subsp. novicida U112 ADR71924.1
ABK89391.1
AJI60298.1
A0Q576  
 lipid A Kdo hydrolase (KdhA;FTT_0399c) 3.2.1.124 pubmed
Francisella tularensis subsp. tularensis SCHU S4 CAG45032.1 Q5NHP8  
 lipid A Kdo hydrolase (KdhA;HP0580;HP_0580) 3.2.1.124 pubmed
Helicobacter pylori 26695 AAD07646.1
NP_207375.1
O25303  
 lipid A Kdo hydrolase (KdhA;lpg2939) 3.2.1.124 pubmed
Legionella pneumophila subsp. pneumophila str. Philadelphia 1 AAU28985.1
AGH52162.1
Q5ZRE3  
 sialidase (NedA) 3.2.1.18 pubmed
Micromonospora viridifaciens BAA00852.1
AAQ70871.1
Q02834 1EUR[A]
1EUS[A]
1EUT[A]
1EUU[A]
1W8N[A]
1W8O[A]
1WCQ[A,B,C]
2BER[A]
2BQ9[A,B,C]
2BZD[A,B,C]
4J9T[A]
 sialidase M (Siα-AU;AuSia;AUSA) 3.2.1.18 pubmed
Paenarthrobacter ureafaciens IFO 12140 / ATCC 7562 BAD66680.2
AAX22758.1
Q5W7Q2  
 sialidase 3.2.1.18 doi
Paeniclostridium sordellii G12 AAA23280.1
AAB38297.1
P15698
P94675
 
 sialidase 3.2.1.18 pubmed
Paeniclostridium sordellii G39 AAB38298.1 P94676  
 sialidase 3.2.1.18 pubmed
Paeniclostridium sordellii G5 AAB38296.1 P94674  
 sialidase (NanH) 3.2.1.18 pubmed
Pasteurella multocida 86-1913 AAG35310.1 Q9EZV6  
 sialidase (NanB) 3.2.1.18 pubmed
Pasteurella multocida 86-1913 AAG35309.1 Q9EZV7  
 sialidase (PGN_1608) 3.2.1.18 pubmed
Porphyromonas gingivalis ATCC 33277 BAG34127.1
AUR49244.1
B2RL82  
 sialidase (PG0352) 3.2.1.18 pubmed
Porphyromonas gingivalis W83 AAQ65563.1
NP_904664.1
Q7MX62  
 anhydrosialidase (RgNanH;HMPREF1201_01421) (intramolecular) 4.2.2.15 pubmed
Ruminococcus gnavus ETD19277.1 A7B557 4X47[A]
4X49[A]
4X4A[A]
4X6K[A]
 sialidase (NanH;STSA) 3.2.1.18 pubmed
Salmonella enterica LT2 AMG28514.2 P29768 1DIL[A]
1DIM[A]
2SIL[A]
2SIM[A]
3SIL[A]
6TRG[XXX]
6TVI[AAA]
7AEY[AAA]
7AF2[AAA]
 sialidase 3.2.1.18 pubmed
Streptococcus intermedius ATCC 27335 BAJ15290.1 E0CZJ4  
 sialidase A (NanA) 3.2.1.18 pubmed
Streptococcus pneumoniae 6 CAA51473.1
ACJ76903.1
B8XTT3
P62575
Q59959
B[nd]
5KKY[A,B]
7A54[A]
7A5X[A]
 sialidase B (NanB) 3.2.1.18 pubmed
pubmed
Streptococcus pneumoniae 6 AAC44396.1
AAW08718.1
Q54727  
 sialidase B (NanB) 3.2.1.18 pubmed
pubmed
Streptococcus pneumoniae 6 AAC44396.1 Q54727  
 sialidase (NanC;SPCG_0853) 3.2.1.18 pubmed
pubmed
Streptococcus pneumoniae CGSP14 ACB90105.1 B2IP34  
 sialidase (NanC;SPCG_0853) 3.2.1.18 pubmed
pubmed
Streptococcus pneumoniae CGSP14 ACB90105.1 B2IP34  
 neuraminidase (NanA) (fragment) 3.2.1.18 pubmed
Streptococcus pneumoniae CL54 = 145 GM92 CAI94566.1    
 sialidase (NanA;SPD_1504) 3.2.1.18 pubmed
Streptococcus pneumoniae D39 ABJ55437.1 A0A0H2ZQ85
Q04J78
 
 neuraminidase (NanC) 3.2.1.18 pubmed
pubmed
Streptococcus pneumoniae G54 ACF56230.1 A0A0B7LH44
A0A0H2UQE4
A0A182DW00
B5E561
4YW0[A,B]
4YW1[A,B]
4YW2[A,B]
4YW3[A,B]
4YW4[A,B]
4YW5[A,B]
4YZ1[A,B]
4YZ2[A,B]
4YZ3[A,B]
4YZ4[A,B]
4YZ5[A,B]
5F9T[A,B]
 neuraminidase (NanC) 3.2.1.18 pubmed
pubmed
Streptococcus pneumoniae G54 ACF56230.1 A0A0B7LH44
A0A0H2UQE4
A0A182DW00
B5E561
4YW0[A,B]
4YW1[A,B]
4YW2[A,B]
4YW3[A,B]
4YW4[A,B]
4YW5[A,B]
4YZ1[A,B]
4YZ2[A,B]
4YZ3[A,B]
4YZ4[A,B]
4YZ5[A,B]
5F9T[A,B]
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 pubmed
pubmed
pubmed
pubmed
Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727 2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
4XE9[A]
4XHB[A]
4XHX[A]
4XIK[A]
4XIL[A]
4XIO[A]
4XJ8[A]
4XJ9[A]
4XJA[A]
4XJU[A]
4XJW[A]
4XJZ[A]
4XMA[A]
4XMI[A]
4XOG[A]
4XYX[A]
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 pubmed
pubmed
pubmed
pubmed
Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727 2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
4XE9[A]
4XHB[A]
4XHX[A]
4XIK[A]
4XIL[A]
4XIO[A]
4XJ8[A]
4XJ9[A]
4XJA[A]
4XJU[A]
4XJW[A]
4XJZ[A]
4XMA[A]
4XMI[A]
4XOG[A]
4XYX[A]
 sialidase (NanH;TF0036;BFO_2207) 3.2.1.18 pubmed
Tannerella forsythia 92A2 AEW22573.1 G8UIQ1  
 exo-neuraminidase (TdNeu;TDE0471) 3.2.1.18   Treponema denticola ATCC 35405 AAS10966.1
NP_971085.1
Q73QH2  
 sialidase (NanH) 3.2.1.18 pubmed
Trueperella pyogenes AAK15462.1 Q9AHP2  
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 pubmed
pubmed
Vibrio cholerae 569B 395 AAA27546.1 A5F7A4
P0C6E9
P37060
1KIT[A]
1W0O[A]
1W0P[A]
6EKS[A]
6EKU[A]
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 pubmed
pubmed
Vibrio cholerae 569B 395 AAA27546.1 A5F7A4
P0C6E9
P37060
1KIT[A]
1W0O[A]
1W0P[A]
6EKS[A]
6EKU[A]
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D
 2-keto-3-deoxynononic acid sialidase (KDNase;AfKDNase;Afu4g13800;AFUA_4G13800) (6407) 3.2.1.18
3.2.1.-
pubmed
pubmed
Aspergillus fumigatus Af293 EAL89414.2 Q4WQS0 2XCY[A,B]
2XZI[A,B]
2XZJ[A,B]
2XZK[A,B]
4M4N[A,B]
4M4U[A,B]
4M4V[A,B]
 KDNase (ATEG_04964) 3.2.1.- doi
Aspergillus terreus NIH2624 Q0CMX0   B[nd]
7P1B[A]
7P1D[A]
7P1E[A]
7P1F[A]
7P1O[A]
 ganglioside sialidase (Neu3) 3.2.1.18 pubmed
Bos taurus BAA75071.1
AAE69071.1
NP_776547.1
O97859  
 sialidase 3.2.1.18 pubmed
Cricetulus griseus AAA19746.1 Q64393  
 sialidase (Neu3.2) 3.2.1.18 pubmed
Danio rerio AAH77080.1
AAH96984.1
AAI52169.1
ABO30983.1
A7MCG3
A7TUD4
Q4V9A4
Q6DEM9
 
 sialidase (Neu4) 3.2.1.18 pubmed
Danio rerio AAH95117.1
AAI65570.1
ABO45315.1
Q503Z4  
 sialidase (Neu3.3) 3.2.1.18 pubmed
Danio rerio AAI25932.1
AAI16604.1
AAI64496.1
ABO30989.1
ABO30991.1
A0JMM3
B8LF84
Q1JPT6
 
 sialidase (Neu3.1) 3.2.1.18 pubmed
Danio rerio AAI27593.1
ABO30984.1
A0PJS4
A7TUD5
 
 ganglioside sialidase (Neu3) 3.2.1.18 pubmed
Homo sapiens AAE69072.1
AAI36398.1
AAI44060.1
ACM83942.1
BAA82611.1
BAF83131.1
BAG51074.1
BAG64566.1
CAB96131.1
CAE90379.1
NP_006647.2
XP_035091.1
A0A024R5N6
B4E0V4
Q9UQ49
 
 sialidase (Neu2) (cytosolic) 3.2.1.18 pubmed
Homo sapiens CAB41449.1
AAH69151.1
AAI07054.1
AAY24360.1
NP_005374.1
Q9Y3R4 1SNT[A]
1SO7[A]
1VCU[A,B]
2F0Z[A]
2F10[A]
2F11[A]
2F12[A]
2F13[A]
2F24[A]
2F25[A,B]
2F26[A]
2F27[A,B]
2F28[A]
2F29[A,B]
4NC5[A]
4NCS[A]
 lysosomal sialidase (Neu1;Neu-1;NanH;G9) 3.2.1.18 pubmed
Homo sapiens AAB96774.1
AAD09239.1
AAD21814.1
AAH00722.1
AAH11900.1
AAP35870.1
ACM80442.1
ACM85519.1
AQY76954.1
AQY76955.1
BAB63297.1
BAD92248.1
BAF83655.1
CAA55356.1
CAG32998.1
CAG46714.1
CAI17742.1
CAI18221.1
CAI41850.1
CAM26147.1
CAQ08322.1
CAQ09153.1
CAQ09305.1
CAQ09512.1
NP_000425.1
A0A1U9X836
A8K4K1
Q59GU8
Q5JQI0
Q6IBT5
Q99519
 
 sialidase (Neu4;LOC129807) (long-form mitochondria;short-form ER) 3.2.1.18 pubmed
Homo sapiens AAH12899.2
AAH63465.1
AAI05975.1
AAI17215.1
AAP34475.1
AAX82022.1
ABA66598.1
BAF82110.1
BAF82765.1
BAG52266.1
BAH12778.1
BAH13385.1
CAC81904.1
NP_542779.2
A8K056
A8K211
B3KR54
B7Z542
Q3KR05
Q8WWR8
 
 intramolecular trans-sialidase L (MDSA) 4.2.2.15 pubmed
pubmed
Macrobdella decora AAC47263.1 Q27701 1SLI[A]
1SLL[A]
2SLI[A]
3SLI[A]
4SLI[A]
 intramolecular trans-sialidase L (MDSA) 4.2.2.15 pubmed
pubmed
Macrobdella decora AAC47263.1 Q27701 1SLI[A]
1SLL[A]
2SLI[A]
3SLI[A]
4SLI[A]
 sialidase (Neu1;Neu-1;G9) (lysosomal) 3.2.1.18 pubmed
Mus musculus AAC84167.1
AAC53536.1
AAH04666.1
BAE26586.1
CAA72215.1
CAD91185.1
NP_035023.2
O35657
Q3UL64
Q7TSW3
 
 cytosolic sialidase 3.2.1.18 pubmed
Mus musculus BAB39152.1
AAH26408.1
AAI05658.1
AAI05659.1
AAI05660.1
AAI05662.1
ACM77811.1
BAA92867.1
BAE26342.1
NP_056565.1
C0KJU9
Q0VGI4
Q3ULV6
Q8R0U7
Q9JMH3
 
 sialidase (Neu3) 3.2.1.18 pubmed
Mus musculus BAA92868.1
AAI16893.1
AAI16925.1
BAC34251.1
BAE22130.1
NP_057929.1
Q543I9
Q9JMH7
 
 sialidase 3a (Neu3A) 3.2.1.18 pubmed
Oryzias latipes Hd-rR BAL03608.1 G3XKV6  
 sialidase 3b (Neu3B) 3.2.1.18 pubmed
Oryzias latipes Hd-rR BAL03609.1 G3XKV7  
 sialidase 4 (Neu4) 3.2.1.18 pubmed
Oryzias latipes Hd-rR BAM74165.1 H2LPW5  
 sialidase 3.2.1.18 pubmed
Rattus norvegicus BAA03805.1
AAH91154.1
BAA09169.1
NP_058826.1
Q5BK97
Q64627
 
 KDNase 3.2.1.- doi
Trichophyton rubrum CMCC(F)T1i OAL63013.1   B[nd]
C[nd]
D[nd]
7P1Q[A]
7P1R[A]
7P1S[A]
7P1U[A]
7P1V[A]
 2,3-trans-sialidase (TbSA C2;Tb927.8.7350) 2.4.1.- pubmed
Trypanosoma brucei brucei TREU927 AAX69221.1 Q57YT7  
 trans-sialidase (Ts1e-1;TconTS1) (fragment) 2.4.1.- pubmed
Trypanosoma congolense CCD30512.1
CAD59552.1
CAH04004.1
G0WJG7
Q7YZT3
 
 trans-sialidase (Ts1B) (fragment) 2.4.1.- pubmed
Trypanosoma congolense CCD30509.1 G0WJG4  
 trans-sialidase 2.4.1.- pubmed
Trypanosoma cruzi AAO30669.1
AAT21541.1
ABH92705.1
BAA09334.1
Q26964  
 trans-sialidase (TcTS) 2.4.1.- pubmed
Trypanosoma cruzi AAA66352.1
AAO30670.1
AAT21542.1
Q26966 1MR5[A]
1MS0[A,B]
1MS1[A,B]
1MS3[A,B]
1MS4[A,B]
1MS5[A,B]
1MS8[A,B]
1MS9[A,B]
1S0I[A]
1S0J[A]
1S0K[A]
2AH2[A]
3B69[A]
3OPZ[A,B,C,M]
3PJQ[A]
 sialidase 85-1.1 3.2.1.18 pubmed
Trypanosoma cruzi CL AAA30245.1 P18269  
 sialidase SA85-1.2 3.2.1.18 pubmed
Trypanosoma cruzi CL AAA30246.1 Q03625  
 trans-sialidase (TcTS;Tc00.1047053509495.30) 2.4.1.- pubmed
Trypanosoma cruzi CL Brener EAN85580.1 Q4CZ79  
 trans-sialidase (TcTS-12) 2.4.1.- pubmed
Trypanosoma cruzi CL BRENER ACF17926.1 B3VSM4  
 trans-sialidase (TcTS-15) 2.4.1.- pubmed
Trypanosoma cruzi CL BRENER ACF17927.1 B3VSM5  
 trans-sialidase (TcTS-24) 2.4.1.- pubmed
Trypanosoma cruzi CL BRENER ACF17928.1 B3VSM6  
 trans-sialidase (TcTS-46) 2.4.1.- pubmed
Trypanosoma cruzi CL BRENER ACF17929.1 B3VSM7  
 trans-sialidase (TcTS-49) 2.4.1.- pubmed
Trypanosoma cruzi CL BRENER ACF17930.1 B3VSM8  
 trans-sialidase 2.4.1.- pubmed
Trypanosoma cruzi TULAHUEN AAA99444.1 Q26969  
 trans-sialidase (TCTS) 2.4.1.- pubmed
Trypanosoma cruzi Y-STRAIN CAC34453.1
ABH92692.1
Q9BHJ5  
 sialidase (TeSA) 3.2.1.18 pubmed
Trypanosoma evansi ACM43506.1    
 sialidase (TrSA) 3.2.1.18 pubmed
Trypanosoma rangeli AAC95493.1
AAC95494.1
AAC95495.1
O44049
Q7JNE5
Q7JNE6
1MZ5[A]
1MZ6[A]
1N1S[A]
1N1T[A]
1N1V[A]
1N1Y[A]
1WCS[A]
2A75[A]
2AGS[A]
2FHR[A]
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