Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); 2-keto-3-deoxynononic acid hydrolase (EC 3.2.1.-); anhydrosialidase (EC 4.2.2.15); 3-deoxy-D-manno-octulosonic-acid hydrolase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (3547); Uniprot accession (686); PDB accession (144); 3D entries (19); cryst (0)
All (3289) Archaea (1) Bacteria (2885) Eukaryota (371) Viruses (32) Structure (19) Characterized (96)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 sialidase (NanH) 3.2.1.18 Actinomyces viscosus T14V AAA21932.1 Q44562  
 sialidase (BF1729) 3.2.1.18 Bacteroides fragilis YCH46 BAA05853.1
AAA22912.1
BAC56895.1
BAC56895.2
BAD48476.1
P31206
P31206
 
 bimodular α-1,5-rhamnosidase / α-2,3-KDO-hydrolase (BT1013) 3.2.1.40
3.2.1.-
Bacteroides thetaiotaomicron VPI-5482 AAO76120.1
NP_809926.1
Q8A904  
 sialidase (BtsA;BTSA;BT0455) 3.2.1.18 Bacteroides thetaiotaomicron VPI-5482 AAO75562.1
NP_809368.1
Q8AAK9 4BBW[A]
 exo-α-sialidase (SiaBb2;BBP_0054) 3.2.1.18 Bifidobacterium bifidum JCM 1254 BAK26854.1    
 α-2,6- / α-2,3-sialidase (NanH1;Blon_0646) 3.2.1.- Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ51753.1 B7GPM3  
 α-2,6- / α-2,3-sialidase (NanH2;Blon_2348) 3.2.1.- Bifidobacterium longum subsp. infantis ATCC 15697 = JCM 1222 = DSM 20088 ACJ53406.1 B7GNQ0  
 sialidase (SiaC;CAPCAMM2a;Ccan_04790) 3.2.1.18 Capnocytophaga canimorsus Cc5 AEK22601.1
ACA13563.1
B5SV83  
 sialidase (NanA) (fragment) 3.2.1.18 Clostridium chauvoei JF4135 CAR82361.1 E1UGY4  
 sialidase 1 'small' 3.2.1.18 Clostridium perfringens A99 CAA68780.1 P10481  
 exo-α-sialidase 'large' (NanH) 3.2.1.18 Clostridium perfringens A99 CAA60796.1 Q59310  
 sialidase 2 (NanH) 3.2.1.18 Clostridium perfringens ATCC 10543 CAA50436.1 Q59311  
 sialidase (CpNanI;CPF_0721) 3.2.1.18 Clostridium perfringens ATCC 13124 ABG83208.1 Q0TT67 4L2E[A]
5TSP[A,B]
 exo-α-sialidase (NanJ;CPE0553) 3.2.1.18 Clostridium perfringens str. 13 BAB80259.1
NP_561469.1
Q8XMY5  
 exo-α-sialidase (NanI;CPSA;CPE0725) 3.2.1.18 Clostridium perfringens str. 13 BAB80431.1
NP_561641.1
Q8XMG4 2BF6[A]
2VK5[A]
2VK6[A]
2VK7[A,B]
 sialidase 3.2.1.18 Clostridium septicum NC0054714 CAA44916.1 P29767  
 sialidase (NanH;SiaH) 3.2.1.18 Clostridium tertium CAA69951.1 P77848  
 trans-sialidase (NanH;NanA) 2.4.1.- Corynebacterium diphtheriae KCTC 3075 ACS34893.1 C6JSW6  
 sialidase (NanA) 3.2.1.18 Edwardsiella tarda TX01 AFP73415.1    
 sialidase (NanH) 3.2.1.18 Erysipelothrix rhusiopathiae FUJISAWA BAB40435.1 Q9AJR8  
 lipid A Kdo hydrolase (KdhA;FTL_0465) 3.2.1.- Francisella tularensis subsp. holarctica LVS CAJ78905.1
AJI59416.1
Q2A4W5  
 lipid A Kdo hydrolase (KdoH1) (sialidase-like subunit) 3.2.1.- Francisella tularensis subsp. novicida U112 ADR71924.1
ABK89391.1
AJI60298.1
A0Q576  
 lipid A Kdo hydrolase (KdhA;FTT_0399c) 3.2.1.- Francisella tularensis subsp. tularensis SCHU S4 CAG45032.1    
 lipid A Kdo hydrolase (KdhA;HP0580;HP_0580) 3.2.1.- Helicobacter pylori 26695 AAD07646.1
NP_207375.1
   
 lipid A Kdo hydrolase (KdhA;lpg2939) 3.2.1.- Legionella pneumophila subsp. pneumophila str. Philadelphia 1 AAU28985.1
AGH52162.1
Q5ZRE3  
 sialidase (NedA) 3.2.1.18 Micromonospora viridifaciens BAA00852.1
AAQ70871.1
Q02834 1EUR[A]
1EUS[A]
1EUT[A]
1EUU[A]
1W8N[A]
1W8O[A]
1WCQ[A,B,C]
2BER[A]
2BQ9[A,B,C]
2BZD[A,B,C]
4J9T[A]
 sialidase M (Siα-AU;AuSia;AUSA) 3.2.1.18 Paenarthrobacter ureafaciens IFO 12140 / ATCC 7562 BAD66680.2
AAX22758.1
Q5W7Q2  
 sialidase 3.2.1.18 Paeniclostridium sordellii G12 AAA23280.1
AAB38297.1
P15698
P94675
 
 sialidase 3.2.1.18 Paeniclostridium sordellii G39 AAB38298.1 P94676  
 sialidase 3.2.1.18 Paeniclostridium sordellii G5 AAB38296.1 P94674  
 sialidase (NanH) 3.2.1.18 Pasteurella multocida 86-1913 AAG35310.1 Q9EZV6  
 sialidase (NanB) 3.2.1.18 Pasteurella multocida 86-1913 AAG35309.1 Q9EZV7  
 sialidase (PGN_1608) 3.2.1.18 Porphyromonas gingivalis ATCC 33277 BAG34127.1 B2RL82  
 sialidase (PG0352) 3.2.1.18 Porphyromonas gingivalis W83 AAQ65563.1
NP_904664.1
Q7MX62  
 anhydrosialidase (RgNanH;HMPREF1201_01421) (intramolecular) 4.2.2.15 Ruminococcus gnavus ETD19277.1   4X47[A]
4X49[A]
4X4A[A]
4X6K[A]
 sialidase (NanH;STSA) 3.2.1.18 Salmonella typhimurium TA262 AAA27168.1 P29768 1DIL[A]
1DIM[A]
2SIL[A]
2SIM[A]
3SIL[A]
 sialidase 3.2.1.18 Streptococcus intermedius ATCC 27335 BAJ15290.1 E0CZJ4  
 sialidase A (NanA) 3.2.1.18 Streptococcus pneumoniae 6 CAA51473.1
ACJ76903.1
B8XTT3
P62575
Q59959
5KKY[A,B]
 sialidase B (NanB) 3.2.1.18 Streptococcus pneumoniae 6 AAC44396.1
AAW08718.1
Q54727  
 sialidase B (NanB) 3.2.1.18 Streptococcus pneumoniae 6 AAC44396.1 Q54727  
 sialidase (NanC;SPCG_0853) 3.2.1.18 Streptococcus pneumoniae CGSP14 ACB90105.1 B2IP34  
 sialidase (NanC;SPCG_0853) 3.2.1.18 Streptococcus pneumoniae CGSP14 ACB90105.1 B2IP34  
 sialidase (NanA;SPD_1504) 3.2.1.18 Streptococcus pneumoniae D39 ABJ55437.1 Q04J78  
 neuraminidase (NanC) 3.2.1.18 Streptococcus pneumoniae G54 ACF56230.1 B5E561 4YW0[A,B]
4YW1[A,B]
4YW2[A,B]
4YW3[A,B]
4YW4[A,B]
4YW5[A,B]
4YZ1[A,B]
4YZ2[A,B]
4YZ3[A,B]
4YZ4[A,B]
4YZ5[A,B]
5F9T[A,B]
 neuraminidase (NanC) 3.2.1.18 Streptococcus pneumoniae G54 ACF56230.1 B5E561 4YW0[A,B]
4YW1[A,B]
4YW2[A,B]
4YW3[A,B]
4YW4[A,B]
4YW5[A,B]
4YZ1[A,B]
4YZ2[A,B]
4YZ3[A,B]
4YZ4[A,B]
4YZ5[A,B]
5F9T[A,B]
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727 2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
4XE9[A]
4XHB[A]
4XHX[A]
4XIK[A]
4XIL[A]
4XIO[A]
4XJ8[A]
4XJ9[A]
4XJA[A]
4XJU[A]
4XJW[A]
4XJZ[A]
4XMA[A]
4XMI[A]
4XOG[A]
4XYX[A]
 intramolecular trans-sialidase B (NanB;SP_1687) 4.2.2.15 Streptococcus pneumoniae TIGR4 AAK75766.1
NP_346126.1
Q54727 2JKB[A]
2VW0[A]
2VW1[A]
2VW2[A]
4FOQ[A]
4FOV[A]
4FOW[A]
4FOY[A]
4FP2[A]
4FP3[A]
4FPC[A]
4FPE[A]
4FPF[A]
4FPG[A]
4FPH[A]
4FPJ[A]
4FPK[A]
4FPL[A]
4FPO[B]
4FPY[A]
4FQ4[A]
4XE9[A]
4XHB[A]
4XHX[A]
4XIK[A]
4XIL[A]
4XIO[A]
4XJ8[A]
4XJ9[A]
4XJA[A]
4XJU[A]
4XJW[A]
4XJZ[A]
4XMA[A]
4XMI[A]
4XOG[A]
4XYX[A]
 sialidase (NanH;TF0036;BFO_2207) 3.2.1.18 Tannerella forsythia 92A2 ATCC 43037 AEW22573.1    
 exo-neuraminidase (TdNeu;TDE0471) 3.2.1.18 Treponema denticola ATCC 35405 AAS10966.1
NP_971085.1
Q73QH2  
 sialidase (NanH) 3.2.1.18 Trueperella pyogenes AAK15462.1 Q9AHP2  
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1 P37060 1KIT[A]
1W0O[A]
1W0P[A]
 sialidase / neuraminidase (NanH;VcNA;VCSA) 3.2.1.18 Vibrio cholerae 569B 395 AAA27546.1 P37060 1KIT[A]
1W0O[A]
1W0P[A]
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 2-keto-3-deoxynononic acid sialidase (KDNase;AfKDNase;Afu4g13800;AFUA_4G13800) (6407) 3.2.1.18
3.2.1.-
Aspergillus fumigatus Af293 EAL89414.2   2XCY[A,B]
2XZI[A,B]
2XZJ[A,B]
2XZK[A,B]
4M4N[A,B]
4M4U[A,B]
4M4V[A,B]
 ganglioside sialidase (Neu3) 3.2.1.18 Bos taurus BAA75071.1
AAE69071.1
NP_776547.1
O97859  
 sialidase 3.2.1.18 Cricetulus griseus AAA19746.1 Q64393  
 sialidase (Neu3.2) 3.2.1.18 Danio rerio AAH77080.1
AAH96984.1
AAI52169.1
ABO30983.1
Q6DEM9  
 sialidase (Neu4) 3.2.1.18 Danio rerio AAH95117.1
AAI65570.1
ABO45315.1
Q503Z4  
 sialidase (Neu3.3) 3.2.1.18 Danio rerio AAI25932.1
AAI16604.1
AAI64496.1
ABO30989.1
ABO30991.1
A0JMM3  
 sialidase (Neu3.1) 3.2.1.18 Danio rerio AAI27593.1
ABO30984.1
A0PJS4  
 ganglioside sialidase (Neu3) 3.2.1.18 Homo sapiens AAE69072.1
AAI36398.1
AAI44060.1
ACM83942.1
BAA82611.1
BAF83131.1
BAG51074.1
BAG64566.1
CAB96131.1
CAE90379.1
NP_006647.2
XP_035091.1
Q9UQ49  
 sialidase (Neu2) (cytosolic) 3.2.1.18 Homo sapiens CAB41449.1
AAH69151.1
AAI07054.1
AAY24360.1
NP_005374.1
Q9Y3R4 1SNT[A]
1SO7[A]
1VCU[A,B]
2F0Z[A]
2F10[A]
2F11[A]
2F12[A]
2F13[A]
2F24[A]
2F25[A,B]
2F26[A]
2F27[A,B]
2F28[A]
2F29[A,B]
4NC5[A]
4NCS[A]
 lysosomal sialidase (Neu1;Neu-1;NanH;G9) 3.2.1.18 Homo sapiens AAB96774.1
AAD09239.1
AAD21814.1
AAH00722.1
AAH11900.1
AAP35870.1
ACM80442.1
ACM85519.1
AQY76954.1
AQY76955.1
BAB63297.1
BAD92248.1
BAF83655.1
CAA55356.1
CAG32998.1
CAG46714.1
CAI17742.1
CAI18221.1
CAI41850.1
CAM26147.1
CAQ08322.1
CAQ09153.1
CAQ09305.1
CAQ09512.1
NP_000425.1
Q5JQI0
Q99519
 
 sialidase (Neu4;LOC129807) (long-form mitochondria;short-form ER) 3.2.1.18 Homo sapiens AAH12899.2
AAH63465.1
AAI05975.1
AAI17215.1
AAP34475.1
AAX82022.1
ABA66598.1
BAF82110.1
BAF82765.1
BAG52266.1
BAH12778.1
BAH13385.1
CAC81904.1
NP_542779.2
A8K056
B3KR54
Q8WWR8
 
 intramolecular trans-sialidase L (MDSA) 4.2.2.15 Macrobdella decora AAC47263.1 Q27701 1SLI[A]
1SLL[A]
2SLI[A]
3SLI[A]
4SLI[A]
 intramolecular trans-sialidase L (MDSA) 4.2.2.15 Macrobdella decora AAC47263.1 Q27701 1SLI[A]
1SLL[A]
2SLI[A]
3SLI[A]
4SLI[A]
 sialidase (Neu1;Neu-1;G9) (lysosomal) 3.2.1.18 Mus musculus AAC84167.1
AAC53536.1
AAH04666.1
BAE26586.1
CAA72215.1
CAD91185.1
NP_035023.2
O35657
Q3UL64
Q7TSW3
 
 cytosolic sialidase 3.2.1.18 Mus musculus BAB39152.1
AAH26408.1
AAI05658.1
AAI05659.1
AAI05660.1
AAI05662.1
ACM77811.1
BAA92867.1
BAE26342.1
NP_056565.1
Q0VGI4
Q8R0U7
Q9JMH3
 
 sialidase (Neu3) 3.2.1.18 Mus musculus BAA92868.1
AAI16893.1
AAI16925.1
BAC34251.1
BAE22130.1
NP_057929.1
Q543I9
Q9JMH7
 
 sialidase 3a (Neu3A) 3.2.1.18 Oryzias latipes Hd-rR BAL03608.1    
 sialidase 3b (Neu3B) 3.2.1.18 Oryzias latipes Hd-rR BAL03609.1    
 sialidase 4 (Neu4) 3.2.1.18 Oryzias latipes Hd-rR BAM74165.1    
 sialidase (Pc22g00140) 3.2.1.18 Penicillium rubens Wisconsin 54-1255 CAT16707.1
CAP97302.1
CAX30683.1
B6HP74  
 sialidase 3.2.1.18 Rattus norvegicus BAA03805.1
AAH91154.1
BAA09169.1
NP_058826.1
Q64627  
 sialidase (Neu1) 3.2.1.18 Rattus norvegicus BAB21443.1
AAI00640.1
CAE83976.1
NP_113710.1
Q99PW3  
 sialidase (Neu3) 3.2.1.18 Rattus norvegicus BAB32440.1
AAI00626.1
NP_446462.1
Q99PW5  
 2-2,3-trans-sialidase (TbSA C2;Tb927.8.7350) 2.4.1.- Trypanosoma brucei AAX69221.1 Q57YT7  
 trans-sialidase (Ts1e-1;TconTS1) (fragment) 2.4.1.- Trypanosoma congolense CCD30512.1
CAD59552.1
CAH04004.1
Q7YZT3  
 trans-sialidase (Ts1B) (fragment) 2.4.1.- Trypanosoma congolense CCD30509.1    
 trans-sialidase 2.4.1.- Trypanosoma cruzi AAC98544.1
BAD99565.1
BAD99566.1
Q26850  
 trans-sialidase 2.4.1.- Trypanosoma cruzi AAO30669.1
AAT21541.1
ABH92705.1
BAA09334.1
Q26964  
 trans-sialidase (TcTS) 2.4.1.- Trypanosoma cruzi AAA66352.1
AAO30670.1
AAT21542.1
Q26966 1MR5[A]
1MS0[A,B]
1MS1[A,B]
1MS3[A,B]
1MS4[A,B]
1MS5[A,B]
1MS8[A,B]
1MS9[A,B]
1S0I[A]
1S0J[A]
1S0K[A]
2AH2[A]
3B69[A]
3OPZ[A,B,C,M]
3PJQ[A]
 sialidase 85-1.1 3.2.1.18 Trypanosoma cruzi CL AAA30245.1 P18269  
 sialidase SA85-1.2 3.2.1.18 Trypanosoma cruzi CL AAA30246.1 Q03625  
 trans-sialidase (TcTS;Tc00.1047053509495.30) 2.4.1.- Trypanosoma cruzi CL Brener EAN85580.1    
 trans-sialidase (TcTS-12) 2.4.1.- Trypanosoma cruzi CL BRENER ACF17926.1 B3VSM4  
 trans-sialidase (TcTS-15) 2.4.1.- Trypanosoma cruzi CL BRENER ACF17927.1 B3VSM5  
 trans-sialidase (TcTS-24) 2.4.1.- Trypanosoma cruzi CL BRENER ACF17928.1 B3VSM6  
 trans-sialidase (TcTS-46) 2.4.1.- Trypanosoma cruzi CL BRENER ACF17929.1 B3VSM7  
 trans-sialidase (TcTS-49) 2.4.1.- Trypanosoma cruzi CL BRENER ACF17930.1 B3VSM8  
 trans-sialidase 2.4.1.- Trypanosoma cruzi TULAHUEN AAA99444.1 Q26969  
 trans-sialidase (TCTS) 2.4.1.- Trypanosoma cruzi Y-STRAIN CAC34453.1
ABH92692.1
Q9BHJ5  
 sialidase (TrSA) 3.2.1.18 Trypanosoma rangeli AAC95493.1
AAC95494.1
AAC95495.1
O44049 1MZ5[A]
1MZ6[A]
1N1S[A]
1N1T[A]
1N1V[A]
1N1Y[A]
2A75[A]
2AGS[A]
2FHR[A]
 sialidase 3.2.1.18 Trypanosoma rangeli AAA18835.1 Q08672  
 sialidase (fragment) 3.2.1.18 Trypanosoma rangeli AAC47213.1 Q27063  
 sialidase 3.2.1.18 Trypanosoma rangeli AAC47214.1 Q27064  
Viruses
Protein Name EC#OrganismGenBank UniprotPDB/3D
 sialidase 3.2.1.18 Frog adenovirus 1 AAF86921.1
NP_062432.1
Q9III6  
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