Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (7303); Uniprot accession (682); PDB accession (159); 3D entries (21); cryst (0)
All (7041) Archaea (1) Bacteria (6522) Eukaryota (459) Viruses (52) unclassified (7) Structure (21) Characterized (97)
| 1 | 2 | 3 | 4 | 5 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 CB5_LOCUS25028 (fragment)   Ananas comosus var. bracteatus VUW74443.1
CAB5276718.1
   
 CB5_LOCUS1899   Ananas comosus var. bracteatus VUW51322.1
CAB5253597.1
   
 CB5_LOCUS2438   Ananas comosus var. bracteatus CAD1819227.1    
 sialidase 3 (Neu3)   Anguilla japonica BBK08074.1    
 AARE701A_ LOCUS 21765   Arabidopsis arenosa CAE6246080.1    
 At5g57700   Arabidopsis thaliana ABL66729.1
ABN04833.1
AED96937.1
AED96938.1
AED96939.1
AED96940.1
ANM69688.1
Q3E8A0  
 DS421_1g22030   Arachis hypogaea QHO50380.1    
 DS421_1g22040   Arachis hypogaea QHO50381.1    
 DS421_11g350210   Arachis hypogaea QHO21847.1    
 DS421_11g350210   Arachis hypogaea QHO21847.1    
 G4B11_001939   Aspergillus flavus AF13 QMW38703.1    
 F9C07_1010146   Aspergillus flavus NRRL 3357 QRD87235.1    
 G4B84_001869   Aspergillus flavus NRRL3357 QMW26624.1    
 2-keto-3-deoxynononic acid sialidase (KDNase;AfKDNase;Afu4g13800;AFUA_4G13800) (6407) 3.2.1.18
3.2.1.-
Aspergillus fumigatus Af293 EAL89414.2   2XCY[A,B]
2XZI[A,B]
2XZJ[A,B]
2XZK[A,B]
4M4N[A,B]
4M4U[A,B]
4M4V[A,B]
 AKAW2_60324S   Aspergillus luchuensis IFO 4308 BCS02060.1    
 ALUC_60302S   Aspergillus luchuensis RIB2601 BCS13746.1    
 An15g04260   Aspergillus niger CBS 513.88 CAK97293.1 A2R5G8  
 AO090005000203   Aspergillus oryzae RIB40 BAE55299.1 Q2UT16  
 APUU_41633A   Aspergillus puulaauensis MK2 BCS25189.1    
 APUU_31740S   Aspergillus puulaauensis MK2 BCS23515.1    
 APUU_40009A   Aspergillus puulaauensis MK2 BCS23565.1    
 sialidase-1a (Neu1A)   Astyanax mexicanus BCM73181.1    
 sialidase-1b (Neu1B)   Astyanax mexicanus BCM73182.1    
 Bathy16g00540   Bathycoccus prasinos RCC1105 CCO20205.1    
 Bathy17g00380   Bathycoccus prasinos RCC1105 CCO20385.1    
 Bathy08g04480   Bathycoccus prasinos RCC1105 CCO17529.1    
 Bathy08g01990   Bathycoccus prasinos RCC1105 CCO17967.1    
 Bathy10g03050   Bathycoccus prasinos RCC1105 CCO18064.1    
 Bathy04g01130   Bathycoccus prasinos RCC1105 CCO16089.1    
 Bathy05g00010   Bathycoccus prasinos RCC1105 CCO16590.1    
 Bathy06g00870   Bathycoccus prasinos RCC1105 CCO17015.1    
 Bathy08g03560   Bathycoccus prasinos RCC1105 CCO17660.1    
 Bathy14g00020   Bathycoccus prasinos RCC1105 CCO19653.1    
 Bathy04g00010   Bathycoccus prasinos RCC1105 CCO16144.1    
 Bathy15g00720   Bathycoccus prasinos RCC1105 CCO20068.1    
 Bathy11g03110   Bathycoccus prasinos RCC1105 CCO18691.1    
 Bathy01g05620   Bathycoccus prasinos RCC1105 CCO14569.1    
 Bathy01g02780   Bathycoccus prasinos RCC1105 CCO14665.1    
 Bathy09g00330   Bathycoccus prasinos RCC1105 CCO66844.1    
 ganglioside sialidase (Neu3) 3.2.1.18 Bos taurus BAA75071.1
AAE69071.1
NP_776547.1
O97859  
 Neu1   Bos taurus AAI34572.1
AAX14675.1
BAF64705.1
A6BMK7  
 NEU1 (fragment)   Bos taurus AAY57798.1 Q3KUS4  
 CDS3   Branchiostoma floridae AAM18894.1
AAP78738.1
Q8T750  
 neuraminidase-like 2 (fragment)   Branchiostoma floridae AAP78741.1 Q6XA13  
 BOLC3T13925H   Brassica oleracea VDC87601.1    
 BRAA03T10577Z   Brassica rapa VDC79359.1    
 NEU1-like protein (fragment)   Callithrix jacchus ABQ22731.1 A6MKZ0  
 ORF (fragment)   Callorhinchus milii AFP09348.1    
 ORF (fragment)   Callorhinchus milii AFP10096.1    
 Neu1 (LOC481717)   Canis lupus familiaris XP_538838.2    
 sialidase 2 (Neu2)   Castor fiber AJE28210.1    
 A3770_01p00940   Chloropicon primus CCMP1205 QDZ17576.1    
 A3770_03p23490   Chloropicon primus CCMP1205 QDZ19831.1    
 A3770_04p29450   Chloropicon primus CCMP1205 QDZ20427.1    
 A3770_02p19230   Chloropicon primus CCMP1205 QDZ19405.1    
 A3770_06p43010   Chloropicon primus CCMP1205 QDZ21783.1    
 A3770_02p11390 (fragment)   Chloropicon primus CCMP1205 QDZ18621.1    
 A3770_03p20240   Chloropicon primus CCMP1205 QDZ19506.1    
 A3770_01p00300   Chloropicon primus CCMP1205 QDZ17512.1    
 A3770_09p56020 (fragment)   Chloropicon primus CCMP1205 QDZ23084.1    
 CSTEINMANNI_LOCUS4563122   Coregonus sp. balchen CAB1351335.1    
 CSTEINMANNI_LOCUS2411883   Coregonus sp. balchen CAB1333015.1    
 CSTEINMANNI_LOCUS1016227   Coregonus sp. balchen CAB1321104.1    
 CSTEINMANNI_LOCUS508934   Coregonus sp. balchen CAB1316010.1    
 CSTEINMANNI_LOCUS4188021 (fragment)   Coregonus sp. balchen CAB1348287.1    
 α-Kdo-ase, partial   Crassostrea virginica AKN35211.1    
 sialidase I (Neu1)   Cricetulus griseus ACL52160.1 B8Y440  
 sialidase III (Neu3)   Cricetulus griseus ACL52161.1 B8Y441  
 sialidase 3.2.1.18 Cricetulus griseus AAA19746.1 Q64393  
 CGB_H0050C   Cryptococcus gattii WM276 ADV23792.1    
 CNAG_02255   Cryptococcus neoformans var. grubii H99 AFR95572.2
AFR95572.1
   
 CKF44_002026   Cryptococcus neoformans var. grubii KN99 AUB25393.1    
 CNE02900   Cryptococcus neoformans var. neoformans JEC21 AAW43695.1 Q5KGN6  
 sialidase (Neu3.2) 3.2.1.18 Danio rerio AAH77080.1
AAH96984.1
AAI52169.1
ABO30983.1
Q6DEM9  
 sialidase (Neu4) 3.2.1.18 Danio rerio AAH95117.1
AAI65570.1
ABO45315.1
Q503Z4  
 CH211-222E23.1-001 (Neu1)   Danio rerio CAK04566.1
AAI33833.1
NP_001038374.1
Q1LWP9  
 sialidase (Neu3.3) 3.2.1.18 Danio rerio AAI25932.1
AAI16604.1
AAI64496.1
ABO30989.1
ABO30991.1
A0JMM3  
 sialidase (Neu3.1) 3.2.1.18 Danio rerio AAI27593.1
ABO30984.1
A0PJS4  
 Neu3.4   Danio rerio ABO30987.1 A7TUD7  
 Neu3.5   Danio rerio ABO30985.1 A7TUD6  
 sialidase 1 (Neu1)   Danio rerio RIKEN WT (RW) BBD12706.1    
 DSTB1V02_LOCUS14265 (fragment)   Darwinula stevensoni CAD7254519.1    
 DSTB1V02_LOCUS14265 (fragment)   Darwinula stevensoni CAD7254519.1    
 C2857_000482   Epichloe festucae Fl1 QPH09593.1    
 CEK26_011575   Fusarium fujikuroi Augusto2 QGI98506.1    
 CEK27_011593   Fusarium fujikuroi CSV1 QGI67622.1    
 CEK25_011580   Fusarium fujikuroi I1.3 QGI84851.1    
 FFUJ_14037   Fusarium fujikuroi IMI 58289 CCT71969.1    
 FGRAMCML3066_01t04419.1   Fusarium graminearum CZS77267.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF73999.1    
 FOBC_02665   Fusarium oxysporum Fo47 QKD48655.1    
 FVRRES_02150   Fusarium venenatum A3/5 CEI65638.1    
 sialidase (Neu3) (membrane-bound)   Gallus gallus ADJ19117.1    
 membrane-bound sialidase (Neu3)   Gallus gallus ADJ19118.1    
 unknown   Glycine max ACU18568.1 C6T9R6  
 ganglioside sialidase (Neu3) 3.2.1.18 Homo sapiens AAE69072.1
AAI36398.1
AAI44060.1
ACM83942.1
BAA82611.1
BAF83131.1
BAG51074.1
BAG64566.1
CAB96131.1
CAE90379.1
NP_006647.2
XP_035091.1
Q9UQ49  
 sialidase (Neu2) (cytosolic) 3.2.1.18 Homo sapiens CAB41449.1
AAH69151.1
AAI07054.1
AAY24360.1
NP_005374.1
Q9Y3R4 1SNT[A]
1SO7[A]
1VCU[A,B]
2F0Z[A]
2F10[A]
2F11[A]
2F12[A]
2F13[A]
2F24[A]
2F25[A,B]
2F26[A]
2F27[A,B]
2F28[A]
2F29[A,B]
4NC5[A]
4NCS[A]
 lysosomal sialidase (Neu1;Neu-1;NanH;G9) 3.2.1.18 Homo sapiens AAB96774.1
AAD09239.1
AAD21814.1
AAH00722.1
AAH11900.1
AAP35870.1
ACM80442.1
ACM85519.1
AQY76954.1
AQY76955.1
BAB63297.1
BAD92248.1
BAF83655.1
CAA55356.1
CAG32998.1
CAG46714.1
CAI17742.1
CAI18221.1
CAI41850.1
CAM26147.1
CAQ08322.1
CAQ09153.1
CAQ09305.1
CAQ09512.1
NP_000425.1
Q5JQI0
Q99519
 
 sialidase (Neu4;LOC129807) (long-form mitochondria;short-form ER) 3.2.1.18 Homo sapiens AAH12899.2
AAH63465.1
AAI05975.1
AAI17215.1
AAP34475.1
AAX82022.1
ABA66598.1
BAF82110.1
BAF82765.1
BAG52266.1
BAH12778.1
BAH13385.1
CAC81904.1
NP_542779.2
A8K056
B3KR54
Q8WWR8
 
 ORF (Neu4)   Ictalurus punctatus AHH38364.1    
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