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Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (5098); Uniprot accession (686); PDB accession (146); 3D entries (19); cryst (0)
Summary
All (4861) Archaea (1) Bacteria (4415) Eukaryota (389) Viruses (34) unclassified (22) Structure (19) Characterized (96)
| 1 | 2 | 3 | 4 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 At5g57700   Arabidopsis thaliana ABL66729.1
ABN04833.1
AED96937.1
AED96938.1
AED96939.1
AED96940.1
ANM69688.1		 Q3E8A0  
 2-keto-3-deoxynononic acid sialidase (KDNase;AfKDNase;Afu4g13800;AFUA_4G13800) (6407) 3.2.1.18
3.2.1.-		 Aspergillus fumigatus Af293 EAL89414.2   2XCY[A,B]
2XZI[A,B]
2XZJ[A,B]
2XZK[A,B]
4M4N[A,B]
4M4U[A,B]
4M4V[A,B]
 An15g04260   Aspergillus niger CBS 513.88 CAK97293.1 A2R5G8  
 AO090005000203   Aspergillus oryzae RIB40 BAE55299.1 Q2UT16  
 Bathy16g00540   Bathycoccus prasinos RCC1105 CCO20205.1    
 Bathy17g00380   Bathycoccus prasinos RCC1105 CCO20385.1    
 Bathy08g04480   Bathycoccus prasinos RCC1105 CCO17529.1    
 Bathy08g01990   Bathycoccus prasinos RCC1105 CCO17967.1    
 Bathy10g03050   Bathycoccus prasinos RCC1105 CCO18064.1    
 Bathy04g01130   Bathycoccus prasinos RCC1105 CCO16089.1    
 Bathy05g00010   Bathycoccus prasinos RCC1105 CCO16590.1    
 Bathy06g00870   Bathycoccus prasinos RCC1105 CCO17015.1    
 Bathy08g03560   Bathycoccus prasinos RCC1105 CCO17660.1    
 Bathy14g00020   Bathycoccus prasinos RCC1105 CCO19653.1    
 Bathy04g00010   Bathycoccus prasinos RCC1105 CCO16144.1    
 Bathy15g00720   Bathycoccus prasinos RCC1105 CCO20068.1    
 Bathy11g03110   Bathycoccus prasinos RCC1105 CCO18691.1    
 Bathy01g05620   Bathycoccus prasinos RCC1105 CCO14569.1    
 Bathy01g02780   Bathycoccus prasinos RCC1105 CCO14665.1    
 Bathy09g00330   Bathycoccus prasinos RCC1105 CCO66844.1    
 ganglioside sialidase (Neu3) 3.2.1.18 Bos taurus BAA75071.1
AAE69071.1
NP_776547.1		 O97859  
 Neu1   Bos taurus AAI34572.1
AAX14675.1
BAF64705.1		 A6BMK7  
 NEU1 (fragment)   Bos taurus AAY57798.1 Q3KUS4  
 CDS3   Branchiostoma floridae AAM18894.1
AAP78738.1		 Q8T750  
 neuraminidase-like 2 (fragment)   Branchiostoma floridae AAP78741.1 Q6XA13  
 BOLC3T13925H   Brassica oleracea VDC87601.1    
 BRAA03T10577Z   Brassica rapa VDC79359.1    
 NEU1-like protein (fragment)   Callithrix jacchus ABQ22731.1 A6MKZ0  
 ORF (fragment)   Callorhinchus milii AFP09348.1    
 ORF (fragment)   Callorhinchus milii AFP10096.1    
 Neu1 (LOC481717)   Canis lupus familiaris XP_538838.2    
 sialidase 2 (Neu2)   Castor fiber AJE28210.1    
 α-Kdo-ase, partial   Crassostrea virginica AKN35211.1    
 sialidase I (Neu1)   Cricetulus griseus ACL52160.1 B8Y440  
 sialidase III (Neu3)   Cricetulus griseus ACL52161.1 B8Y441  
 sialidase 3.2.1.18 Cricetulus griseus AAA19746.1 Q64393  
 CGB_H0050C   Cryptococcus gattii WM276 ADV23792.1    
 CNAG_02255   Cryptococcus neoformans var. grubii H99 AFR95572.2
AFR95572.1		    
 CKF44_002026   Cryptococcus neoformans var. grubii KN99 AUB25393.1    
 CNE02900   Cryptococcus neoformans var. neoformans JEC21 AAW43695.1 Q5KGN6  
 sialidase (Neu3.2) 3.2.1.18 Danio rerio AAH77080.1
AAH96984.1
AAI52169.1
ABO30983.1		 Q6DEM9  
 sialidase (Neu4) 3.2.1.18 Danio rerio AAH95117.1
AAI65570.1
ABO45315.1		 Q503Z4  
 CH211-222E23.1-001 (Neu1)   Danio rerio CAK04566.1
AAI33833.1
NP_001038374.1		 Q1LWP9  
 sialidase (Neu3.3) 3.2.1.18 Danio rerio AAI25932.1
AAI16604.1
AAI64496.1
ABO30989.1
ABO30991.1		 A0JMM3  
 sialidase (Neu3.1) 3.2.1.18 Danio rerio AAI27593.1
ABO30984.1		 A0PJS4  
 Neu3.4   Danio rerio ABO30987.1 A7TUD7  
 Neu3.5   Danio rerio ABO30985.1 A7TUD6  
 sialidase 1 (Neu1)   Danio rerio RIKEN WT (RW) BBD12706.1    
 FFUJ_14037   Fusarium fujikuroi IMI 58289 CCT71969.1    
 unnamed protein product   Fusarium graminearum PH-1 CEF73999.1    
 FVRRES_02150   Fusarium venenatum A3/5 CEI65638.1    
 sialidase (Neu3) (membrane-bound)   Gallus gallus ADJ19117.1    
 membrane-bound sialidase (Neu3)   Gallus gallus ADJ19118.1    
 unknown   Glycine max ACU18568.1 C6T9R6  
 ganglioside sialidase (Neu3) 3.2.1.18 Homo sapiens AAE69072.1
AAI36398.1
AAI44060.1
ACM83942.1
BAA82611.1
BAF83131.1
BAG51074.1
BAG64566.1
CAB96131.1
CAE90379.1
NP_006647.2
XP_035091.1		 Q9UQ49  
 sialidase (Neu2) (cytosolic) 3.2.1.18 Homo sapiens CAB41449.1
AAH69151.1
AAI07054.1
AAY24360.1
NP_005374.1		 Q9Y3R4 1SNT[A]
1SO7[A]
1VCU[A,B]
2F0Z[A]
2F10[A]
2F11[A]
2F12[A]
2F13[A]
2F24[A]
2F25[A,B]
2F26[A]
2F27[A,B]
2F28[A]
2F29[A,B]
4NC5[A]
4NCS[A]
 lysosomal sialidase (Neu1;Neu-1;NanH;G9) 3.2.1.18 Homo sapiens AAB96774.1
AAD09239.1
AAD21814.1
AAH00722.1
AAH11900.1
AAP35870.1
ACM80442.1
ACM85519.1
AQY76954.1
AQY76955.1
BAB63297.1
BAD92248.1
BAF83655.1
CAA55356.1
CAG32998.1
CAG46714.1
CAI17742.1
CAI18221.1
CAI41850.1
CAM26147.1
CAQ08322.1
CAQ09153.1
CAQ09305.1
CAQ09512.1
NP_000425.1		 Q5JQI0
Q99519		  
 sialidase (Neu4;LOC129807) (long-form mitochondria;short-form ER) 3.2.1.18 Homo sapiens AAH12899.2
AAH63465.1
AAI05975.1
AAI17215.1
AAP34475.1
AAX82022.1
ABA66598.1
BAF82110.1
BAF82765.1
BAG52266.1
BAH12778.1
BAH13385.1
CAC81904.1
NP_542779.2		 A8K056
B3KR54
Q8WWR8		  
 ORF (Neu4)   Ictalurus punctatus AHH38364.1    
 ORF (Neu1)   Ictalurus punctatus AHH42613.1    
 sialidase 3 (Neu3)   Lepisosteus oculatus BBF90656.1    
 sialidase 4 (Neu4)   Lepisosteus oculatus BBG56146.1    
 sialidase-4 isoform 1, partial (Neu4) (fragment)   Macaca mulatta AFE69054.1    
 sialidase-3, partial (Neu3) (fragment)   Macaca mulatta AFE69772.1    
 sialidase-1 precursor (Neu1)   Macaca mulatta AFE78411.1    
 sialidase-1 precursor (Neu1)   Macaca mulatta AFH32517.1
AFI37231.1		    
 intramolecular trans-sialidase L (MDSA) 4.2.2.15 Macrobdella decora AAC47263.1 Q27701 1SLI[A]
1SLL[A]
2SLI[A]
3SLI[A]
4SLI[A]
 intramolecular trans-sialidase L (MDSA) 4.2.2.15 Macrobdella decora AAC47263.1 Q27701 1SLI[A]
1SLL[A]
2SLI[A]
3SLI[A]
4SLI[A]
 MtrDRAFT_AC136954g2v1   Medicago truncatula ABE81277.1
ABE81277.2		    
 MtrDRAFT_AC157348g16v1   Medicago truncatula ABE86419.1
ABO79513.1		    
 MtrDRAFT_AC157348g13v1   Medicago truncatula ABE86417.1    
 neuraminidase 4   Mus musculus AAP81169.1
AAH70438.1
BAC28641.1
BAH79965.1
NP_776133.1		 C5NTX9
Q6NS66
Q8BZL1		  
 sialidase (Neu1;Neu-1;G9) (lysosomal) 3.2.1.18 Mus musculus AAC84167.1
AAC53536.1
AAH04666.1
BAE26586.1
CAA72215.1
CAD91185.1
NP_035023.2		 O35657
Q3UL64
Q7TSW3		  
 cytosolic sialidase 3.2.1.18 Mus musculus BAB39152.1
AAH26408.1
AAI05658.1
AAI05659.1
AAI05660.1
AAI05662.1
ACM77811.1
BAA92867.1
BAE26342.1
NP_056565.1		 Q0VGI4
Q8R0U7
Q9JMH3		  
 sialidase (Neu3) 3.2.1.18 Mus musculus BAA92868.1
AAI16893.1
AAI16925.1
BAC34251.1
BAE22130.1
NP_057929.1		 Q543I9
Q9JMH7		  
 sialidase 1   Mustela putorius furo AES02815.1    
 sialidase 1a (Neu1A)   Oreochromis niloticus BAR71186.1    
 sialidase 4 (Neu4) (fragment)   Oreochromis niloticus BAR79852.1    
 sialidase neu1b   Oreochromis niloticus BAT70756.1    
 sialidase 3a (Neu3A)   Oreochromis niloticus BAO79779.1    
 ORF   Oreochromis niloticus BAO79780.1    
 ORF   Oreochromis niloticus BAO79781.1    
 sialidase 3d (Neu3D)   Oreochromis niloticus BAO79782.1    
 sialidase 3e (Neu3E)   Oreochromis niloticus BAO79783.1    
 OSNPB_070516050 (Os07g0516050)   Oryza sativa Japonica Group BAT01757.1    
 Os07g0516000   Oryza sativa Japonica Group BAF21693.1
BAT01756.1		 Q7F0N4  
 sialidase 3a (Neu3A) 3.2.1.18 Oryzias latipes Hd-rR BAL03608.1    
 sialidase 3b (Neu3B) 3.2.1.18 Oryzias latipes Hd-rR BAL03609.1    
 sialidase 4 (Neu4) 3.2.1.18 Oryzias latipes Hd-rR BAM74165.1    
 sialidase 1 (Neu1)   Oryzias latipes Hd-rR BAO47775.1    
 Pc21g12200   Penicillium rubens Wisconsin 54-1255 CAP96117.1 B6HLA6  
 sialidase (Pc22g00140) 3.2.1.18 Penicillium rubens Wisconsin 54-1255 CAT16707.1
CAP97302.1
CAX30683.1		 B6HP74  
 182F10 (fragment)   Philodina roseola ACD54789.1 B3G4P1  
 DKFZp468G0924 (probable fragment)   Pongo abelii CAH89766.1 Q5REP1  
 DKFZp469E1532   Pongo abelii CAH89635.1 Q5RAF4  
 DKFZp468K0928   Pongo abelii CAH91256.1 Q5RAF4  
 DKFZp459L0538 (fragment)   Pongo abelii CAH91396.1 Q5RAF4  
 sialidase 1 (Neu1)   Pseudorca crassidens BBG43806.1    
 PoMZ_05120   Pyricularia oryzae QBZ63439.1    
 sialidase 3.2.1.18 Rattus norvegicus BAA03805.1
AAH91154.1
BAA09169.1
NP_058826.1		 Q64627  
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