Glycoside Hydrolase Family 33

Known Activities	sialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); 2-keto-3-deoxynononic acid sialidase (EC 3.2.1.-)
Mechanism	Retaining
Clan	GH-E
3D Structure Status	6-fold β-propeller
Catalytic Nucleophile/Base	Tyr+Glu
Catalytic Proton Donor	Not known
External resources	HOMSTRAD; InterPro; MEGAZYME; PFAM;
Statistics	GenBank accession (1171); Uniprot accession (653); PDB accession (83); 3D entries (12); cryst (0)

Summary

All (938) Bacteria (683) Eukaryota (245) Viruses (10) Structure (12 ) Characterized (76)

Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
exo-α-sialidase (NanI;CPE0725)	3.2.1.18	Clostridium perfringens str. 13	BAB80431.1 NP_561641.1	Q8XMG4	2BF6[A] 2VK5[A] 2VK6[A] 2VK7[A,B]
sialidase (NedA)	3.2.1.18	Micromonospora viridifaciens	AAQ70871.1 BAA00852.1	Q02834	1EUR[A] 1EUS[A] 1EUT[A] 1EUU[A] 1W8N[A] 1W8O[A] 1WCQ[A,B,C] 2BER[A] 2BQ9[A,B,C] 2BZD[A,B,C]
sialidase (NanH)	3.2.1.18	Salmonella typhimurium TA262	AAA27168.1	P29768.4	1DIL[A] 1DIM[A] 2SIL[A] 2SIM[A] 3SIL[A]
sialidase A (NanA)		Streptococcus pneumoniae R6	AAL00340.1 ACJ76904.1 ACO21301.1 NP_359129.1	P62576	2VVZ[A,B] 2W20[A,B] 3H71[A,B] 3H72[A,B] 3H73[A,B]
(trans-)sialidase B (NanB;SP1687)	2.4.1.- 3.2.1.18	Streptococcus pneumoniae TIGR4	AAK75766.1 AAK75766.1 NP_346126.1 NP_346126.1		2JKB[A,A] 2VW0[A,A] 2VW1[A,A] 2VW2[A,A]
neuraminidase (NanA;SpneT_02001817)		Streptococcus pneumoniae TIGR4	ZP_01407762.1		2YA4[A,B] 2YA5[A,B] 2YA6[A,B] 2YA7[A,B,C,D] 2YA8[A,B]
sialidase (NanH)	3.2.1.18	Vibrio cholerae 569B 395	AAA27546.1 AAA27546.1	P37060.1 P37060.1	1KIT[A,A] 1W0O[A,A] 1W0P[A,A]
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
2-keto-3-deoxynononic acid sialidase (KDNase;Afu4g13800) (6407)	3.2.1.- 3.2.1.18	Aspergillus fumigatus Af293	EAL89414.2		2XCY[A,B] 2XZI[A,B] 2XZJ[A,B] 2XZK[A,B]
sialidase (Neu2) (cytosolic)	3.2.1.18	Homo sapiens	AAH69151.1 AAI07054.1 AAY24360.1 CAB41449.1 NP_005374.1	Q9Y3R4	1SNT[A] 1SO7[A] 1VCU[A,B] 2F0Z[A] 2F10[A] 2F11[A] 2F12[A] 2F13[A] 2F24[A] 2F25[A,B] 2F26[A] 2F27[A,B] 2F28[A] 2F29[A,B]
sialidase L	3.2.1.18	Macrobdella decora	AAC47263.1 AAC47263.1	Q27701 Q27701	1SLI[A,A] 1SLL[A,A] 2SLI[A,A] 3SLI[A,A] 4SLI[A,A]
trans-sialidase	2.4.1.-	Trypanosoma cruzi	AAA66352.1 AAO30670.1 AAT21542.1	Q26966	1MR5[A] 1MS0[A,B] 1MS1[A,B] 1MS3[A,B] 1MS4[A,B] 1MS5[A,B] 1MS8[A,B] 1MS9[A,B] 1S0I[A] 1S0J[A] 1S0K[A] 2AH2[A] 3B69[A] 3OPZ[A,B,C,M] 3PJQ[A]
sialidase	3.2.1.18	Trypanosoma rangeli	AAC95493.1 AAC95494.1 AAC95495.1	O44049	1MZ5[A] 1MZ6[A] 1N1S[A] 1N1T[A] 1N1V[A] 1N1Y[A] 2A75[A] 2AGS[A] 2FHR[A]