Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); 2-keto-3-deoxynononic acid hydrolase (EC 3.2.1.-); anhydrosialidase (EC 4.2.2.15); 3-deoxy-D-manno-octulosonic-acid hydrolase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (3614); Uniprot accession (686); PDB accession (146); 3D entries (19); cryst (0)
All (3359) Archaea (1) Bacteria (2954) Eukaryota (371) Viruses (33) Structure (19) Characterized (96)
| 1 | 2 | 3 | 4 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 glycoprotein 82 kDa (gp82 subfamily C3) (fragment)   Trypanosoma cruzi PERU1 BAF74654.1 A7BI52  
 glycoprotein 82 kDa (gp82 subfamily A6) (fragment)   Trypanosoma cruzi PERU2 BAF74646.1 A7BI39  
 glycoprotein 82 kDa (gp82 subfamily A7) (fragment)   Trypanosoma cruzi PERU2 BAF74647.1 A7BI45  
 glycoprotein 82 kDa (gp82 subfamily B3) (fragment)   Trypanosoma cruzi PERU2 BAF74650.1 A7BI48  
 glycoprotein 82 kDa (gp82 subfamily B4) (fragment)   Trypanosoma cruzi PERU2 BAF74651.1 A7BI49  
 glycoprotein 82 kDa (gp82 subfamily C4) (fragment)   Trypanosoma cruzi PERU2 BAF74655.1 A7BI52  
 trans-sialidase, partial (Tsα-1) (fragment)   Trypanosoma cruzi Silvio X10 cl1 TSA-1 AID66714.1    
 TcC2-ORF6   Trypanosoma cruzi SYLVIO AAP80764.1 Q7YZX6  
 TcC2-ORF3   Trypanosoma cruzi SYLVIO AAP80761.1 Q7YZX9  
 unknown (fragment)   Trypanosoma cruzi SYLVIO AAP80760.1 Q7YZY0  
 surface protein-2   Trypanosoma cruzi SYLVIO X10/4 ABQ53590.1 A5JUX5  
 trans-sialidase, partial   Trypanosoma cruzi TCC793 AHI17181.1    
 trans-sialidase, partial   Trypanosoma cruzi TCC793 AHI17182.1    
 surface antigen PHGST#5 (fragment)   Trypanosoma cruzi TULAHUEN AAC98688.2 O96579  
 amastigote surface protein 2 (Asp-2) (partial)   Trypanosoma cruzi Tulahuen ADB82626.1 D3KAW2  
 trans-sialidase 2.4.1.- Trypanosoma cruzi TULAHUEN AAA99444.1 Q26969  
 surface protein-2   Trypanosoma cruzi TULAHUEN ABQ53591.1 A5JUX6  
 FL-160-CRP (fragment)   Trypanosoma cruzi Y CL7 CAO78608.1
CAO78611.1
CAO78616.1
A6Q0T2  
 FL-160-CRP (fragment)   Trypanosoma cruzi Y CL7 CAO78609.1
CAO78613.1
A6Q0T3  
 FL-160-CRP (fragment)   Trypanosoma cruzi Y CL7 CAO78610.1 A6Q0T4  
 FL-160-CRP (fragment)   Trypanosoma cruzi Y CL7 CAO78612.1 A6Q0T6  
 FL-160-CRP (fragment)   Trypanosoma cruzi Y CL7 CAO78614.1 A6Q0T8  
 FL-160-CRP (fragment)   Trypanosoma cruzi Y CL7 CAO78615.1 A6Q0T9  
 trans-sialidase (TCTS) 2.4.1.- Trypanosoma cruzi Y-STRAIN CAC34453.1
ABH92692.1
Q9BHJ5  
 trans-sialidase, partial (fragment)   Trypanosoma dionisii TCC211 AHI17188.1    
 trans-sialidase, partial   Trypanosoma dionisii TCC211 AHI17189.1    
 sialidase (TeSA) (partial)   Trypanosoma evansi ACM43506.1 B9VS11  
 trans-sialidase, partial   Trypanosoma evansi AHB33196.1    
 surface glycoprotein (Gp-1)   Trypanosoma rangeli AAY46228.1 Q4W4T2  
 sialidase (TrSA) 3.2.1.18 Trypanosoma rangeli AAC95493.1
AAC95494.1
AAC95495.1
O44049 1MZ5[A]
1MZ6[A]
1N1S[A]
1N1T[A]
1N1V[A]
1N1Y[A]
2A75[A]
2AGS[A]
2FHR[A]
 sialidase 3.2.1.18 Trypanosoma rangeli AAA18835.1 Q08672  
 sialidase (fragment) 3.2.1.18 Trypanosoma rangeli AAC47213.1 Q27063  
 sialidase 3.2.1.18 Trypanosoma rangeli AAC47214.1 Q27064  
 4G07   Trypanosoma rangeli AFX73249.1    
 ORF   Trypanosoma rangeli AGN32966.1    
 ORF   Trypanosoma rangeli AGN32969.1    
 ORF   Trypanosoma rangeli AGN32984.1    
 ORF (fragment)   Trypanosoma rangeli AGN33000.1    
 ORF (fragment)   Trypanosoma rangeli AGN32995.1    
 ORF (fragment)   Trypanosoma rangeli AGN32996.1    
 ORF (fragment)   Trypanosoma rangeli AGN33002.1    
 ORF (fragment)   Trypanosoma rangeli AGN33003.1    
 ORF (fragment)   Trypanosoma rangeli AGN33008.1    
 ORF (fragment)   Trypanosoma rangeli AGN33013.1    
 ORF (fragment)   Trypanosoma rangeli AGN33014.1    
 ORF (fragment)   Trypanosoma rangeli AGN33015.1    
 ORF (fragment)   Trypanosoma rangeli AGN33016.1    
 ORF (fragment)   Trypanosoma rangeli AGN33018.1    
 ORF (fragment)   Trypanosoma rangeli M/CAN/VE/82/DOG82 ACO87648.1 C3U1A4  
 ORF (fragment)   Trypanosoma rangeli M/CAN/VE/82/DOG82 ACO87649.1 C3U1A5  
 TrGP   Trypanosoma rangeli M/CAN/VE/82/DOG82 ACO87650.1 C3U1A6  
 TrGP   Trypanosoma rangeli M/CAN/VE/82/DOG82 ACO87651.1 C3U1A7  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87640.1 C3U196  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87641.1 C3U197  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87642.1 C3U198  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87643.1 C3U199  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87653.1 C3U1A9  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87654.1 C3U1B0  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87655.1 C3U1B1  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87656.1 C3U1B2  
 ORF (fragment)   Trypanosoma rangeli MHOM/Ve/99/CH-99 ACO87657.1 C3U1B3  
 trans-sialidase, partial   Trypanosoma rangeli TCC012 AHI17190.1    
 TVY486_0706570 (fragment)   Trypanosoma vivax Y486 CCC49342.1    
 TVY486_0806830   Trypanosoma vivax Y486 CCC50076.1    
 VIGAN_02083000 (Vigan.02g083000) (fragment)   Vigna angularis var. angularis BAT78183.1    
 VIGAN_01471600 (Vigan.01g471600)   Vigna angularis var. angularis BAT76676.1    
 VIGAN_01471500 (Vigan.01g471500)   Vigna angularis var. angularis BAT76675.1    
 Unknown (protein for MGC:81958)   Xenopus laevis AAH74168.1 Q6GMA3  
 Unknown (MGC:181090 IMAGE:8886027)   Xenopus tropicalis PopA AAI60978.1 B1H2F2  
 unknown (fragment)   Zea mays ACG41080.1 B6TVE7  
 unknown   Zea mays ACG24666.1
ACN25581.1
   
 unknown (ZM_BFb0001J07) (fragment)   Zea mays B73 ACF79583.1 B4FBU0  
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