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Glycoside Hydrolase Family 33

Activities in FamilyTrans-sialidase (EC 2.4.1.-);
2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-);
Kdo hydrolase (EC 3.2.1.124);
Exo-α-sialidase (EC 3.2.1.18);
Anhydrosialidase (EC 4.2.2.15);
Mechanism Retaining e
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesCAZypedia; HOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (11188); Uniprot accession (128); PDB accession (186); 3D entries (29); cryst (0)
Summary
Download GH33 (11185) Taxonomic display Structure (29) Characterized (97)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Tb927.5.440   Trypanosoma brucei brucei TREU927 AAX70245.1    
 Tb927.5.640   Trypanosoma brucei brucei TREU927 AAX70417.1    
 Tb927.7.7480   Trypanosoma brucei brucei TREU927 AAX79971.1    
 Tb927.5.440b   Trypanosoma brucei brucei TREU927 CAQ55522.1    
 neuraminidase   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH10947.1    
 TbgDal_V430   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH10905.1    
 TbgDal_II3310   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH09584.1    
 TbgDal_XI9090   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH17790.1    
 TbgDal_VII8790   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH13037.1    
 neuraminidase   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH13818.1    
 TbgDal_XI12770   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH18158.1    
 TbgDal_VII7980 (fragment)   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH12930.1    
 ORF   Trypanosoma carassii AAN38833.1    
 trans-sialidase (Ts1e-1;TconTS1) (fragment) 2.4.1.- Trypanosoma congolense CCD30512.1
CAD59552.1
CAH04004.1		 G0WJG7
Q7YZT3		  
 trans-sialidase (Ts1a) (fragment)   Trypanosoma congolense CCD30508.1    
 trans-sialidase (Ts1B) (fragment) 2.4.1.- Trypanosoma congolense CCD30509.1 G0WJG4  
 trans-sialidase (Ts1C) (fragment)   Trypanosoma congolense CCD30510.1    
 trans-sialidase (Ts1D) (fragment)   Trypanosoma congolense CCD30511.1    
 trans-sialidase (Ts1e-2) (fragment)   Trypanosoma congolense CCD30513.1    
 trans-sialidase (Ts1F) (fragment)   Trypanosoma congolense CCD30514.1    
 trans-sialidase (Ts1G) (fragment)   Trypanosoma congolense CCD30515.1    
 trans-sialidase (Ts1H) (fragment)   Trypanosoma congolense CCD30516.1    
 trans-sialidase (Ts1I) (fragment)   Trypanosoma congolense CCD30517.1    
 trans-sialidase (Ts1J) (fragment)   Trypanosoma congolense CCD30518.1    
 TCIL3000_2_1400   Trypanosoma congolense IL3000 CCC89562.1    
 TCIL3000_7_5530   Trypanosoma congolense IL3000 CCC91739.1    
 TS2 (fragment)   Trypanosoma congolense STIB 249 CAD59553.1
CAH04005.1		    
 TS2 protein   Trypanosoma congolense STIB249 CDI70086.1    
 TS3 protein   Trypanosoma congolense STIB249 CDI70087.1    
 TS4 protein   Trypanosoma congolense STIB249 CDI70088.1    
 trans-sialidase, partial   Trypanosoma conorhini TCC025E AHI17185.1    
 trans-sialidase, partial   Trypanosoma conorhini TCC025E AHI17186.1    
 trans-sialidase, partial (fragment)   Trypanosoma conorhini TCC025E AHI17187.1    
 amastigote surface protein 4 (Asp-4)   Trypanosoma cruzi ACI02314.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74321.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74322.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74323.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74324.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74325.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74326.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74327.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74328.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74329.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74330.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74332.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74333.1    
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74334.1    
 surface protein-2 (ASP-2)   Trypanosoma cruzi AAO84045.1
AAO84046.1		    
 surface protein-2 (Asp-2)   Trypanosoma cruzi AAO84044.1    
 trans-sialidase, partial (fragment)   Trypanosoma cruzi AWG47886.1
AWG47887.1
AWG47888.1
AWG47889.1
AWG47890.1
AWG47891.1
AWG47892.1
AWG47893.1
AWG47894.1
AWG47895.1
AWG47896.1
AWG47897.1
AWG47898.1
AWG47899.1
AWG47900.1
AWG47901.1
AWG47902.1
AWG47903.1
AWG47904.1
AWG47905.1
AWG47906.1
AWG47907.1
AWG47908.1
AWG47909.1
AWG47910.1
AWG47911.1
AWG47912.1
AWG47913.1
AWG47914.1
AWG47915.1
AWG47916.1
AWG47917.1
AWG47918.1
AWG47919.1
AWG47920.1
AWG47921.1
AWG47922.1
AWG47923.1
AWG47924.1
AWG47925.1
AWG47926.1
AWG47927.1
AWG47928.1
AWG47929.1
AWG47930.1
AWG47931.1
AWG47932.1
AWG47933.1
AWG47934.1
AWG47935.1
AWG47936.1
AWG47937.1
AWG47938.1
AWG47939.1
AWG47940.1
AWG47941.1
AWG47942.1
AWG47943.1		    
 Gp-85 (fragment)   Trypanosoma cruzi AAQ74647.1    
 Sp1   Trypanosoma cruzi AAQ74641.1    
 trypomastigote ligand   Trypanosoma cruzi AAS00641.1    
 trans-sialidase (Sp1) (fragment)   Trypanosoma cruzi ADX23545.1    
 trans-sialidase (Sp2) (fragment)   Trypanosoma cruzi ADX23547.1    
 82-kDa surface antigen (fragment)   Trypanosoma cruzi AEM66559.1    
 surface glycoprotein Tc-85/35 (fragment)   Trypanosoma cruzi AAP32144.1    
 surface glycoprotein Tc-85/10 (fragment)   Trypanosoma cruzi AAP32145.1    
 surface glycoprotein Tc-85/11 (fragment)   Trypanosoma cruzi AAP32146.1    
 surface glycoprotein Tc-85/13 (fragment)   Trypanosoma cruzi AAP32147.1    
 surface glycoprotein Tc-85/16 (fragment)   Trypanosoma cruzi AAP32148.1    
 surface glycoprotein Tc-85/19 (fragment)   Trypanosoma cruzi AAP32149.1    
 surface glycoprotein Tc-85/20 (fragment)   Trypanosoma cruzi AAP32150.1    
 surface glycoprotein Tc-85/32 (fragment)   Trypanosoma cruzi AAP32151.1    
 surface glycoprotein Tc85-45 (fragment)   Trypanosoma cruzi AAO62997.1    
 surface glycoprotein Tc85-26 (fragment)   Trypanosoma cruzi AAO62998.1    
 complement regulatory protein   Trypanosoma cruzi AAB49414.1    
 surface antigen Gp85   Trypanosoma cruzi AAA30150.1
AAA03205.1		    
 surface glycoprotein   Trypanosoma cruzi AAA18827.1    
 surface glycoprotein   Trypanosoma cruzi AAD10618.1    
 surface glycoprotein   Trypanosoma cruzi AAD10619.1    
 surface glycoprotein (Tsα-E3)   Trypanosoma cruzi AAD10620.1    
 surface glycoprotein (Tc85-11)   Trypanosoma cruzi AAD13347.1    
 surface protein   Trypanosoma cruzi BAA31361.1
BAA74524.1		    
 surface protein 1   Trypanosoma cruzi AAB18265.1    
 TCNA   Trypanosoma cruzi AAA30255.1
ABH92708.1		    
 trans-sialidase   Trypanosoma cruzi AAC98544.1
BAD99565.1
BAD99566.1		    
 trans-sialidase 2.4.1.- Trypanosoma cruzi AAO30669.1
AAT21541.1
ABH92705.1
BAA09334.1		 Q26964  
 trans-sialidase (TcTS) 2.4.1.- Trypanosoma cruzi AAA66352.1
AAO30670.1
AAT21542.1		 Q26966 1MR5[A]
1MS0[A,B]
1MS1[A,B]
1MS3[A,B]
1MS4[A,B]
1MS5[A,B]
1MS8[A,B]
1MS9[A,B]
1S0I[A]
1S0J[A]
1S0K[A]
2AH2[A]
3B69[A]
3OPZ[A,B,C,M]
3PJQ[A]
 trans-sialidase (fragment)   Trypanosoma cruzi AAC47166.1    
 trans-sialidase (inactive)   Trypanosoma cruzi BAA09333.1
AAA99442.1
AAA99443.1
ABH92706.1		    
 trans-sialidase homolog   Trypanosoma cruzi BAA09335.1    
 trans-sialidase TSA-T20A (fragment)   Trypanosoma cruzi AAB36926.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01541.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01542.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01543.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01544.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01545.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01546.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01547.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01548.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01549.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01550.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01551.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01552.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01553.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01554.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01555.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01556.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01557.1    
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