Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (6329); Uniprot accession (681); PDB accession (152); 3D entries (21); cryst (0)
All (6088) Archaea (1) Bacteria (5613) Eukaryota (431) Viruses (37) unclassified (6) Structure (21) Characterized (97)
| 1 | 2 | 3 | 4 | 5 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 sialidase 1   Mustela putorius furo AES02815.1    
 sialidase, partial (fragment)   Opalina sp. OP10 QGJ83549.1    
 sialidase (fragment)   Opalinidae sp. Opal32 QGJ83574.1    
 sialidase, partial (fragment)   Opalinidae sp. Opal32 QGJ83575.1    
 sialidase 1a (Neu1A)   Oreochromis niloticus BAR71186.1    
 sialidase 4 (Neu4) (fragment)   Oreochromis niloticus BAR79852.1    
 sialidase neu1b   Oreochromis niloticus BAT70756.1    
 sialidase 3a (Neu3A)   Oreochromis niloticus BAO79779.1    
 ORF   Oreochromis niloticus BAO79780.1    
 ORF   Oreochromis niloticus BAO79781.1    
 sialidase 3d (Neu3D)   Oreochromis niloticus BAO79782.1    
 sialidase 3e (Neu3E)   Oreochromis niloticus BAO79783.1    
 OSNPB_070516050 (Os07g0516050)   Oryza sativa Japonica Group BAT01757.1    
 Os07g0516000   Oryza sativa Japonica Group BAF21693.1
BAT01756.1
Q7F0N4  
 sialidase 3a (Neu3A) 3.2.1.18 Oryzias latipes Hd-rR BAL03608.1    
 sialidase 3b (Neu3B) 3.2.1.18 Oryzias latipes Hd-rR BAL03609.1    
 sialidase 4 (Neu4) 3.2.1.18 Oryzias latipes Hd-rR BAM74165.1    
 sialidase 1 (Neu1)   Oryzias latipes Hd-rR BAO47775.1    
 Pc21g12200   Penicillium rubens Wisconsin 54-1255 CAP96117.1 B6HLA6  
 sialidase (Pc22g00140) 3.2.1.18 Penicillium rubens Wisconsin 54-1255 CAT16707.1
CAP97302.1
CAX30683.1
B6HP74  
 182F10 (fragment)   Philodina roseola ACD54789.1 B3G4P1  
 DKFZp468G0924 (probable fragment)   Pongo abelii CAH89766.1 Q5REP1  
 DKFZp469E1532   Pongo abelii CAH89635.1 Q5RAF4  
 DKFZp468K0928   Pongo abelii CAH91256.1 Q5RAF4  
 DKFZp459L0538 (fragment)   Pongo abelii CAH91396.1 Q5RAF4  
 ORF (fragment)   Potamotrygon motoro QFF91256.1    
 ORF (fragment)   Potamotrygon motoro QFF91253.1    
 ORF   Potamotrygon motoro QFF91260.1    
 ORF (fragment)   Potamotrygon motoro QFF91259.1    
 ORF   Potamotrygon motoro QFF91252.1    
 ORF   Potamotrygon motoro QFF91255.1    
 ORF   Potamotrygon motoro QFF91258.1    
 ORF   Potamotrygon motoro QFF91251.1    
 ORF (fragment)   Potamotrygon motoro QFF91254.1    
 ORF (fragment)   Potamotrygon motoro QFF91261.1    
 ORF (fragment)   Potamotrygon motoro QFF91257.1    
 Prudu_000787   Prunus dulcis BBG92919.1    
 sialidase 1 (Neu1)   Pseudorca crassidens BBG43806.1    
 PoMZ_05120   Pyricularia oryzae QBZ63439.1    
 sialidase 3.2.1.18 Rattus norvegicus BAA03805.1
AAH91154.1
BAA09169.1
NP_058826.1
Q64627  
 sialidase (Neu1) 3.2.1.18 Rattus norvegicus BAB21443.1
AAI00640.1
CAE83976.1
NP_113710.1
Q99PW3  
 sialidase (Neu3) 3.2.1.18 Rattus norvegicus BAB32440.1
AAI00626.1
NP_446462.1
Q99PW5  
 ORF   Saccoglossus kowalevskii ALR88583.1    
 ORF   Saccoglossus kowalevskii ALR88582.1    
 SMAX5B_013492   Scophthalmus maximus AWO98938.1    
 SMAX5B_004198   Scophthalmus maximus AWP00131.1    
 SMAX5B_015811 (fragment)   Scophthalmus maximus AWP21371.1    
 SMAX5B_015811   Scophthalmus maximus AWP21373.1    
 SMAX5B_015811   Scophthalmus maximus AWP21372.1    
 sialidase neu4   Seriola dumerili BBG56813.1    
 SBAB-707F1.8-001 (Neu1)   Sus scrofa CAN87707.1
ABX82833.1
A5PF10
B9TSS6
 
 Neu1   Takifugu rubripes ABQ62949.1 A7TVK3  
 Neu3   Takifugu rubripes ABQ62950.1 A7TVK4  
 Neu4   Takifugu rubripes ABQ62951.1 A7TVK5  
 MYCTH_2306764   Thermothelomyces thermophilus ATCC 42464 AEO58960.1    
 CAMPLR22A2D_LOCUS2140   Triticum aestivum SPT17530.1    
 putative trans-sialidase B38p   Trypanosoma brucei AAG32055.1 Q9GSF0  
 Tsi1   Trypanosoma brucei ANTAT 1.1 AAG09432.1 Q9GU83  
 Tb927.2.5280   Trypanosoma brucei brucei TREU927 AAQ15986.1
AAX80006.1
Q585U3
Q7YUQ9
 
 2-2,3-trans-sialidase (TbSA C2;Tb927.8.7350) 2.4.1.- Trypanosoma brucei brucei TREU927 AAX69221.1 Q57YT7  
 Tb927.8.7340   Trypanosoma brucei brucei TREU927 AAX69223.1 A0MH09
Q57YT6
 
 Tb927.7.6830 (fragment)   Trypanosoma brucei brucei TREU927 AAX69473.1 Q57Y46  
 Tb927.7.6850   Trypanosoma brucei brucei TREU927 AAX69677.1 Q57XJ2  
 Tb927.5.440   Trypanosoma brucei brucei TREU927 AAX70245.1 Q57VW9  
 Tb927.5.640   Trypanosoma brucei brucei TREU927 AAX70417.1 Q57VF2  
 Tb927.7.7480   Trypanosoma brucei brucei TREU927 AAX79971.1 Q57TY5  
 Tb927.5.440b   Trypanosoma brucei brucei TREU927 CAQ55522.1 B2ZWD4  
 neuraminidase   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH10947.1 C9ZNG9  
 TbgDal_V430   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH10905.1 C9ZNC7  
 TbgDal_II3310   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH09584.1 C9ZJM5  
 TbgDal_XI9090   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH17790.1 D0A7Y9  
 TbgDal_VII8790   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH13037.1 C9ZUF0  
 neuraminidase   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH13818.1 C9ZWM9  
 TbgDal_XI12770   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH18158.1 D0A907  
 TbgDal_VII7980 (fragment)   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH12930.1 C9ZU44  
 ORF   Trypanosoma carassii AAN38833.1 Q8I672  
 trans-sialidase (Ts1e-1;TconTS1) (fragment) 2.4.1.- Trypanosoma congolense CCD30512.1
CAD59552.1
CAH04004.1
Q7YZT3  
 trans-sialidase (Ts1a) (fragment)   Trypanosoma congolense CCD30508.1    
 trans-sialidase (Ts1B) (fragment) 2.4.1.- Trypanosoma congolense CCD30509.1    
 trans-sialidase (Ts1C) (fragment)   Trypanosoma congolense CCD30510.1    
 trans-sialidase (Ts1D) (fragment)   Trypanosoma congolense CCD30511.1    
 trans-sialidase (Ts1e-2) (fragment)   Trypanosoma congolense CCD30513.1    
 trans-sialidase (Ts1F) (fragment)   Trypanosoma congolense CCD30514.1    
 trans-sialidase (Ts1G) (fragment)   Trypanosoma congolense CCD30515.1    
 trans-sialidase (Ts1H) (fragment)   Trypanosoma congolense CCD30516.1    
 trans-sialidase (Ts1I) (fragment)   Trypanosoma congolense CCD30517.1    
 trans-sialidase (Ts1J) (fragment)   Trypanosoma congolense CCD30518.1    
 TCIL3000_2_1400   Trypanosoma congolense IL3000 CCC89562.1    
 TCIL3000_7_5530   Trypanosoma congolense IL3000 CCC91739.1    
 TS2 (fragment)   Trypanosoma congolense STIB 249 CAD59553.1
CAH04005.1
Q7YZT2  
 TS2 protein   Trypanosoma congolense STIB249 CDI70086.1    
 TS3 protein   Trypanosoma congolense STIB249 CDI70087.1    
 TS4 protein   Trypanosoma congolense STIB249 CDI70088.1    
 trans-sialidase, partial   Trypanosoma conorhini TCC025E AHI17185.1    
 trans-sialidase, partial   Trypanosoma conorhini TCC025E AHI17186.1    
 trans-sialidase, partial (fragment)   Trypanosoma conorhini TCC025E AHI17187.1    
 Sequence 65 from patent US 6228372   Trypanosoma cruzi AAE69226.1
AAN22488.1
   
 amastigote surface protein 4 (Asp-4)   Trypanosoma cruzi ACI02314.1 B5U6T9  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74321.1 C9DS87  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74322.1 C9DS88  
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