Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); 2-keto-3-deoxynononic acid hydrolase (EC 3.2.1.-); anhydrosialidase (EC 4.2.2.15); 3-deoxy-D-manno-octulosonic-acid hydrolase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (3614); Uniprot accession (686); PDB accession (146); 3D entries (19); cryst (0)
All (3359) Archaea (1) Bacteria (2954) Eukaryota (371) Viruses (33) Structure (19) Characterized (96)
| 1 | 2 | 3 | 4 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D
 putative trans-sialidase B38p   Trypanosoma brucei AAG32055.1 Q9GSF0  
 Tb927.2.5280   Trypanosoma brucei AAQ15986.1
AAX80006.1
Q585U3
Q7YUQ9
 
 2-2,3-trans-sialidase (TbSA C2;Tb927.8.7350) 2.4.1.- Trypanosoma brucei AAX69221.1 Q57YT7  
 Tb927.8.7340   Trypanosoma brucei AAX69223.1 A0MH09
Q57YT6
 
 Tb927.7.6830 (fragment)   Trypanosoma brucei AAX69473.1 Q57Y46  
 Tb927.7.6850   Trypanosoma brucei AAX69677.1 Q57XJ2  
 Tb927.5.440   Trypanosoma brucei AAX70245.1 Q57VW9  
 Tb927.5.640   Trypanosoma brucei AAX70417.1 Q57VF2  
 Tb927.7.7480   Trypanosoma brucei AAX79971.1 Q57TY5  
 Tsi1   Trypanosoma brucei ANTAT 1.1 AAG09432.1 Q9GU83  
 Tb927.5.440b   Trypanosoma brucei brucei TREU927 TREU 927/4 GUTAT10.1 CAQ55522.1 B2ZWD4  
 neuraminidase   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH10947.1 C9ZNG9  
 TbgDal_V430   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH10905.1 C9ZNC7  
 TbgDal_II3310   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH09584.1 C9ZJM5  
 TbgDal_XI9090   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH17790.1 D0A7Y9  
 TbgDal_VII8790   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH13037.1 C9ZUF0  
 neuraminidase   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH13818.1 C9ZWM9  
 TbgDal_XI12770   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH18158.1 D0A907  
 TbgDal_VII7980 (fragment)   Trypanosoma brucei gambiense DAL972 Dal 927 clone 1 (MHOM/CI/86/DAL972) CBH12930.1 C9ZU44  
 ORF   Trypanosoma carassii AAN38833.1 Q8I672  
 trans-sialidase (Ts1e-1;TconTS1) (fragment) 2.4.1.- Trypanosoma congolense CCD30512.1
CAD59552.1
CAH04004.1
Q7YZT3  
 trans-sialidase (Ts1a) (fragment)   Trypanosoma congolense CCD30508.1    
 trans-sialidase (Ts1B) (fragment) 2.4.1.- Trypanosoma congolense CCD30509.1    
 trans-sialidase (Ts1C) (fragment)   Trypanosoma congolense CCD30510.1    
 trans-sialidase (Ts1D) (fragment)   Trypanosoma congolense CCD30511.1    
 trans-sialidase (Ts1e-2) (fragment)   Trypanosoma congolense CCD30513.1    
 trans-sialidase (Ts1F) (fragment)   Trypanosoma congolense CCD30514.1    
 trans-sialidase (Ts1G) (fragment)   Trypanosoma congolense CCD30515.1    
 trans-sialidase (Ts1H) (fragment)   Trypanosoma congolense CCD30516.1    
 trans-sialidase (Ts1I) (fragment)   Trypanosoma congolense CCD30517.1    
 trans-sialidase (Ts1J) (fragment)   Trypanosoma congolense CCD30518.1    
 TCIL3000_2_1400   Trypanosoma congolense IL3000 CCC89562.1    
 TCIL3000_7_5530   Trypanosoma congolense IL3000 CCC91739.1    
 TS2 (fragment)   Trypanosoma congolense STIB 249 CAD59553.1
CAH04005.1
Q7YZT2  
 TS2 protein   Trypanosoma congolense STIB249 CDI70086.1    
 TS3 protein   Trypanosoma congolense STIB249 CDI70087.1    
 TS4 protein   Trypanosoma congolense STIB249 CDI70088.1    
 trans-sialidase, partial   Trypanosoma conorhini TCC025E AHI17185.1    
 trans-sialidase, partial   Trypanosoma conorhini TCC025E AHI17186.1    
 trans-sialidase, partial (fragment)   Trypanosoma conorhini TCC025E AHI17187.1    
 Sequence 65 from patent US 6228372   Trypanosoma cruzi AAE69226.1
AAN22488.1
   
 amastigote surface protein 4 (Asp-4)   Trypanosoma cruzi ACI02314.1 B5U6T9  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74321.1 C9DS87  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74322.1 C9DS88  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74323.1 C9DS89  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74324.1 C9DS90  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74325.1 C9DS91  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74326.1 C9DS92  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74327.1 C9DS93  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74328.1 C9DS94  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74329.1 C9DS95  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74330.1 C9DS96  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74332.1 C9DS98  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74333.1 C9DS99  
 trans-sialidase (TS) (fragment)   Trypanosoma cruzi ACV74334.1 C9DSA0  
 surface protein-2 (ASP-2)   Trypanosoma cruzi AAO84045.1
AAO84046.1
Q86DL6
Q86DL7
 
 surface protein-2 (Asp-2)   Trypanosoma cruzi AAO84044.1 Q86DL8  
 Gp-85 (fragment)   Trypanosoma cruzi AAQ74647.1 Q6WAZ1  
 Sp1   Trypanosoma cruzi AAQ74641.1 Q6WAZ7  
 trypomastigote ligand   Trypanosoma cruzi AAS00641.1 Q6R526  
 trans-sialidase (Sp1) (fragment)   Trypanosoma cruzi ADX23545.1    
 trans-sialidase (Sp2) (fragment)   Trypanosoma cruzi ADX23547.1    
 82-kDa surface antigen (fragment)   Trypanosoma cruzi AEM66559.1    
 surface glycoprotein Tc-85/35 (fragment)   Trypanosoma cruzi AAP32144.1 Q2VYD4  
 surface glycoprotein Tc-85/10 (fragment)   Trypanosoma cruzi AAP32145.1 Q2VYD3  
 surface glycoprotein Tc-85/11 (fragment)   Trypanosoma cruzi AAP32146.1 Q2VYD2  
 surface glycoprotein Tc-85/13 (fragment)   Trypanosoma cruzi AAP32147.1 Q2VYD1  
 surface glycoprotein Tc-85/16 (fragment)   Trypanosoma cruzi AAP32148.1 Q2VYD0  
 surface glycoprotein Tc-85/19 (fragment)   Trypanosoma cruzi AAP32149.1 Q2VYC9  
 surface glycoprotein Tc-85/20 (fragment)   Trypanosoma cruzi AAP32150.1 Q2VYC8  
 surface glycoprotein Tc-85/32 (fragment)   Trypanosoma cruzi AAP32151.1 Q2VYC7  
 surface glycoprotein Tc85-45 (fragment)   Trypanosoma cruzi AAO62997.1 Q2VYD6  
 surface glycoprotein Tc85-26 (fragment)   Trypanosoma cruzi AAO62998.1 Q2VYD5  
 complement regulatory protein   Trypanosoma cruzi AAB49414.1 Q26889  
 surface antigen Gp85   Trypanosoma cruzi AAA30150.1
AAA03205.1
Q03877  
 surface glycoprotein   Trypanosoma cruzi AAA18827.1 Q08661  
 surface glycoprotein   Trypanosoma cruzi AAD10618.1 Q26851  
 surface glycoprotein   Trypanosoma cruzi AAD10619.1 Q26852  
 surface glycoprotein (Tsα-E3)   Trypanosoma cruzi AAD10620.1 Q26853  
 surface glycoprotein (Tc85-11)   Trypanosoma cruzi AAD13347.1 O77209  
 surface protein   Trypanosoma cruzi BAA31361.1
BAA74524.1
O76141  
 surface protein 1   Trypanosoma cruzi AAB18265.1 Q94798  
 TCNA   Trypanosoma cruzi AAA30255.1
ABH92708.1
P23253  
 trans-sialidase 2.4.1.- Trypanosoma cruzi AAC98544.1
BAD99565.1
BAD99566.1
Q26850  
 trans-sialidase 2.4.1.- Trypanosoma cruzi AAO30669.1
AAT21541.1
ABH92705.1
BAA09334.1
Q26964  
 trans-sialidase (TcTS) 2.4.1.- Trypanosoma cruzi AAA66352.1
AAO30670.1
AAT21542.1
Q26966 1MR5[A]
1MS0[A,B]
1MS1[A,B]
1MS3[A,B]
1MS4[A,B]
1MS5[A,B]
1MS8[A,B]
1MS9[A,B]
1S0I[A]
1S0J[A]
1S0K[A]
2AH2[A]
3B69[A]
3OPZ[A,B,C,M]
3PJQ[A]
 trans-sialidase (fragment)   Trypanosoma cruzi AAC47166.1 Q26887  
 trans-sialidase (inactive)   Trypanosoma cruzi BAA09333.1
AAA99442.1
AAA99443.1
ABH92706.1
Q26963
Q26967
Q26968
 
 trans-sialidase homolog   Trypanosoma cruzi BAA09335.1 Q26965  
 trans-sialidase TSA-T20A (fragment)   Trypanosoma cruzi AAB36926.1 P90604  
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01541.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01542.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01543.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01544.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01545.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01546.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01547.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01548.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01549.1    
 trans-sialidase, partial (TS) (fragment)   Trypanosoma cruzi AGA01550.1    
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