Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (5159); Uniprot accession (686); PDB accession (146); 3D entries (19); cryst (0)
All (4922) Archaea (1) Bacteria (4488) Eukaryota (393) Viruses (34) unclassified (6) Structure (19) Characterized (96)
| 1 | ... | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ... | 46 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 CDCE8392_0286   Corynebacterium diphtheriae CDCE 8392 AEX71288.1    
 CDCE8392_0488 (NanH)   Corynebacterium diphtheriae CDCE 8392 AEX71488.1    
 CHUV2995_00350 (NanA)   Corynebacterium diphtheriae CHUV2995 SPJ39571.1    
 CHUV2995_00654 (NedA)   Corynebacterium diphtheriae CHUV2995 SPJ39870.1    
 A6J36_10310   Corynebacterium diphtheriae FDAARGOS_197 ARB88654.1    
 A6J36_11360   Corynebacterium diphtheriae FDAARGOS_197 ARB89035.1    
 CDHC01_0286   Corynebacterium diphtheriae HC01 AEX73539.1    
 CDHC01_0481 (NanH)   Corynebacterium diphtheriae HC01 AEX73734.1    
 CDHC02_0291   Corynebacterium diphtheriae HC02 AEX75787.1    
 CDHC02_0488 (NanH)   Corynebacterium diphtheriae HC02 AEX75984.1    
 CDHC03_0263   Corynebacterium diphtheriae HC03 AEX77994.1    
 CDHC03_0467 (NanH)   Corynebacterium diphtheriae HC03 AEX78198.1    
 CDHC04_0246   Corynebacterium diphtheriae HC04 AEX80239.1    
 CDHC04_0446 (NanH)   Corynebacterium diphtheriae HC04 AEX80439.1    
 CDB402_0252   Corynebacterium diphtheriae INCA 402 AEX45563.1    
 CDB402_0452 (NanH)   Corynebacterium diphtheriae INCA 402 AEX45763.1    
 trans-sialidase (NanH;NanA) 2.4.1.- Corynebacterium diphtheriae KCTC 3075 ACS34893.1 C6JSW6  
 sialidase (NanI;NanB)   Corynebacterium diphtheriae KCTC 3075 ACS34894.1 C6JSW7  
 DIP0543   Corynebacterium diphtheriae NCTC 13129 CAE49054.1
NP_938919.1
   
 DIP0330   Corynebacterium diphtheriae NCTC 13129 CAE48837.1
NP_938718.1
   
 ERS451417_00260 (NanI)   Corynebacterium diphtheriae NCTC11397 CKG64847.1    
 ERS451417_00477 (NanH)   Corynebacterium diphtheriae NCTC11397 CKG71642.1    
 NCTC3529_02012 (NanI)   Corynebacterium diphtheriae NCTC3529 VEJ67015.1    
 NCTC3529_02215 (NanH)   Corynebacterium diphtheriae NCTC3529 VEJ67212.1    
 NCTC7838_00130 (NanI)   Corynebacterium diphtheriae NCTC7838 VEJ62914.1    
 NCTC7838_00336 (NanH)   Corynebacterium diphtheriae NCTC7838 VEJ63114.1    
 CDPW8_0344   Corynebacterium diphtheriae PW8 AEX69006.1    
 CDPW8_0542 (NanH)   Corynebacterium diphtheriae PW8 AEX69204.1    
 E4653_01335   Corynebacterium diphtheriae subsp. lausannense CMCNS703 QBZ28802.1    
 E4653_02585   Corynebacterium diphtheriae subsp. lausannense CMCNS703 QBZ28989.1    
 E4651_01760   Corynebacterium diphtheriae TH1526 QBY12475.1    
 E4651_00730   Corynebacterium diphtheriae TH1526 QBY10552.1    
 CDVA01_0230   Corynebacterium diphtheriae VA01 AEX82499.1    
 CDVA01_0429 (NanH)   Corynebacterium diphtheriae VA01 AEX82698.1    
 CEPID_03560   Corynebacterium epidermidicanis DSM 45586 AKK02590.1    
 CGERO_05070 (NanA)   Corynebacterium geronticis W8 AZA11326.1    
 RXN02478   Corynebacterium glutamicum CAC26191.1 Q8NMC8  
 FRXA02513 / RXN02513 (fragment)   Corynebacterium glutamicum CAC26187.1
AAW20926.1
CAC26186.1
CAL31683.1
CAL31684.1
   
 RXA00984 (fragment)   Corynebacterium glutamicum CAC26185.1
CAL31682.1
   
 CGBL_0116740 (NanH) (fragment)   Corynebacterium glutamicum AJ1511 BAV23396.1    
 CGBL_0116750 (NanH) (fragment)   Corynebacterium glutamicum AJ1511 BAV23397.1    
 CGBL_0125870 (NanH)   Corynebacterium glutamicum AJ1511 BAV24278.1    
 cg1756 (NanH)   Corynebacterium glutamicum ATCC 13032 CAF21565.1
BAB98949.1
CCH24715.1
NP_600771.1
Q6M535  
 cg2935 (NanP)   Corynebacterium glutamicum ATCC 13032 BAC00044.1
ABC13268.1
CAF21311.1
CAL31688.1
CCH25780.1
NP_601849.1
Q8NMC8  
 CYL77_13430   Corynebacterium glutamicum ATCC 13032 AUI02045.1    
 BBD29_12965   Corynebacterium glutamicum ATCC 13869 ANU34577.1    
 cgc1_2935 (NanP)   Corynebacterium glutamicum C1 ASW14966.1    
 cgc1_1756 (NanH)   Corynebacterium glutamicum C1 ASW14166.1    
 AC079_13165   Corynebacterium glutamicum CP18 ALP51049.1    
 C0I99_01430   Corynebacterium glutamicum HA AUI02860.1    
 cgp_2935 (NanP)   Corynebacterium glutamicum MB001 AGT06367.1    
 cgp_1756 (NanH)   Corynebacterium glutamicum MB001 AGT05516.1    
 N24_2734 (NanP)   Corynebacterium glutamicum N24 BAU96996.1    
 cgR_1608   Corynebacterium glutamicum R BAF54600.1    
 cgR_2554   Corynebacterium glutamicum R BAF55566.1    
 C624_13025   Corynebacterium glutamicum SCgG1 AGN20172.1    
 C624_08555   Corynebacterium glutamicum SCgG1 AGN19286.1    
 C629_13030   Corynebacterium glutamicum SCgG2 AGN23196.1    
 C629_08565   Corynebacterium glutamicum SCgG2 AGN22311.1    
 B7P23_15235   Corynebacterium glutamicum TQ2223 ARV66138.1    
 B7P23_05095   Corynebacterium glutamicum TQ2223 ARV64311.1    
 APT58_13045   Corynebacterium glutamicum USDA-ARS-USMARC-56828 AMA01077.1    
 BSP99_13380   Corynebacterium glutamicum XV APT08329.1    
 A3654_08265   Corynebacterium glutamicum YI ANE08356.1    
 C627_08425 (fragment)   Corynebacterium glutamicum ZL-6 ANR65645.1    
 C627_13015   Corynebacterium glutamicum ZL-6 ANR66531.1    
 C627_08430 (fragment)   Corynebacterium glutamicum ZL-6 ANR65646.1    
 ckrop_1872 (NanI)   Corynebacterium kroppenstedtii DSM 44385 ACR18588.1 C4LL83  
 NCTC11138_01978 (Nanh_1) (fragment)   Corynebacterium kutscheri NCTC11138 VEH10988.1    
 NCTC11138_01979 (Nanh_2) (fragment)   Corynebacterium kutscheri NCTC11138 VEH10989.1    
 NCTC3655_01301 (Nanh_2) (fragment)   Corynebacterium kutscheri NCTC3655 VEH80532.1    
 NCTC3655_01300 (Nanh_1) (fragment)   Corynebacterium kutscheri NCTC3655 VEH80531.1    
 NCTC3655_01302 (Nanh_3) (fragment)   Corynebacterium kutscheri NCTC3655 VEH80533.1    
 NCTC949_00323 (NanH)   Corynebacterium kutscheri NCTC949 VEH04891.1    
 CMUST_11800   Corynebacterium mustelae DSM 45274 AKK06671.1    
 CMUST_04910   Corynebacterium mustelae DSM 45274 AKK05320.1    
 CPELA_06120 (NanA)   Corynebacterium pelargi 136/3 QAU52491.1    
 CPHO_04675   Corynebacterium phocae M408/89/1 APT92300.1    
 CPPEL_06340 (NanA)   Corynebacterium pseudopelargi 812CH AZA09383.1    
 neuraminidase (NanH)   Corynebacterium pseudotuberculosis 04MAT QBI74461.1    
 Cp1002_0387   Corynebacterium pseudotuberculosis 1002 ADL20287.1 D9Q6J2  
 neuraminidase (NanH)   Corynebacterium pseudotuberculosis 1002B ALM77000.1    
 Cp12C_0413 (NanH)   Corynebacterium pseudotuberculosis 12C AKJ55057.1    
 Cp226_0402 (NanH)   Corynebacterium pseudotuberculosis 226 AKC73144.1    
 Cp258_0396 (NanH)   Corynebacterium pseudotuberculosis 258 AJF93848.1    
 Cp262_0396 (NanH)   Corynebacterium pseudotuberculosis 262 AKP08063.2    
 Cp267_0402 (NanH)   Corynebacterium pseudotuberculosis 267 AFH51310.1    
 Cp29156_0391 (NanH)   Corynebacterium pseudotuberculosis 29156 AKI58795.1    
 Cp3995_0391 (NanH)   Corynebacterium pseudotuberculosis 3/99-5 AEX38862.1    
 Cp31_0399 (NanH)   Corynebacterium pseudotuberculosis 31 AKN59634.1    
 A4R72_02270   Corynebacterium pseudotuberculosis 32 APB10365.1    
 A4R71_02285   Corynebacterium pseudotuberculosis 33 APB12413.1    
 A4R69_02280   Corynebacterium pseudotuberculosis 34 APB28708.1    
 A4R68_02280   Corynebacterium pseudotuberculosis 35 APB14459.1    
 A4R67_02275   Corynebacterium pseudotuberculosis 36 APB16504.1    
 A4R66_02280   Corynebacterium pseudotuberculosis 38 APB18553.1    
 neuraminidase (NanH)   Corynebacterium pseudotuberculosis 38MAT QBI72361.1    
 A4R65_02275   Corynebacterium pseudotuberculosis 39 APB20594.1    
 Cp4202_0383 (NanH)   Corynebacterium pseudotuberculosis 42/02-A AEP69653.1    
 A4R64_02065   Corynebacterium pseudotuberculosis 43 APB22605.1    
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