Glycoside Hydrolase Family 33

Activities in Familysialidase or neuraminidase (EC 3.2.1.18); trans-sialidase (EC 2.4.1.-); anhydrosialidase (EC 4.2.2.15); Kdo hydrolase (EC 3.2.1.-); 2-keto-3-deoxynononic acid hydrolase / KDNase (EC 3.2.1.-)
Mechanism Retaining
ClanGH-E
3D Structure Status6-fold β-propeller
Catalytic Nucleophile/BaseTyr+Glu
Catalytic Proton DonorNot known
External resourcesHOMSTRAD;
Commercial Enzyme Provider(s)MEGAZYME;
Statistics GenBank accession (5098); Uniprot accession (686); PDB accession (146); 3D entries (19); cryst (0)
All (4861) Archaea (1) Bacteria (4415) Eukaryota (389) Viruses (34) unclassified (22) Structure (19) Characterized (96)
| 1 | ... | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | ... | 46 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ROD_15131   Citrobacter rodentium ICC168 CBG88277.1 D2TIF0  
 CLS_13500   [Clostridium] cf. saccharolyticum K10 CBK76990.1 D6DH16  
 BTM20_05845   Clostridium chauvoei 12S0467 ATD54786.1    
 BTM21_07215   Clostridium chauvoei DSM 7528 ATD57534.1    
 NanA (fragment)   Clostridium chauvoei JF3703 CAR82360.1 E1UGY3  
 sialidase (NanA) (fragment) 3.2.1.18 Clostridium chauvoei JF4135 CAR82361.1 E1UGY4  
 CCH01_10370   Clostridium chauvoei JF4335 SLK16343.1    
 C6H62_05085   Clostridium chauvoei SBP 07/09 QBJ75069.1    
 sialidase 1 'small' 3.2.1.18 Clostridium perfringens A99 CAA68780.1 P10481  
 exo-α-sialidase 'large' (NanH) 3.2.1.18 Clostridium perfringens A99 CAA60796.1 Q59310  
 sialidase 2 (NanH) 3.2.1.18 Clostridium perfringens ATCC 10543 CAA50436.1 Q59311  
 sialidase (CpNanI;CPF_0721) 3.2.1.18 Clostridium perfringens ATCC 13124 ABG83208.1 Q0TT67 4L2E[A]
5TSP[A,B]
 CPF_0985   Clostridium perfringens ATCC 13124 ABG84018.1 Q0TSF8  
 CPF_0532   Clostridium perfringens ATCC 13124 ABG84247.1 Q0TTQ4  
 NanI, partial   Clostridium perfringens CN3718 APZ74275.1    
 BXT91_02895   Clostridium perfringens CP15 AQW22891.1    
 BXT91_04080   Clostridium perfringens CP15 AQW23115.1    
 BXT91_05085   Clostridium perfringens CP15 AQW23307.1    
 BXT94_04320   Clostridium perfringens Del1 AQW26025.1    
 BXT94_09915   Clostridium perfringens Del1 AQW27075.1    
 BXT94_05545   Clostridium perfringens Del1 AQW26258.1    
 BG908_09070   Clostridium perfringens EHE-NE18 ASY51800.1
AWS26319.1
   
 BG908_04100   Clostridium perfringens EHE-NE18 ASY50870.1
AWS25363.1
   
 BG908_02920   Clostridium perfringens EHE-NE18 ASY50649.1
AWS25149.1
   
 BG908_05115   Clostridium perfringens EHE-NE18 ASY51063.1
AWS25561.1
   
 FORC3_0555   Clostridium perfringens FORC_003 ALG47932.1    
 FORC3_1686   Clostridium perfringens FORC_003 ALG49063.1    
 FORC3_0922   Clostridium perfringens FORC_003 ALG48299.1    
 FORC3_0721   Clostridium perfringens FORC_003 ALG48098.1    
 FORC25_0523   Clostridium perfringens FORC_025 AOY52943.1    
 FORC25_0716   Clostridium perfringens FORC_025 AOY53136.1    
 FORC25_0968   Clostridium perfringens FORC_025 AOY53385.1    
 JFP55_03020   Clostridium perfringens JP55 AMN31934.1    
 JFP55_05480   Clostridium perfringens JP55 AMN32383.1    
 JFP55_04220   Clostridium perfringens JP55 AMN32150.1    
 JFP838_05320   Clostridium perfringens JP838 AMN35195.1    
 JFP838_04060   Clostridium perfringens JP838 AMN34958.1    
 JFP838_02940   Clostridium perfringens JP838 AMN34751.1    
 C8114_03905   Clostridium perfringens JXJA17 AXH51780.1    
 C8114_03000   Clostridium perfringens JXJA17 AXH51610.1    
 C8114_05170   Clostridium perfringens JXJA17 AXH52021.1    
 CMR01_06170   Clostridium perfringens LLY_N11 ATD48363.1    
 CMR01_11265   Clostridium perfringens LLY_N11 ATD49336.1    
 CMR01_12460   Clostridium perfringens LLY_N11 ATD49562.1    
 CMR01_10260   Clostridium perfringens LLY_N11 ATD49144.1    
 NCTC13170_01802   Clostridium perfringens NCTC13170 SQG39657.1    
 NCTC13170_00586 (NanJ)   Clostridium perfringens NCTC13170 SQG37829.1    
 NCTC13170_01032 (NanH)   Clostridium perfringens NCTC13170 SQG38313.1    
 NCTC13170_00788 (NanI)   Clostridium perfringens NCTC13170 SQG38020.1    
 NCTC2837_01045 (NanH)   Clostridium perfringens NCTC2837 SQI04019.1    
 NCTC2837_00795 (Nani_2) (fragment)   Clostridium perfringens NCTC2837 SQI03506.1    
 NCTC2837_00604 (Nanj_2) (fragment)   Clostridium perfringens NCTC2837 SQI03144.1    
 CPR_0877   Clostridium perfringens SM101 ABG86307.1 Q0SUK5  
 exo-α-sialidase (NanJ;CPE0553) 3.2.1.18 Clostridium perfringens str. 13 BAB80259.1
NP_561469.1
Q8XMY5  
 exo-α-sialidase (NanI;CPSA;CPE0725) 3.2.1.18 Clostridium perfringens str. 13 BAB80431.1
NP_561641.1
Q8XMG4 2BF6[A]
2VK5[A]
2VK6[A]
2VK7[A,B]
 neuraminidase   Clostridium saccharoperbutylacetonicum N1-4(HMT) AGF57738.1    
 CP523_12745   Clostridium septicum DSM 7534 AYE35220.1    
 CP523_01750   Clostridium septicum DSM 7534 AYE33273.1    
 sialidase 3.2.1.18 Clostridium septicum NC0054714 CAA44916.1 P29767  
 EI377_12270   Clostridium septicum VAT12 QAS61444.1    
 EI377_07620   Clostridium septicum VAT12 QAS60616.1    
 neuraminidase   [Clostridium] sphenoides JCM 1415 ATCC 19403 SET85419.1    
 ZP_02867864.1   Clostridium spiroforme DSM 1552 ZP_02867864.1 B1C387  
 sialidase (NanH;SiaH) 3.2.1.18 Clostridium tertium CAA69951.1 P77848  
 neuraminidase   Cohaesibacter sp. ES.047 SNY92957.1    
 EAV92_22715   Cohnella sp. 18JY8-7 AYQ75794.1    
 O987_20575   Comamonas testosteroni TK102 AIJ48208.1    
 CC1_03920   Coprococcus catus GD/7 CBK79325.1 D4J4Q4  
 JI75_01895   Coriobacteriaceae bacterium 68-1-3 AJC11622.1    
 CAQU_07700   Corynebacterium aquilae DSM 44791 S-613 APT84974.1    
 CAQU_01300   Corynebacterium aquilae DSM 44791 S-613 APT83930.1    
 H924_11155   Corynebacterium callunae DSM 20147 AGG67659.1    
 CCASEI_03525   Corynebacterium casei LMG S-19264 AHI19285.1    
 CCHOA_05190 (NanA)   Corynebacterium choanis 200CH AZA13443.1    
 CDES_12030   Corynebacterium deserti GIMN1.010 ALC06756.1    
 CD241_0285   Corynebacterium diphtheriae 241 AEX43353.1    
 CD241_0480 (NanH)   Corynebacterium diphtheriae 241 AEX43547.1    
 CD31A_0333   Corynebacterium diphtheriae 31A AEX41018.1    
 CD31A_0540 (NanH)   Corynebacterium diphtheriae 31A AEX41224.1    
 BS112_10690   Corynebacterium diphtheriae B-D-16-78 APM36886.1    
 BS112_09660   Corynebacterium diphtheriae B-D-16-78 APM36707.1    
 CDBH8_0495 (NanH)   Corynebacterium diphtheriae BH8 AEX48020.1    
 CDBH8_0280   Corynebacterium diphtheriae BH8 AEX47805.1    
 B11Q_00514 (NanH)   Corynebacterium diphtheriae BQ11 AWR15220.1    
 CDC7B_0498 (NanH)   Corynebacterium diphtheriae C7 (beta) AEX66697.1    
 CDC7B_0282   Corynebacterium diphtheriae C7 (beta) AEX66482.1    
 CDCE8392_0286   Corynebacterium diphtheriae CDCE 8392 AEX71288.1    
 CDCE8392_0488 (NanH)   Corynebacterium diphtheriae CDCE 8392 AEX71488.1    
 CHUV2995_00350 (NanA)   Corynebacterium diphtheriae CHUV2995 SPJ39571.1    
 CHUV2995_00654 (NedA)   Corynebacterium diphtheriae CHUV2995 SPJ39870.1    
 A6J36_10310   Corynebacterium diphtheriae FDAARGOS_197 ARB88654.1    
 A6J36_11360   Corynebacterium diphtheriae FDAARGOS_197 ARB89035.1    
 CDHC01_0286   Corynebacterium diphtheriae HC01 AEX73539.1    
 CDHC01_0481 (NanH)   Corynebacterium diphtheriae HC01 AEX73734.1    
 CDHC02_0291   Corynebacterium diphtheriae HC02 AEX75787.1    
 CDHC02_0488 (NanH)   Corynebacterium diphtheriae HC02 AEX75984.1    
 CDHC03_0263   Corynebacterium diphtheriae HC03 AEX77994.1    
 CDHC03_0467 (NanH)   Corynebacterium diphtheriae HC03 AEX78198.1    
 CDHC04_0246   Corynebacterium diphtheriae HC04 AEX80239.1    
 CDHC04_0446 (NanH)   Corynebacterium diphtheriae HC04 AEX80439.1    
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