Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | ... | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | ... | 46 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 AMED_1329   Amycolatopsis mediterranei U32 ADJ43143.1 D8I6Z3  
 AMED_1405   Amycolatopsis mediterranei U32 ADJ43219.1 D8I8C0  
 AMED_3405   Amycolatopsis mediterranei U32 ADJ45191.1 D8I5V2  
 AMED_3924   Amycolatopsis mediterranei U32 ADJ45703.1 D8HNW1  
 AMED_3995   Amycolatopsis mediterranei U32 ADJ45772.1 D8HPV0  
 AMED_5616   Amycolatopsis mediterranei U32 ADJ47369.1 D8I7E9  
 AMED_6432   Amycolatopsis mediterranei U32 ADJ48164.1 D8HYL7  
 AMED_7377   Amycolatopsis mediterranei U32 ADJ49091.1 D8I9C4  
 AMED_8378 (fragment)   Amycolatopsis mediterranei U32 ADJ50074.1 D8HIZ7  
 AMED_8379   Amycolatopsis mediterranei U32 ADJ50075.1 D8HIZ8  
 AMED_8990 (fragment)   Amycolatopsis mediterranei U32 ADJ50680.1 D8HKQ3  
 AMETH_5313   Amycolatopsis methanolica 239 AIJ25405.1    
 SD37_33250   Amycolatopsis orientalis B-37 ANN20000.1    
 SD37_20645   Amycolatopsis orientalis B-37 ANN17818.1    
 SD37_20540 (fragment)   Amycolatopsis orientalis B-37 ANN17801.1    
 SD37_17035   Amycolatopsis orientalis B-37 ANN17177.1    
 SD37_33790   Amycolatopsis orientalis B-37 ANN20088.1    
 SD37_20610   Amycolatopsis orientalis B-37 ANN17813.1    
 SD37_19620   Amycolatopsis orientalis B-37 ANN17638.1    
 SD37_20620   Amycolatopsis orientalis B-37 ANN17815.1    
 SD37_33300   Amycolatopsis orientalis B-37 ANN22198.1    
 SD37_17895   Amycolatopsis orientalis B-37 ANN17333.1    
 SD37_40550   Amycolatopsis orientalis B-37 ANN21253.1    
 SD37_40550   Amycolatopsis orientalis B-37 ANN21253.1    
 SD37_40550   Amycolatopsis orientalis B-37 ANN21253.1    
 SD37_23140   Amycolatopsis orientalis B-37 ANN18250.1    
 SD37_04685   Amycolatopsis orientalis B-37 ANN15024.1    
 SD37_29115   Amycolatopsis orientalis B-37 ANN19275.1    
 SD37_21780   Amycolatopsis orientalis B-37 ANN18019.1    
 SD37_20615   Amycolatopsis orientalis B-37 ANN17814.1    
 SD37_20630   Amycolatopsis orientalis B-37 ANN21904.1    
 SD37_20625   Amycolatopsis orientalis B-37 ANN17816.1    
 SD37_23285   Amycolatopsis orientalis B-37 ANN18272.1    
 SD37_23150   Amycolatopsis orientalis B-37 ANN21966.1    
 SD37_23175   Amycolatopsis orientalis B-37 ANN18254.1    
 AORI_1566   Amycolatopsis orientalis HCCB10007 AGM04154.1    
 AORI_3326   Amycolatopsis orientalis HCCB10007 AGM05911.1    
 AORI_3823   Amycolatopsis orientalis HCCB10007 AGM06408.1    
 AORI_7158   Amycolatopsis orientalis HCCB10007 AGM09740.1    
 AORI_0266   Amycolatopsis orientalis HCCB10007 AGM02855.1    
 AORI_1456   Amycolatopsis orientalis HCCB10007 AGM04044.1    
 AORI_2116   Amycolatopsis orientalis HCCB10007 AGM04704.1    
 NIES21_47680 (AbfB)   Anabaenopsis circularis NIES-21 BAY18914.1    
 CB4_01935   Aneurinibacillus soli CB4 BAU27761.1    
 A9P82_10280   Arachidicoccus sp. BS20 ANI89639.1    
 AA314_00818   Archangium gephyra DSM 2261 AKI99191.1    
 AA314_06444   Archangium gephyra DSM 2261 AKJ04818.1    
 AA314_05226   Archangium gephyra DSM 2261 AKJ03600.1    
 AA314_03283   Archangium gephyra DSM 2261 AKJ01657.1    
 AA314_03856   Archangium gephyra DSM 2261 AKJ02230.1    
 AA314_07852   Archangium gephyra DSM 2261 AKJ06226.1    
 AA314_03284   Archangium gephyra DSM 2261 AKJ01658.1    
 AA314_08135   Archangium gephyra DSM 2261 AKJ06509.1    
 AA314_02856   Archangium gephyra DSM 2261 AKJ01230.1    
 AA314_07861   Archangium gephyra DSM 2261 AKJ06235.1    
 AL755_10110   Arthrobacter sp. ERGS1:01 ALE05739.1    
 ARUE_c07320 (Bgla2)   Arthrobacter sp. Rue61a AFR27665.1    
 β-1,3-glucanase (laminaripentaose-producing) (GlcI) 3.2.1.39 Arthrobacter sp. YCWD3 BAA04892.1 Q59146  
 CGK93_04050   Arthrobacter sp. YN ASN22347.1    
 CGK93_20045   Arthrobacter sp. YN ASN21710.1    
 CGK93_10875   Arthrobacter sp. YN ASN20115.1    
 CGK93_05515   Arthrobacter sp. YN ASN19209.1    
 WR51_29905   Bacillus cereus CMCC P0011 ANC17132.1    
 WR47_28765   Bacillus cereus CMCC P0021 ANC11104.1    
 FORC47_p099   Bacillus cereus FORC_047 ASL62451.1    
 BCQ_1809   Bacillus cereus Q1 ACM12237.1 B9IX27  
 β-1,3(4)-glucanase M (BglM) 3.2.1.39
3.2.1.6
3.2.1.73
Bacillus circulans IAM1165 BAC06195.1 Q8KKH3  
 BG05_3499   Bacillus mycoides ATCC 6462 AJH18485.1    
 B7492_32505   Bacillus mycoides Gnyt1 ARJ25761.1    
 B7492_30520   Bacillus mycoides Gnyt1 ARJ25411.1    
 pectate lyase 4.2.2.2 Bacillus sp. AAI12 AAE59747.1
AAS29294.1
   
 pectate lyase   Bacillus sp. JAMB750 BAK39698.1    
 unnamed protein product   Bacillus thuringiensis CAS92778.1    
 Cry41Ab1   Bacillus thuringiensis A1462 BAD35163.1 Q6BE06  
 Cry42Aa1   Bacillus thuringiensis A1462 BAD35166.1 Q6BE03  
 Cry41Aa1   Bacillus thuringiensis A1462 BAD35160.1
BAD35157.1
Q6BE09  
 Cry-related protein   Bacillus thuringiensis B3 AHN52957.1    
 insect toxin protein   Bacillus thuringiensis E65-3 AEX56522.1    
 BTF1_32201   Bacillus thuringiensis HD-789 AFQ30525.1    
 BTF1_32411   Bacillus thuringiensis HD-789 AFQ30565.1    
 BTF1_32411   Bacillus thuringiensis HD-789 AFQ30565.1    
 AS86_5750   Bacillus thuringiensis HD1002 AJH03295.1    
 A3L20_32290   Bacillus thuringiensis HD12 AMR88637.1    
 A3L20_32290   Bacillus thuringiensis HD12 AMR88637.1    
 ORF   Bacillus thuringiensis HS18-1 AER28314.1    
 ORF   Bacillus thuringiensis HS18-1 AER28314.1    
 AC241_30300   Bacillus thuringiensis HS18-1 AKR12990.1    
 AC241_30450   Bacillus thuringiensis HS18-1 AKR13014.1    
 AC241_30000   Bacillus thuringiensis HS18-1 AKR12943.1    
 ORF   Bacillus thuringiensis HS18-1 AEX56523.1    
 BCM43_29740   Bacillus thuringiensis KNU-07 ANV74614.1    
 MC28_C065   Bacillus thuringiensis MC28 AFU17013.1    
 MC28_D171   Bacillus thuringiensis MC28 AFU17220.1    
 MC28_E051   Bacillus thuringiensis MC28 AFU17310.1
ADV33305.1
   
 MC28_E051   Bacillus thuringiensis MC28 AFU17310.1
ADV33305.1
   
 MC28_E065   Bacillus thuringiensis MC28 AFU17324.1    
 MC28_E164   Bacillus thuringiensis MC28 AFU17423.1    
 MC28_F002   Bacillus thuringiensis MC28 AFU17446.1    
 MC28_E079   Bacillus thuringiensis MC28 AFU17338.1    
 ORF   Bacillus thuringiensis Sbt029 AEH76822.1    
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