Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5775); Uniprot accession (902); PDB accession (144); 3D entries (57); cryst (1)
All (5552) Archaea (19) Bacteria (4920) Eukaryota (570) Viruses (30) unclassified (13) Structure (57 - 1 cryst) Characterized (99)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 AMES_8368   Amycolatopsis mediterranei S699 AFO81901.1
AEK47190.1
   
 AMES_7266   Amycolatopsis mediterranei S699 AFO80799.1
AEK46052.1
   
 AMES_6338   Amycolatopsis mediterranei S699 AFO79874.1
AEK45067.1
   
 AMES_3878   Amycolatopsis mediterranei S699 AFO77414.1
AEK42483.1
   
 AMES_3261 (AbfA)   Amycolatopsis mediterranei S699 AFO76797.1
AEK41843.1
   
 AMES_3259   Amycolatopsis mediterranei S699 AFO76795.1
AEK41841.1
   
 AMES_3886   Amycolatopsis mediterranei S699 AEK42492.1
AFO77422.1
   
 AMES_7708 (AbfA)   Amycolatopsis mediterranei S699 AFO81241.1
AEK46510.1
   
 AMES_1396   Amycolatopsis mediterranei S699 AFO74932.1
AEK39916.1
   
 AMED_7828   Amycolatopsis mediterranei U32 ADJ49536.1 D8HQB2  
 AMED_1296   Amycolatopsis mediterranei U32 ADJ43110.1 D8I6W0  
 AMED_1469   Amycolatopsis mediterranei U32 ADJ43282.1 D8I8I3  
 AMED_1923 (GalA)   Amycolatopsis mediterranei U32 ADJ43732.1 D8HQM1  
 AMED_2373   Amycolatopsis mediterranei U32 ADJ44169.1 D8HUX1  
 AMED_2907 (AbfA)   Amycolatopsis mediterranei U32 ADJ44701.1 D8I114  
 AMED_3093   Amycolatopsis mediterranei U32 ADJ44884.1 D8I2P8  
 AMED_3290   Amycolatopsis mediterranei U32 ADJ45079.1 D8I5J0  
 AMED_3291   Amycolatopsis mediterranei U32 ADJ45080.1 D8I5J1  
 AMED_3292 (AbfA)   Amycolatopsis mediterranei U32 ADJ45081.1 D8I5J2  
 AMED_3293   Amycolatopsis mediterranei U32 ADJ45082.1 D8I5J3  
 AMED_3295   Amycolatopsis mediterranei U32 ADJ45084.1 D8I5J5  
 AMED_3297 (AbfA)   Amycolatopsis mediterranei U32 ADJ45086.1 D8I5J7  
 AMED_3298   Amycolatopsis mediterranei U32 ADJ45087.1 D8I5J8  
 AMED_3411   Amycolatopsis mediterranei U32 ADJ45197.1 D8I5V8  
 AMED_3412   Amycolatopsis mediterranei U32 ADJ45198.1 D8I5V9  
 AMED_3579   Amycolatopsis mediterranei U32 ADJ45365.1 D8I8M7  
 AMED_3579   Amycolatopsis mediterranei U32 ADJ45365.1 D8I8M7  
 AMED_3680   Amycolatopsis mediterranei U32 ADJ45463.1 D8I8X5  
 AMED_3713   Amycolatopsis mediterranei U32 ADJ45494.1 D8HMI4  
 AMED_3747   Amycolatopsis mediterranei U32 ADJ45526.1 D8HML6  
 AMED_3748   Amycolatopsis mediterranei U32 ADJ45527.1 D8HML7  
 AMED_3932   Amycolatopsis mediterranei U32 ADJ45711.1 D8HNW9  
 AMED_3933   Amycolatopsis mediterranei U32 ADJ45712.1 D8HNX0  
 AMED_3984   Amycolatopsis mediterranei U32 ADJ45762.1 D8HPU0  
 AMED_3985   Amycolatopsis mediterranei U32 ADJ45763.1 D8HPU1  
 AMED_3987   Amycolatopsis mediterranei U32 ADJ45765.1 D8HPU3  
 AMED_3993   Amycolatopsis mediterranei U32 ADJ45770.1 D8HPU8  
 AMED_3994 (AbfA)   Amycolatopsis mediterranei U32 ADJ45771.1 D8HPU9  
 AMED_4817 (AbfA)   Amycolatopsis mediterranei U32 ADJ46583.1 D8HY95  
 AMED_5153   Amycolatopsis mediterranei U32 ADJ46916.1 D8I1I5  
 AMED_5452   Amycolatopsis mediterranei U32 ADJ47212.1 D8I4N8  
 AMED_5532   Amycolatopsis mediterranei U32 ADJ47290.1 D8I622  
 AMED_5599   Amycolatopsis mediterranei U32 ADJ47352.1 D8I684  
 AMED_6431   Amycolatopsis mediterranei U32 ADJ48163.1 D8HYL6  
 AMED_7386 (GalA)   Amycolatopsis mediterranei U32 ADJ49100.1 D8I9D3  
 AMED_7482   Amycolatopsis mediterranei U32 ADJ49196.1 D8I9M9  
 AMED_7822   Amycolatopsis mediterranei U32 ADJ49530.1 D8HQA6  
 AMED_7823 (GalA)   Amycolatopsis mediterranei U32 ADJ49531.1 D8HQA7  
 AMED_7824 (AbfA)   Amycolatopsis mediterranei U32 ADJ49532.1 D8HQA8  
 AMED_7829   Amycolatopsis mediterranei U32 ADJ49537.1 D8HQB3  
 AMED_8377   Amycolatopsis mediterranei U32 ADJ50073.1 D8HIZ6  
 AMED_8380   Amycolatopsis mediterranei U32 ADJ50076.1 D8HIZ9  
 AMED_8497   Amycolatopsis mediterranei U32 ADJ50193.1 D8HJB6  
 AMED_1329   Amycolatopsis mediterranei U32 ADJ43143.1 D8I6Z3  
 AMED_1405   Amycolatopsis mediterranei U32 ADJ43219.1 D8I8C0  
 AMED_3405   Amycolatopsis mediterranei U32 ADJ45191.1 D8I5V2  
 AMED_3924   Amycolatopsis mediterranei U32 ADJ45703.1 D8HNW1  
 AMED_3995   Amycolatopsis mediterranei U32 ADJ45772.1 D8HPV0  
 AMED_5616   Amycolatopsis mediterranei U32 ADJ47369.1 D8I7E9  
 AMED_6432   Amycolatopsis mediterranei U32 ADJ48164.1 D8HYL7  
 AMED_7377   Amycolatopsis mediterranei U32 ADJ49091.1 D8I9C4  
 AMED_8378 (fragment)   Amycolatopsis mediterranei U32 ADJ50074.1 D8HIZ7  
 AMED_8379   Amycolatopsis mediterranei U32 ADJ50075.1 D8HIZ8  
 AMED_8990 (fragment)   Amycolatopsis mediterranei U32 ADJ50680.1 D8HKQ3  
 AMETH_5313   Amycolatopsis methanolica 239 AIJ25405.1    
 SD37_33250   Amycolatopsis orientalis B-37 ANN20000.1    
 SD37_20645   Amycolatopsis orientalis B-37 ANN17818.1    
 SD37_20540 (fragment)   Amycolatopsis orientalis B-37 ANN17801.1    
 SD37_17035   Amycolatopsis orientalis B-37 ANN17177.1    
 SD37_33790   Amycolatopsis orientalis B-37 ANN20088.1    
 SD37_20610   Amycolatopsis orientalis B-37 ANN17813.1    
 SD37_19620   Amycolatopsis orientalis B-37 ANN17638.1    
 SD37_20620   Amycolatopsis orientalis B-37 ANN17815.1    
 SD37_33300   Amycolatopsis orientalis B-37 ANN22198.1    
 SD37_17895   Amycolatopsis orientalis B-37 ANN17333.1    
 SD37_40550   Amycolatopsis orientalis B-37 ANN21253.1    
 SD37_40550   Amycolatopsis orientalis B-37 ANN21253.1    
 SD37_40550   Amycolatopsis orientalis B-37 ANN21253.1    
 SD37_23140   Amycolatopsis orientalis B-37 ANN18250.1    
 SD37_04685   Amycolatopsis orientalis B-37 ANN15024.1    
 SD37_29115   Amycolatopsis orientalis B-37 ANN19275.1    
 SD37_21780   Amycolatopsis orientalis B-37 ANN18019.1    
 SD37_20615   Amycolatopsis orientalis B-37 ANN17814.1    
 SD37_20630   Amycolatopsis orientalis B-37 ANN21904.1    
 SD37_20625   Amycolatopsis orientalis B-37 ANN17816.1    
 SD37_23285   Amycolatopsis orientalis B-37 ANN18272.1    
 SD37_23150   Amycolatopsis orientalis B-37 ANN21966.1    
 SD37_23175   Amycolatopsis orientalis B-37 ANN18254.1    
 AORI_1566   Amycolatopsis orientalis HCCB10007 AGM04154.1    
 AORI_3326   Amycolatopsis orientalis HCCB10007 AGM05911.1    
 AORI_3823   Amycolatopsis orientalis HCCB10007 AGM06408.1    
 AORI_7158   Amycolatopsis orientalis HCCB10007 AGM09740.1    
 AORI_0266   Amycolatopsis orientalis HCCB10007 AGM02855.1    
 AORI_1456   Amycolatopsis orientalis HCCB10007 AGM04044.1    
 AORI_2116   Amycolatopsis orientalis HCCB10007 AGM04704.1    
 CU254_25965   Amycolatopsis sp. AA4 ATY13489.1    
 CU254_25965   Amycolatopsis sp. AA4 ATY13489.1    
 CU254_25965   Amycolatopsis sp. AA4 ATY13489.1    
 CU254_05190   Amycolatopsis sp. AA4 ATY09920.1    
 CU254_34645   Amycolatopsis sp. AA4 ATY14968.1    
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