Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (8917); Uniprot accession (900); PDB accession (160); 3D entries (62); cryst (1)
All (8859) Archaea (29) Bacteria (8098) Eukaryota (684) Viruses (35) unclassified (13) Structure (62 - 1 cryst) Characterized (101)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 81 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ACPOL_2734   Acidisarcina polymorpha SBC82 AXC12047.1    
 ACPOL_2545   Acidisarcina polymorpha SBC82 AXC11865.1    
 ACPOL_2545   Acidisarcina polymorpha SBC82 AXC11865.1    
 ACPOL_2963   Acidisarcina polymorpha SBC82 AXC12265.1    
 ACPOL_2963   Acidisarcina polymorpha SBC82 AXC12265.1    
 LuPra_05212 (Abn-ts_2)   Acidobacteria bacterium DSM 100886 AMY11942.1    
 ACP_0871   Acidobacterium capsulatum ATCC 51196 ACO32851.1 C1F2X0  
 G7045_08895   Acidovorax sp. HDW3 QIL44366.1    
 C380_15030   Acidovorax sp. KKS102 AFU46703.1    
 FPL17_07370   Acinetobacter dispersus NCCP 16014 QHH97383.1    
 FPL18_14240   Acinetobacter gyllenbergii NCCP 16015 QHH94899.1    
 Ahae11616_07180   Acinetobacter haemolyticus 11616 QHI32445.1    
 Ahae2126ch_07185   Acinetobacter haemolyticus 2126ch QHI25972.1    
 AhaeAN3_06440   Acinetobacter haemolyticus AN3 QHI19623.1    
 AhaeAN4_10110   Acinetobacter haemolyticus AN4 QHI16910.1    
 AhaeAN43_07150   Acinetobacter haemolyticus AN43 QHI13171.1    
 AhaeAN54_008550   Acinetobacter haemolyticus AN54 QDJ92109.1    
 AhaeAN59_07220   Acinetobacter haemolyticus AN59 QHI09907.1    
 AhaeINNSZ174_10215   Acinetobacter haemolyticus INNSZ174 QHI29814.1    
 DX910_12200   Acinetobacter haemolyticus sz1652 AZN68882.1    
 DX910_17170   Acinetobacter haemolyticus sz1652 AZN69862.1    
 AHTJR_06845   Acinetobacter haemolyticus TJR01 QBQ16001.1    
 AHTJS_06760   Acinetobacter haemolyticus TJS01 APR70108.1    
 FK537_14360   Acinetobacter indicus 94-2 QIZ60211.1    
 FSC09_06570   Acinetobacter indicus B18 QIC70091.1    
 FSC02_08540   Acinetobacter indicus CMG3-2 QIC79165.1    
 FSC17_07080   Acinetobacter indicus FS42-2 QIC76226.1    
 FHP22_08505   Acinetobacter indicus HY20 QFS17551.1    
 FSC05_06320   Acinetobacter indicus MMS9-2 QIC73341.1    
 F2A31_06635   Acinetobacter sp. C16S1 QER39401.1    
 BEN74_02855   Acinetobacter sp. WCHAc010034 AYA01900.1    
 GJD93_05390   Acinetobacter towneri 19110F47 QGM27145.1    
 GVU25_08500   Acinetobacter towneri 205 QIV92829.1    
 UA74_19810   Actinoalloteichus fjordicus ADI127-7 APU15987.1    
 UA74_27530   Actinoalloteichus fjordicus ADI127-7 APU17509.1    
 AHOG_17785   Actinoalloteichus hoggarensis DSM 45943 ASO21182.1    
 AHOG_25390 (AbfB)   Actinoalloteichus hoggarensis DSM 45943 ASO22683.1    
 AHOG_22090   Actinoalloteichus hoggarensis DSM 45943 ASO22033.1    
 TL08_24460   Actinoalloteichus hymeniacidonis HPA177(T) (=DSM 45092(T)) AOS65670.1    
 C1701_20950   Actinoalloteichus sp. AHMU CJ021 AUS80402.1    
 C1701_02885   Actinoalloteichus sp. AHMU CJ021 AUS77493.1    
 C1701_17620   Actinoalloteichus sp. AHMU CJ021 AUS79845.1    
 UA75_28075   Actinoalloteichus sp. GBA129-24 APU23586.1    
 UA75_20310   Actinoalloteichus sp. GBA129-24 APU22051.1    
 NCTC8529_00800   Actinobacillus equuli NCTC8529 VEE90422.1    
 NCTC9435_03319 (fragment)   Actinobacillus equuli NCTC9435 VEI47402.1    
 ACEE_07815 (fragment)   Actinobacillus equuli subsp. equuli 19392 AIZ79674.1    
 NCTC10568_02344   Actinobacillus lignieresii NCTC10568 VEB27546.1    
 CHY23_01064   Actinobacillus pleuropneumoniae KL 16 ASU15823.1    
 NCTC10976_02147   Actinobacillus pleuropneumoniae NCTC10976 VEJ17982.1    
 NCTC11384_02187   Actinobacillus pleuropneumoniae NCTC11384 SQF65811.1    
 DRF63_10620   Actinobacillus pleuropneumoniae S4074 AXA22426.1    
 APPSER1_10625   Actinobacillus pleuropneumoniae serovar 1 str. 4074 AWG96356.1    
 APJL_1995   Actinobacillus pleuropneumoniae serovar 3 str. JL03 ABY70543.1 B0BTX6  
 APL_1948   Actinobacillus pleuropneumoniae serovar 5b str. L20 ABN75026.1 A3N3P0  
 APP7_2036   Actinobacillus pleuropneumoniae serovar 7 str. AP76 ACE62688.1 B3H318  
 MIDG2331_02176   Actinobacillus pleuropneumoniae serovar 8 CUU53394.1    
 ASU1_07520   Actinobacillus suis ATCC 33415 AIJ31765.1    
 ASU2_07445   Actinobacillus suis H91-0380 AFU19627.1    
 SAMEA4504061_01576   Actinobacillus suis NCTC12996 SNV36070.1    
 EF847_15430   Actinobacteria bacterium YIM 96077 AYY13883.1    
 xylanase II (XylII) (fragment)   Actinomadura sp. FC7 AAA17888.1
AAO97631.1
AAQ80272.1
Q59139  
 F7P10_06210   Actinomadura sp. WMMB499 QFG26872.1    
 F7P10_27850   Actinomadura sp. WMMB499 QFG24372.1    
 F7P10_21070   Actinomadura sp. WMMB499 QFG23240.1    
 F7P10_06215   Actinomadura sp. WMMB499 QFG20801.1    
 F7P10_10810   Actinomadura sp. WMMB499 QFG21550.1    
 F7P10_10815   Actinomadura sp. WMMB499 QFG21551.1    
 actinohivin (Ath)   actinomycete K97-0003 BAA97578.1
AAN99135.1
Q9KWN0 3A07[A,B]
4DEN[A]
4END[A]
4G1R[A,C]
4G1S[A]
4P6A[A]
 SAMN04489716_4359   Actinoplanes derwentensis DSM 43941 SDT53506.1    
 SAMN04489716_2149   Actinoplanes derwentensis DSM 43941 SDS97814.1    
 SAMN04489716_7045   Actinoplanes derwentensis DSM 43941 SDT74640.1    
 SAMN04489716_3019   Actinoplanes derwentensis DSM 43941 SDT25471.1    
 SAMN04489716_9061   Actinoplanes derwentensis DSM 43941 SDT80101.1    
 SAMN04489716_4630   Actinoplanes derwentensis DSM 43941 SDT57818.1    
 SAMN04489716_4358   Actinoplanes derwentensis DSM 43941 SDT53490.1    
 SAMN04489716_2150   Actinoplanes derwentensis DSM 43941 SDS97841.1    
 SAMN04489716_9542   Actinoplanes derwentensis DSM 43941 SDT81215.1    
 SAMN04489716_9542   Actinoplanes derwentensis DSM 43941 SDT81215.1    
 SAMN04489716_2875   Actinoplanes derwentensis DSM 43941 SDT21472.1    
 SAMN04489716_9606   Actinoplanes derwentensis DSM 43941 SDT81378.1    
 SAMN04489716_8791   Actinoplanes derwentensis DSM 43941 SDT79450.1    
 SAMN04489716_4356   Actinoplanes derwentensis DSM 43941 SDT53467.1    
 SAMN04489716_3154   Actinoplanes derwentensis DSM 43941 SDT29034.1    
 SAMN04489716_0823   Actinoplanes derwentensis DSM 43941 SDS45579.1    
 SAMN04489716_3389   Actinoplanes derwentensis DSM 43941 SDT34677.1    
 SAMN04489716_2838   Actinoplanes derwentensis DSM 43941 SDT20333.1    
 SAMN04489716_5669   Actinoplanes derwentensis DSM 43941 SDT68742.1    
 SAMN04489716_4520   Actinoplanes derwentensis DSM 43941 SDT56085.1    
 SAMN04489716_5361   Actinoplanes derwentensis DSM 43941 SDT66543.1    
 SAMN04489716_2952   Actinoplanes derwentensis DSM 43941 SDT23632.1    
 SAMN04489716_2820   Actinoplanes derwentensis DSM 43941 SDT19755.1    
 SAMN04489716_2359   Actinoplanes derwentensis DSM 43941 SDT04936.1    
 SAMN04489716_1514   Actinoplanes derwentensis DSM 43941 SDS74768.1    
 SAMN04489716_1906   Actinoplanes derwentensis DSM 43941 SDS89210.1    
 SAMN04489716_2458   Actinoplanes derwentensis DSM 43941 SDT08346.1    
 SAMN04489716_5668   Actinoplanes derwentensis DSM 43941 SDT68735.1    
 SAMN04489716_9062   Actinoplanes derwentensis DSM 43941 SDT80103.1    
 SAMN04489716_2360   Actinoplanes derwentensis DSM 43941 SDT04982.1    
 SAMN04489716_1299   Actinoplanes derwentensis DSM 43941 SDS66128.1    
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