Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (18099); Uniprot accession (139); PDB accession (165); 3D entries (60); cryst (1)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 170 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 IAD21_02460   Abditibacteriota bacterium IAD-21 BCM90606.1    
 IAD21_05494 (Abn-ts_3)   Abditibacteriota bacterium IAD-21 BCM93603.1    
 IAD21_00661   Abditibacteriota bacterium IAD-21 BCM88819.1    
 IAD21_00661   Abditibacteriota bacterium IAD-21 BCM88819.1    
 IAD21_04330   Abditibacteriota bacterium IAD-21 BCM92450.1    
 IAD21_04576   Abditibacteriota bacterium IAD-21 BCM92694.1    
 IAD21_00174 (Sacc_1)   Abditibacteriota bacterium IAD-21 BCM88343.1    
 IAD21_00174 (Sacc_1)   Abditibacteriota bacterium IAD-21 BCM88343.1    
 IAD21_04564   Abditibacteriota bacterium IAD-21 BCM92682.1    
 IAD21_00118   Abditibacteriota bacterium IAD-21 BCM88287.1    
 IAD21_00176 (Sacc_2)   Abditibacteriota bacterium IAD-21 BCM88345.1    
 IAD21_04577   Abditibacteriota bacterium IAD-21 BCM92695.1    
 IAD21_04577   Abditibacteriota bacterium IAD-21 BCM92695.1    
 IAD21_01109 (Abn-ts_1)   Abditibacteriota bacterium IAD-21 BCM89264.1    
 MQE35_04050   Abyssalbus ytuae MT3330 UOB18468.1    
 AcGH5 / AceceDRAFT_1592   Acetivibrio cellulolyticus CD2 EFL62381.1 E1KC96  
 Clocl_2763   Acetivibrio clariflavus DSM 19732 AEV69316.1    
 HVS_04240 (Cele3)   Acetivibrio saccincola GGR1 AUG56790.1    
 AD2_01574   Acetivibrio thermocellus AD2 ALX08567.1    
 AD2_02890   Acetivibrio thermocellus AD2 ALX09868.1    
 [arabinogalactan] exo-β-1,3-galactanase (Ct1,3Gal43A; CtGH43; Cthe_0661) (1,3Gal43A)   Acetivibrio thermocellus ATCC 27405 ABN51896.1 A3DD67 3VSF[A,B,C,D,E,F]
3VSZ[A,B,C,D,E,F]
3VT0[A,B,C,D,E,F]
3VT1[A,B,C,D,E,F]
3VT2[A,B,C,D,E,F]
 xylanase (M6;CtM6;CtXyl5A;Cthe_2193) (arabinoxylan-specific) (Xyl5A)   Acetivibrio thermocellus ATCC 27405 ABN53395.1 A3DHG6 5AK1[A]
5G56[A]
 Clo1313_2856   Acetivibrio thermocellus DSM 1313 ADU75836.1    
 Clo1313_1563   Acetivibrio thermocellus DSM 1313 ADU74624.1    
 LQRI_2901   Acetivibrio thermocellus DSM 2360 LQRI ANV77642.1    
 LQRI_1575   Acetivibrio thermocellus DSM 2360 LQRI ANV76316.1    
 Cther_1146   Acetivibrio thermocellus JW20 EFB38194.1    
 N1236_14670   Acetivibrio thermocellus M3 UWV46765.1    
 N1236_08320   Acetivibrio thermocellus M3 UWV45590.1    
 ACPOL_2734   Acidisarcina polymorpha SBC82 AXC12047.1    
 ACPOL_2545   Acidisarcina polymorpha SBC82 AXC11865.1    
 ACPOL_2545   Acidisarcina polymorpha SBC82 AXC11865.1    
 ACPOL_2963   Acidisarcina polymorpha SBC82 AXC12265.1    
 ACPOL_2963   Acidisarcina polymorpha SBC82 AXC12265.1    
 LuPra_05212 (Abn-ts_2)   Acidobacteria bacterium DSM 100886 AMY11942.1    
 ACP_0871   Acidobacterium capsulatum ATCC 51196 ACO32851.1    
 acdb102_02550   Acidothermaceae bacterium B102 BEP11944.1    
 acdb102_16200   Acidothermaceae bacterium B102 BEP13309.1    
 acdb102_16200   Acidothermaceae bacterium B102 BEP13309.1    
 acdb102_16200   Acidothermaceae bacterium B102 BEP13309.1    
 acdb102_02310   Acidothermaceae bacterium B102 BEP11920.1    
 acdb102_39880   Acidothermaceae bacterium B102 BEP15677.1    
 acdb102_39880   Acidothermaceae bacterium B102 BEP15677.1    
 acdb102_36350   Acidothermaceae bacterium B102 BEP15324.1    
 EXV95_01915   Acidovorax sp. JMULE5 QLA79528.1    
 C380_15030   Acidovorax sp. KKS102 AFU46703.1    
 M5C99_03990   Acidovorax sp. NCPPB 2350 WCM93901.1    
 M5C98_20255   Acidovorax sp. NCPPB 3576 WCM87649.1    
 ACBO_13920   Acinetobacter bouvetii JCM 18991 BCU64601.1    
 FPL17_07370   Acinetobacter dispersus NCCP 16014 QHH97383.1    
 FPL18_14240   Acinetobacter gyllenbergii NCCP 16015 QHH94899.1    
 Ahae11616_07180   Acinetobacter haemolyticus 11616 QHI32445.1    
 Ahae2126ch_07185   Acinetobacter haemolyticus 2126ch QHI25972.1    
 AhaeAN3_06440   Acinetobacter haemolyticus AN3 QHI19623.1    
 AhaeAN4_10110   Acinetobacter haemolyticus AN4 QHI16910.1    
 AhaeAN43_07150   Acinetobacter haemolyticus AN43 QHI13171.1    
 AhaeAN54_008550   Acinetobacter haemolyticus AN54 QDJ92109.1    
 AhaeAN59_07220   Acinetobacter haemolyticus AN59 QHI09907.1    
 PGW89_15180   Acinetobacter haemolyticus HW-2 WHR57736.1    
 AhaeINNSZ174_10215   Acinetobacter haemolyticus INNSZ174 QHI29814.1    
 SDC64_06760   Acinetobacter haemolyticus JS-1us WPO68618.1    
 DX910_12200   Acinetobacter haemolyticus sz1652 AZN68882.1    
 DX910_17170   Acinetobacter haemolyticus sz1652 AZN69862.1    
 AHTJR_06845   Acinetobacter haemolyticus TJR01 QBQ16001.1    
 AHTJS_06760   Acinetobacter haemolyticus TJS01 APR70108.1    
 F9230_08820   Acinetobacter johnsonii AJ14 UJA04441.1    
 NDN12_11115   Acinetobacter sp. C26G USA48775.1    
 NDN13_02320   Acinetobacter sp. C32I USA54055.1    
 LZP46_10420   Acinetobacter sp. SCLZS86 UIZ56805.1    
 O1450_09980   Acinetobacter sp. TR11 WAU72447.1    
 O1449_05435   Acinetobacter sp. TR3 WAU77617.1    
 BEN74_02855   Acinetobacter sp. WCHAc010034 AYA01900.1    
 GJD93_05390   Acinetobacter towneri 19110F47 QGM27145.1    
 GVU25_08500   Acinetobacter towneri 205 QIV92829.1    
 IHE36_09355   Acinetobacter towneri AT232 UNT61148.1    
 IHE37_08735   Acinetobacter towneri AT235 UNT63784.1    
 J4G44_11125   Acinetobacter towneri GX3 QTD58843.1    
 J4G45_05340   Acinetobacter towneri GX5 QTD62589.1    
 J4G46_04905   Acinetobacter towneri GX7 QTD65138.1    
 QSG83_05340 (fragment)   Acinetobacter towneri SAAt401 WOE29604.1    
 O4J62_08965   Acinetobacter towneri TT1-3_T WPC31346.1    
 LF296_06905   Acinetobacter vivianii KJ-1 WDZ52499.1    
 NYE86_13650   Actinacidiphila bryophytorum DS3 UWE13747.1    
 NYE86_22830   Actinacidiphila bryophytorum DS3 UWE13865.1    
 NYE86_19875   Actinacidiphila bryophytorum DS3 UWE13826.1    
 NYE86_24950 (fragment)   Actinacidiphila bryophytorum DS3 UWE13907.1    
 NYE86_12825   Actinacidiphila bryophytorum DS3 UWE13729.1    
 NYE86_34275   Actinacidiphila bryophytorum DS3 UWE14061.1    
 NYE86_34580   Actinacidiphila bryophytorum DS3 UWE13296.1    
 NYE86_22855   Actinacidiphila bryophytorum DS3 UWE11279.1    
 NYE86_13225   Actinacidiphila bryophytorum DS3 UWE09590.1    
 NYE86_18295 (fragment)   Actinacidiphila bryophytorum DS3 UWE10478.1    
 NYE86_02670   Actinacidiphila bryophytorum DS3 UWE07740.1    
 NYE86_15645   Actinacidiphila bryophytorum DS3 UWE10005.1    
 NYE86_22935   Actinacidiphila bryophytorum DS3 UWE11292.1    
 NYE86_22695   Actinacidiphila bryophytorum DS3 UWE11250.1    
 NYE86_13665   Actinacidiphila bryophytorum DS3 UWE09659.1    
 NYE86_22170   Actinacidiphila bryophytorum DS3 UWE11152.1    
 NYE86_22930   Actinacidiphila bryophytorum DS3 UWE11291.1    
 NYE86_23295   Actinacidiphila bryophytorum DS3 UWE11353.1    
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