Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 46 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 B737_8855 (fragment)   Amycolatopsis mediterranei RB AGT89515.1    
 RAM_43025   Amycolatopsis mediterranei S699 AEK47072.1
AFO81783.1
   
 RAM_18735   Amycolatopsis mediterranei S699 AEK42233.1
AFO77175.1
   
 RAM_20365   Amycolatopsis mediterranei S699 AEK42553.1
AFO77483.1
   
 RAM_19085   Amycolatopsis mediterranei S699 AEK42303.1
AFO77239.1
   
 RAM_16735   Amycolatopsis mediterranei S699 AEK41835.1
AFO76790.1
   
 RAM_28565   Amycolatopsis mediterranei S699 AEK44190.1
AFO79063.1
   
 RAM_06740   Amycolatopsis mediterranei S699 AEK39840.1
AFO74857.1
   
 RAM_40205   Amycolatopsis mediterranei S699 AEK46508.1
AFO81239.1
   
 RAM_18195   Amycolatopsis mediterranei S699 AEK42125.1
AFO77076.1
   
 RAM_18195   Amycolatopsis mediterranei S699 AEK42125.1
AFO77076.1
   
 RAM_14765   Amycolatopsis mediterranei S699 AEK41441.1
AFO76412.1
   
 RAM_43015   Amycolatopsis mediterranei S699 AEK47070.1
AFO81781.1
   
 RAM_28195   Amycolatopsis mediterranei S699 AEK44116.1
AFO79001.1
   
 RAM_16780   Amycolatopsis mediterranei S699 AEK41844.1
AFO76798.1
   
 RAM_17320   Amycolatopsis mediterranei S699 AEK41950.1
AFO76903.1
   
 RAM_43030   Amycolatopsis mediterranei S699 AEK47073.1
AFO81784.1
   
 RAM_26250   Amycolatopsis mediterranei S699 AEK43727.1
AFO78627.1
   
 RAM_37970   Amycolatopsis mediterranei S699 AEK46061.1
AFO80808.1
   
 RAM_20355   Amycolatopsis mediterranei S699 AEK42551.1
AFO77481.1
   
 RAM_40240   Amycolatopsis mediterranei S699 AEK46515.1
AFO81246.1
   
 RAM_16745   Amycolatopsis mediterranei S699 AEK41837.1
AFO76792.1
   
 RAM_06575   Amycolatopsis mediterranei S699 AEK39807.1
AFO74824.1
   
 RAM_20315   Amycolatopsis mediterranei S699 AEK42543.1
AFO77474.1
   
 RAM_17350   Amycolatopsis mediterranei S699 AEK41956.1
AFO76908.1
   
 RAM_19080   Amycolatopsis mediterranei S699 AEK42302.1
AFO77238.1
   
 RAM_20360   Amycolatopsis mediterranei S699 AEK42552.1
AFO77482.1
   
 RAM_20325   Amycolatopsis mediterranei S699 AEK42545.1
AFO77476.1
   
 RAM_07455   Amycolatopsis mediterranei S699 AEK39983.1
AFO74995.1
   
 RAM_20045   Amycolatopsis mediterranei S699 AEK42493.1
AFO77423.1
   
 RAM_09755   Amycolatopsis mediterranei S699 AEK40441.1
AFO75443.1
   
 RAM_40210   Amycolatopsis mediterranei S699 AEK46509.1
AFO81240.1
   
 RAM_27790   Amycolatopsis mediterranei S699 AEK44035.1
AFO78923.1
   
 RAM_38455   Amycolatopsis mediterranei S699 AEK46158.1
AFO80904.1
   
 RAM_16750   Amycolatopsis mediterranei S699 AEK41838.1
AFO76793.1
   
 RAM_32975   Amycolatopsis mediterranei S699 AEK45068.1
AFO79875.1
   
 RAM_24520   Amycolatopsis mediterranei S699 AEK43384.1
AFO78294.1
   
 RAM_12070   Amycolatopsis mediterranei S699 AEK40904.1
AFO75882.1
   
 RAM_18905   Amycolatopsis mediterranei S699 AEK42267.1
AFO77206.1
   
 RAM_15730   Amycolatopsis mediterranei S699 AEK41634.1
AFO76595.1
   
 RAM_20310   Amycolatopsis mediterranei S699 AEK42542.1
AFO77473.1
   
 RAM_16740   Amycolatopsis mediterranei S699 AEK41836.1
AFO76791.1
   
 RAM_17355   Amycolatopsis mediterranei S699 AEK41957.1
AFO76909.1
   
 RAM_40235   Amycolatopsis mediterranei S699 AEK46514.1
AFO81245.1
   
 RAM_28675   Amycolatopsis mediterranei S699 AEK44212.1
AFO79080.1
   
 RAM_43020 (fragment)   Amycolatopsis mediterranei S699 AEK47071.1
AFO81782.1
   
 RAM_46115 (fragment)   Amycolatopsis mediterranei S699 AEK47688.1
AFO82386.1
   
 AMES_8368   Amycolatopsis mediterranei S699 AFO81901.1
AEK47190.1
   
 AMES_7266   Amycolatopsis mediterranei S699 AFO80799.1
AEK46052.1
   
 AMES_6338   Amycolatopsis mediterranei S699 AFO79874.1
AEK45067.1
   
 AMES_3878   Amycolatopsis mediterranei S699 AFO77414.1
AEK42483.1
   
 AMES_3261 (AbfA)   Amycolatopsis mediterranei S699 AFO76797.1
AEK41843.1
   
 AMES_3259   Amycolatopsis mediterranei S699 AFO76795.1
AEK41841.1
   
 AMES_3886   Amycolatopsis mediterranei S699 AEK42492.1
AFO77422.1
   
 AMES_7708 (AbfA)   Amycolatopsis mediterranei S699 AFO81241.1
AEK46510.1
   
 AMES_1396   Amycolatopsis mediterranei S699 AFO74932.1
AEK39916.1
   
 AMED_7828   Amycolatopsis mediterranei U32 ADJ49536.1 D8HQB2  
 AMED_1296   Amycolatopsis mediterranei U32 ADJ43110.1 D8I6W0  
 AMED_1469   Amycolatopsis mediterranei U32 ADJ43282.1 D8I8I3  
 AMED_1923 (GalA)   Amycolatopsis mediterranei U32 ADJ43732.1 D8HQM1  
 AMED_2373   Amycolatopsis mediterranei U32 ADJ44169.1 D8HUX1  
 AMED_2907 (AbfA)   Amycolatopsis mediterranei U32 ADJ44701.1 D8I114  
 AMED_3093   Amycolatopsis mediterranei U32 ADJ44884.1 D8I2P8  
 AMED_3290   Amycolatopsis mediterranei U32 ADJ45079.1 D8I5J0  
 AMED_3291   Amycolatopsis mediterranei U32 ADJ45080.1 D8I5J1  
 AMED_3292 (AbfA)   Amycolatopsis mediterranei U32 ADJ45081.1 D8I5J2  
 AMED_3293   Amycolatopsis mediterranei U32 ADJ45082.1 D8I5J3  
 AMED_3295   Amycolatopsis mediterranei U32 ADJ45084.1 D8I5J5  
 AMED_3297 (AbfA)   Amycolatopsis mediterranei U32 ADJ45086.1 D8I5J7  
 AMED_3298   Amycolatopsis mediterranei U32 ADJ45087.1 D8I5J8  
 AMED_3411   Amycolatopsis mediterranei U32 ADJ45197.1 D8I5V8  
 AMED_3412   Amycolatopsis mediterranei U32 ADJ45198.1 D8I5V9  
 AMED_3579   Amycolatopsis mediterranei U32 ADJ45365.1 D8I8M7  
 AMED_3579   Amycolatopsis mediterranei U32 ADJ45365.1 D8I8M7  
 AMED_3680   Amycolatopsis mediterranei U32 ADJ45463.1 D8I8X5  
 AMED_3713   Amycolatopsis mediterranei U32 ADJ45494.1 D8HMI4  
 AMED_3747   Amycolatopsis mediterranei U32 ADJ45526.1 D8HML6  
 AMED_3748   Amycolatopsis mediterranei U32 ADJ45527.1 D8HML7  
 AMED_3932   Amycolatopsis mediterranei U32 ADJ45711.1 D8HNW9  
 AMED_3933   Amycolatopsis mediterranei U32 ADJ45712.1 D8HNX0  
 AMED_3984   Amycolatopsis mediterranei U32 ADJ45762.1 D8HPU0  
 AMED_3985   Amycolatopsis mediterranei U32 ADJ45763.1 D8HPU1  
 AMED_3987   Amycolatopsis mediterranei U32 ADJ45765.1 D8HPU3  
 AMED_3993   Amycolatopsis mediterranei U32 ADJ45770.1 D8HPU8  
 AMED_3994 (AbfA)   Amycolatopsis mediterranei U32 ADJ45771.1 D8HPU9  
 AMED_4817 (AbfA)   Amycolatopsis mediterranei U32 ADJ46583.1 D8HY95  
 AMED_5153   Amycolatopsis mediterranei U32 ADJ46916.1 D8I1I5  
 AMED_5452   Amycolatopsis mediterranei U32 ADJ47212.1 D8I4N8  
 AMED_5532   Amycolatopsis mediterranei U32 ADJ47290.1 D8I622  
 AMED_5599   Amycolatopsis mediterranei U32 ADJ47352.1 D8I684  
 AMED_6431   Amycolatopsis mediterranei U32 ADJ48163.1 D8HYL6  
 AMED_7386 (GalA)   Amycolatopsis mediterranei U32 ADJ49100.1 D8I9D3  
 AMED_7482   Amycolatopsis mediterranei U32 ADJ49196.1 D8I9M9  
 AMED_7822   Amycolatopsis mediterranei U32 ADJ49530.1 D8HQA6  
 AMED_7823 (GalA)   Amycolatopsis mediterranei U32 ADJ49531.1 D8HQA7  
 AMED_7824 (AbfA)   Amycolatopsis mediterranei U32 ADJ49532.1 D8HQA8  
 AMED_7829   Amycolatopsis mediterranei U32 ADJ49537.1 D8HQB3  
 AMED_8377   Amycolatopsis mediterranei U32 ADJ50073.1 D8HIZ6  
 AMED_8380   Amycolatopsis mediterranei U32 ADJ50076.1 D8HIZ9  
 AMED_8497   Amycolatopsis mediterranei U32 ADJ50193.1 D8HJB6  
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