Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5533); Uniprot accession (902); PDB accession (143); 3D entries (56); cryst (1)
All (5278) Archaea (18) Bacteria (4665) Eukaryota (558) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | ... | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ... | 47 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 BM47_2126 (fragment)   Burkholderia mallei India86-567-2 AJX49724.1    
 RY29_04020   Burkholderia mallei JHU ATE36900.1    
 RY29_04020   Burkholderia mallei JHU ATE36900.1    
 RY29_18195   Burkholderia mallei JHU ATE39635.1    
 RY29_18195   Burkholderia mallei JHU ATE39635.1    
 BM94_3579   Burkholderia mallei KC_1092 AJX65837.1    
 BM94_3579   Burkholderia mallei KC_1092 AJX65837.1    
 BM94_2235 (fragment)   Burkholderia mallei KC_1092 AJX64716.1    
 BM94_2235 (fragment)   Burkholderia mallei KC_1092 AJX64716.1    
 BMA10299_1921   Burkholderia mallei NCTC 10229 ABM99806.1
ABM99018.2
A2S198
A2S199
 
 BMA10299_1921   Burkholderia mallei NCTC 10229 ABM99806.1
ABM99018.2
A2S198
A2S199
 
 BMA10299_A0506   Burkholderia mallei NCTC 10229 ABN01297.1 A2S3I5  
 BMA10299_A0506   Burkholderia mallei NCTC 10229 ABN01297.1 A2S3I5  
 BMA10247_A0596   Burkholderia mallei NCTC 10247 ABO03150.1 A3MC11  
 BMA10247_A0596   Burkholderia mallei NCTC 10247 ABO03150.1 A3MC11  
 BMA10247_0650 (fragment)   Burkholderia mallei NCTC 10247 ABO05596.1 A3MIY1  
 BMA10247_0650 (fragment)   Burkholderia mallei NCTC 10247 ABO05596.1 A3MIY1  
 BM44_3178   Burkholderia mallei NCTC 10247 AIS25870.1    
 BM44_3178   Burkholderia mallei NCTC 10247 AIS25870.1    
 BM44_2394 (fragment)   Burkholderia mallei NCTC 10247 AIS28575.1    
 BM44_2394 (fragment)   Burkholderia mallei NCTC 10247 AIS28575.1    
 BMASAVP1_1713   Burkholderia mallei SAVP1 ABM48230.1 A1UZA4  
 BMASAVP1_1713   Burkholderia mallei SAVP1 ABM48230.1 A1UZA4  
 BMASAVP1_A1368   Burkholderia mallei SAVP1 ABM52922.1 A1V397  
 NM78_08690   Burkholderia mallei Turkey1 ATD89056.1    
 NM78_08690   Burkholderia mallei Turkey1 ATD89056.1    
 NM78_18305   Burkholderia mallei Turkey1 ATD90949.1    
 NM78_18305   Burkholderia mallei Turkey1 ATD90949.1    
 NW99_23405   Burkholderia mallei Turkey10 ATE45434.1    
 NW99_23405   Burkholderia mallei Turkey10 ATE45434.1    
 NW99_09035   Burkholderia mallei Turkey10 ATE42714.1    
 NW99_09035   Burkholderia mallei Turkey10 ATE42714.1    
 NW91_22495   Burkholderia mallei Turkey2 ATD96446.1    
 NW91_22495   Burkholderia mallei Turkey2 ATD96446.1    
 NW91_08695   Burkholderia mallei Turkey2 ATD93815.1    
 NW91_08695   Burkholderia mallei Turkey2 ATD93815.1    
 NW92_23115   Burkholderia mallei Turkey3 ATE01305.1    
 NW92_23115   Burkholderia mallei Turkey3 ATE01305.1    
 NW92_09105   Burkholderia mallei Turkey3 ATD98627.1    
 NW92_09105   Burkholderia mallei Turkey3 ATD98627.1    
 NW93_23410   Burkholderia mallei Turkey4 ATE06224.1    
 NW93_23410   Burkholderia mallei Turkey4 ATE06224.1    
 NW93_09320   Burkholderia mallei Turkey4 ATE03535.1    
 NW93_09320   Burkholderia mallei Turkey4 ATE03535.1    
 NW94_23200   Burkholderia mallei Turkey5 ATE11097.1    
 NW94_23200   Burkholderia mallei Turkey5 ATE11097.1    
 NW94_09020   Burkholderia mallei Turkey5 ATE08409.1    
 NW94_09020   Burkholderia mallei Turkey5 ATE08409.1    
 NW95_09010   Burkholderia mallei Turkey6 ATE13280.1    
 NW95_09010   Burkholderia mallei Turkey6 ATE13280.1    
 NW95_23260   Burkholderia mallei Turkey6 ATE15986.1    
 NW95_23260   Burkholderia mallei Turkey6 ATE15986.1    
 NW96_23190   Burkholderia mallei Turkey7 ATE20879.1    
 NW96_23190   Burkholderia mallei Turkey7 ATE20879.1    
 NW96_09015   Burkholderia mallei Turkey7 ATE18175.1    
 NW96_09015   Burkholderia mallei Turkey7 ATE18175.1    
 NW97_23015   Burkholderia mallei Turkey8 ATE25736.1    
 NW97_23015   Burkholderia mallei Turkey8 ATE25736.1    
 NW97_09205   Burkholderia mallei Turkey8 ATE23096.1    
 NW97_09205   Burkholderia mallei Turkey8 ATE23096.1    
 NW98_23385   Burkholderia mallei Turkey9 ATE30616.1    
 NW98_23385   Burkholderia mallei Turkey9 ATE30616.1    
 NW98_05765   Burkholderia mallei Turkey9 ATE27338.1    
 NW98_05765   Burkholderia mallei Turkey9 ATE27338.1    
 DM82_5775   Burkholderia oklahomensis BDU AIO69482.1    
 DM82_5775   Burkholderia oklahomensis BDU AIO69482.1    
 DM82_365   Burkholderia oklahomensis BDU AIO67524.1    
 BG90_665   Burkholderia oklahomensis C6786 AJX32983.1    
 BG90_4858   Burkholderia oklahomensis C6786 AJX35457.1    
 BG90_4858   Burkholderia oklahomensis C6786 AJX35457.1    
 BBW_2113   Burkholderia pseudomallei 1026b AJX09066.1    
 BBW_2113   Burkholderia pseudomallei 1026b AJX09066.1    
 BBW_4181   Burkholderia pseudomallei 1026b AJX10945.1    
 BBW_4181   Burkholderia pseudomallei 1026b AJX10945.1    
 BURPS1106A_1597   Burkholderia pseudomallei 1106a ABN90672.1 A3NU47  
 BURPS1106A_A2233   Burkholderia pseudomallei 1106a ABN93314.1 A3P7F6  
 BURPS1106A_A2233   Burkholderia pseudomallei 1106a ABN93314.1 A3P7F6  
 BURPS1710b_1758   Burkholderia pseudomallei 1710b ABA49405.1 Q3JTE4  
 BURPS1710b_A0712   Burkholderia pseudomallei 1710b ABA53419.1 Q3JKN2  
 BURPS1710b_A0712   Burkholderia pseudomallei 1710b ABA53419.1 Q3JKN2  
 ACT79_03355   Burkholderia pseudomallei 350105 ALB10091.1    
 ACT79_03355   Burkholderia pseudomallei 350105 ALB10091.1    
 BP3921G_50480   Burkholderia pseudomallei 3921 CDU31689.1    
 BP3921G_50480   Burkholderia pseudomallei 3921 CDU31689.1    
 BP3921G_13990   Burkholderia pseudomallei 3921 CDU28065.1    
 BP3921G_13990   Burkholderia pseudomallei 3921 CDU28065.1    
 BP3921G_13990   Burkholderia pseudomallei 3921 CDU28065.1    
 BG92_1571   Burkholderia pseudomallei 406e AJW91170.1    
 BG92_5309   Burkholderia pseudomallei 406e AJW87989.1    
 BG92_5309   Burkholderia pseudomallei 406e AJW87989.1    
 DP50_2635 (fragment)   Burkholderia pseudomallei 576 AIO96380.1    
 DP50_2635 (fragment)   Burkholderia pseudomallei 576 AIO96380.1    
 DP50_4620   Burkholderia pseudomallei 576 AIO99550.1    
 DP50_4620   Burkholderia pseudomallei 576 AIO99550.1    
 BURPS668_1572   Burkholderia pseudomallei 668 ABN82627.1 A3N8E2  
 BURPS668_A2317   Burkholderia pseudomallei 668 ABN86237.1 A3NLU0  
 BURPS668_A2317   Burkholderia pseudomallei 668 ABN86237.1 A3NLU0  
 BG97_3260   Burkholderia pseudomallei 7894 AJX79943.1    
 BG97_3260   Burkholderia pseudomallei 7894 AJX79943.1    
 BG97_6091   Burkholderia pseudomallei 7894 AJX83341.1    
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