Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | ... | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | ... | 46 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 NW94_23200   Burkholderia mallei Turkey5 ATE11097.1    
 NW94_09020   Burkholderia mallei Turkey5 ATE08409.1    
 NW94_09020   Burkholderia mallei Turkey5 ATE08409.1    
 NW95_09010   Burkholderia mallei Turkey6 ATE13280.1    
 NW95_09010   Burkholderia mallei Turkey6 ATE13280.1    
 NW95_23260   Burkholderia mallei Turkey6 ATE15986.1    
 NW95_23260   Burkholderia mallei Turkey6 ATE15986.1    
 NW96_23190   Burkholderia mallei Turkey7 ATE20879.1    
 NW96_23190   Burkholderia mallei Turkey7 ATE20879.1    
 NW96_09015   Burkholderia mallei Turkey7 ATE18175.1    
 NW96_09015   Burkholderia mallei Turkey7 ATE18175.1    
 NW97_23015   Burkholderia mallei Turkey8 ATE25736.1    
 NW97_23015   Burkholderia mallei Turkey8 ATE25736.1    
 NW97_09205   Burkholderia mallei Turkey8 ATE23096.1    
 NW97_09205   Burkholderia mallei Turkey8 ATE23096.1    
 NW98_23385   Burkholderia mallei Turkey9 ATE30616.1    
 NW98_23385   Burkholderia mallei Turkey9 ATE30616.1    
 NW98_05765   Burkholderia mallei Turkey9 ATE27338.1    
 NW98_05765   Burkholderia mallei Turkey9 ATE27338.1    
 DM82_5775   Burkholderia oklahomensis BDU AIO69482.1    
 DM82_5775   Burkholderia oklahomensis BDU AIO69482.1    
 DM82_365   Burkholderia oklahomensis BDU AIO67524.1    
 BG90_665   Burkholderia oklahomensis C6786 AJX32983.1    
 BG90_4858   Burkholderia oklahomensis C6786 AJX35457.1    
 BG90_4858   Burkholderia oklahomensis C6786 AJX35457.1    
 BBW_2113   Burkholderia pseudomallei 1026b AJX09066.1    
 BBW_2113   Burkholderia pseudomallei 1026b AJX09066.1    
 BBW_4181   Burkholderia pseudomallei 1026b AJX10945.1    
 BBW_4181   Burkholderia pseudomallei 1026b AJX10945.1    
 BURPS1106A_1597   Burkholderia pseudomallei 1106a ABN90672.1 A3NU47  
 BURPS1106A_A2233   Burkholderia pseudomallei 1106a ABN93314.1 A3P7F6  
 BURPS1106A_A2233   Burkholderia pseudomallei 1106a ABN93314.1 A3P7F6  
 BURPS1710b_1758   Burkholderia pseudomallei 1710b ABA49405.1 Q3JTE4  
 BURPS1710b_A0712   Burkholderia pseudomallei 1710b ABA53419.1 Q3JKN2  
 BURPS1710b_A0712   Burkholderia pseudomallei 1710b ABA53419.1 Q3JKN2  
 ACT79_03355   Burkholderia pseudomallei 350105 ALB10091.1    
 ACT79_03355   Burkholderia pseudomallei 350105 ALB10091.1    
 BP3921G_50480   Burkholderia pseudomallei 3921 CDU31689.1    
 BP3921G_50480   Burkholderia pseudomallei 3921 CDU31689.1    
 BP3921G_13990   Burkholderia pseudomallei 3921 CDU28065.1    
 BP3921G_13990   Burkholderia pseudomallei 3921 CDU28065.1    
 BP3921G_13990   Burkholderia pseudomallei 3921 CDU28065.1    
 BG92_1571   Burkholderia pseudomallei 406e AJW91170.1    
 BG92_5309   Burkholderia pseudomallei 406e AJW87989.1    
 BG92_5309   Burkholderia pseudomallei 406e AJW87989.1    
 DP50_2635 (fragment)   Burkholderia pseudomallei 576 AIO96380.1    
 DP50_2635 (fragment)   Burkholderia pseudomallei 576 AIO96380.1    
 DP50_4620   Burkholderia pseudomallei 576 AIO99550.1    
 DP50_4620   Burkholderia pseudomallei 576 AIO99550.1    
 BURPS668_1572   Burkholderia pseudomallei 668 ABN82627.1 A3N8E2  
 BURPS668_A2317   Burkholderia pseudomallei 668 ABN86237.1 A3NLU0  
 BURPS668_A2317   Burkholderia pseudomallei 668 ABN86237.1 A3NLU0  
 BG97_3260   Burkholderia pseudomallei 7894 AJX79943.1    
 BG97_3260   Burkholderia pseudomallei 7894 AJX79943.1    
 BG97_6091   Burkholderia pseudomallei 7894 AJX83341.1    
 BG97_6091   Burkholderia pseudomallei 7894 AJX83341.1    
 AMS56_25545   Burkholderia pseudomallei 982 ALC60121.1    
 AMS56_25545   Burkholderia pseudomallei 982 ALC60121.1    
 AMS56_12780 (fragment)   Burkholderia pseudomallei 982 ALC57584.1    
 AMS56_12780 (fragment)   Burkholderia pseudomallei 982 ALC57584.1    
 X996_5988   Burkholderia pseudomallei A79A AIV92285.1    
 X996_5988   Burkholderia pseudomallei A79A AIV92285.1    
 X996_2781 (fragment)   Burkholderia pseudomallei A79A AIV95688.1    
 X996_2781 (fragment)   Burkholderia pseudomallei A79A AIV95688.1    
 X995_2831 (fragment)   Burkholderia pseudomallei B03 AIV91262.1    
 X995_2831 (fragment)   Burkholderia pseudomallei B03 AIV91262.1    
 X995_5100   Burkholderia pseudomallei B03 AIV87839.1    
 X995_5100   Burkholderia pseudomallei B03 AIV87839.1    
 JE55_3036 (fragment)   Burkholderia pseudomallei BDP AIP78909.1    
 JE55_3036 (fragment)   Burkholderia pseudomallei BDP AIP78909.1    
 JE55_6168   Burkholderia pseudomallei BDP AIP82334.1    
 JE55_6168   Burkholderia pseudomallei BDP AIP82334.1    
 DP45_02650   Burkholderia pseudomallei BEJ AJX38353.1    
 DP45_02650   Burkholderia pseudomallei BEJ AJX38353.1    
 DP45_05542   Burkholderia pseudomallei BEJ AJX40928.1    
 DP45_05542   Burkholderia pseudomallei BEJ AJX40928.1    
 DP46_4168   Burkholderia pseudomallei BEK AIO84278.1    
 DP46_4168   Burkholderia pseudomallei BEK AIO84278.1    
 DP46_265   Burkholderia pseudomallei BEK AIO85414.1    
 DP48_2045 (fragment)   Burkholderia pseudomallei BEO AIO88594.1    
 DP48_2045 (fragment)   Burkholderia pseudomallei BEO AIO88594.1    
 DP48_4855   Burkholderia pseudomallei BEO AIO92881.1    
 DP48_4855   Burkholderia pseudomallei BEO AIO92881.1    
 DP51_580 (fragment)   Burkholderia pseudomallei BEZ AIP02988.1    
 DP51_580 (fragment)   Burkholderia pseudomallei BEZ AIP02988.1    
 DP51_3600   Burkholderia pseudomallei BEZ AIP02242.1    
 DP51_3600   Burkholderia pseudomallei BEZ AIP02242.1    
 DP55_3756   Burkholderia pseudomallei BFB AIP07402.1    
 DP55_3756   Burkholderia pseudomallei BFB AIP07402.1    
 DP55_3273 (fragment)   Burkholderia pseudomallei BFB AIP11091.1    
 DP55_3273 (fragment)   Burkholderia pseudomallei BFB AIP11091.1    
 DP60_4397   Burkholderia pseudomallei BGR AIP17500.1    
 DP60_4397   Burkholderia pseudomallei BGR AIP17500.1    
 DP60_3446 (fragment)   Burkholderia pseudomallei BGR AIP15365.1    
 DP60_3446 (fragment)   Burkholderia pseudomallei BGR AIP15365.1    
 TR70_4603 (AbfB)   Burkholderia pseudomallei Bp1651 ALJ73719.1    
 TR70_4603 (AbfB)   Burkholderia pseudomallei Bp1651 ALJ73719.1    
 TR70_0264 (XlnA)   Burkholderia pseudomallei Bp1651 ALJ69856.1    
 TR70_0264 (XlnA)   Burkholderia pseudomallei Bp1651 ALJ69856.1    
 BPC006_I1643   Burkholderia pseudomallei BPC006 AFR15519.1    
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