Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5533); Uniprot accession (902); PDB accession (143); 3D entries (56); cryst (1)
All (5278) Archaea (18) Bacteria (4665) Eukaryota (558) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | ... | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | ... | 47 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 CGK93_10875   Arthrobacter sp. YN ASN20115.1    
 CGK93_05515   Arthrobacter sp. YN ASN19209.1    
 WR51_29905   Bacillus cereus CMCC P0011 ANC17132.1    
 WR47_28765   Bacillus cereus CMCC P0021 ANC11104.1    
 FORC47_p099   Bacillus cereus FORC_047 ASL62451.1    
 BCQ_1809   Bacillus cereus Q1 ACM12237.1 B9IX27  
 β-1,3(4)-glucanase M (BglM) 3.2.1.39
3.2.1.6
3.2.1.73
Bacillus circulans IAM1165 BAC06195.1 Q8KKH3  
 BG05_3499   Bacillus mycoides ATCC 6462 AJH18485.1    
 B7492_32505   Bacillus mycoides Gnyt1 ARJ25761.1    
 B7492_30520   Bacillus mycoides Gnyt1 ARJ25411.1    
 pectate lyase 4.2.2.2 Bacillus sp. AAI12 AAE59747.1
AAS29294.1
   
 pectate lyase   Bacillus sp. JAMB750 BAK39698.1    
 unnamed protein product   Bacillus thuringiensis CAS92778.1    
 Cry41Ab1   Bacillus thuringiensis A1462 BAD35163.1 Q6BE06  
 Cry42Aa1   Bacillus thuringiensis A1462 BAD35166.1 Q6BE03  
 Cry41Aa1   Bacillus thuringiensis A1462 BAD35160.1
BAD35157.1
Q6BE09  
 Cry-related protein   Bacillus thuringiensis B3 AHN52957.1    
 insect toxin protein   Bacillus thuringiensis E65-3 AEX56522.1    
 BTF1_32201   Bacillus thuringiensis HD-789 AFQ30525.1    
 BTF1_32411   Bacillus thuringiensis HD-789 AFQ30565.1    
 BTF1_32411   Bacillus thuringiensis HD-789 AFQ30565.1    
 AS86_5750   Bacillus thuringiensis HD1002 AJH03295.1    
 A3L20_32290   Bacillus thuringiensis HD12 AMR88637.1    
 A3L20_32290   Bacillus thuringiensis HD12 AMR88637.1    
 ORF   Bacillus thuringiensis HS18-1 AER28314.1    
 ORF   Bacillus thuringiensis HS18-1 AER28314.1    
 AC241_30300   Bacillus thuringiensis HS18-1 AKR12990.1    
 AC241_30450   Bacillus thuringiensis HS18-1 AKR13014.1    
 AC241_30000   Bacillus thuringiensis HS18-1 AKR12943.1    
 ORF   Bacillus thuringiensis HS18-1 AEX56523.1    
 BCM43_29740   Bacillus thuringiensis KNU-07 ANV74614.1    
 MC28_C065   Bacillus thuringiensis MC28 AFU17013.1    
 MC28_D171   Bacillus thuringiensis MC28 AFU17220.1    
 MC28_E051   Bacillus thuringiensis MC28 AFU17310.1
ADV33305.1
   
 MC28_E051   Bacillus thuringiensis MC28 AFU17310.1
ADV33305.1
   
 MC28_E065   Bacillus thuringiensis MC28 AFU17324.1    
 MC28_E164   Bacillus thuringiensis MC28 AFU17423.1    
 MC28_F002   Bacillus thuringiensis MC28 AFU17446.1    
 MC28_E079   Bacillus thuringiensis MC28 AFU17338.1    
 ORF   Bacillus thuringiensis Sbt029 AEH76822.1    
 A9498_31550   Bacillus thuringiensis serovar coreanensis ST7 ANN35896.1    
 A9498_28915   Bacillus thuringiensis serovar coreanensis ST7 ANN35453.1    
 A9498_29535   Bacillus thuringiensis serovar coreanensis ST7 ANN35658.1    
 A9498_29550   Bacillus thuringiensis serovar coreanensis ST7 ANN35547.1    
 PBt054   Bacillus thuringiensis serovar israelensis CAD30104.1 Q8KNU9  
 PBt054   Bacillus thuringiensis serovar israelensis CAD30104.1 Q8KNU9  
 PBt152   Bacillus thuringiensis serovar israelensis CAD30184.1 Q8KNP4  
 ORF   Bacillus thuringiensis serovar israelensis 1.24 ASO64511.1    
 ORF   Bacillus thuringiensis serovar israelensis 1.24 ASO64511.1    
 hemagglutinin-related protein (plasmid)   Bacillus thuringiensis serovar israelensis 1.24 ASO64578.1    
 ATN07_33745   Bacillus thuringiensis serovar israelensis AM65-52 AND28683.1    
 ATN07_33745   Bacillus thuringiensis serovar israelensis AM65-52 AND28683.1    
 ATN07_33560   Bacillus thuringiensis serovar israelensis AM65-52 AND28648.1    
 ATN07_34550   Bacillus thuringiensis serovar israelensis AM65-52 AND28830.1    
 ATN07_29875   Bacillus thuringiensis serovar israelensis AM65-52 APF32705.1    
 toxin (plasmid)   Bacillus thuringiensis serovar israelensis HD522 BAV56204.1    
 toxin (plasmid)   Bacillus thuringiensis serovar israelensis HD522 BAV56204.1    
 BG08_6214   Bacillus thuringiensis serovar kurstaki HD 1 AJK37933.1    
 BTK_31084   Bacillus thuringiensis serovar kurstaki str. HD-1 AIE37804.1    
 DF16_pBMB400orf00380   Bacillus thuringiensis serovar kurstaki str. YBT-1520 AIM35215.1    
 YBT1520_31234   Bacillus thuringiensis serovar kurstaki str. YBT-1520 AHZ54746.1    
 KNN_06946   Bacillus thuringiensis serovar tolworthi Pasteur Institute Standard strain BAR87679.1    
 insecticidal crystal protein 6   Bacillus thuringiensis SK700 AJW76687.1    
 insecticidal crystal protein 6   Bacillus thuringiensis SK700 AJW76687.1    
 XI92_29830   Bacillus thuringiensis YC-10 AKJ62375.1    
 CHH28_07170   Bacterioplanes sanyensis NV9 ASP38465.1    
 CHH28_07310   Bacterioplanes sanyensis NV9 ASP38492.1    
 BcellWH2_02913 (Abn-ts_3)   Bacteroides cellulosilyticus WH2 ALJ60152.1    
 BcellWH2_02970   Bacteroides cellulosilyticus WH2 ALJ60208.1    
 AB656_00595   Bifidobacterium actinocoloniiforme DSM 22766 AKV55018.1    
 BADO_1512   Bifidobacterium adolescentis 22L AII76920.1    
 BADO_1512   Bifidobacterium adolescentis 22L AII76920.1    
 BADO_1512   Bifidobacterium adolescentis 22L AII76920.1    
 BBMN23_1664   Bifidobacterium adolescentis BBMN23 AJE06636.1    
 BBMN23_1664   Bifidobacterium adolescentis BBMN23 AJE06636.1    
 BBMN23_1664   Bifidobacterium adolescentis BBMN23 AJE06636.1    
 Bang102_001540   Bifidobacterium angulatum GT102 AMK57293.1    
 Bang102_001540   Bifidobacterium angulatum GT102 AMK57293.1    
 Bang102_001540   Bifidobacterium angulatum GT102 AMK57293.1    
 BBBF_0047   Bifidobacterium bifidum ATCC 29521 = JCM 1255 = DSM 20456 BAQ97254.1    
 BBBF_0047   Bifidobacterium bifidum ATCC 29521 = JCM 1255 = DSM 20456 BAQ97254.1    
 BBBF_0047   Bifidobacterium bifidum ATCC 29521 = JCM 1255 = DSM 20456 BAQ97254.1    
 RY70_101   Bifidobacterium bifidum BF3 ALE10489.1    
 RY70_101   Bifidobacterium bifidum BF3 ALE10489.1    
 RY70_101   Bifidobacterium bifidum BF3 ALE10489.1    
 BBB_0050 (LytC)   Bifidobacterium bifidum BGN4 AFL03647.1    
 BBB_0050 (LytC)   Bifidobacterium bifidum BGN4 AFL03647.1    
 BBB_0050 (LytC)   Bifidobacterium bifidum BGN4 AFL03647.1    
 BBJK_01493 (LytC)   Bifidobacterium bifidum LMG 13195 JCM 7004 BBA48030.1    
 BBJK_01493 (LytC)   Bifidobacterium bifidum LMG 13195 JCM 7004 BBA48030.1    
 BBJK_01493 (LytC)   Bifidobacterium bifidum LMG 13195 JCM 7004 BBA48030.1    
 BBPR_0052   Bifidobacterium bifidum PRL2010 ADP35190.1 E4NY16  
 BBPR_0052   Bifidobacterium bifidum PRL2010 ADP35190.1 E4NY16  
 BBPR_0052   Bifidobacterium bifidum PRL2010 ADP35190.1 E4NY16  
 BBIF_0048 (LytC)   Bifidobacterium bifidum S17 ADO52253.1 E3ENH5  
 BBIF_0048 (LytC)   Bifidobacterium bifidum S17 ADO52253.1 E3ENH5  
 BBIF_0048 (LytC)   Bifidobacterium bifidum S17 ADO52253.1 E3ENH5  
 BBTM_01803 (LytC)   Bifidobacterium bifidum TMC 3115 BBA56115.1    
 BBTM_01803 (LytC)   Bifidobacterium bifidum TMC 3115 BBA56115.1    
 BBTM_01803 (LytC)   Bifidobacterium bifidum TMC 3115 BBA56115.1    
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