Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 46 |
Protein Name EC#OrganismGenBank UniprotPDB/3D
 Amir_4031   Actinosynnema mirum DSM 43827 ACU37894.1 C6WFV8  
 Amir_4331   Actinosynnema mirum DSM 43827 ACU38183.1 C6WIU3  
 Amir_5321   Actinosynnema mirum DSM 43827 ACU39141.1 C6W969  
 Amir_0110   Actinosynnema mirum DSM 43827 ACU34082.1 C6WDT7  
 Amir_0110   Actinosynnema mirum DSM 43827 ACU34082.1 C6WDT7  
 Amir_1850   Actinosynnema mirum DSM 43827 ACU35798.1 C6WE55  
 Amir_2556   Actinosynnema mirum DSM 43827 ACU36493.1 C6WMG4  
 Amir_2560   Actinosynnema mirum DSM 43827 ACU36497.1 C6WMG8  
 Amir_3106   Actinosynnema mirum DSM 43827 ACU37020.1 C6W7Z9  
 Amir_3107   Actinosynnema mirum DSM 43827 ACU37021.1 C6W800  
 Amir_3108   Actinosynnema mirum DSM 43827 ACU37022.1 C6W801  
 Amir_3537   Actinosynnema mirum DSM 43827 ACU37429.1 C6WAW0  
 Amir_3796   Actinosynnema mirum DSM 43827 ACU37676.1 C6WD57  
 Amir_3927   Actinosynnema mirum DSM 43827 ACU37797.1 C6WEJ7  
 Amir_4151   Actinosynnema mirum DSM 43827 ACU38006.1 C6WH87  
 Amir_4177   Actinosynnema mirum DSM 43827 ACU38032.1 C6WHB3  
 Amir_4198   Actinosynnema mirum DSM 43827 ACU38053.1 C6WHD4  
 Amir_4199   Actinosynnema mirum DSM 43827 ACU38054.1 C6WHD5  
 Amir_4621   Actinosynnema mirum DSM 43827 ACU38454.1 C6WMU1  
 Amir_4828   Actinosynnema mirum DSM 43827 ACU38655.1 C6WPF3  
 Amir_4964   Actinosynnema mirum DSM 43827 ACU38790.1 C6WQV0  
 Amir_4966   Actinosynnema mirum DSM 43827 ACU38792.1 C6WQV2  
 CNX65_15750   Actinosynnema pretiosum X47 ATE54566.1    
 CNX65_08320   Actinosynnema pretiosum X47 ATE53294.1    
 CNX65_18875   Actinosynnema pretiosum X47 ATE55095.1    
 CNX65_12995   Actinosynnema pretiosum X47 ATE54094.1    
 CNX65_20755   Actinosynnema pretiosum X47 ATE55413.1    
 CNX65_12965   Actinosynnema pretiosum X47 ATE54090.1    
 CNX65_20185   Actinosynnema pretiosum X47 ATE55314.1    
 CNX65_17925   Actinosynnema pretiosum X47 ATE58235.1    
 CNX65_20915   Actinosynnema pretiosum X47 ATE55440.1    
 CNX65_18980   Actinosynnema pretiosum X47 ATE55111.1    
 CNX65_23985   Actinosynnema pretiosum X47 ATE58353.1    
 CNX65_16045   Actinosynnema pretiosum X47 ATE54615.1    
 CNX65_20760   Actinosynnema pretiosum X47 ATE55414.1    
 CNX65_15740   Actinosynnema pretiosum X47 ATE54564.1    
 CNX65_24495   Actinosynnema pretiosum X47 ATE56040.1    
 CNX65_00550   Actinosynnema pretiosum X47 ATE51961.1    
 CNX65_00550   Actinosynnema pretiosum X47 ATE51961.1    
 CNX65_15745   Actinosynnema pretiosum X47 ATE54565.1    
 CNX65_20765   Actinosynnema pretiosum X47 ATE55415.1    
 CNX65_09245   Actinosynnema pretiosum X47 ATE53456.1    
 CNX65_08255   Actinosynnema pretiosum X47 ATE53282.1    
 CNX65_21695   Actinosynnema pretiosum X47 ATE55581.1    
 CNX65_26500   Actinosynnema pretiosum X47 ATE56384.1    
 CNX65_23060   Actinosynnema pretiosum X47 ATE55802.1    
 ADH66_16220   Acutalibacter muris KB18 ASB42067.1    
 ADH66_12860   Acutalibacter muris KB18 ASB41462.1    
 BOQ57_22135   Aeromonas aquatica MX16A APJ17399.1    
 CK627_03770   Aeromonas dhakensis KN-Mc-6U21 ASX09959.1    
 CK627_03765   Aeromonas dhakensis KN-Mc-6U21 ASX09958.1    
 AH4AK4_0032   Aeromonas hydrophila 4AK4 AHE47548.1    
 VU14_00350   Aeromonas hydrophila AH10 AKA15439.1    
 TK34_00135   Aeromonas hydrophila AHNIH1 ANT66042.1    
 RY45_00135   Aeromonas hydrophila AL06-06 AJQ52575.1    
 V428_00140   Aeromonas hydrophila AL09-71 AHX30553.1    
 AhyD4_00135   Aeromonas hydrophila D4 ALZ78113.1    
 A9258_00185   Aeromonas hydrophila GYK1 ANR98154.1    
 V469_00140   Aeromonas hydrophila J-1 AJE34427.1    
 AS145_00135   Aeromonas hydrophila JBN2301 ALQ61413.1    
 AHML_00120   Aeromonas hydrophila ML09-119 AGM41809.1    
 U876_00140   Aeromonas hydrophila NJ-35 AKJ32623.1    
 V429_00140   Aeromonas hydrophila pc104A AHX67350.1    
 AHA_0028   Aeromonas hydrophila subsp. hydrophila ATCC 7966 ABK35934.1 A0KED0  
 AI20_19500   Aeromonas hydrophila YL17 AHV37272.1    
 AI20_19505   Aeromonas hydrophila YL17 AHV37273.1    
 B224_5308   Aeromonas media WS AHX63076.1    
 CE456_02120   Aeromonas salmonicida S121 ASI25283.1    
 CE463_02165   Aeromonas salmonicida S44 ASI29602.1    
 CE462_01045   Aeromonas salmonicida S68 ASI33733.1    
 BHG40_03925   Aeromonas salmonicida subsp. masoucida RFAS1 ATD37194.1    
 ASA_0030   Aeromonas salmonicida subsp. salmonicida A449 ABO88240.1 A4SH68  
 WL1483_1951   Aeromonas schubertii WL1483 ALP41370.1    
 WL1483_14   Aeromonas schubertii WL1483 ALP39433.1    
 O23A_p3604   Aeromonas sp. O23A ARW84343.1    
 WM43_12765   Aeromonas veronii AVNIH1 ANB53465.1    
 B565_0022   Aeromonas veronii B565 AEB48057.1    
 A6033_04460   Aeromonas veronii CB51 ANB67968.1    
 AMS64_00290   Aeromonas veronii TH0426 AMQ40948.1    
 SAMN05444050_1324   Afipia sp. GAS231 SDN34383.1    
 β-agarase (AgaB34) Agarivorans albus YKW-34 ABW77762.1 A8W969  
 β-agarase (AgaA)   Agarivorans gilvus WH0801 AFN94094.1    
 β-agarase (AgaJA3;Hz4) Agarivorans sp. JA-1 / HZ105 ADY17921.1    
 alginate lyase (AlyL2)
Agarivorans sp. L11 AJO61885.1    
 β-agarase (AgaA) Agarivorans sp. LQ48 ACM50513.1 C9WIW7  
 ATC03_03580   Agromyces aureus AR33 ANJ25953.1    
 ATC03_03580   Agromyces aureus AR33 ANJ25953.1    
 ATC03_17300   Agromyces aureus AR33 ANJ28198.1    
 S7S_12670   Alcanivorax pacificus W11-5 AJD48946.1    
 CDL62_06395   Alkalitalea saponilacus DSM 24412 ASB48785.1    
 CDL62_06395   Alkalitalea saponilacus DSM 24412 ASB48785.1    
 CDL62_12930   Alkalitalea saponilacus DSM 24412 ASB49975.1    
 CDL62_06150   Alkalitalea saponilacus DSM 24412 ASB48747.1    
 CDL62_16830   Alkalitalea saponilacus DSM 24412 ASB51201.1    
 CDL62_05490   Alkalitalea saponilacus DSM 24412 ASB48631.1    
 CDL62_06390   Alkalitalea saponilacus DSM 24412 ASB48784.1    
 CDL62_11795   Alkalitalea saponilacus DSM 24412 ASB49770.1    
 CDL62_16805   Alkalitalea saponilacus DSM 24412 ASB50690.1    
 CDL62_00650   Alkalitalea saponilacus DSM 24412 ASB47762.1    
 ORF   Alloactinosynnema sp. L-07 CRK60110.1    

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