Carbohydrate-Binding Module Family 13

Known Activities	Modules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Status	b-trefoil
Note	Previously known as cellulose-binding domain family XIII (CBD XIII).
External resources	HOMSTRAD;
Statistics	GenBank accession (2377); Uniprot accession (891); PDB accession (85); 3D entries (41); cryst (1)

Summary

All (1793) Archaea (13) Bacteria (1361) Eukaryota (401) Viruses (10) unclassified (8) Structure (41 - 1 cryst) Characterized (87)


Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
actinohivin (Ath)		actinomycete K97-0003	AAN99135.1 BAA97578.1		3A07[A,B] 4DEN[A]
non-toxin haemagglutinin HA34		Clostridium botulinum ALLERGAN-HALL A	AAQ06328.1 ABD65469.1 ABE20280.1 ACQ22029.1 ACS02888.1	Q45871	1YBI[A,B]
non-toxin haemagglutinin HA34		Clostridium botulinum ALLERGAN-HALL A	AAQ06328.1 ABD65469.1 ABE20280.1 ACQ22029.1 ACS02888.1	Q45871	1YBI[A,B]
neurotoxin (Hα-33;Ha1;BoNT)		Clostridium botulinum D-4947	BAA90659.1	P46084	2E4M[A,B]
neurotoxin (Hα-33;Ha1;BoNT)		Clostridium botulinum D-4947	BAA90659.1	P46084	2E4M[A,B]
exo-β-1,3-galactanase (Ct1,3Gal43A;Cthe_0661) (1,3Gal43A)	3.2.1.145	Clostridium thermocellum ATCC 27405	ABN51896.1	A3DD67	3VSF[A,B,C,D,E,F] 3VSZ[A,B,C,D,E,F] 3VT0[A,B,C,D,E,F] 3VT1[A,B,C,D,E,F] 3VT2[A,B,C,D,E,F]
mosquitocidal toxin (Mtx1)		Lysinibacillus sphaericus LP1-G	AAA22601.1 AAN04906.1 CAA02791.1	Q03988	2VSA[A] 2VSE[A,B]
mosquitocidal toxin (Mtx1)		Lysinibacillus sphaericus LP1-G	AAA22601.1 AAN04906.1 CAA02791.1	Q03988	2VSA[A] 2VSE[A,B]
mosquitocidal toxin (Mtx1)		Lysinibacillus sphaericus LP1-G	AAA22601.1 AAN04906.1 CAA02791.1	Q03988	2VSA[A] 2VSE[A,B]
mosquitocidal toxin (Mtx1)		Lysinibacillus sphaericus LP1-G	AAA22601.1 AAN04906.1 CAA02791.1	Q03988	2VSA[A] 2VSE[A,B]
lectin (Rv1419)		Mycobacterium tuberculosis H37Rv	AFN49328.1 CAB02167.1 CCP44178.1 NP_215935.1	P71688	cryst
β-L-arabinopyranosidase (AgaA2;SaArap27A;SAV_2186) (Arap27A)	3.2.1.88	Streptomyces avermitilis MA-4680	BAC69897.1 NP_823362.1		3A21[A,B] 3A22[A,B] 3A23[A,B]
xylanase A (XlnA) (Xyn10A)	3.2.1.8	Streptomyces lividans 1326 / IAF18	AAC26525.1 AAO97633.1	P26514	1KNL[A] 1KNM[A] 1KNN[A] 1MC9[A]
β-1,4-xylanase (XynA;FXYN;SoXyn10A) (Xyn10A)	3.2.1.8	Streptomyces olivaceoviridis E-86		Q7SI98	1ISV[A,B] 1ISW[A,B] 1ISX[A,B] 1ISY[A,B] 1ISZ[A,B] 1IT0[A,B] 1V6U[A,B] 1V6V[A,B] 1V6W[A,B] 1V6X[A,B] 2D1Z[A,B] 2D20[A,B] 2D22[A,B] 2D23[A,B] 2D24[A,B] 1XYF[A]
Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
agglutinin (AAG)		Abrus precatorius	AAF28309.1	Q9M6E9	2AMZ[B] 2Q3N[B] 2ZR1[B,D]
agglutinin (AAG)		Abrus precatorius	AAF28309.1	Q9M6E9	2AMZ[B] 2Q3N[B] 2ZR1[B,D]
lectin		Cucumaria echinata	BAC75827.1 BAK19472.1 BAK19473.1 BAK19476.1	Q868M7	1VCL[A,B] 2Z48[A,B] 2Z49[A,B]
lectin		Cucumaria echinata	BAC75827.1 BAK19472.1 BAK19473.1 BAK19476.1	Q868M7	1VCL[A,B] 2Z48[A,B] 2Z49[A,B]
UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferase T2 (GalNAc-T2;ppGalNAcT2;GalNT2)	2.4.1.41	Homo sapiens	AAH41120.1 ACC22257.1 ACS13744.1 BAF82737.1 BAH12448.1 BAH13288.1 CAA59381.1 CAC00585.2 CAI22902.1 CAI23447.1 NP_004472.1	Q10471	2FFU[A] 2FFV[A,B]
UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 10 (GalNT10;ppGalNAcT10;pp-GalNAc-T10)	2.4.1.41	Homo sapiens	AAH07224.2 AAH72450.1 AAH98444.1 AAP65372.1 AAP65373.1 AAP65378.1 AAP65379.1 ABA33148.1 ABA33149.1 ABA33154.1 ABA33155.1 BAB14676.1 BAC56890.1 BAG54441.1 CAB46378.1 CAD44532.1 CAE91109.1 NP_060010.2 NP_938080.1	Q86SR1 Q86SR1	2D7I[A] 2D7R[A]
agglutinin (MOA)		Marasmius oreades	AAL47680.1 ABC05318.1 ABC05319.1 ABC05320.1 ABC05337.1 ABC05339.1	Q8X123	2IHO[A] 3EF2[A,B,C,D]
UDP-GalNAc: polypeptide α-N-acetylgalactosaminyltransferase T1 (GalNAc-T1;ppGalNAcTase-1;Galnt1)	2.4.1.41	Mus musculus	AAB58477.1 AAH56215.1 AAH90962.1 BAE28617.1 NP_038842.2	O08912 O08912	1XHB[A]
lectin (Psl1a)		Polyporus squamosus	BAC87875.1	Q75WT9	3PHZ[A,B]
ricin B-chain (RTB)		Ricinus communis	AAB22582.1 AAY06525.1 ABC05333.1 ADG29030.1 ADG29032.1 ADG29033.1 ADG29035.1 ADG29036.1 ADG29037.1 ADG29038.1 ADG29039.1 ADG29040.1 ADG29043.1 ADG29044.1 ADG29046.1 ADG29047.1 ADG29048.1 ADG29049.1 ADG29050.1 ADG29051.1 ADG29056.1 ADG29058.1 ADG29060.1 ADG29061.1 ADG29062.1 ADG29066.1 ADG29068.1 ADG29069.1 ADG29071.1 ADG29073.1 ADG29074.1 ADG29075.1 ADG29077.1 ADG29078.1 ADG29079.1 ADG29080.1 ADG29081.1 ADG29082.1 ADG29083.1 ADG29084.1 ADG29086.1 ADG29088.1 ADG29089.1 ADG29090.1 ADG29091.1 ADG29092.1 ADG29093.1 ADG29097.1 ADG29099.1 ADG29100.1 ADG29102.1 ADG29106.1 ADG29108.1 ADG29109.1 ADG29111.1 ADG29112.1 ADG29113.1 ADG29114.1 ADG29115.1 ADG29116.1 ADG29117.1 CAA01058.1 CAA26230.1 CAA26939.1 CAA37095.1	B9T8T0 P02879	2AAI[B] 3RTI[B] 3RTJ[B]
ricin B-chain (RTB)		Ricinus communis	AAB22582.1 AAY06525.1 ABC05334.1 ADG29030.1 ADG29032.1 ADG29033.1 ADG29035.1 ADG29036.1 ADG29037.1 ADG29038.1 ADG29039.1 ADG29040.1 ADG29043.1 ADG29044.1 ADG29046.1 ADG29047.1 ADG29048.1 ADG29049.1 ADG29050.1 ADG29051.1 ADG29056.1 ADG29058.1 ADG29060.1 ADG29061.1 ADG29062.1 ADG29066.1 ADG29068.1 ADG29069.1 ADG29071.1 ADG29073.1 ADG29074.1 ADG29075.1 ADG29077.1 ADG29078.1 ADG29079.1 ADG29080.1 ADG29081.1 ADG29082.1 ADG29083.1 ADG29084.1 ADG29086.1 ADG29088.1 ADG29089.1 ADG29090.1 ADG29091.1 ADG29092.1 ADG29093.1 ADG29097.1 ADG29099.1 ADG29100.1 ADG29102.1 ADG29106.1 ADG29108.1 ADG29109.1 ADG29111.1 ADG29112.1 ADG29113.1 ADG29114.1 ADG29115.1 ADG29116.1 ADG29117.1 CAA01058.1 CAA26230.1 CAA26939.1 CAA37095.1	B9T8T0 P02879	2AAI[B] 3RTI[B] 3RTJ[B]
agglutinin (RCA)		Ricinus communis	AAA33869.1 AAB22584.1	P06750	1RZO[B,D]
agglutinin (RCA)		Ricinus communis	AAA33869.1 AAB22584.1	P06750	1RZO[B,D]
ebulin 1 / type 2 ribosome-inactivating protein (Ebu1)		Sambucus ebulus	AAB27855.1 ABC05335.1 CAC33178.1	Q9AVR2	1HWM[B] 1HWN[B] 1HWO[B] 1HWP[B]
ebulin 1 / type 2 ribosome-inactivating protein (Ebu1)		Sambucus ebulus	ABC05336.1 CAC33178.1	Q9AVR2	1HWM[B] 1HWN[B] 1HWO[B] 1HWP[B]
ribosome-inactivating protein (AVl)		Sambucus nigra	AAL04123.1 AAN86130.1	Q8GT32 Q945S2	3C9Z[A] 3CA0[A] 3CA1[A] 3CA3[A] 3CA4[A] 3CA5[A] 3CA6[A] 3CAH[A]
ribosome-inactivating protein (AVl)		Sambucus nigra	AAL04123.1 AAN86130.1	Q8GT32 Q945S2	3C9Z[A] 3CA0[A] 3CA1[A] 3CA3[A] 3CA4[A] 3CA5[A] 3CA6[A] 3CAH[A]
ribosome-inactivating protein		Viscum album	AAT37532.1	Q6ITZ3	1PC8[B] 1TFM[B] 1YF8[B]
ribosome-inactivating protein		Viscum album	AAT37532.1	Q6ITZ3	1PC8[B] 1TFM[B] 1YF8[B]
lectin I (ML-I)		Viscum album	AAL87006.1 AAR25545.1 AAR25546.1 ABA32657.1 ABA32659.1 ABA32660.1 ABA32661.1 ABA32662.1 ABA32663.1 ABA32664.1	P81446 P81830	1ONK[B] 1OQL[B] 1SZ6[B] 2R9K[B] 2RG9[B] 3CEF[B] 3D7W[B] 3O5W[B] 4EB2[B]
lectin I (ML-I)		Viscum album	AAL87006.1 AAR25545.1 AAR25546.1 ABA32657.1 ABA32659.1 ABA32660.1 ABA32661.1 ABA32662.1 ABA32663.1 ABA32664.1	P81446 P81830	1ONK[B] 1OQL[B] 1SZ6[B] 2R9K[B] 2RG9[B] 3CEF[B] 3D7W[B] 3O5W[B] 4EB2[B]
Viruses
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D
toxin (Ha1;Hα-33)		Clostridium botulinum D phage 1873	BAA75082.1 CAA44261.1		3AJ5[A,B] 3AJ6[A,B]
toxin (Ha1;Hα-33)		Clostridium botulinum D phage 1873	BAA75082.1 CAA44261.1		3AJ5[A,B] 3AJ6[A,B]
toxin (Ha1)		Clostridium botulinum D phage CB16	BAA75077.1		1QXM[A,B] 2EHI[A,B] 2EHM[A,B] 2EHN[A,B]
toxin (Ha1)		Clostridium botulinum D phage CB16	BAA75077.1		1QXM[A,B] 2EHI[A,B] 2EHM[A,B] 2EHN[A,B]
toxin (Ha1;Hα-33;Antp-33)		Clostridium botulinum phage 1C 468	CAA51311.1	P46084 Q38196	3AH1[A,B] 3AH2[A,B] 3AH4[A,B]
toxin (Ha1;Hα-33;Antp-33)		Clostridium botulinum phage 1C 468	CAA51311.1	P46084 Q38196	3AH1[A,B] 3AH2[A,B] 3AH4[A,B]
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