Carbohydrate-Binding Module Family 13

Known ActivitiesModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusb-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (2377); Uniprot accession (891); PDB accession (85); 3D entries (41); cryst (1)
All (1793) Archaea (13) Bacteria (1361) Eukaryota (401) Viruses (10) unclassified (8) Structure (41 - 1 cryst) Characterized (87)
Bacteria
Protein Name EC#OrganismGenBankUniprotPDB/3D
 actinohivin (Ath)   actinomycete K97-0003 AAN99135.1
BAA97578.1
  3A07[A,B]
4DEN[A]
 non-toxin haemagglutinin HA34   Clostridium botulinum ALLERGAN-HALL A AAQ06328.1
ABD65469.1
ABE20280.1
ACQ22029.1
ACS02888.1
Q45871 1YBI[A,B]
 non-toxin haemagglutinin HA34   Clostridium botulinum ALLERGAN-HALL A AAQ06328.1
ABD65469.1
ABE20280.1
ACQ22029.1
ACS02888.1
Q45871 1YBI[A,B]
 neurotoxin (Hα-33;Ha1;BoNT)   Clostridium botulinum D-4947 BAA90659.1 P46084 2E4M[A,B]
 neurotoxin (Hα-33;Ha1;BoNT)   Clostridium botulinum D-4947 BAA90659.1 P46084 2E4M[A,B]
 exo-β-1,3-galactanase (Ct1,3Gal43A;Cthe_0661) (1,3Gal43A) 3.2.1.145 Clostridium thermocellum ATCC 27405 ABN51896.1 A3DD67 3VSF[A,B,C,D,E,F]
3VSZ[A,B,C,D,E,F]
3VT0[A,B,C,D,E,F]
3VT1[A,B,C,D,E,F]
3VT2[A,B,C,D,E,F]
 mosquitocidal toxin (Mtx1)   Lysinibacillus sphaericus LP1-G AAA22601.1
AAN04906.1
CAA02791.1
Q03988 2VSA[A]
2VSE[A,B]
 mosquitocidal toxin (Mtx1)   Lysinibacillus sphaericus LP1-G AAA22601.1
AAN04906.1
CAA02791.1
Q03988 2VSA[A]
2VSE[A,B]
 mosquitocidal toxin (Mtx1)   Lysinibacillus sphaericus LP1-G AAA22601.1
AAN04906.1
CAA02791.1
Q03988 2VSA[A]
2VSE[A,B]
 mosquitocidal toxin (Mtx1)   Lysinibacillus sphaericus LP1-G AAA22601.1
AAN04906.1
CAA02791.1
Q03988 2VSA[A]
2VSE[A,B]
 lectin (Rv1419)   Mycobacterium tuberculosis H37Rv AFN49328.1
CAB02167.1
CCP44178.1
NP_215935.1
P71688 cryst
 β-L-arabinopyranosidase (AgaA2;SaArap27A;SAV_2186) (Arap27A) 3.2.1.88 Streptomyces avermitilis MA-4680 BAC69897.1
NP_823362.1
  3A21[A,B]
3A22[A,B]
3A23[A,B]
 xylanase A (XlnA) (Xyn10A) 3.2.1.8 Streptomyces lividans 1326 / IAF18 AAC26525.1
AAO97633.1
P26514 1KNL[A]
1KNM[A]
1KNN[A]
1MC9[A]
 β-1,4-xylanase (XynA;FXYN;SoXyn10A) (Xyn10A) 3.2.1.8 Streptomyces olivaceoviridis E-86   Q7SI98 1ISV[A,B]
1ISW[A,B]
1ISX[A,B]
1ISY[A,B]
1ISZ[A,B]
1IT0[A,B]
1V6U[A,B]
1V6V[A,B]
1V6W[A,B]
1V6X[A,B]
2D1Z[A,B]
2D20[A,B]
2D22[A,B]
2D23[A,B]
2D24[A,B]
1XYF[A]
Eukaryota
Protein Name EC#OrganismGenBankUniprotPDB/3D
 agglutinin (AAG)   Abrus precatorius AAF28309.1 Q9M6E9 2AMZ[B]
2Q3N[B]
2ZR1[B,D]
 agglutinin (AAG)   Abrus precatorius AAF28309.1 Q9M6E9 2AMZ[B]
2Q3N[B]
2ZR1[B,D]
 lectin   Cucumaria echinata BAC75827.1
BAK19472.1
BAK19473.1
BAK19476.1
Q868M7 1VCL[A,B]
2Z48[A,B]
2Z49[A,B]
 lectin   Cucumaria echinata BAC75827.1
BAK19472.1
BAK19473.1
BAK19476.1
Q868M7 1VCL[A,B]
2Z48[A,B]
2Z49[A,B]
 UDP-GalNAc:polypeptide α-N-acetylgalactosaminyltransferase T2 (GalNAc-T2;ppGalNAcT2;GalNT2) 2.4.1.41 Homo sapiens AAH41120.1
ACC22257.1
ACS13744.1
BAF82737.1
BAH12448.1
BAH13288.1
CAA59381.1
CAC00585.2
CAI22902.1
CAI23447.1
NP_004472.1
Q10471 2FFU[A]
2FFV[A,B]
 UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase 10 (GalNT10;ppGalNAcT10;pp-GalNAc-T10) 2.4.1.41 Homo sapiens AAH07224.2
AAH72450.1
AAH98444.1
AAP65372.1
AAP65373.1
AAP65378.1
AAP65379.1
ABA33148.1
ABA33149.1
ABA33154.1
ABA33155.1
BAB14676.1
BAC56890.1
BAG54441.1
CAB46378.1
CAD44532.1
CAE91109.1
NP_060010.2
NP_938080.1
Q86SR1
Q86SR1
2D7I[A]
2D7R[A]
 agglutinin (MOA)   Marasmius oreades AAL47680.1
ABC05318.1
ABC05319.1
ABC05320.1
ABC05337.1
ABC05339.1
Q8X123 2IHO[A]
3EF2[A,B,C,D]
 UDP-GalNAc: polypeptide α-N-acetylgalactosaminyltransferase T1 (GalNAc-T1;ppGalNAcTase-1;Galnt1) 2.4.1.41 Mus musculus AAB58477.1
AAH56215.1
AAH90962.1
BAE28617.1
NP_038842.2
O08912
O08912
1XHB[A]
 lectin (Psl1a)   Polyporus squamosus BAC87875.1 Q75WT9 3PHZ[A,B]
 ricin B-chain (RTB)   Ricinus communis AAB22582.1
AAY06525.1
ABC05333.1
ADG29030.1
ADG29032.1
ADG29033.1
ADG29035.1
ADG29036.1
ADG29037.1
ADG29038.1
ADG29039.1
ADG29040.1
ADG29043.1
ADG29044.1
ADG29046.1
ADG29047.1
ADG29048.1
ADG29049.1
ADG29050.1
ADG29051.1
ADG29056.1
ADG29058.1
ADG29060.1
ADG29061.1
ADG29062.1
ADG29066.1
ADG29068.1
ADG29069.1
ADG29071.1
ADG29073.1
ADG29074.1
ADG29075.1
ADG29077.1
ADG29078.1
ADG29079.1
ADG29080.1
ADG29081.1
ADG29082.1
ADG29083.1
ADG29084.1
ADG29086.1
ADG29088.1
ADG29089.1
ADG29090.1
ADG29091.1
ADG29092.1
ADG29093.1
ADG29097.1
ADG29099.1
ADG29100.1
ADG29102.1
ADG29106.1
ADG29108.1
ADG29109.1
ADG29111.1
ADG29112.1
ADG29113.1
ADG29114.1
ADG29115.1
ADG29116.1
ADG29117.1
CAA01058.1
CAA26230.1
CAA26939.1
CAA37095.1
B9T8T0
P02879
2AAI[B]
3RTI[B]
3RTJ[B]
 ricin B-chain (RTB)   Ricinus communis AAB22582.1
AAY06525.1
ABC05334.1
ADG29030.1
ADG29032.1
ADG29033.1
ADG29035.1
ADG29036.1
ADG29037.1
ADG29038.1
ADG29039.1
ADG29040.1
ADG29043.1
ADG29044.1
ADG29046.1
ADG29047.1
ADG29048.1
ADG29049.1
ADG29050.1
ADG29051.1
ADG29056.1
ADG29058.1
ADG29060.1
ADG29061.1
ADG29062.1
ADG29066.1
ADG29068.1
ADG29069.1
ADG29071.1
ADG29073.1
ADG29074.1
ADG29075.1
ADG29077.1
ADG29078.1
ADG29079.1
ADG29080.1
ADG29081.1
ADG29082.1
ADG29083.1
ADG29084.1
ADG29086.1
ADG29088.1
ADG29089.1
ADG29090.1
ADG29091.1
ADG29092.1
ADG29093.1
ADG29097.1
ADG29099.1
ADG29100.1
ADG29102.1
ADG29106.1
ADG29108.1
ADG29109.1
ADG29111.1
ADG29112.1
ADG29113.1
ADG29114.1
ADG29115.1
ADG29116.1
ADG29117.1
CAA01058.1
CAA26230.1
CAA26939.1
CAA37095.1
B9T8T0
P02879
2AAI[B]
3RTI[B]
3RTJ[B]
 agglutinin (RCA)   Ricinus communis AAA33869.1
AAB22584.1
P06750 1RZO[B,D]
 agglutinin (RCA)   Ricinus communis AAA33869.1
AAB22584.1
P06750 1RZO[B,D]
 ebulin 1 / type 2 ribosome-inactivating protein (Ebu1)   Sambucus ebulus AAB27855.1
ABC05335.1
CAC33178.1
Q9AVR2 1HWM[B]
1HWN[B]
1HWO[B]
1HWP[B]
 ebulin 1 / type 2 ribosome-inactivating protein (Ebu1)   Sambucus ebulus ABC05336.1
CAC33178.1
Q9AVR2 1HWM[B]
1HWN[B]
1HWO[B]
1HWP[B]
 ribosome-inactivating protein (AVl)   Sambucus nigra AAL04123.1
AAN86130.1
Q8GT32
Q945S2
3C9Z[A]
3CA0[A]
3CA1[A]
3CA3[A]
3CA4[A]
3CA5[A]
3CA6[A]
3CAH[A]
 ribosome-inactivating protein (AVl)   Sambucus nigra AAL04123.1
AAN86130.1
Q8GT32
Q945S2
3C9Z[A]
3CA0[A]
3CA1[A]
3CA3[A]
3CA4[A]
3CA5[A]
3CA6[A]
3CAH[A]
 ribosome-inactivating protein   Viscum album AAT37532.1 Q6ITZ3 1PC8[B]
1TFM[B]
1YF8[B]
 ribosome-inactivating protein   Viscum album AAT37532.1 Q6ITZ3 1PC8[B]
1TFM[B]
1YF8[B]
 lectin I (ML-I)   Viscum album AAL87006.1
AAR25545.1
AAR25546.1
ABA32657.1
ABA32659.1
ABA32660.1
ABA32661.1
ABA32662.1
ABA32663.1
ABA32664.1
P81446
P81830
1ONK[B]
1OQL[B]
1SZ6[B]
2R9K[B]
2RG9[B]
3CEF[B]
3D7W[B]
3O5W[B]
4EB2[B]
 lectin I (ML-I)   Viscum album AAL87006.1
AAR25545.1
AAR25546.1
ABA32657.1
ABA32659.1
ABA32660.1
ABA32661.1
ABA32662.1
ABA32663.1
ABA32664.1
P81446
P81830
1ONK[B]
1OQL[B]
1SZ6[B]
2R9K[B]
2RG9[B]
3CEF[B]
3D7W[B]
3O5W[B]
4EB2[B]
Viruses
Protein Name EC#OrganismGenBankUniprotPDB/3D
 toxin (Ha1;Hα-33)   Clostridium botulinum D phage 1873 BAA75082.1
CAA44261.1
  3AJ5[A,B]
3AJ6[A,B]
 toxin (Ha1;Hα-33)   Clostridium botulinum D phage 1873 BAA75082.1
CAA44261.1
  3AJ5[A,B]
3AJ6[A,B]
 toxin (Ha1)   Clostridium botulinum D phage CB16 BAA75077.1   1QXM[A,B]
2EHI[A,B]
2EHM[A,B]
2EHN[A,B]
 toxin (Ha1)   Clostridium botulinum D phage CB16 BAA75077.1   1QXM[A,B]
2EHI[A,B]
2EHM[A,B]
2EHN[A,B]
 toxin (Ha1;Hα-33;Antp-33)   Clostridium botulinum phage 1C 468 CAA51311.1 P46084
Q38196
3AH1[A,B]
3AH2[A,B]
3AH4[A,B]
 toxin (Ha1;Hα-33;Antp-33)   Clostridium botulinum phage 1C 468 CAA51311.1 P46084
Q38196
3AH1[A,B]
3AH2[A,B]
3AH4[A,B]
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