Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (6914); Uniprot accession (901); PDB accession (151); 3D entries (58); cryst (1)
All (6764) Archaea (23) Bacteria (6094) Eukaryota (602) Viruses (32) unclassified (13) Structure (58 - 1 cryst) Characterized (99)
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Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 APASM_3141   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX30506.1    
 APASM_4323   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX31688.1    
 APASM_3139   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX30504.1    
 APASM_3716   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX31081.1    
 APASM_4889   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX32254.1    
 APASM_1678   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX29043.1    
 APASM_3536   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX30901.1    
 APASM_3140   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX30505.1    
 APASM_4133   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX31498.1    
 APASM_4159   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX31524.1    
 APASM_0108   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX27473.1    
 APASM_3185   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX30550.1    
 APASM_1663   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX29028.1    
 APASM_4134   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX31499.1    
 APASM_4182   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX31547.1    
 APASM_5374   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX32739.1    
 APASM_4018   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX31383.1    
 APASM_2582   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX29947.1    
 APASM_5023   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX32388.1    
 APASM_4135   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX31500.1    
 APASM_3927   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX31292.1    
 APASM_4636   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX32001.1    
 APASM_2586   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX29951.1    
 APASM_4181   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX31546.1    
 APASM_1858   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX29223.1    
 APASM_5025   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX32390.1    
 CNX65_15750   Actinosynnema pretiosum X47 ATE54566.1    
 CNX65_08320   Actinosynnema pretiosum X47 ATE53294.1    
 CNX65_18875   Actinosynnema pretiosum X47 ATE55095.1    
 CNX65_12995   Actinosynnema pretiosum X47 ATE54094.1    
 CNX65_20755   Actinosynnema pretiosum X47 ATE55413.1    
 CNX65_12965   Actinosynnema pretiosum X47 ATE54090.1    
 CNX65_20185   Actinosynnema pretiosum X47 ATE55314.1    
 CNX65_17925   Actinosynnema pretiosum X47 ATE58235.1    
 CNX65_20915   Actinosynnema pretiosum X47 ATE55440.1    
 CNX65_18980   Actinosynnema pretiosum X47 ATE55111.1    
 CNX65_23985   Actinosynnema pretiosum X47 ATE58353.1    
 CNX65_16045   Actinosynnema pretiosum X47 ATE54615.1    
 CNX65_20760   Actinosynnema pretiosum X47 ATE55414.1    
 CNX65_15740   Actinosynnema pretiosum X47 ATE54564.1    
 CNX65_24495   Actinosynnema pretiosum X47 ATE56040.1    
 CNX65_00550   Actinosynnema pretiosum X47 ATE51961.1    
 CNX65_00550   Actinosynnema pretiosum X47 ATE51961.1    
 CNX65_15745   Actinosynnema pretiosum X47 ATE54565.1    
 CNX65_20765   Actinosynnema pretiosum X47 ATE55415.1    
 CNX65_09245   Actinosynnema pretiosum X47 ATE53456.1    
 CNX65_08255   Actinosynnema pretiosum X47 ATE53282.1    
 CNX65_21695   Actinosynnema pretiosum X47 ATE55581.1    
 CNX65_26500   Actinosynnema pretiosum X47 ATE56384.1    
 CNX65_23060   Actinosynnema pretiosum X47 ATE55802.1    
 ADH66_16220   Acutalibacter muris KB18 ASB42067.1    
 ADH66_12860   Acutalibacter muris KB18 ASB41462.1    
 BOQ57_22135   Aeromonas aquatica MX16A APJ17399.1    
 VI35_00140   Aeromonas caviae 8LM ATP89065.1    
 MC60_013025   Aeromonas caviae FDAARGOS_72 AUU22815.1    
 ACGSH8M1_000300   Aeromonas caviae GSH8M-1 BBG87364.1    
 NCTC12244_00027   Aeromonas caviae NCTC12244 SQH57642.1    
 C0708_18045   Aeromonas caviae R25-2 AXB10173.1    
 C1C92_06550   Aeromonas caviae R25-6 AXB00676.1    
 C1C91_08100   Aeromonas caviae T25-39 AXB04968.1    
 CK627_03770   Aeromonas dhakensis KN-Mc-6U21 ASX09959.1    
 CK627_03765   Aeromonas dhakensis KN-Mc-6U21 ASX09958.1    
 NCTC12917_00030   Aeromonas encheleia NCTC12917 VEG94566.1    
 AH4AK4_0032   Aeromonas hydrophila 4AK4 AHE47548.1    
 VU14_00350   Aeromonas hydrophila AH10 AKA15439.1    
 TK34_00135   Aeromonas hydrophila AHNIH1 ANT66042.1    
 RY45_00135   Aeromonas hydrophila AL06-06 AJQ52575.1    
 V428_00140   Aeromonas hydrophila AL09-71 AHX30553.1    
 AhyD4_00135   Aeromonas hydrophila D4 ALZ78113.1    
 A9258_00185   Aeromonas hydrophila GYK1 ANR98154.1    
 V469_00140   Aeromonas hydrophila J-1 AJE34427.1    
 AS145_00135   Aeromonas hydrophila JBN2301 ALQ61413.1    
 C7K70_22485   Aeromonas hydrophila KN-Mc-1R2 AVP86591.1    
 AHML_00120   Aeromonas hydrophila ML09-119 AGM41809.1    
 U876_00140   Aeromonas hydrophila NJ-35 AKJ32623.1    
 V429_00140   Aeromonas hydrophila pc104A AHX67350.1    
 AHA_0028   Aeromonas hydrophila subsp. hydrophila ATCC 7966 ABK35934.1 A0KED0  
 C1A23_02060   Aeromonas hydrophila subsp. hydrophila WCHAH045096 AWA04540.1    
 AI20_19500   Aeromonas hydrophila YL17 AHV37272.1    
 AI20_19505   Aeromonas hydrophila YL17 AHV37273.1    
 BFW97_00170   Aeromonas hydrophila ZYAH72 AXV28033.1    
 BFW41_00135   Aeromonas hydrophila ZYAH75 AXV32423.1    
 B224_5308   Aeromonas media WS AHX63076.1    
 C7N77_03975   Aeromonas rivipollensis KN-Mc-11N1 AVP95441.1    
 CHQ57_00155   Aeromonas salmonicida A527 ATU96036.1    
 CE456_02120   Aeromonas salmonicida S121 ASI25283.1    
 CE463_02165   Aeromonas salmonicida S44 ASI29602.1    
 CE462_01045   Aeromonas salmonicida S68 ASI33733.1    
 BHG40_03925   Aeromonas salmonicida subsp. masoucida RFAS1 ATD37194.1    
 Asalp_00280   Aeromonas salmonicida subsp. pectinolytica 34mel ATP07294.1    
 C5P03_00160   Aeromonas salmonicida subsp. salmonicida 01-B526 AYO61428.1    
 ASA_0030   Aeromonas salmonicida subsp. salmonicida A449 ABO88240.1 A4SH68  
 WL1483_1951   Aeromonas schubertii WL1483 ALP41370.1    
 WL1483_14   Aeromonas schubertii WL1483 ALP39433.1    
 C2U37_07225   Aeromonas sp. ASNIH1 AUZ79475.1    
 C3F36_10100   Aeromonas sp. ASNIH2 AUY09858.1    
 C2U39_22375   Aeromonas sp. ASNIH3 AUV14610.1    
 C2U40_23085   Aeromonas sp. ASNIH4 AUZ77429.1    
 C2U30_13815   Aeromonas sp. ASNIH5 AUT42666.1    
 C2U47_09925   Aeromonas sp. ASNIH7 AUV16881.1    
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