Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (6296); Uniprot accession (901); PDB accession (146); 3D entries (57); cryst (1)
All (6120) Archaea (23) Bacteria (5454) Eukaryota (598) Viruses (32) unclassified (13) Structure (57 - 1 cryst) Characterized (99)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 55 |
Protein Name EC#OrganismGenBank UniprotPDB/3D
 CK627_03770   Aeromonas dhakensis KN-Mc-6U21 ASX09959.1    
 CK627_03765   Aeromonas dhakensis KN-Mc-6U21 ASX09958.1    
 AH4AK4_0032   Aeromonas hydrophila 4AK4 AHE47548.1    
 VU14_00350   Aeromonas hydrophila AH10 AKA15439.1    
 TK34_00135   Aeromonas hydrophila AHNIH1 ANT66042.1    
 RY45_00135   Aeromonas hydrophila AL06-06 AJQ52575.1    
 V428_00140   Aeromonas hydrophila AL09-71 AHX30553.1    
 AhyD4_00135   Aeromonas hydrophila D4 ALZ78113.1    
 A9258_00185   Aeromonas hydrophila GYK1 ANR98154.1    
 V469_00140   Aeromonas hydrophila J-1 AJE34427.1    
 AS145_00135   Aeromonas hydrophila JBN2301 ALQ61413.1    
 C7K70_22485   Aeromonas hydrophila KN-Mc-1R2 AVP86591.1    
 AHML_00120   Aeromonas hydrophila ML09-119 AGM41809.1    
 U876_00140   Aeromonas hydrophila NJ-35 AKJ32623.1    
 V429_00140   Aeromonas hydrophila pc104A AHX67350.1    
 AHA_0028   Aeromonas hydrophila subsp. hydrophila ATCC 7966 ABK35934.1 A0KED0  
 C1A23_02060   Aeromonas hydrophila subsp. hydrophila WCHAH045096 AWA04540.1    
 AI20_19500   Aeromonas hydrophila YL17 AHV37272.1    
 AI20_19505   Aeromonas hydrophila YL17 AHV37273.1    
 B224_5308   Aeromonas media WS AHX63076.1    
 C7N77_03975   Aeromonas rivipollensis KN-Mc-11N1 AVP95441.1    
 CHQ57_00155   Aeromonas salmonicida A527 ATU96036.1    
 CE456_02120   Aeromonas salmonicida S121 ASI25283.1    
 CE463_02165   Aeromonas salmonicida S44 ASI29602.1    
 CE462_01045   Aeromonas salmonicida S68 ASI33733.1    
 BHG40_03925   Aeromonas salmonicida subsp. masoucida RFAS1 ATD37194.1    
 Asalp_00280   Aeromonas salmonicida subsp. pectinolytica 34mel ATP07294.1    
 ASA_0030   Aeromonas salmonicida subsp. salmonicida A449 ABO88240.1 A4SH68  
 WL1483_1951   Aeromonas schubertii WL1483 ALP41370.1    
 WL1483_14   Aeromonas schubertii WL1483 ALP39433.1    
 C2U37_07225   Aeromonas sp. ASNIH1 AUZ79475.1    
 C3F36_10100   Aeromonas sp. ASNIH2 AUY09858.1    
 C2U39_22375   Aeromonas sp. ASNIH3 AUV14610.1    
 C2U40_23085   Aeromonas sp. ASNIH4 AUZ77429.1    
 C2U30_13815   Aeromonas sp. ASNIH5 AUT42666.1    
 C2U47_09925   Aeromonas sp. ASNIH7 AUV16881.1    
 CK910_04530   Aeromonas sp. CA23 ATL97844.1    
 CK911_17435   Aeromonas sp. CU5 ATL94387.1    
 O23A_p3604   Aeromonas sp. O23A ARW84343.1    
 WM43_12765   Aeromonas veronii AVNIH1 ANB53465.1    
 B565_0022   Aeromonas veronii B565 AEB48057.1    
 A6033_04460   Aeromonas veronii CB51 ANB67968.1    
 AMS64_00290   Aeromonas veronii TH0426 AMQ40948.1    
 CVS41_00425   Aeromonas veronii X11 ATY75738.1    
 CVS42_00195   Aeromonas veronii X12 ATY79418.1    
 SAMN05444050_1324   Afipia sp. GAS231 SDN34383.1    
 β-agarase (AgaB34) Agarivorans albus YKW-34 ABW77762.1 A8W969  
 β-agarase (AgaA)   Agarivorans gilvus WH0801 AFN94094.1    
 β-agarase (AgaJA3;Hz4) Agarivorans sp. JA-1 / HZ105 ADY17921.1    
 alginate lyase (AlyL2)
Agarivorans sp. L11 AJO61885.1
 β-agarase (AgaA) Agarivorans sp. LQ48 ACM50513.1 C9WIW7  
 ATC03_03580   Agromyces aureus AR33 ANJ25953.1    
 ATC03_03580   Agromyces aureus AR33 ANJ25953.1    
 ATC03_17300   Agromyces aureus AR33 ANJ28198.1    
 C7S18_17810   Ahniella affigens D13 AVQ00170.1    
 S7S_12670   Alcanivorax pacificus W11-5 AJD48946.1    
 CDL62_06395   Alkalitalea saponilacus DSM 24412 ASB48785.1    
 CDL62_06395   Alkalitalea saponilacus DSM 24412 ASB48785.1    
 CDL62_12930   Alkalitalea saponilacus DSM 24412 ASB49975.1    
 CDL62_06150   Alkalitalea saponilacus DSM 24412 ASB48747.1    
 CDL62_16830   Alkalitalea saponilacus DSM 24412 ASB51201.1    
 CDL62_05490   Alkalitalea saponilacus DSM 24412 ASB48631.1    
 CDL62_06390   Alkalitalea saponilacus DSM 24412 ASB48784.1    
 CDL62_11795   Alkalitalea saponilacus DSM 24412 ASB49770.1    
 CDL62_16805   Alkalitalea saponilacus DSM 24412 ASB50690.1    
 CDL62_00650   Alkalitalea saponilacus DSM 24412 ASB47762.1    
 ORF   Alloactinosynnema sp. L-07 CRK60110.1    
 ORF   Alloactinosynnema sp. L-07 CRK62161.1    
 ORF   Alloactinosynnema sp. L-07 CRK62161.1    
 SAMN04489726_0689   Allokutzneria albata DSM 44149 SDM26796.1    
 SAMN04489726_3129   Allokutzneria albata DSM 44149 SDM73493.1    
 SAMN04489726_7766 (fragment)   Allokutzneria albata DSM 44149 SDN68637.1    
 SAMN04489726_2465   Allokutzneria albata DSM 44149 SDM60382.1    
 SAMN04489726_4244   Allokutzneria albata DSM 44149 SDM96818.1    
 SAMN04489726_2493   Allokutzneria albata DSM 44149 SDM61034.1    
 SAMN04489726_2732   Allokutzneria albata DSM 44149 SDM65380.1    
 SAMN04489726_4644   Allokutzneria albata DSM 44149 SDN04960.1    
 SAMN04489726_4644   Allokutzneria albata DSM 44149 SDN04960.1    
 WYH_02206 (Abn-tS)   Altererythrobacter atlanticus 26DY36 AKH43239.1    
 AVL56_11045   Alteromonas addita R10SW13 AMJ94778.1    
 BM523_01310   Alteromonas mediterranea AR43 APD92746.1    
 BM525_01300   Alteromonas mediterranea CP49 APD96360.1    
 BM526_01370   Alteromonas mediterranea RG65 APE00617.1    
 I607_09395 (fragment)   Alteromonas mediterranea U4 AGP85674.1    
 AV939_15860   Alteromonas sp. Mac1 AMJ88929.1    
 AV939_10915   Alteromonas sp. Mac1 AMJ87035.1    
 AV940_15615   Alteromonas sp. Mac2 AMJ92778.1    
 AV940_10685   Alteromonas sp. Mac2 AMJ90896.1    
 AOR13_312   Alteromonas stellipolaris LMG 21856 ALM89366.1    
 AOR13_1359   Alteromonas stellipolaris LMG 21856 ALM90400.1    
 AVL57_16920   Alteromonas stellipolaris LMG 21861 AMJ76501.1    
 AVL57_11855   Alteromonas stellipolaris LMG 21861 AMJ74593.1    
 A6K25_08825   Alteromonas stellipolaris PQQ-42 ANB23544.1    
 A6K25_14090   Alteromonas stellipolaris PQQ-42 ANB22305.1    
 A6F57_05775   Alteromonas stellipolaris PQQ-44 ANB27419.1    
 A6F57_00650   Alteromonas stellipolaris PQQ-44 ANB23850.1    
 A4R43_13575   Amycolatopsis albispora WP1 AXB43451.1    
 A4R43_06925   Amycolatopsis albispora WP1 AXB42294.1    
 A4R43_07010   Amycolatopsis albispora WP1 AXB42309.1    
 A4R43_11605   Amycolatopsis albispora WP1 AXB43115.1    

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