Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 46 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 ORF   Alloactinosynnema sp. L-07 CRK62161.1    
 ORF   Alloactinosynnema sp. L-07 CRK62161.1    
 SAMN04489726_0689   Allokutzneria albata DSM 44149 SDM26796.1    
 SAMN04489726_3129   Allokutzneria albata DSM 44149 SDM73493.1    
 SAMN04489726_7766 (fragment)   Allokutzneria albata DSM 44149 SDN68637.1    
 SAMN04489726_2465   Allokutzneria albata DSM 44149 SDM60382.1    
 SAMN04489726_4244   Allokutzneria albata DSM 44149 SDM96818.1    
 SAMN04489726_2493   Allokutzneria albata DSM 44149 SDM61034.1    
 SAMN04489726_2732   Allokutzneria albata DSM 44149 SDM65380.1    
 SAMN04489726_4644   Allokutzneria albata DSM 44149 SDN04960.1    
 SAMN04489726_4644   Allokutzneria albata DSM 44149 SDN04960.1    
 WYH_02206 (Abn-tS)   Altererythrobacter atlanticus 26DY36 AKH43239.1    
 AVL56_11045   Alteromonas addita R10SW13 AMJ94778.1    
 BM523_01310   Alteromonas mediterranea AR43 APD92746.1    
 BM525_01300   Alteromonas mediterranea CP49 APD96360.1    
 BM526_01370   Alteromonas mediterranea RG65 APE00617.1    
 I607_09395 (fragment)   Alteromonas mediterranea U4 AGP85674.1    
 AV939_15860   Alteromonas sp. Mac1 AMJ88929.1    
 AV939_10915   Alteromonas sp. Mac1 AMJ87035.1    
 AV940_15615   Alteromonas sp. Mac2 AMJ92778.1    
 AV940_10685   Alteromonas sp. Mac2 AMJ90896.1    
 AOR13_312   Alteromonas stellipolaris LMG 21856 ALM89366.1    
 AOR13_1359   Alteromonas stellipolaris LMG 21856 ALM90400.1    
 AVL57_16920   Alteromonas stellipolaris LMG 21861 AMJ76501.1    
 AVL57_11855   Alteromonas stellipolaris LMG 21861 AMJ74593.1    
 A6K25_08825   Alteromonas stellipolaris PQQ-42 ANB23544.1    
 A6K25_14090   Alteromonas stellipolaris PQQ-42 ANB22305.1    
 A6F57_05775   Alteromonas stellipolaris PQQ-44 ANB27419.1    
 A6F57_00650   Alteromonas stellipolaris PQQ-44 ANB23850.1    
 AJAP_01375   Amycolatopsis japonica MG417-CF17 AIG73212.1    
 AJAP_20045   Amycolatopsis japonica MG417-CF17 AIG76870.1    
 AJAP_32255   Amycolatopsis japonica MG417-CF17 AIG79265.1    
 AJAP_03195   Amycolatopsis japonica MG417-CF17 AIG73565.1    
 AJAP_31660   Amycolatopsis japonica MG417-CF17 AIG79154.1    
 SAMN04489733_4265   Amycolatopsis keratiniphila FH 1893 SDU43891.1    
 SAMN04489733_5820   Amycolatopsis keratiniphila FH 1893 SDU54508.1    
 SAMN04489733_4455   Amycolatopsis keratiniphila FH 1893 SDU45245.1    
 SAMN04489733_3714   Amycolatopsis keratiniphila FH 1893 SDU39376.1    
 SAMN04489733_1990   Amycolatopsis keratiniphila FH 1893 SDU20003.1    
 SAMN04489733_7122   Amycolatopsis keratiniphila FH 1893 SDU61903.1    
 SAMN04489733_7121   Amycolatopsis keratiniphila FH 1893 SDU61897.1    
 BB31_12485   Amycolatopsis lurida NRRL 2430 AJK54151.1    
 BB31_08195   Amycolatopsis lurida NRRL 2430 AJK59669.1    
 BB31_33740   Amycolatopsis lurida NRRL 2430 AJK58048.1    
 BB31_20860   Amycolatopsis lurida NRRL 2430 AJK55703.1    
 BB31_04200   Amycolatopsis lurida NRRL 2430 AJK52688.1    
 BB31_04195   Amycolatopsis lurida NRRL 2430 AJK52687.1    
 B737_5091   Amycolatopsis mediterranei RB AGT85755.1    
 B737_3639   Amycolatopsis mediterranei RB AGT84303.1    
 B737_3670   Amycolatopsis mediterranei RB AGT84334.1    
 B737_3262   Amycolatopsis mediterranei RB AGT83926.1    
 B737_4758 (AbfA)   Amycolatopsis mediterranei RB AGT85422.1    
 B737_3886   Amycolatopsis mediterranei RB AGT84550.1    
 B737_3937   Amycolatopsis mediterranei RB AGT84601.1    
 B737_3947   Amycolatopsis mediterranei RB AGT84611.1    
 B737_3540   Amycolatopsis mediterranei RB AGT84204.1    
 B737_3540   Amycolatopsis mediterranei RB AGT84204.1    
 B737_7712   Amycolatopsis mediterranei RB AGT88373.1    
 B737_3367 (GalA)   Amycolatopsis mediterranei RB AGT84031.1    
 B737_1322   Amycolatopsis mediterranei RB AGT81986.1    
 B737_7275 (GalA)   Amycolatopsis mediterranei RB AGT87936.1    
 B737_8252   Amycolatopsis mediterranei RB AGT88913.1    
 B737_5527   Amycolatopsis mediterranei RB AGT86191.1    
 B737_3372   Amycolatopsis mediterranei RB AGT84036.1    
 B737_3254   Amycolatopsis mediterranei RB AGT83918.1    
 B737_7713   Amycolatopsis mediterranei RB AGT88374.1    
 B737_2877 (AbfA)   Amycolatopsis mediterranei RB AGT83541.1    
 B737_1397   Amycolatopsis mediterranei RB AGT82061.1    
 B737_2347   Amycolatopsis mediterranei RB AGT83011.1    
 B737_3946 (AbfA)   Amycolatopsis mediterranei RB AGT84610.1    
 B737_3938   Amycolatopsis mediterranei RB AGT84602.1    
 B737_8369   Amycolatopsis mediterranei RB AGT89030.1    
 B737_3702   Amycolatopsis mediterranei RB AGT84366.1    
 B737_3259   Amycolatopsis mediterranei RB AGT83923.1    
 B737_6339 (XynA)   Amycolatopsis mediterranei RB AGT87003.1    
 B737_5465   Amycolatopsis mediterranei RB AGT86129.1    
 B737_8251 (SrfJ)   Amycolatopsis mediterranei RB AGT88912.1    
 B737_7708 (AbfA)   Amycolatopsis mediterranei RB AGT88369.1    
 B737_3255   Amycolatopsis mediterranei RB AGT83919.1    
 B737_3945   Amycolatopsis mediterranei RB AGT84609.1    
 B737_1460   Amycolatopsis mediterranei RB AGT82124.1    
 B737_3703   Amycolatopsis mediterranei RB AGT84367.1    
 B737_7707 (GalA)   Amycolatopsis mediterranei RB AGT88368.1    
 B737_1289   Amycolatopsis mediterranei RB AGT81953.1    
 B737_7371   Amycolatopsis mediterranei RB AGT88032.1    
 B737_3373   Amycolatopsis mediterranei RB AGT84037.1    
 B737_3887   Amycolatopsis mediterranei RB AGT84551.1    
 B737_3261 (AbfA)   Amycolatopsis mediterranei RB AGT83925.1    
 B737_7706   Amycolatopsis mediterranei RB AGT88367.1    
 B737_6338   Amycolatopsis mediterranei RB AGT87002.1    
 B737_3060   Amycolatopsis mediterranei RB AGT83724.1    
 B737_5387   Amycolatopsis mediterranei RB AGT86051.1    
 B737_8249   Amycolatopsis mediterranei RB AGT88910.1    
 B737_3256 (AbfA)   Amycolatopsis mediterranei RB AGT83920.1    
 B737_3940   Amycolatopsis mediterranei RB AGT84604.1    
 B737_3257   Amycolatopsis mediterranei RB AGT83921.1    
 B737_1908 (GalA)   Amycolatopsis mediterranei RB AGT82572.1    
 B737_7266   Amycolatopsis mediterranei RB AGT87927.1    
 B737_8250 (fragment)   Amycolatopsis mediterranei RB AGT88911.1    
 B737_5544   Amycolatopsis mediterranei RB AGT86208.1    
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