Carbohydrate-Binding Module Family 13

Activities in FamilyModules of approx. 150 residues which always appear as a threefold internal repeat. The only apparent exception to this, xylanase II of Actinomadura sp. FC7 (GenBank U08894), is in fact not completely sequenced. These modules were first identified in several plant lectins such as ricin or agglutinin of Ricinus communis which bind galactose residues. The three-dimensional structure of a plant lectin has been determined and displays a pseudo-threefold symmetry in accord with the observed sequence threefold repeat. These modules have since been found in a number of other proteins of various functions including glycoside hydrolases and glycosyltransferases. While in the plant lectins this module binds mannose, binding to xylan has been demonstrated in the Streptomyces lividans xylanase A and arabinofuranosidase B. Binding to GalNAc has been shown for the corresponding module of GalNAc transferase 4. For the other proteins, the binding specificity of these modules has not been established. The pseudo three-fold symmetry of the CBM13 module has now been confirmed in the 3-D structure of the intact, two-domain, xylanase of Streptomyces olivaceoviridis.
3D Structure Statusβ-trefoil
NotePreviously known as cellulose-binding domain family XIII (CBD XIII).
External resourcesHOMSTRAD;
Statistics GenBank accession (5439); Uniprot accession (902); PDB accession (142); 3D entries (56); cryst (1)
All (5178) Archaea (18) Bacteria (4566) Eukaryota (557) Viruses (26) unclassified (11) Structure (56 - 1 cryst) Characterized (99)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | ... | 46 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D
 AFR_33250   Actinoplanes friuliensis DSM 7358 AGZ44908.1    
 AFR_39020   Actinoplanes friuliensis DSM 7358 AGZ46058.1    
 AFR_42300   Actinoplanes friuliensis DSM 7358 AGZ46714.1    
 AMIS_60150   Actinoplanes missouriensis 431 BAL91235.1    
 AMIS_60450   Actinoplanes missouriensis 431 BAL91265.1    
 AMIS_60450   Actinoplanes missouriensis 431 BAL91265.1    
 AMIS_60510   Actinoplanes missouriensis 431 BAL91271.1    
 AMIS_71340   Actinoplanes missouriensis 431 BAL92354.1    
 AMIS_73120   Actinoplanes missouriensis 431 BAL92532.1    
 AMIS_63000   Actinoplanes missouriensis 431 BAL91520.1    
 AMIS_8420   Actinoplanes missouriensis 431 BAL86062.1    
 AMIS_10370   Actinoplanes missouriensis 431 BAL86257.1    
 AMIS_23860   Actinoplanes missouriensis 431 BAL87606.1    
 AMIS_25140   Actinoplanes missouriensis 431 BAL87734.1    
 AMIS_25150   Actinoplanes missouriensis 431 BAL87735.1    
 AMIS_28000   Actinoplanes missouriensis 431 BAL88020.1    
 AMIS_28300   Actinoplanes missouriensis 431 BAL88050.1    
 AMIS_28310   Actinoplanes missouriensis 431 BAL88051.1    
 AMIS_28330   Actinoplanes missouriensis 431 BAL88053.1    
 AMIS_28340   Actinoplanes missouriensis 431 BAL88054.1    
 AMIS_29270   Actinoplanes missouriensis 431 BAL88147.1    
 AMIS_32500   Actinoplanes missouriensis 431 BAL88470.1    
 AMIS_41600   Actinoplanes missouriensis 431 BAL89380.1    
 AMIS_42910   Actinoplanes missouriensis 431 BAL89511.1    
 AMIS_44580   Actinoplanes missouriensis 431 BAL89678.1    
 AMIS_46890   Actinoplanes missouriensis 431 BAL89909.1    
 AMIS_49380   Actinoplanes missouriensis 431 BAL90158.1    
 AMIS_10380   Actinoplanes missouriensis 431 BAL86258.1    
 AMIS_27960   Actinoplanes missouriensis 431 BAL88016.1    
 K924_0031   Actinoplanes sp. N902-109 AGL12187.1
AGL16461.1
   
 K924_0032   Actinoplanes sp. N902-109 AGL12188.1    
 L083_3530   Actinoplanes sp. N902-109 AGL17040.1    
 L083_3530   Actinoplanes sp. N902-109 AGL17040.1    
 L083_0411   Actinoplanes sp. N902-109 AGL13921.1    
 L083_1314   Actinoplanes sp. N902-109 AGL14824.1    
 L083_2069   Actinoplanes sp. N902-109 AGL15579.1    
 L083_2536   Actinoplanes sp. N902-109 AGL16046.1    
 L083_2683   Actinoplanes sp. N902-109 AGL16193.1    
 L083_2718   Actinoplanes sp. N902-109 AGL16228.1    
 L083_2950   Actinoplanes sp. N902-109 AGL16460.1    
 L083_3176 (GlcI)   Actinoplanes sp. N902-109 AGL16686.1    
 L083_3241   Actinoplanes sp. N902-109 AGL16751.1    
 L083_3265   Actinoplanes sp. N902-109 AGL16775.1    
 L083_3276 (GalC)   Actinoplanes sp. N902-109 AGL16786.1    
 L083_3279 (GaA)   Actinoplanes sp. N902-109 AGL16789.1    
 L083_3279 (GaA)   Actinoplanes sp. N902-109 AGL16789.1    
 L083_3284   Actinoplanes sp. N902-109 AGL16794.1    
 L083_3572   Actinoplanes sp. N902-109 AGL17082.1    
 L083_4273   Actinoplanes sp. N902-109 AGL17783.1    
 L083_4844   Actinoplanes sp. N902-109 AGL18354.1    
 L083_5546   Actinoplanes sp. N902-109 AGL19056.1    
 L083_5602   Actinoplanes sp. N902-109 AGL19112.1    
 L083_5607   Actinoplanes sp. N902-109 AGL19117.1    
 L083_6234 (GbA)   Actinoplanes sp. N902-109 AGL19744.1    
 L083_6441   Actinoplanes sp. N902-109 AGL19951.1    
 L083_6977   Actinoplanes sp. N902-109 AGL20487.1    
 L083_7236 (GlcA)   Actinoplanes sp. N902-109 AGL20746.1    
 L083_8082   Actinoplanes sp. N902-109 AGL21592.1    
 L083_2786   Actinoplanes sp. N902-109 AGL16296.1    
 L083_4364   Actinoplanes sp. N902-109 AGL17874.1    
 L083_6085   Actinoplanes sp. N902-109 AGL19595.1    
 ACPL_1035   Actinoplanes sp. SE50/110 AEV81932.1
SLL97738.1
   
 ACPL_1477   Actinoplanes sp. SE50/110 AEV82374.1
SLL98179.1
   
 ACPL_2739   Actinoplanes sp. SE50/110 AEV83634.1
SLL99629.1
   
 ACPL_2739   Actinoplanes sp. SE50/110 AEV83634.1
SLL99629.1
   
 ACPL_2992   Actinoplanes sp. SE50/110 AEV83887.1
SLL99377.1
   
 ACPL_3003   Actinoplanes sp. SE50/110 AEV83898.1
SLL99366.1
   
 ACPL_3006 (GlcI)   Actinoplanes sp. SE50/110 AEV83901.1
SLL99363.1
   
 ACPL_3009   Actinoplanes sp. SE50/110 AEV83904.1
SLL99360.1
   
 ACPL_3014 (XlnA)   Actinoplanes sp. SE50/110 AEV83909.1
SLL99355.1
   
 ACPL_3177   Actinoplanes sp. SE50/110 AEV84072.1
SLL99871.1
   
 ACPL_3245 (GlcA)   Actinoplanes sp. SE50/110 AEV84140.1
SLL99939.1
   
 ACPL_3316 (EstA)   Actinoplanes sp. SE50/110 AEV84211.1
SLM00010.1
   
 ACPL_3372   Actinoplanes sp. SE50/110 AEV84267.1
SLM00066.1
   
 ACPL_3561   Actinoplanes sp. SE50/110 AEV84456.1
SLM00256.1
   
 ACPL_3561   Actinoplanes sp. SE50/110 AEV84456.1
SLM00256.1
   
 ACPL_3660   Actinoplanes sp. SE50/110 AEV84555.1
SLM00355.1
   
 ACPL_3855 (ManA)   Actinoplanes sp. SE50/110 AEV84750.1
SLM00549.1
   
 ACPL_3865   Actinoplanes sp. SE50/110 AEV84760.1
SLM00559.1
   
 ACPL_4205   Actinoplanes sp. SE50/110 AEV85100.1
SLM00898.1
   
 ACPL_4647   Actinoplanes sp. SE50/110 AEV85538.1
SLM01341.1
   
 ACPL_4729   Actinoplanes sp. SE50/110 AEV85620.1
SLM01423.1
   
 ACPL_4779   Actinoplanes sp. SE50/110 AEV85670.1
SLM01473.1
   
 ACPL_4941 (AbfB)   Actinoplanes sp. SE50/110 AEV85830.1
SLM01636.1
   
 ACPL_6037   Actinoplanes sp. SE50/110 AEV86924.1
SLM02731.1
   
 ACPL_6174   Actinoplanes sp. SE50/110 AEV87059.1
SLM02869.1
   
 ACPL_7578   Actinoplanes sp. SE50/110 AEV88458.1
SLM04281.1
   
 ACPL_7598   Actinoplanes sp. SE50/110 AEV88478.1
SLM04301.1
   
 ACPL_342   Actinoplanes sp. SE50/110 AEV81239.1
SLL97045.1
   
 ACPL_348   Actinoplanes sp. SE50/110 AEV81245.1
SLL97051.1
   
 ACPL_2106 (fragment)   Actinoplanes sp. SE50/110 AEV83003.1
SLL98806.1
   
 ACPL_4904   Actinoplanes sp. SE50/110 AEV85795.1
SLM01599.1
   
 ACPL_6175 (GalC)   Actinoplanes sp. SE50/110 AEV87060.1
SLM02870.1
   
 ACPL_6556   Actinoplanes sp. SE50/110 AEV87438.1
SLM03254.1
   
 ACPL_3688   Actinoplanes sp. SE50/110 CAJ81035.1
AEV84583.1
SLM00383.1
Q27GR1  
 ACPL_3689   Actinoplanes sp. SE50/110 CAJ81036.1
AEV84584.1
SLM00384.1
Q27GR0  
 SAMN04489717_0881   Actinopolymorpha singaporensis DSM 22024 SDR87740.1    
 Amir_1665   Actinosynnema mirum DSM 43827 ACU35614.1 C6WBP6  
 Amir_3154   Actinosynnema mirum DSM 43827 ACU37065.1 C6W844  
 Amir_3944   Actinosynnema mirum DSM 43827 ACU37811.1 C6WEL1  
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