Activities in Sub Family	β-mannosidase (EC 3.2.1.25); Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (1559); Uniprot accession (72); PDB accession (29); 3D entries (11); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
H9L15_00785		Sphingomonas daechungensis KACC 18115	QNP43414.1			7
PPZ50_16280		Sphingomonas hankookensis SZ.B2R2	WCP71875.1			7
TS85_09230		Sphingomonas hengshuiensis WHSC-8	AJP74397.1			7
TS85_01390		Sphingomonas hengshuiensis WHSC-8	AJP70767.1			7
BJP26_18350		Sphingomonas melonis TY	AOW25267.1			7
CVN68_06785		Sphingomonas psychrotolerans Cra20	ATY31708.1			7
H9L12_00340		Sphingomonas rhizophila KACC 19189	QNN65148.1			7
KV697_00225		Sphingomonas sanguinis NP2-R2	QXT35884.1			7
PIB19_06730		Sphingomonas sp. 7/4-4	WBY09058.1			7
LRS08_12130		Sphingomonas sp. J315	UUX98335.1			7
BXU08_02495		Sphingomonas sp. LM7	AQR72688.1			7
O3305_05740		Sphingomonas sp. NIBR02145 NIBR 02145	WHU04093.1			7
E5673_11860		Sphingomonas sp. PAMC26645	QCB44385.1			7
LZ586_04900		Sphingomonas sp. S2-65	UYY59427.1			7
FPZ54_11515		Sphingomonas suaedae XS-10	QDX26586.1			7
LPB140_03620		Sphingorhabdus lutea LPB0140	APG62054.1			7
ETR14_13065		Sphingosinicella sp. BN140058	QAY77330.1			7
RPR59_10805		Stakelama sp. W311	WNO52944.1			7
HYC88_02310 (fragment)		Streptomyces sp. CB00271	QNQ32618.1			7
C2142_00020 (fragment)		Streptomyces sp. CB01881	AUY47625.1			7
D1J63_06325		Streptomyces sp. KPB2	AZM74611.1			7
RKE32_02960		Streptomyces sp. Li-HN-5-13	WNW36589.1			7
RKE32_26960		Streptomyces sp. Li-HN-5-13	WNW40892.1			7
HUT15_06095		Streptomyces sp. NA03103	QKW60117.1			7
E5N77_28630		Streptomyces sp. SS52	QCB25359.1			7
P0M04_07680		Telluria mixta ACM 1762	WEM97590.1			7
TJEJU_3613		Tenacibaculum jejuense KCTC 22618	SNR17256.1			7
WKI14_19755		Teredinibacter turnerae SR01903	WYH49311.1			7
WKW49_19250		Teredinibacter turnerae SR02026	WYH53316.1			7
TERTU_4415		Teredinibacter turnerae T7901	ACR14510.1			7
WKI13_00850		Teredinibacter turnerae T7902	WYH45523.1			7
QH948_13345		Tessaracoccus sp. T21	WGT47080.1			7
Tter_2698		Thermobaculum terrenum ATCC BAA-798	ACZ43586.1			7
KTA_41780		Thermogemmatispora argillosa A3-2	BBH95979.1			7
KTA_13030		Thermogemmatispora argillosa A3-2	BBH93104.1			7
FHQ07_10740		Thermomonas aquatica SY21	QDA58535.1			7
H9L16_02590		Thermomonas carbonis KCTC 42013	QNN70531.1			7
KTC_24390		Thermosporothrix sp. COM3	BBH87688.1			7
β-mannanase (ManB; TmMan5; TM1227) (Man5)	3.2.1.78	Thermotoga maritima MSB8	AAD36302.1 AAM56792.1 AAM56796.1 ACM94273.1 AGL50158.1 AHD18866.1 AKE29003.1 CAB56854.1 CAH68693.1 CAT81455.1 NP_229032.1	Q9RIK9 Q9X0V4 R4P2R8		7
THMB_1253		Thermotoga maritima Tma100	AKE30875.1			7
THMC_1253		Thermotoga maritima Tma200	AKE27138.1			7
β-mannanase (ManB; TnMan5) (Man5)	3.2.1.78	Thermotoga neapolitana 5068	CAB56856.1 AAK53459.1	Q9RIK7		7
CTN_1345		Thermotoga neapolitana DSM 4359	ACM23521.1			7
endo-β-1,4-mannanase (Man;TpMan;TpManGH5;Tpet_1542)	3.2.1.78	Thermotoga petrophila RKU-1	ABQ47550.1 YP_001245126.1	A5IMX7	3PZ9[A] 3PZG[A] 3PZI[A] 3PZM[A] 3PZN[A] 3PZO[A] 3PZQ[A] 6TN6[A]	7
Tnap_1565		Thermotoga petrophila RKU-10	ADA67641.1			7
T2812B_07895		Thermotoga sp. 2812B	AIY87106.1			7
TRQ2_1591		Thermotoga sp. RQ2	ACB09927.1			7
TRQ7_08200		Thermotoga sp. RQ7	AJG41423.1			7
Trebr_1918		Treponema brennaborense DSM 12168	AEE17337.1			7
Turpa_1015		Turneriella parva DSM 21527	AFM11664.1			7
GH5		uncultured bacterium	AQQ75211.1			7
IL_C5_CDS_2		uncultured bacterium	SIP56248.1			7
GH5_7		uncultured bacterium	CAK9710332.1			7
GH5_7-CE7		uncultured bacterium	CAK9711171.1			7
GH5_7-CE7		uncultured bacterium	CAK9711842.1			7
GH5_7-CE7		uncultured bacterium	CAK9711059.1			7
GH5_7-CE7		uncultured bacterium	CAK9712409.1			7
GH5_7-CE7		uncultured bacterium	CAK9712542.1			7
ManEM1		uncultured bacterium	AHC00282.1			7
mannosidase (fragment)		uncultured bacterium	AGG23326.1			7
ORF		uncultured bacterium Contig196	AHF25220.1			7
LPB138_12950		Urechidicola croceus LPB0138	AOW22114.1			7
PYE67_13470		Vibrio aestuarianus U17	WGK87137.1			7
PYE51_17990		Vibrio aestuarianus U29	WGK83248.1			7
VCSRO45_2970		Vibrio cholerae RIMD 2214283	BCK15350.1			7
VCSRO51_2933		Vibrio cholerae RIMD 2214289	BCK22494.1			7
AL536_06090		Vibrio fluvialis ATCC 33809	AMF93025.1			7
KKIDH5335_31860		Vibrio fluvialis IDH05335	BEI24854.1			7
FIU11_17760		Vibrio furnissii FDAARGOS_777	QDC94579.1			7
vfu_B00528		Vibrio furnissii NCTC 11218	ADT88760.1			7
IUJ52_20995		Vibrio furnissii PartQ-Vfurnissii-RM8376	UON50020.1			7
QSU95_21435		Vibrio furnissii VFBJ05	WJG23579.1			7
BA893_23975		Vibrio natriegens CCUG 16373	ANQ24655.1			7
G7083_14240		Vibrio sp. HDW18	QIL87027.1			7
β-1,4-mannanase 5C (Man5C)	3.2.1.78	Vibrio sp. MA-138	BAG69482.2 BAG69482.1	B5BQ69		7
J4N39_22455		Vibrio sp. SCSIO 43136	USD67391.1			7
Xcel_2802		Xylanimonas cellulosilytica DSM 15894	ACZ31816.1			7
PBT91_13595		Zunongwangia sp. HGR-M22	WBL24930.1			7
PBT89_03965		Zunongwangia sp. HRR-M8	WBL23119.1			7
INR75_13285		Zunongwangia sp. SCSIO 43204	UAB83167.1			7
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