Activities in Sub Family	β-mannosidase (EC 3.2.1.25); Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (1545); Uniprot accession (72); PDB accession (28); 3D entries (10); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
CS953_10685		Bacillus safensis sami	AYJ90157.1			7
PNF30_11115		Bacillus safensis SRCM125915	WCL56077.1			7
BSA145_16070		Bacillus safensis U14-5	APT47251.1			7
BSA171_11305		Bacillus safensis U17-1	APT54133.1			7
BSA41_06410		Bacillus safensis U41	APT49591.1			7
MXH81_08065		Bacillus safensis ZK-1	UPI93478.1			7
SK061_10005		Bacillus sonorensis PMC204	WPP39051.1			7
S101395_03069		Bacillus sonorensis SRCM101395	ASB89576.1			7
ba103 (Man5A)		Bacillus sp. (in: firmicutes) KW1	QGN03632.1			7
CJO35_09290		Bacillus sp. 1s-1	ASV15341.1			7
JJ692_12995		Bacillus sp. 3a	QSJ00013.1			7
NR984_09475		Bacillus sp. BAC	UVD85717.1			7
BSZ43_09220		Bacillus sp. H15-1	APJ26961.1			7
glycosyl hydrolase family 5 mannanase precursor (ManA)		Bacillus sp. HJ14	AHH02586.2 AHH02586.1			7
JNUCC24_08125		Bacillus sp. JNUCC-24	QWS52071.1			7
R5H20_09445		Bacillus sp. KICET-3	WOV63008.1			7
C1T29_10825 (fragment)		Bacillus sp. MBGLi79	AUZ38770.1			7
GPA07_11500		Bacillus sp. ms-22	QGX66032.1			7
H7F24_13470		Bacillus sp. PAMC22265	QNK43493.1			7
H7F25_06905		Bacillus sp. PAMC28571	QNH49199.1			7
H7F26_15730		Bacillus sp. PAMC28748	QNH42870.1			7
JVX94_06400		Bacillus sp. PDNC022	QRY38592.1			7
K9N56_09465		Bacillus sp. PM8313	UBF35066.1			7
RHP70_08560		Bacillus sp. SG20001	WNF52430.1			7
DI291_09530		Bacillus sp. SUBG0010	QSF98623.1			7
QR42_07965		Bacillus sp. WP8	AIZ60203.1			7
R0126_15890		Bacillus stratosphericus AIMST-CREST02	WOQ72095.1			7
BK049_00270		Bacillus xiamenensis VV3	AOZ87243.1			7
NF868_07325		Bacillus zhangzhouensis XN149	UYO36972.1			7
BRDCF_09535		Bacteroidales bacterium CF	AGX08895.1 AGY54507.1			7
U5907_08230		Bacteroidales bacterium MB20-C3-3	WRQ32561.1			7
K6V21_01970		Bacteroides cellulosilyticus BFG-250	UBD70223.1			7
NXW88_02255		Bacteroides cellulosilyticus BFG-371	UVP51787.1			7
INE78_01641		Bacteroides cellulosilyticus CL06T03C01	QUT89666.1			7
NWT25_02125		Bacteroides cellulosilyticus PL2022	UWZ90047.1			7
BcellWH2_02031		Bacteroides cellulosilyticus WH2	ALJ59276.1			7
NQ546_04665		Bacteroides eggerthii DSM 20697	UWN88770.1			7
I6J51_00805		Bacteroides eggerthii FDAARGOS_1221	QRQ48893.1			7
BF638R_0823		Bacteroides fragilis 638R	CBW21396.1			7
NC657_14940		Bacteroides fragilis 86-5443-2-2	USA56353.1			7
MB0529_00763		Bacteroides fragilis BE1	CUA17419.1			7
K6V22_03240		Bacteroides fragilis BFG-1	UBF17532.1			7
NXW51_07880		Bacteroides fragilis BFG-13	UVQ03985.1			7
NXV04_07465		Bacteroides fragilis BFG-14	UVP08348.1			7
NXX28_07115		Bacteroides fragilis BFG-16	UVO83473.1			7
NXW03_07810		Bacteroides fragilis BFG-167	UVQ85435.1			7
NXV54_07440		Bacteroides fragilis BFG-17	UVP87153.1			7
NXY24_07430		Bacteroides fragilis BFG-18	UVP17164.1			7
NXY03_07270		Bacteroides fragilis BFG-23	UVQ56922.1			7
NXW55_07700		Bacteroides fragilis BFG-300	UVS01400.1			7
NXW06_06985		Bacteroides fragilis BFG-310	UVP95395.1			7
NXX17_07635		Bacteroides fragilis BFG-317	UVR19543.1			7
NXW10_08275		Bacteroides fragilis BFG-403	UVO62692.1			7
NXV32_07575		Bacteroides fragilis BFG-435	UVO87776.1			7
NXV34_07885		Bacteroides fragilis BFG-448	UVP91434.1			7
NXX41_06880		Bacteroides fragilis BFG-480	UVP47839.1			7
NXY37_07960		Bacteroides fragilis BFG-481	UVQ89676.1			7
NXW39_07160		Bacteroides fragilis BFG-49	UVO91340.1			7
NXX63_07710		Bacteroides fragilis BFG-502	UVR71531.1			7
NXV19_07245		Bacteroides fragilis BFG-504	UVQ16479.1			7
NXV41_07805		Bacteroides fragilis BFG-506	UVS22620.1			7
NXW33_03755		Bacteroides fragilis BFG-509	UVP65438.1			7
NXW46_07795		Bacteroides fragilis BFG-518	UVR31074.1			7
NXV60_07970		Bacteroides fragilis BFG-526	UVS40919.1			7
NXW36_07975		Bacteroides fragilis BFG-536	UVS31186.1			7
NXV70_07415		Bacteroides fragilis BFG-539	UVR62009.1			7
NXX16_07200		Bacteroides fragilis BFG-569	UVS59063.1			7
NXY10_08260		Bacteroides fragilis BFG-57	UVR35363.1			7
NXY12_07680		Bacteroides fragilis BFG-584	UVQ52851.1			7
NXV67_07440		Bacteroides fragilis BFG-604	UVR84113.1			7
NXX88_07410		Bacteroides fragilis BFG-634	UVQ20444.1			7
NXW69_07715		Bacteroides fragilis BFG-640	UVP70076.1			7
NXV98_08380		Bacteroides fragilis BFG-642	UVR49529.1			7
NXW83_07140		Bacteroides fragilis BFG-7	UVR88175.1			7
NXX45_07760		Bacteroides fragilis BFG-70	UVR57928.1			7
NXX67_08240		Bacteroides fragilis BFG-79	UVS05778.1			7
NXV17_07690		Bacteroides fragilis BFG-85	UVP39375.1			7
NXW54_07495		Bacteroides fragilis BFG-89	UVO79596.1			7
NXX84_07155		Bacteroides fragilis BFG-9	UVR53586.1			7
NXX30_07715		Bacteroides fragilis BFG-95	UVP99691.1			7
VU15_03540		Bacteroides fragilis BOB25	AKA54083.1			7
E0L14_08080		Bacteroides fragilis CCUG4856T	QCT77359.1			7
INE73_04253		Bacteroides fragilis CL03T12C07	QUU05892.1			7
EC81_008315		Bacteroides fragilis DCMOUH0017B	QCQ53807.1			7
EE52_007650		Bacteroides fragilis DCMOUH0018B	QCQ49303.1			7
HR50_007820		Bacteroides fragilis DCMOUH0042B	QCQ40509.1			7
IA74_007305		Bacteroides fragilis DCMOUH0067B	QCQ35920.1			7
IB64_008315		Bacteroides fragilis DCMOUH0085B	QCQ31640.1			7
EC80_008290		Bacteroides fragilis DCMSKEJBY0001B	QCQ44843.1			7
KQP58_06535		Bacteroides fragilis DH4096B	UYV06329.1			7
F7887_07295		Bacteroides fragilis DK1985	QRM69806.1			7
I6J55_10060		Bacteroides fragilis FDAARGOS_1225	QRP91221.1			7
FOC69_11755		Bacteroides fragilis FDAARGOS_763	QKH85006.1			7
RJT02_07030		Bacteroides fragilis H-2631	MDV3109311.1			7
K0E65_06785		Bacteroides fragilis IHMA_13	UHZ88465.1			7
K0E66_07180		Bacteroides fragilis IHMA_4	UHZ84433.1			7
BUN20_01115		Bacteroides fragilis Q1F2	AUI45335.1			7
AE940_01030		Bacteroides fragilis S14	ANQ62842.1			7
BF0840		Bacteroides fragilis YCH46	BAD47591.1			7
Bache_0234		Bacteroides helcogenes P 36-108	ADV42264.1			7
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