Activities in Sub Family	β-mannosidase (EC 3.2.1.25); Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (1545); Uniprot accession (72); PDB accession (28); 3D entries (10); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
MQE35_05845		Abyssalbus ytuae MT3330	UOB18814.1			7
NCTC10172_01384		Acholeplasma hippikon NCTC10172	VEU83309.1			7
β-mannanase (ManA)		Acidothermus cellulolyticus	ABJ41262.1 ABJ41263.1 ABJ41266.1			7
mannanase (Acel_0616)		Acidothermus cellulolyticus 11B	ABK52389.1			7
NYE86_14960		Actinacidiphila bryophytorum DS3	UWE09882.1			7
ACTOB_005479		Actinoplanes oblitus NRRL 3884	WIM93499.1			7
Q0Z83_020970		Actinoplanes sichuanensis 03-723	BEL03906.1			7
TPMA0078_32660		Actinoplanes sp. TPMA0078	BFD51862.1			7
SAMN04489717_0883		Actinopolymorpha singaporensis DSM 22024	SDR87823.1			7
LQZ07_22490		Agarivorans sp. B2Z047	UQN42511.1			7
LQZ07_22495		Agarivorans sp. B2Z047	UQN42512.1			7
LQZ07_22470		Agarivorans sp. B2Z047	UQN42507.1			7
A5CPEGH6_09140		Alistipes dispar 5CPEGH6	BBL06276.1			7
A3BBH6_12770		Alistipes onderdonkii subsp. vulgaris 3BBH6	BBL01041.1			7
LVQ62_12305		Allobranchiibius sp. GilTou73	UIJ33918.1			7
D1815_10480		Aquimarina sp. AD1	AXT56158.1			7
D1816_19590		Aquimarina sp. AD10	AXT62471.1			7
D1818_21435		Aquimarina sp. BL5	AXT53265.1			7
FF099_03455		Aquisalinus flavus D11M-2	UNE47179.1			7
F0U59_06795		Archangium gephyra Arg 2	WNG54525.1			7
AA314_01832		Archangium gephyra DSM 2261	AKJ00206.1			7
KYC5002_43975		Archangium gephyra KYC5002	WPB75936.1			7
F0U60_07465		Archangium minus Cbm 6	WNG43948.1			7
F0U60_08515		Archangium minus Cbm 6	WNG44142.1			7
F0U61_08520		Archangium violaceum Cbvi 34	WNG33668.1			7
F0U61_07535		Archangium violaceum Cbvi 34	WNG33485.1			7
JQX13_21960		Archangium violaceum SDU34	QRK12452.1			7
JRI60_45090		Archangium violaceum SDU8	QRN96129.1			7
Astex_2880		Asticcacaulis excentricus CB 48	ADU14517.1			7
EM6_2786		Asticcacaulis excentricus M6	BBF82157.1			7
LH365_07855		Asticcacaulis sp. AND118	UDF02361.1			7
ATDW_28830		Asticcacaulis sp. DW145	BEV12387.1			7
OVA03_02770		Asticcacaulis sp. SL142	WAC48865.1			7
Q1W73_13185		Asticcacaulis sp. ZE23SCel15	WKL56622.1			7
FF125_04085		Aureibaculum algae 10Alg115	QCX37652.1			7
AsAng_0044260		Aureispira sp. EL160426	BDS13685.1			7
QP953_06415		Aureispira sp. CCB-E	WMX15996.1			7
RE735_11530		Bacillus aerius NEB1378	WMT27765.1			7
BAE_15700		Bacillus aerophilus 232	QAR54176.1			7
L2D31_08110		Bacillus aerophilus KJ82	UJM29224.1			7
HRJ37_08510		Bacillus altitudinis 11-1-1	QKJ40207.1			7
I4W80_08140		Bacillus altitudinis 1817	QSI46053.1			7
NIZ93_08135		Bacillus altitudinis 1943r2a1	USY52786.1			7
Q6357_17005		Bacillus altitudinis 28M1-1	WLF30071.1			7
NMH04_08365		Bacillus altitudinis 47	UTX10449.1			7
JNE42_08535		Bacillus altitudinis 63-2-2	QRF85097.1			7
J9319_08435		Bacillus altitudinis 6ww6	QTV14112.1			7
LOS13_12990		Bacillus altitudinis ABT_AC37	WBL50447.1			7
NM966_08145		Bacillus altitudinis B12	UTV34402.1			7
RI02_08025		Bacillus altitudinis BA06	QKL21613.1			7
NP445_08240		Bacillus altitudinis BDGP7	UUH75813.1			7
INQ56_08210		Bacillus altitudinis BIM B-263	QOV51209.1			7
QNH40_08275		Bacillus altitudinis CES-OCA-19	WHX73195.1			7
EVS87_008175		Bacillus altitudinis CHB19	QEO62178.1			7
LIS79_08510		Bacillus altitudinis CMF5	USK25995.1			7
D0438_04060		Bacillus altitudinis Cr2-1	QDZ94129.1			7
QRD87_08815		Bacillus altitudinis D9_B_49	WJE31965.1			7
P5623_06630		Bacillus altitudinis DSM 103869	WEZ72459.1			7
SA286_08115		Bacillus altitudinis ECC22	WRO27582.1			7
U2873_08355		Bacillus altitudinis F7	WQH40507.1			7
QNH34_08230		Bacillus altitudinis G6S2	WHY06996.1			7
BPGQ101_08710		Bacillus altitudinis GQYP101	QCU18939.1			7
MMZ59_08085		Bacillus altitudinis JYY-02	UNG02698.1			7
KIV12_13680		Bacillus altitudinis LZP 02	QXJ47228.1			7
NC3_15620		Bacillus altitudinis NC3	BDC58602.1			7
CSE15_08310		Bacillus altitudinis P-10	ATP93954.1			7
RZ534_08400		Bacillus altitudinis RS1	WOI42923.1			7
QJS65_08240		Bacillus altitudinis Sample7_7	WHF28613.1			7
EQK04_08025		Bacillus altitudinis SCU11	QKL25345.1 QXY95729.1			7
CFN77_08490		Bacillus altitudinis SGAir0031	ATH72233.1			7
TM2_15600		Bacillus altitudinis TM2	BDC54891.1			7
MTX65_08260		Bacillus altitudinis UKM RB11	UOG09234.1			7
QJS56_03985		Bacillus altitudinis VUMS1	WGV01395.1			7
JKL50_04410		Bacillus altitudinis ws31	QQX15366.1			7
G3M80_08490		Bacillus altitudinis ZAP62	QII24620.1			7
BGLY_1877		Bacillus glycinifermentans	SCA85700.1			7
EQZ20_09650		Bacillus glycinifermentans SRCM103574	QAT65157.1			7
QYM22_09915		Bacillus glycinifermentans SRCM12603	WKB79129.1			7
BLDA23_10220		Bacillus licheniformis 0DA23-1	AXF88643.1			7
BL14DL4_04369		Bacillus licheniformis 14ADL4	AVI49506.1			7
NIZ94_09300		Bacillus licheniformis 2096tsa1	USY60905.1			7
EJ992_09520		Bacillus licheniformis ATCC 14580	QCX99206.1			7
SR852_15480		Bacillus licheniformis ATCC 14580	WQG61011.1			7
CPQ91_09265		Bacillus licheniformis ATCC 9789	ATI76022.1			7
BL1202_02035		Bacillus licheniformis BL1202	AOP14983.1			7
CD200_09505		Bacillus licheniformis CBA7132	AWV40657.1			7
V5G23_21150		Bacillus licheniformis CP13	WWA39424.1			7
V5G22_19930		Bacillus licheniformis CP26	WWA25808.1			7
G6536_09590		Bacillus licheniformis CP6	QSV41682.1			7
BLCSL_09220		Bacillus licheniformis CSL2	QDF79002.1			7
MN092_11065		Bacillus licheniformis DSM 13	UNJ87472.1			7
BLi01883 / BL01229		Bacillus licheniformis DSM 13 = ATCC 14580	AAU40778.1 AAU23418.1			7
V2177_09290		Bacillus licheniformis FUA2147	WVP27135.1			7
V2175_11965		Bacillus licheniformis FUA2149	WVP31563.1			7
V2176_06975		Bacillus licheniformis FUA2151	WVP38489.1			7
OSR41_09445		Bacillus licheniformis GN02	WCO64544.1			7
JAV55_09200		Bacillus licheniformis H2	QQA73581.1			7
AB684_08875		Bacillus licheniformis HRBL-15TDI7	AMR10288.1			7
QQ984_09470		Bacillus licheniformis Jrh14-10	WIX00464.1			7
FTE28_02955		Bacillus licheniformis KS28	QNT71943.1			7
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