Glycoside Hydrolase Family 5 / Subf 7

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (508); Uniprot accession (158); PDB accession (26); 3D entries (10); cryst (0)
| 1 | 2 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 β-mannanase (ManA) 3.2.1.78 Acidothermus cellulolyticus ABJ41262.1
ABJ41263.1
ABJ41266.1
    7
 mannanase (Acel_0616)   Acidothermus cellulolyticus 11B ABK52389.1 A0LSH9   7
 SAMN04489717_0883   Actinopolymorpha singaporensis DSM 22024 SDR87823.1     7
 AA314_01832   Archangium gephyra DSM 2261 AKJ00206.1     7
 Astex_2880   Asticcacaulis excentricus CB 48 ADU14517.1 C5SNP2   7
 CSE15_08310   Bacillus altitudinis P-10 ATP93954.1     7
 CFN77_08490   Bacillus altitudinis SGAir0031 ATH72233.1     7
 BGLY_1877   Bacillus glycinifermentans SCA85700.1     7
 CPQ91_09265   Bacillus licheniformis ATCC 9789 ATI76022.1     7
 BL1202_02035   Bacillus licheniformis BL1202 AOP14983.1     7
 BLi01883 / BL01229   Bacillus licheniformis DSM 13 = ATCC 14580 AAU40778.1
AAU23418.1
Q65JI6   7
 AB684_08875   Bacillus licheniformis HRBL-15TDI7 AMR10288.1     7
 YdhT (fragment)   Bacillus licheniformis MD1 CAH10345.1 Q5K2L9   7
 Cel5D (Cel5D)   Bacillus licheniformis MSB03 ACY72383.1 D1L8C8   7
 B37_01402   Bacillus licheniformis SCCB 37 ARC73454.1     7
 B14_02580   Bacillus licheniformis SCDB 14 ARC65578.1     7
 B34_00222   Bacillus licheniformis SCDB 34 ARC67665.1     7
 BaDB11_04389   Bacillus licheniformis SCK B11 ARC62952.1     7
 S100141_01269   Bacillus licheniformis SRCM100141 ARW42591.1     7
 glycoside hydrolase (Gh5C)   Bacillus licheniformis SVD1 BAL45506.1     7
 MUY_001894 (CelD)   Bacillus licheniformis WX-02 AKQ73026.1     7
 BaLi_c19170 (CelD)   Bacillus paralicheniformis ATCC 9945a AGN36285.1     7
 SC10_B2orf02858 (fragment)   Bacillus paralicheniformis BL-09 AJO18131.1     7
 BLMD_09340   Bacillus paralicheniformis MDJK30 ARA85657.1     7
 VP59_07445   Bacillus pumilus C4 ANT56640.1     7
 β-mannanase   Bacillus pumilus GBSW 19 AHF81566.1     7
 BS467_15785   Bacillus pumilus GLB197 APP17114.1     7
 ID12_13295   Bacillus pumilus GR-8 AKU32339.1     7
 ASM07_07620   Bacillus pumilus ku-bf1 AMB89777.1     7
 BW16_08670   Bacillus pumilus MTCC B6033 AHL71452.1     7
 SAMEA4076707_01656   Bacillus pumilus NCTC10337 SNV02448.1     7
 AKO65_15415   Bacillus pumilus NJ-M2 ALM29338.1     7
 AKO66_11740   Bacillus pumilus NJ-V ANY97356.1     7
 AMR71_11735   Bacillus pumilus NJ-V2 ALM45875.1     7
 BEN31_07990   Bacillus pumilus PDSLzg-1 AOC56743.1     7
 BPUM_1561   Bacillus pumilus SAFR-032 ABV62243.1 A8FDC6   7
 UP15_08390   Bacillus pumilus SH-B11 AMM88977.1     7
 UP12_08105   Bacillus pumilus SH-B9 AMM97310.1     7
 BTUAT1_15770   Bacillus pumilus TUAT1 BAT48711.1     7
 VT48_08320   Bacillus pumilus W3 AKC66023.1     7
 BRL64_08220   Bacillus safensis BRM1 ARD56165.1     7
 BSL056_08100   Bacillus safensis KCTC 12796BP APJ10920.1     7
 BSA145_16070   Bacillus safensis U14-5 APT47251.1     7
 BSA171_11305   Bacillus safensis U17-1 APT54133.1     7
 BSA41_06410   Bacillus safensis U41 APT49591.1     7
 S101395_03069   Bacillus sonorensis SRCM101395 ASB89576.1     7
 CJO35_09290   Bacillus sp. 1s-1 ASV15341.1     7
 BSZ43_09220   Bacillus sp. H15-1 APJ26961.1     7
 glycosyl hydrolase family 5 mannanase precursor (ManA)   Bacillus sp. HJ14 AHH02586.2
AHH02586.1
    7
 QR42_07965   Bacillus sp. WP8 AIZ60203.1     7
 BK049_00270   Bacillus xiamenensis VV3 AOZ87243.1     7
 BRDCF_09535   Bacteroidales bacterium CF AGX08895.1
AGY54507.1
    7
 BcellWH2_02031   Bacteroides cellulosilyticus WH2 ALJ59276.1     7
 EL88_18305   Bacteroides dorei isolate HS1_L1_B_010 AII64978.1     7
 BF638R_0823   Bacteroides fragilis 638R CBW21396.1 E1WLN2   7
 MB0529_00763   Bacteroides fragilis BE1 CUA17419.1     7
 VU15_03540   Bacteroides fragilis BOB25 AKA54083.1     7
 AE940_01030   Bacteroides fragilis S14 ANQ62842.1     7
 BF0840   Bacteroides fragilis YCH46 BAD47591.1 Q64Y35   7
 Bache_0234   Bacteroides helcogenes P 36-108 ADV42264.1     7
 Bacsa_1708   Bacteroides salanitronis DSM 18170 ADY36271.1     7
 BZG35_09065   Brevundimonas sp. LM2 AQR61788.1     7
 Cabys_3541   Caldithrix abyssi DSM 13497 LF13 APF20287.1     7
 CC0801   Caulobacter crescentus CB15 AAK22786.1
NP_419618.1
Q9AA10   7
 CCNA_00843   Caulobacter crescentus NA1000 ACL94308.1 B8H1I5   7
 Cseg_3572   Caulobacter segnis ATCC 21756 ADG11997.1 D5VNC4   7
 Caul_1040   Caulobacter sp. K31 ABZ70170.1 B0SX09   7
 CA607_04270   Caulobacter vibrioides CB1 ATC27643.1     7
 CA606_11550   Caulobacter vibrioides CB13b1a ATC32914.1     7
 CA608_04100   Caulobacter vibrioides CB2 ATC23772.1     7
 endo-β-1,4-mannanase 5C (CjMan5C;CJA_3470) (Man5C) 3.2.1.78 Cellvibrio japonicus Ueda107 ACE82655.1
AAO31761.1
B3PG16
Q840C0
  7
 CJA_0244 (Man5D)   Cellvibrio japonicus Ueda107 ACE83583.1 B3PGI9   7
 β-mannosidase 5A (Man5A) 3.2.1.25 Cellvibrio mixtus NCIMB 8633 AAS19695.1 Q6QT42 1UUQ[A]
1UZ4[A]
7
 CBR65_15160   Cellvibrio sp. PSBB006 ARU28676.1     7
 B0D95_16680   Cellvibrio sp. PSBB023 AQT61563.1     7
 CM240_3326   Clostridium bornimense M2/40 CDM70443.1     7
 CCDG5_1678   [Clostridium] cellulosi CDZ24786.1     7
 mannanase (Man5B)   Clostridium cellulovorans BAV13033.1     7
 mannanase (Man5B)   Clostridium cellulovorans BAV13033.1     7
 Clocel_3099 (Man5B) 3.2.1.78 Clostridium cellulovorans 743B ADL52789.1 D9STQ5   7
 Clocel_3099 (Man5B) 3.2.1.78 Clostridium cellulovorans 743B ADL52789.1 D9STQ5   7
 Clole_3357   Clostridium lentocellum DSM 5427 ADZ85047.1     7
 Clole_3357   Clostridium lentocellum DSM 5427 ADZ85047.1     7
 Cspa_c18630   Clostridium saccharoperbutylacetonicum N1-4(HMT) AGF55633.1     7
 Clo1100_1828   Clostridium sp. BNL1100 AEY66038.1     7
 A9D14_07180   Croceicoccus marinus E4A9 ARU16013.1     7
 EUS_25310   [Eubacterium] siraeum 70/3 CBK97477.1 D4JWK8   7
 ES1_05570   [Eubacterium] siraeum V10Sc8a CBL33682.1 D4MIU9   7
 FLA_5534   Filimonas lacunae NBRC 104114 BAV09485.1     7
 MY04_5414   Flammeovirga sp. MY04 ANQ52746.1     7
 endo-β-1,4-mannosidase   Flammeovirga yaeyamensis MY04 ACY02070.1 D0PR27   7
 SY85_04865   Flavisolibacter tropicus LCS9 ANE49924.1     7
 BB050_02607   Flavobacterium johnsoniae GSE09 AOC95704.1     7
 Fjoh_4958   Flavobacterium johnsoniae UW101 ABQ07957.1 A5FA10   7
 ALW18_02940   Flavobacterium psychrophilum Z1 AOE51560.1     7
 AMR72_02940   Flavobacterium psychrophilum Z2 ALM47936.1     7
 BN863_30830   Formosa agariphila KMM 3901 CDF80795.1     7
 FsymDg_2977   Frankia symbiont of Datisca glomerata 4085684 AEH10294.1     7
 β-mannanase (ManF) 3.2.1.78 Geobacillus stearothermophilus MCA2184 AAC71692.1 Q9ZI87   7
 GRFL_0929   Gramella flava JLT2011 APU67653.1     7
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