Activities in Sub Family	β-mannosidase (EC 3.2.1.25); Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (1559); Uniprot accession (72); PDB accession (29); 3D entries (11); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
HND39_04095		Ignavibacteriota bacterium isolate IGN2	QKJ95522.1			7
HND40_08110		Ignavibacteriota bacterium isolate IGN3	QKJ99517.1			7
BN2497_6121		Janthinobacterium sp. CG23_2	CUI21285.1			7
L0B70_12210		Kaistella sp. 97-N-M2	UJF29585.1			7
HUT16_28295 (fragment)		Kitasatospora sp. NA04385	QKW22457.1			7
OU787_27025		Kitasatospora sp. YST-16	WAL74837.1			7
OU787_02965		Kitasatospora sp. YST-16	WAL70549.1			7
JVX88_19850		Leptolyngbya sp. 7M	QYO62342.1			7
MKD41_13510		Lutibacter sp. A64	UMB53342.1			7
MHL31_12660		Lutibacter sp. A80	UMB59922.1			7
FKV23_01325		Lysobacter alkalisoli SJ-36	QDH68892.1			7
RBH95_15830		Mangrovimonas sp. YM274	WMI68603.1			7
MARGE09_P2964		Marinagarivorans cellulosilyticus GE09	BCD98763.1			7
CJ739_712		Mariniflexile sp. TRM1-10	AXP79808.1			7
IV454_05020		Massilia antarctica P9640	QPI50926.1			7
HH212_06805		Massilia forsythiae GN2-R2	QJE03226.1			7
DPH57_01500		Massilia sp. YMA4	AXA89968.1			7
CR152_10365		Massilia violaceinigra B2	ATQ74882.1			7
INH39_08280		Massilia violaceinigra sipir	UOD31666.1			7
MROS_0511		Melioribacter roseus P3M-2	AFN73754.1			7
MEBOL_004303		Melittangium boletus DSM 14713	ATB30841.1			7
LRP31_27065		Mesorhizobium mediterraneum R31	WIW52677.1			7
NL534_02135		Mesorhizobium opportunistum C232B	WJI39088.1			7
M5D98_30200		Mesorhizobium opportunistum WSM1558	UQS64319.1			7
MesoLj131a_50440		Mesorhizobium sp. 131-2-1	BCG96180.1			7
A9K68_020030		Mesorhizobium sp. AA22	QIA23811.1			7
FJ974_29535		Mesorhizobium sp. B1-1-8	UCI10455.1			7
EJ072_09630 (fragment)		Mesorhizobium sp. M2A.F.Ca.ET.046.03.2.1	AZO34685.1			7
EJ073_11765		Mesorhizobium sp. M4B.F.Ca.ET.058.02.1.1	AZO48415.1			7
EJ075_00525		Mesorhizobium sp. M6A.T.Cr.TU.016.01.1.1	AZO69272.1			7
Mnod_6857		Methylobacterium nodulans ORS 2060	ACL61603.1			7
CLZ_01115		Methylobacterium sp. CLZ	QIJ73320.1			7
GU700_01115		Methylobacterium sp. NI91	QIJ78224.1			7
F7D14_17200		Methylocystis parvus BRCS2	QGM99048.1			7
MMG94_02340		Methylocystis parvus OBBP	WBK00585.1			7
T9R20_01815		Microbacterium invictum X-18	WQB70717.1			7
G5T42_07645		Microbacterium sp. 4R-513	QIG39370.1			7
endo 1-4 betamannosidase, partial		Microbacterium sp. CIAB417	UNU90936.1			7
AUP74_03275		Microbulbifer aggregans CCB-MM1	AOS98641.1			7
GNX18_10770		Microbulbifer sp. SH-1	QIL90184.1			7
GA0070611_5887		Micromonospora auratinigra DSM 44815	SBT52970.1			7
GA0070614_4517		Micromonospora coxensis DSM 45161	SCG69299.1			7
Jiend_14850		Micromonospora endophytica NBRC 109090	BCJ58063.1			7
GA0074704_1933		Micromonospora siamensis DSM 45097	SCG46694.1			7
LLH06_08290		Mucilaginibacter daejeonensis KACC 14964	UEG54961.1			7
MgSA37_01551		Mucilaginibacter gotjawali SA3-7	BAU53384.1			7
H7F38_13020		Nakamurella sp. PAMC28650	QNK79253.1			7
H7F38_06040		Nakamurella sp. PAMC28650	QNK82300.1			7
NHH88_11300		Oxalobacteraceae bacterium OTU3CAMAD1	USX16329.1			7
NHH73_10710		Oxalobacteraceae bacterium OTU3CINTB1	USX28717.1			7
NHH82_11305		Oxalobacteraceae bacterium OTU3REALA1	USX22704.1			7
EHS13_07860		Paenibacillus psychroresistens ML311-T8	QGQ94798.1			7
EHS13_07855 (fragment)		Paenibacillus psychroresistens ML311-T8	QGQ94797.1			7
Palpr_1818		Paludibacter propionicigenes WB4	ADQ79957.1			7
BV455_01549		Parageobacillus caldoxylosilyticus ER4B	QXJ38243.1			7
PcaKH15_01970		Parageobacillus caldoxylosilyticus KH1-5	BDG34291.1			7
PcaKH16_01990		Parageobacillus caldoxylosilyticus KH1-6	BDG38060.1			7
PcaKH35_01840		Parageobacillus caldoxylosilyticus KH3-5	BDG41839.1			7
SAMN04489860_0290		Paraoerskovia marina DSM 22126	SDR88201.1			7
RUI03_00370		Parvularcula sp. LCG005	WOI53462.1			7
JBW_04414		Pelosinus fermentans JBW45	AJQ29745.1			7
FIV42_24985		Persicimonas caeni YN101	QDG53879.1			7
FRD00_24980		Persicimonas caeni YN101	QED35100.1			7
C7M71_017580		Peterkaempfera bronchialis DSM 106435	AXI78954.1			7
QNN11_08040		Phocaeicola dorei 2	WHX11243.1			7
GKD17_16310		Phocaeicola dorei DSM 17855	QJR77822.1			7
NQ486_23120		Phocaeicola dorei DSM 17855	UWN84760.1			7
EL88_18305		Phocaeicola dorei isolate HS1_L_1_B_010	AII64978.1			7
GN305_14870		Phocaeicola dorei JR01	QJR73285.1			7
GN306_14500		Phocaeicola dorei JR02	QJR68955.1			7
GN307_14475		Phocaeicola dorei JR03	QJR64690.1			7
Bacsa_1708		Phocaeicola salanitronis DSM 18170	ADY36271.1			7
Psuf_047960		Phytohabitans suffuscus NBRC 105367	BCB87483.1			7
C6W10_13285		Plantactinospora sp. BB1	AVT37274.1			7
C6361_25565		Plantactinospora sp. BC1	AVT32268.1			7
LPB03_10205		Polaribacter vadi LPB0003	AOW19072.1			7
RJD25_29040		Pontibacter sp. G13	WNJ21586.1			7
E2E27_07750		Porphyrobacter sp. YT40	QDH34221.1			7
ADJ77_04205		Prevotella fusca JCM 17724 W1435	AKU69032.1			7
J5A51_11325		Prevotella fusca JCM 17724 W1435	QUB86659.1			7
prwr041_21250		Prevotella herbatica WR041	BCS86232.1			7
CRM71_02275		Prevotella jejuni CD3_33	AUI54275.1			7
J5A63_05900		Prevotella jejuni F0106	QUB80388.1			7
J4857_02065		Prevotella jejuni F0697	QUB78431.1			7
HMPREF0659_A5424		Prevotella melaninogenica ATCC 25845	ADK96349.1			7
J5A58_09000		Prevotella melaninogenica F0054	QUB77226.1			7
J5A56_03965		Prevotella melaninogenica F0091	QUB72484.1			7
J5A68_06645		Prevotella melaninogenica F0299	QUB67716.1			7
J5A68_12000		Prevotella melaninogenica F0299	QUB69105.1			7
J5A57_01780		Prevotella melaninogenica F0300	QUB65854.1			7
J5A54_05895		Prevotella melaninogenica F0301	QUB62849.1			7
J4861_09480		Prevotella melaninogenica F0516	QUB61046.1			7
J5A71_03860		Prevotella melaninogenica F0692	QUB57791.1			7
J5A72_02245		Prevotella melaninogenica F0695	QUB56462.1			7
CEP85_02375		Prevotella melaninogenica FDAARGOS_306	ASE17030.1			7
FIU21_06410		Prevotella melaninogenica FDAARGOS_760	QKH88618.1			7
PMEL1_00463		Prevotella melaninogenica GAI 07411	BBA28560.1			7
J4864_09120		Prevotella multiformis F0096	QUB71323.1			7
AXF22_07430		Prevotella scopos JCM 17725 W2052	ANR73224.1			7
J4856_07405		Prevotella scopos JCM 17725 W2052	QUB45959.1			7
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