Activities in Sub Family	β-mannosidase (EC 3.2.1.25); Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (1559); Uniprot accession (72); PDB accession (29); 3D entries (11); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
CLFE_048450		Clostridium felsineum DSM 794	URZ18757.1			7
CLROS_047320		Clostridium roseum DSM 6424	URZ09316.1			7
CROST_047800		Clostridium roseum DSM 7320	URZ14002.1			7
Cspa_c18630		Clostridium saccharoperbutylacetonicum N1-4(HMT)	AGF55633.1			7
Clo1100_1828		Clostridium sp. BNL1100	AEY66038.1			7
A9D14_07180		Croceicoccus marinus E4A9	ARU16013.1			7
H4O24_08720		Croceicoccus marinus OT19	QNE04090.1			7
Daura_25280 (fragment)		Dactylosporangium aurantiacum NRRL B-8018	UWZ59179.1			7
Daura_25290 (fragment)		Dactylosporangium aurantiacum NRRL B-8018	UWZ59181.1			7
Daura_15815		Dactylosporangium aurantiacum NRRL B-8018	UWZ57485.1			7
Dmats_12635		Dactylosporangium matsuzakiense NRRL B-16293	UWZ47174.1			7
Dmats_30675		Dactylosporangium matsuzakiense NRRL B-16293	UWZ41970.1			7
KZZ52_32230		Dactylosporangium sp. AC04546	WVK78659.1			7
KZZ52_32235		Dactylosporangium sp. AC04546	WVK78660.1			7
GCM10020063_063610		Dactylosporangium thailandense JCM 3084	BFE61835.1			7
GCM10020063_013350		Dactylosporangium thailandense JCM 3084	BFE56809.1			7
Dvina_13075		Dactylosporangium vinaceum NRRL B-16297	UAB98924.1			7
Dvina_35850		Dactylosporangium vinaceum NRRL B-16297	UAB93584.1			7
HH213_01680		Duganella dendranthematis AF9R3	QJD93940.1			7
SR858_17840		Duganella zoogloeoides ATCC 25935	WQH02919.1			7
FDZ78_08820		Duncaniella sp. B8	QCP72664.1			7
E7745_05115		Duncaniella sp. C9	QCD38974.1			7
DCPSUM001_02110		Dysgonomonas capnocytophagoides SMU001	BES59967.1			7
G7050_02440		Dysgonomonas sp. HDW5A	QIK58760.1			7
G7051_02845		Dysgonomonas sp. HDW5B	QIK53343.1			7
F7D01_13050		Erythrobacter sp. 3-20A1M	QWC57868.1			7
PS060_01425		Erythrobacter sp. BLCC-B19	WDA41499.1			7
MKP08_12360		Erythrobacter sp. LQ02-29	UNG22082.1			7
LY632_10180		Erythrobacter sp. SDW2	UIP06066.1			7
EUS_25310		[Eubacterium] siraeum 70/3	CBK97477.1			7
NQ549_00325		[Eubacterium] siraeum DSM 15702	UWP25311.1			7
ES1_05570		[Eubacterium] siraeum V10Sc8a	CBL33682.1			7
FLA_5534		Filimonas lacunae NBRC 104114	BAV09485.1			7
LV704_02385		Flagellimonas sp. CMM7	UII80371.1			7
KM029_24950		Flammeovirga kamogawensis YS10	QWG10634.1			7
KM029_25005		Flammeovirga kamogawensis YS10	QWG10645.1			7
EI427_17555		Flammeovirga pectinis L12M1	AZQ63963.1			7
EI427_17610		Flammeovirga pectinis L12M1	AZQ63974.1			7
MY04_5414		Flammeovirga sp. MY04	ANQ52746.1 ANQ52746.2			7
endo-β-1,4-mannosidase		Flammeovirga yaeyamensis MY04	ACY02070.1			7
KMW28_21525		Flammeovirga yaeyamensis NBRC:100898	QWG05006.1			7
KMW28_17205		Flammeovirga yaeyamensis NBRC:100898	QWG01383.1			7
MBM09_07815		Flaviramulus sp. BrNp1-15	ULC60894.1			7
SY85_04865		Flavisolibacter tropicus LCS9	ANE49924.1			7
RHP49_10440		Flavobacteriaceae bacterium HL-DH10	WNH11328.1			7
HYN59_00875		Flavobacterium album HYN0059	AWH83754.1			7
FUA48_00750		Flavobacterium alkalisoli XS-5	QEE48157.1			7
LLY39_21415 (fragment)		Flavobacterium anhuiense T4	URM36918.1			7
DVK85_01185		Flavobacterium arcticum SM1502	AXG72916.1			7
L0669_23075		Flavobacterium bizetiae HJ-32-4	UTN04193.1			7
HYN56_24415		Flavobacterium crocinum HYN0056	AWK07200.1			7
J0383_16460		Flavobacterium endoglycinae BB8	QSW87859.1			7
HYN86_20455		Flavobacterium fluviale HYN0086	AXB58828.1			7
V6624_23155		Flavobacterium ginsenosidimutans YTB16	WXK49921.1			7
M0M44_23240		Flavobacterium humidisoli MMS21-Er5	UPZ15651.1			7
NYQ10_22045		Flavobacterium johnsoniae G16	WJS94763.1			7
BB050_02607		Flavobacterium johnsoniae GSE09	AOC95704.1			7
Fjoh_4958		Flavobacterium johnsoniae UW101	ABQ07957.1			7
SR927_19515		Flavobacterium johnsoniae UW101 ATCC 17061	WQG80198.1			7
HYN48_08050		Flavobacterium magnum HYN0048	AWA30034.1			7
E1750_16655		Flavobacterium nackdongense GS13	QBN20352.1			7
HYN49_08485		Flavobacterium pallidum HYN0049	AWI25933.1			7
NLJ00_24440		Flavobacterium panici BSSL-CR3	UUF14397.1			7
Q1W71_10885		Flavobacterium pectinovorum ZE23VCel01	WKL50259.1			7
ALW18_02940		Flavobacterium psychrophilum Z1	AOE51560.1			7
AMR72_02940		Flavobacterium psychrophilum Z2	ALM47936.1			7
DI487_13630		Flavobacterium sediminis MEBiC07310	AWM14790.1			7
AABD74_21665		Flavobacterium soyae 55	WYZ19760.1			7
FK004_17245		Flavobacterium sp. AJ004	AWG26849.1			7
HAV12_006260		Flavobacterium sp. CLA17	QSB28339.1			7
FLGSB24_42830		Flavobacterium sp. GSB-24	BDU27539.1			7
MKO97_12950		Flavobacterium sp. HJ-32-4	UMY65401.1			7
PQ462_18480		Flavobacterium sp. KACC 22758	WDF58701.1			7
SCB73_01350		Flavobacterium sp. KACC 22761	WPO79041.1			7
PQ463_12565		Flavobacterium sp. KACC 22763	WDF62457.1			7
B0M43_0023775		Flavobacterium sp. KBS0721	QDW23012.1			7
LPB248_16750		Flavobacterium sp. LPB0248 LPB248	QLC67889.1			7
HQN62_15505		Flavobacterium sp. M31R6	QKJ64480.1			7
IHE43_08175		Flavobacterium sp. MDT1-60	QOG04168.1			7
GIY83_00570		Flavobacterium sp. SLB02 SGTM	QGK72615.1			7
N4T20_21215		Flavobacterium sp. TR2	UWY28228.1			7
P0R33_17705		Flavobacterium sp. YJ01	WET01593.1			7
Q1W72_15360		Flavobacterium sp. ZE23DGlu08	WKL43713.1			7
BN863_30830		Formosa agariphila KMM 3901	CDF80795.1			7
FsymDg_2977		Frankia symbiont of Datisca glomerata 4085684	AEH10294.1			7
LVD16_22900		Fulvivirga ligni W9P-11	UII20693.1			7
LVD16_15575		Fulvivirga ligni W9P-11	UII19264.1			7
LVD15_18690		Fulvivirga maritima SW1-E11	UII25318.1			7
LVD17_00415		Fulvivirga ulvae SS9-22	UII32300.1			7
E5Z46_13180		Geobacillus kaustophilus NBRC 102445	QCK83069.1			7
QT236_09225		Geobacillus stearothermophilus EF60063	WJQ02276.1			7
β-mannanase (ManF)	3.2.1.78	Geobacillus stearothermophilus MCA2184	AAC71692.1	Q9ZI87		7
QT234_09625		Geobacillus stearothermophilus SJEF4-2	WJP98988.1			7
IC806_08630 (fragment)		Geobacillus zalihae SURF-114	QNU26210.1			7
IC806_08635 (fragment)		Geobacillus zalihae SURF-114	QNU26211.1			7
NHM04_09035		Gilvimarinus sp. DA14	UTF58626.1			7
DDQ68_01330		Hymenobacter nivis NBRC 111535	AWM31550.1			7
A0257_01725		Hymenobacter psoromatis PAMC 26554	AMR25940.1			7
AXW84_13455		Hymenobacter sp. PAMC 26628	AMJ68178.1			7
HYPP_01312		Hyphomicrobium sp. ghe19	CAA2139147.1			7
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