Activities in Sub Family	β-mannosidase (EC 3.2.1.25); Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (1545); Uniprot accession (72); PDB accession (28); 3D entries (10); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
C3V43_14535		Bacteroides heparinolyticus F0111	AVM59109.1			7
JXR92_001685		Bacteroides humanifaecis KGMB07931	UDB44395.1			7
LIX30_01680		Bacteroides humanifaecis KGMB10229	UDL12023.1			7
DXK01_001935		Bacteroides intestinalis APC919/174	QDO67759.1			7
I1225_01935		Bacteroides intestinalis APC919/174 substr. 8T	UCB35989.1			7
I1224_01935		Bacteroides intestinalis APC919/174 substr. 8W	UCB40231.1			7
EYA81_06425		Bacteroides sp. A1C1	QBJ17987.1			7
NXV86_02050		Bacteroides sp. BFG-257	UVO98853.1			7
H1A11_13355		Bacteroides sp. CACC 737	QMI79434.1			7
ITJ87_01510		Bacteroides sp. HF-162	QPH58293.1			7
DBK98_008755		Bacteroides sp. PHL 2737	QLK82233.1			7
G7Y45_07285		Bacteroides sp. ZJ-18	QTO27337.1			7
NQ510_02095		Bacteroides uniformis ATCC 8492	UWO07774.1			7
NXX72_01255		Bacteroides uniformis BFG-227	UVS17644.1			7
INE75_02952		Bacteroides uniformis CL03T12C37	QUU00599.1			7
INE83_00504		Bacteroides uniformis CL06T03C05	QUT65070.1			7
INE84_01761		Bacteroides uniformis CL06T06C18	QUT62081.1			7
INE90_00431		Bacteroides uniformis CL11T00C07	QUT33697.1			7
I6G58_02750		Bacteroides uniformis FDAARGOS_901	QQA30547.1			7
QWU49_02095		Bacteroides uniformis JCM5828	WNG09924.1			7
Bun01g_02680		Bacteroides uniformis NBRC 113350	BBK85898.1			7
KQP54_11725		Bacteroides uniformis VPI-3537	UYU51479.1			7
V5279_10055		Bradyrhizobium sp. 2S1 26S5	WWP81451.1			7
G6P99_21875		Bradyrhizobium sp. 6(2017) 1S3	QIG94800.1			7
MU852_12540		Brevundimonas albigilva KEME 9005-016	UQV17656.1			7
MU852_16505		Brevundimonas albigilva KEME 9005-016	UQV18300.1			7
M8231_07740		Brevundimonas albigilva TT17	URI16842.1			7
M8231_11670		Brevundimonas albigilva TT17	URI14475.1			7
BZG35_09065		Brevundimonas sp. LM2	AQR61788.1			7
FKQ52_10305		Brevundimonas sp. M20	QDH75006.1			7
KOAAANKH_03045		Brevundimonas sp. NIBR10	WGM48149.1			7
OU998_10195		Brevundimonas sp. SL130	WAC58599.1			7
JIP62_03190		Brevundimonas vitisensis GR-TSA-9	QQQ19139.1			7
F183_24140		Bryobacterales bacterium F-183	BCS38542.1			7
F183_A24210		Bryobacterales bacterium F-183	BDC50105.1			7
Cabys_3541		Caldithrix abyssi DSM 13497 LF13	APF20287.1			7
CS0771_02070		Catellatospora sp. IY07-71	BCJ70663.1			7
CS0771_74210		Catellatospora sp. IY07-71	BCJ77877.1			7
C1707_10860		Caulobacter flavus RHGG3	AYV46726.1			7
Cseg_3572		Caulobacter segnis ATCC 21756	ADG11997.1			7
K8940_19050		Caulobacter segnis CBR1	UAL09850.1			7
MZV50_21550		Caulobacter segnis RL271	USQ95115.1			7
B7G68_18290		Caulobacter segnis TK0059	AVQ03616.1			7
CSW63_19150		Caulobacter sp. FWC26	AZS22559.1			7
Caul_1040		Caulobacter sp. K31	ABZ70170.1			7
KZH45_04175		Caulobacter vibrioides CB S2B lysogen	QXZ52880.1			7
CA607_04270		Caulobacter vibrioides CB1	ATC27643.1			7
CA606_11550		Caulobacter vibrioides CB13b1a	ATC32914.1			7
CC0801		Caulobacter vibrioides CB15	AAK22786.1 NP_419618.1			7
CA608_04100		Caulobacter vibrioides CB2	ATC23772.1			7
EIB18_04305		Caulobacter vibrioides CB2A	AZH12012.1			7
CCNA_00843		Caulobacter vibrioides NA1000	ACL94308.1			7
Clole_3357		Cellulosilyticum lentocellum DSM 5427	ADZ85047.1			7
Clole_3357		Cellulosilyticum lentocellum DSM 5427	ADZ85047.1			7
EKH84_20015		Cellulosilyticum sp. WCF-2	QEH70547.1			7
EKH84_20015		Cellulosilyticum sp. WCF-2	QEH70547.1			7
FY115_01180		Cellvibrio japonicus ADPT1-KOJIBIOSE	QEI21179.1			7
FY115_16765		Cellvibrio japonicus ADPT1-KOJIBIOSE	QEI20852.1			7
FY116_16770		Cellvibrio japonicus ADPT2-NIGEROSE	QEI17275.1			7
FY116_01180		Cellvibrio japonicus ADPT2-NIGEROSE	QEI17604.1			7
FY117_01180		Cellvibrio japonicus ADPT3-ISOMALTOSE	QEI14030.1			7
FY117_16765		Cellvibrio japonicus ADPT3-ISOMALTOSE	QEI13701.1			7
endo-β-1,4-mannanase 5C (CjMan5C;CJA_3470) (Man5C)	3.2.1.78	Cellvibrio japonicus Ueda107	ACE82655.1 AAO31761.1	B3PG16 Q840C0		7
CJA_0244 (Man5D)		Cellvibrio japonicus Ueda107	ACE83583.1			7
β-mannosidase 5A (Man5A) (Man5A)	3.2.1.25	Cellvibrio mixtus NCIMB 8633	AAS19695.1	Q6QT42	1UUQ[A] 1UZ4[A] 7ODJ[A]	7
D0C16_18800		Cellvibrio sp. KY-GH-1	QEY17860.1			7
D0C16_14215		Cellvibrio sp. KY-GH-1	QEY17029.1			7
D0C16_14215		Cellvibrio sp. KY-GH-1	QEY17029.1			7
D0C16_14175		Cellvibrio sp. KY-GH-1	QEY17021.1			7
D0B88_02290		Cellvibrio sp. KY-YJ-3	QEY11185.1			7
CBR65_15160		Cellvibrio sp. PSBB006	ARU28676.1			7
B0D95_16680		Cellvibrio sp. PSBB023	AQT61563.1			7
NNX04_12750		Cellvibrio sp. QJXJ	UUA71281.1			7
SIO70_23345		Chitinophaga sancti HSF-01	WPQ61297.1			7
QQL36_27355		Chitinophaga sp. LS1	WPV65524.1			7
OQ292_12610		Chondrinema litorale WSW3-B12	UZR92699.1			7
GRFL_0929		Christiangramia flava JLT2011	APU67653.1			7
C7S20_04620		Christiangramia fulva SH35	AVR44605.1			7
CRDW_10030		Chryseobacterium gambrini DW100	BEV03629.1			7
PFY09_04950		Chryseobacterium gambrini PL22-1A	WBV53666.1			7
CO230_01210		Chryseobacterium sp. 6424	AYO56873.1			7
EIH07_07115		Chryseobacterium taklimakanense F9257	AZI23746.1			7
EIH08_06030		Chryseobacterium taklimakanense H4753	AZI21418.1			7
CLAUR_046190		Clostridium aurantibutyricum DSM 793	URZ04530.1			7
CM240_3326		Clostridium bornimense M2/40	CDM70443.1			7
CCDG5_1678		[Clostridium] cellulosi	CDZ24786.1			7
mannanase (Man5B)		Clostridium cellulovorans	BAV13033.1			7
mannanase (Man5B)		Clostridium cellulovorans	BAV13033.1			7
Clocel_3099 (Man5B)		Clostridium cellulovorans 743B	ADL52789.1			7
Clocel_3099 (Man5B)		Clostridium cellulovorans 743B	ADL52789.1			7
CLFE_048450		Clostridium felsineum DSM 794	URZ18757.1			7
CLROS_047320		Clostridium roseum DSM 6424	URZ09316.1			7
CROST_047800		Clostridium roseum DSM 7320	URZ14002.1			7
Cspa_c18630		Clostridium saccharoperbutylacetonicum N1-4(HMT)	AGF55633.1			7
Clo1100_1828		Clostridium sp. BNL1100	AEY66038.1			7
A9D14_07180		Croceicoccus marinus E4A9	ARU16013.1			7
H4O24_08720		Croceicoccus marinus OT19	QNE04090.1			7
Daura_25280 (fragment)		Dactylosporangium aurantiacum NRRL B-8018	UWZ59179.1			7
Daura_25290 (fragment)		Dactylosporangium aurantiacum NRRL B-8018	UWZ59181.1			7
Daura_15815		Dactylosporangium aurantiacum NRRL B-8018	UWZ57485.1			7
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