Glycoside Hydrolase Family 5 / Subf 7

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (504); Uniprot accession (158); PDB accession (26); 3D entries (10); cryst (0)
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Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 LPB138_12950   Lutibacter sp. LPB0138 AOW22114.1     7
 MROS_0511   Melioribacter roseus P3M-2 AFN73754.1     7
 MEBOL_004303   Melittangium boletus DSM 14713 ATB30841.1     7
 Mnod_6857   Methylobacterium nodulans ORS 2060 ACL61603.1 B8IHE0   7
 AUP74_03275   Microbulbifer aggregans CCB-MM1 AOS98641.1     7
 GA0070611_5887   Micromonospora auratinigra DSM 44815 SBT52970.1     7
 GA0070614_4517   Micromonospora coxensis DSM 45161 SCG69299.1     7
 GA0074704_1933   Micromonospora siamensis DSM 45097 SCG46694.1     7
 MgSA37_01551   Mucilaginibacter gotjawali SA3-7 BAU53384.1     7
 Palpr_1818   Paludibacter propionicigenes WB4 ADQ79957.1 E4T5G3   7
 SAMN04489860_0290   Paraoerskovia marina DSM 22126 SDR88201.1     7
 JBW_04414   Pelosinus fermentans JBW45 AJQ29745.1     7
 LPB03_10205   Polaribacter vadi LPB0003 AOW19072.1     7
 ADJ77_04205   Prevotella fusca JCM 17724 AKU69032.1     7
 HMPREF0659_A5424   Prevotella melaninogenica ATCC 25845 ADK96349.1 D9RTW4   7
 CEP85_02375   Prevotella melaninogenica FDAARGOS_306 ASE17030.1     7
 PMEL1_00463   Prevotella melaninogenica GAI 07411 BBA28560.1     7
 AXF22_07430   Prevotella scopos JCM 17725 ANR73224.1     7
 HMPREF0669_01845   Prevotella sp. oral taxon 299 str. F0039 EFC70148.2     7
 ORF   Prevotella sp. Sc00026 AGH13973.1     7
 Psesu_0448   Pseudoxanthomonas suwonensis 11-1 ADV26307.1     7
 WQ53_05085   Pseudoxanthomonas suwonensis J1 AKC86242.1     7
 β-mannosidase   Rhizobium leguminosarum bv. trifolii Rt24.2 AOO93386.1     7
 Rleg_6731   Rhizobium leguminosarum bv. trifolii WSM1325 ACS59770.1 C6B6R2   7
 RLEG3_14785   Rhizobium leguminosarum bv. trifolii WSM1689 AHF83002.1     7
 pRL110397   Rhizobium leguminosarum bv. viciae 3841 CAK03350.1 Q1M5Y9   7
 CHY08_09890   Rhizobium leguminosarum bv. viciae BIHB 1148 ASR07397.1     7
 CHR56_04630   Rhizobium leguminosarum bv. viciae BIHB 1217 ASS53919.1     7
 BMW22_14425   Rhizobium leguminosarum Vaf-108 API52651.1     7
 BA011_01990   Rhizobium leguminosarum Vaf10 ANP84627.1     7
 TH63_14930   Rufibacter sp. DG31D AKQ46625.1     7
 DC20_05280   Rufibacter tibetensis 1351 ALI98496.1     7
 RBI_I00793   Ruminococcus bicirculans 80/3 CCO04515.1     7
 Sde_0509 (Man5P)   Saccharophagus degradans 2-40 ABD79773.1 Q21NF6   7
 M5M_16800   Simiduia agarivorans SA1 = DSM 21679 AFV00491.1     7
 M5M_16825   Simiduia agarivorans SA1 = DSM 21679 AFV00496.1
AFV00496.2
    7
 Solca_2505   Solitalea canadensis DSM 3403 AFD07540.1     7
 sce6007   Sorangium cellulosum So ce56 CAN96171.1 A9GCD0   7
 SCE1572_35690   Sorangium cellulosum So0157-2 AGP39357.1     7
 TS85_09230   Sphingomonas hengshuiensis WHSC-8 AJP74397.1     7
 TS85_01390   Sphingomonas hengshuiensis WHSC-8 AJP70767.1     7
 BJP26_18350   Sphingomonas melonis TY AOW25267.1     7
 BXU08_02495   Sphingomonas sp. LM7 AQR72688.1     7
 LPB140_03620   Sphingopyxis sp. LPB0140 APG62054.1     7
 TJEJU_3613   Tenacibaculum jejuense KCTC 22618 SNR17256.1     7
 TERTU_4415   Teredinibacter turnerae T7901 ACR14510.1 C5BJ14   7
 Tter_2698   Thermobaculum terrenum ATCC BAA-798 ACZ43586.1 D1CIL5   7
 β-mannanase (ManB;TM1227) (Man5) 3.2.1.78 Thermotoga maritima MSB8 AAD36302.1
AAM56792.1
AAM56796.1
ACM94273.1
AGL50158.1
AHD18866.1
AKE29003.1
CAB56854.1
CAH68693.1
CAT81455.1
NP_229032.1
Q9X0V4   7
 THMB_1253   Thermotoga maritima Tma100 AKE30875.1     7
 THMC_1253   Thermotoga maritima Tma200 AKE27138.1     7
 Tnap_1565   Thermotoga naphthophila RKU-10 ADA67641.1 D2C4I7   7
 β-mannanase (ManB) (Man5) 3.2.1.78 Thermotoga neapolitana 5068 CAB56856.1
AAK53459.1
Q9RIK7   7
 CTN_1345   Thermotoga neapolitana DSM 4359 ACM23521.1 B9K988   7
 endo-β-1,4-mannanase (Man;TpMan;TpManGH5;Tpet_1542) 3.2.1.78 Thermotoga petrophila RKU-1 ABQ47550.1
YP_001245126.1
A5IMX7 3PZ9[A]
3PZG[A]
3PZI[A]
3PZM[A]
3PZN[A]
3PZO[A]
3PZQ[A]
7
 T2812B_07895   Thermotoga sp. 2812B AIY87106.1     7
 TRQ2_1591   Thermotoga sp. RQ2 ACB09927.1 B1LCB9   7
 TRQ7_08200   Thermotoga sp. RQ7 AJG41423.1     7
 Trebr_1918   Treponema brennaborense DSM 12168 AEE17337.1     7
 Turpa_1015   Turneriella parva DSM 21527 AFM11664.1     7
 GH5   uncultured bacterium AQQ75211.1     7
 ORF   uncultured bacterium SIP56248.1     7
 endo-β-1,4-mannosidase (ManEM1) 3.2.1.- uncultured bacterium AHC00282.1     7
 mannosidase (fragment)   uncultured bacterium AGG23326.1     7
 ORF   uncultured bacterium Contig196 AHF25220.1     7
 AL536_06090   Vibrio fluvialis ATCC 33809 AMF93025.1     7
 vfu_B00528   Vibrio furnissii NCTC 11218 ADT88760.1     7
 BA893_23975   Vibrio natriegens CCUG 16373 ANQ24655.1     7
 β-1,4-mannanase 5C (Man5C) 3.2.1.78 Vibrio sp. MA-138 BAG69482.2
BAG69482.1
B5BQ69   7
 Xcel_2802   Xylanimonas cellulosilytica DSM 15894 ACZ31816.1 D1BYE4   7
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