Glycoside Hydrolase Family 5 / Subf 7

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (508); Uniprot accession (158); PDB accession (26); 3D entries (10); cryst (0)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 β-mannanase (ManA) 3.2.1.78 Acidothermus cellulolyticus ABJ41262.1
ABJ41263.1
ABJ41266.1
    7
 endo-β-1,4-mannanase 5C (CjMan5C;CJA_3470) (Man5C) 3.2.1.78 Cellvibrio japonicus Ueda107 ACE82655.1
AAO31761.1
B3PG16
Q840C0
  7
 β-mannosidase 5A (Man5A) 3.2.1.25 Cellvibrio mixtus NCIMB 8633 AAS19695.1 Q6QT42 1UUQ[A]
1UZ4[A]
7
 Clocel_3099 (Man5B) 3.2.1.78 Clostridium cellulovorans 743B ADL52789.1 D9STQ5   7
 Clocel_3099 (Man5B) 3.2.1.78 Clostridium cellulovorans 743B ADL52789.1 D9STQ5   7
 β-mannanase (ManF) 3.2.1.78 Geobacillus stearothermophilus MCA2184 AAC71692.1 Q9ZI87   7
 β-mannanase (ManB;TM1227) (Man5) 3.2.1.78 Thermotoga maritima MSB8 AAD36302.1
AAM56792.1
AAM56796.1
ACM94273.1
AGL50158.1
AHD18866.1
AKE29003.1
CAB56854.1
CAH68693.1
CAT81455.1
NP_229032.1
Q9X0V4   7
 β-mannanase (ManB) (Man5) 3.2.1.78 Thermotoga neapolitana 5068 CAB56856.1
AAK53459.1
Q9RIK7   7
 endo-β-1,4-mannanase (Man;TpMan;TpManGH5;Tpet_1542) 3.2.1.78 Thermotoga petrophila RKU-1 ABQ47550.1
YP_001245126.1
A5IMX7 3PZ9[A]
3PZG[A]
3PZI[A]
3PZM[A]
3PZN[A]
3PZO[A]
3PZQ[A]
7
 endo-β-1,4-mannosidase (ManEM1) 3.2.1.- uncultured bacterium AHC00282.1     7
 β-1,4-mannanase 5C (Man5C) 3.2.1.78 Vibrio sp. MA-138 BAG69482.2
BAG69482.1
B5BQ69   7
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 β-mannanase (Cel4A) 3.2.1.78 Agaricus bisporus C54-CARB8 CAB76904.1
ABJ41267.1
Q9P893   7
 β-mannanase (Cel4;Cel4b) 3.2.1.78 Agaricus bisporus D649 CAA90423.1 Q92401   7
 endo-β-1,4-mannanase (AtMan5-1;AtMan1;At1g02310) 3.2.1.78 Arabidopsis thaliana AAN72165.1
AAG00883.1
AAL91241.1
AEE27414.1
ANM59069.1
NP_171733.1
NP_171733.2
Q9FZ29   7
 β-mannanase 2 (AtMan2;AtMan5-2;At2g20680) 3.2.1.78 Arabidopsis thaliana AAP40422.1
AAD20927.1
ABG25077.1
AEC07056.1
BAF00487.1
NP_179660.2
Q7Y223
Q9SKU9
  7
 β-mannanase (PM;Man47;AtMAN47) 3.2.1.78 Armillariella tabescens EJLY2098 ABB88954.1 A1X5Y1   7
 β-mannanase (Man1) 3.2.1.78 Aspergillus aculeatus KSM 510 / MRC11624 AAA67426.1 Q00012   7
 β-mannanase (Man5P1;NFIA_113780) 3.2.1.78 Aspergillus fischeri NRRL 181 NRRL 181 / P1 XP_001262744.1     7
 endo-β-1,4-mannanase (Man I;Man II;AFUA_8G07030;Afu8g07030) 3.2.1.78 Aspergillus fumigatus Af293 EAL85463.1 Q4WBS1   7
 endo-β-1,4-mannanase (ManF;Man I;Man II) (partial) 3.2.1.78 Aspergillus fumigatus IMI 385708 ACH58410.1
ACH58411.1
B5LZ77
B5LZ78
Q4WBS1
  7
 endo-β-1,4-mannanase (ManA;AnMan5A;AN3358) (Man5A) 3.2.1.78 Aspergillus nidulans FGSC A4 ABF50863.1
EAA63326.1
Q5B7X2   7
 endo-β-1,4-mannanase (ManB;AnMan5B;AN3297) (Man5B) 3.2.1.78 Aspergillus nidulans FGSC A4 ABF50861.1
EAA63265.1
Q5B833   7
 endo-β-1,4-mannanase (ManC;AnMan5C;AN6427;ANID_06427) (Man5C) 3.2.1.78 Aspergillus nidulans FGSC A4 EAA58449.1
ABF50878.1
Q5AZ53   7
 β-mannanase (Man5;Man5XZ3) (partial) 3.2.1.78 Aspergillus nidulans XZ3 AGG69666.1     7
 endo-β-1,4-mannanase (ManBK) (partial) 3.2.1.78 Aspergillus niger BK 01 ACJ06979.1 B6V876 3WH9[A,B] 7
 β-mannanase (An05g01320) (Man5A) 3.2.1.78 Aspergillus niger CBS 513.88 CAK96471.1 A2QKT4   7
 endo-β-1,4-mannanase (AnMan5A) (acidic) (Man5A) 3.2.1.78 Aspergillus niger LW-1 / E-30 AEY76082.1
AEP84473.1
    7
 endo-β-1,4-mannanase (partial) 3.2.1.78 Aspergillus sp. T16 AHA38074.1     7
 β-mannanase (MANN) 3.2.1.78 Aspergillus sulphureus ABC59553.1 Q2LE69   7
 β-mannanase (AuMan5A) (Man5A) 3.2.1.78 Aspergillus usamii E001 / YL-01-78 ADZ99027.1     7
 endo-β-1,4-mannanase (Man5) 3.2.1.78 Bispora antennata CBS 126.38 AFJ68087.1     7
 endo-β-1,4-mannanase 5A (Man5A) 3.2.1.78 Bispora sp. MEY-1 ACH56965.1 B5LXD7   7
 β-mannanase (CsMan5A) (Man5A) 3.2.1.78 Chaetomium sp. CQ31 ADW82104.1     7
 endo-β-1,4-mannanase (ManA;CaMANA) 3.2.1.78 Coffea arabica CAC08208.1
AAX01860.1
Q9FT02   7
 endo-β-1-4-mannanase (ManB;CaMANB) 3.2.1.78 Coffea arabica CAC08442.1 Q9FT03   7
 endo-β-mannanase (DcMan1) 3.2.1.78 Daucus carota AAN34823.1 Q8H6B4   7
 β-mannanase (GLOTRDRAFT_110405) (Man5A) 3.2.1.78 Gloeophyllum trabeum ATCC 11539 / CBS900.73 EPQ57046.1     7
 endo-β-1,4-mannanase (GmMan1) 3.2.1.78 Glycine max ABG88068.1 Q0PKY2   7
 endo-β-1,4-mannanase (Man1;HvMAN1) 3.2.1.78 Hordeum vulgare subsp. vulgare BAK05001.1
ABC87082.1
Q2I011   7
 β-mannanase (alkali-tolerant) (Man5A) 3.2.1.78 Humicola insolens Y1 ADZ99301.1     7
 endo-β-1,4-mannanase (Man1) 3.2.1.78 Lactuca sativa CAC51690.3 Q93X40   7
 β-mannanase (ManA) 3.2.1.78 Orpinomyces sp. PC-2 AAL01213.1 Q96V96   7
 endo-β-mannanase (Ma;PoMan5A) (Man5A) 3.2.1.78 Penicillium oxalicum GZ-2 AGW24296.1     7
 β-mannanase (Man5C6;Man5) 3.2.1.78 Penicillium sp. enrichment culture clone C6 / ACCC32495 AEV41143.1     7
 endo-β-1,4-mannanase (Man5F63) 3.2.1.78 Penicillium sp. F63 XC-2012 / CGMCC 1669 AFC38441.1     7
 β-mannanase 5D (Man5D) 3.2.1.78 Phanerochaete chrysosporium RP78 ABG79370.1 Q0PQY8   7
 endo-β-1,4-mannanase (Man5AP13) (Man5A) 3.2.1.78 Phialophora sp. CGMCC 3329 / P13 ADF28533.1 D5IF02   7
 endo-β-1,4-mannanase (PaMan5A;Pa_6_490) (Man5A) 3.2.1.78 Podospora anserina S mat+ CAP71606.1
ADO14134.1
CDP31001.1
B2B3C0 3ZIZ[A] 7
 endo-β-1,4-mannanase (Man6;PtrMan6) 3.2.1.78 Populus trichocarpa AFX59322.1
EEF05441.1
    7
 β-mannanase (RmMan5B) (Man5B) 3.2.1.78 Rhizomucor miehei CAU432 AGV01048.1   4LYP[A,B]
4LYQ[A]
4LYR[A]
4NRR[A,B]
4NRS[A,B]
7
 β-mannanase (RmMan5A) (Man5A) 3.2.1.78 Rhizomucor miehei CAU432 / CGMCC 4967 AGC24277.1   4L3M[A]
4QP0[A]
7
 endo-β-mannanase 4a / mannan transglycosylase/hydrolase (Man4;LeMan4;LeMAN4a;LeMAN4i;MTH) 3.2.1.78
2.4.1.-
Solanum lycopersicum AAK97760.1
AAK56557.1
AAK97759.2
Q8L5J1
Q8RVL3
Q93WT4
1RH9[A] 7
 β-mannanase (Man1;LeMAN1) 3.2.1.78 Solanum lycopersicum AAB87859.2 O48540   7
 endo-β-1,4-mannanase (Man5;LeMAN5) 3.2.1.78 Solanum lycopersicum AAM26920.1 Q6YM50   7
 endo-β-1,4-mannanase (Man2;LeMAN2) 3.2.1.78 Solanum lycopersicum AAG00315.2
AAG00315.1
Q9FZ03   7
 β-mannanase (Man5A) 3.2.1.78 Talaromyces leycettanus JCM12802 AJF11663.1     7
 β-mannanase (Man5C1) (acidic) 3.2.1.78 Talaromyces pinophilus C1 AEV40667.1     7
 β-mannanase 3.2.1.78 Talaromyces trachyspermus ATCC 24792 BAP19029.1   3WFL[A] 7
 β-mannanase (Man2;bMan2) 3.2.1.78 Thermothelomyces thermophila C1 AFJ59924.1     7
 β-mannanase (Man5;Man5XZ7) 3.2.1.78 Thielavia arenaria XZ7 AGG69667.1     7
 β-mannanase (ThMan5A) (Man5A) 3.2.1.78 Trichoderma harzianum MGQ2 AGH62580.1     7
 β-mannanase (Man1) 3.2.1.78 Trichoderma longibrachiatum DSM 63060 ADN93457.1 E2FZU3   7
 β-mannanase (TrMan5A) (Man5A) 3.2.1.78 Trichoderma reesei RUTC-30 AAA34208.1
ABJ41268.1
Q99036 1QNO[A]
1QNP[A]
1QNQ[A]
1QNR[A]
1QNS[A]
7
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