Activities in Sub Family	β-mannosidase (EC 3.2.1.25); Endo-β-1,4-mannanase (EC 3.2.1.78);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (1559); Uniprot accession (72); PDB accession (29); 3D entries (11); cryst (0)

Bacteria
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
endo-β-1,4-mannanase 5C (CjMan5C;CJA_3470) (Man5C)	3.2.1.78	pubmed	Cellvibrio japonicus Ueda107	ACE82655.1 AAO31761.1	B3PG16 Q840C0		7
β-mannosidase 5A (Man5A) (Man5A)	3.2.1.25	pubmed	Cellvibrio mixtus NCIMB 8633	AAS19695.1	Q6QT42	1UUQ[A] 1UZ4[A] 7ODJ[A]	7
β-mannanase (ManF)	3.2.1.78	pubmed	Geobacillus stearothermophilus MCA2184	AAC71692.1	Q9ZI87		7
β-mannanase (ManB; TmMan5; TM1227) (Man5)	3.2.1.78	pubmed	Thermotoga maritima MSB8	AAD36302.1 AAM56792.1 AAM56796.1 ACM94273.1 AGL50158.1 AHD18866.1 AKE29003.1 CAB56854.1 CAH68693.1 CAT81455.1 NP_229032.1	Q9RIK9 Q9X0V4 R4P2R8		7
β-mannanase (ManB; TnMan5) (Man5)	3.2.1.78	pubmed	Thermotoga neapolitana 5068	CAB56856.1 AAK53459.1	Q9RIK7		7
endo-β-1,4-mannanase (Man;TpMan;TpManGH5;Tpet_1542)	3.2.1.78	pubmed	Thermotoga petrophila RKU-1	ABQ47550.1 YP_001245126.1	A5IMX7	3PZ9[A] 3PZG[A] 3PZI[A] 3PZM[A] 3PZN[A] 3PZO[A] 3PZQ[A] 6TN6[A]	7
β-1,4-mannanase 5C (Man5C)	3.2.1.78	pubmed	Vibrio sp. MA-138	BAG69482.2 BAG69482.1	B5BQ69		7
Eukaryota
Protein Name	EC#	Reference	Organism	GenBank	Uniprot	PDB/3D	Subf
β-mannanase (Cel4A)	3.2.1.78	pubmed	Agaricus bisporus C54-CARB8	CAB76904.1 ABJ41267.1	Q9P893		7
β-mannanase (Cel4;Cel4b)	3.2.1.78	pubmed	Agaricus bisporus D649	CAA90423.1	Q92401		7
endo-β-1,4-mannanase (AtMan5-1;AtMan1;At1g02310)	3.2.1.78	pubmed	Arabidopsis thaliana	AAN72165.1 AAG00883.1 AAL91241.1 AEE27414.1 ANM59069.1 NP_171733.1 NP_171733.2	A0A178WL81 A0A654E7D2 Q9FZ29		7
β-mannanase 2 (AtMan2;AtMan5-2;At2g20680)	3.2.1.78	doi	Arabidopsis thaliana	AAP40422.1 AAD20927.1 ABG25077.1 AEC07056.1 BAF00487.1 NP_179660.2	Q7Y223 Q9SKU9		7
β-mannanase (PM;Man47;AtMAN47)	3.2.1.78	pubmed	Armillariella tabescens EJLY2098	ABB88954.1	A1X5Y1		7
β-mannanase (Man1)	3.2.1.78	pubmed	Aspergillus aculeatus KSM 510 / MRC11624	AAA67426.1	Q00012		7
β-mannanase (Man5P1;NFIA_113780)	3.2.1.78	pubmed	Aspergillus fischeri NRRL 181 NRRL 181 / P1	XP_001262744.1	A1D8Y6		7
endo-β-1,4-mannanase (Man I;Man II;AFUA_8G07030;Afu8g07030)	3.2.1.78	pubmed	Aspergillus fumigatus Af293	EAL85463.1	Q4WBS1		7
endo-β-1,4-mannanase (ManF;Man I;Man II) (partial)	3.2.1.78	pubmed	Aspergillus fumigatus IMI 385708	ACH58410.1 ACH58411.1	B5LZ77 B5LZ78 Q4WBS1		7
endo-β-1,4-mannanase (ManAK; AKAW_07239	3.2.1.78	pubmed	Aspergillus luchuensis IFO 4308	GAA89125.1			7
endo-β-1,4-mannanase (ManA;AnMan5A;AN3358) (Man5A)	3.2.1.78	pubmed	Aspergillus nidulans FGSC A4	ABF50863.1 EAA63326.1	Q5B7X2		7
endo-β-1,4-mannanase (ManB;AnMan5B;AN3297) (Man5B)	3.2.1.78	pubmed	Aspergillus nidulans FGSC A4	ABF50861.1 EAA63265.1	Q5B833		7
endo-β-1,4-mannanase (ManC;AnMan5C;AN6427;ANID_06427) (Man5C)	3.2.1.78	pubmed	Aspergillus nidulans FGSC A4	EAA58449.1 ABF50878.1	Q5AZ53		7
β-mannanase (Man5;Man5XZ3)	3.2.1.78	pubmed	Aspergillus nidulans XZ3	AGG69666.1	S4TZC3		7
endo-β-1,4-mannanase (ManBK) (partial)	3.2.1.78	pubmed	Aspergillus niger BK 01	ACJ06979.1	B6V876	3WH9[A,B]	7
β-mannanase (An05g01320) (Man5A)	3.2.1.78	pubmed	Aspergillus niger CBS 513.88	CAK96471.1	A2QKT4		7
endo-β-1,4-mannanase (AnMan5A) (acidic) (Man5A)	3.2.1.78	pubmed	Aspergillus niger LW-1 / E-30	AEY76082.1 AEP84473.1	G5CJA5 H2E6Y8		7
endo-β-1,4-mannanase	3.2.1.78	pubmed	Aspergillus sp. T16	AHA38074.1	A0A0B4KYG3		7
β-mannanase (MANN)	3.2.1.78	pubmed	Aspergillus sulphureus	ABC59553.1	Q2LE69		7
β-mannanase	3.2.1.78	pubmed	Aspergillus sulphureus 138284	ABE73149.1			7
β-mannanase (AuMan5A) (Man5A)	3.2.1.78	pubmed	Aspergillus usamii E001 / YL-01-78	ADZ99027.1	F2XJJ2		7
endo-β-1,4-mannanase (Man5)	3.2.1.78	pubmed	Bispora antennata CBS 126.38	AFJ68087.1	I2CMF4		7
endo-β-1,4-mannanase 5A (Man5A)	3.2.1.78	pubmed	Bispora sp. MEY-1	ACH56965.1	B5LXD7		7
β-mannanase (CsMan5A) (Man5A)	3.2.1.78	doi	Chaetomium sp. CQ31	ADW82104.1	G9BZJ2		7
endo-β-1,4-mannanase (ManA;CaMANA)	3.2.1.78	pubmed	Coffea arabica	CAC08208.1 AAX01860.1	Q9FT02		7
endo-β-1-4-mannanase (ManB;CaMANB)	3.2.1.78	pubmed	Coffea arabica	CAC08442.1	Q9FT03		7
mannanase (CC1G_09314; CcMan5C) (Man5C)	3.2.1.78	pubmed	Coprinopsis cinerea okayama7#130	XP_001830154.1			7
endo-β-mannanase (DcMan1)	3.2.1.78	doi	Daucus carota	AAN34823.1	Q8H6B4		7
β-mannanase (Man5A)	3.2.1.78	pubmed	Evansstolkia leycettana JCM12802	AJF11663.1	A0A0B5FP75		7
β-mannanase (GLOTRDRAFT_110405) (Man5A)	3.2.1.78	pubmed	Gloeophyllum trabeum ATCC 11539 / CBS900.73	EPQ57046.1	S7QAW1		7
endo-β-1,4-mannanase (GmMan1; Glyma19g41090.1)	3.2.1.78	pubmed	Glycine max	ABG88068.1	Q0PKY2		7
endo-β-1,4-mannanase (Man1;HvMAN1)	3.2.1.78	pubmed	Hordeum vulgare subsp. vulgare	BAK05001.1 ABC87082.1	F2ECC9 Q2I011		7
β-mannanase (alkali-tolerant) (Man5A)	3.2.1.78	pubmed	Humicola insolens Y1	ADZ99301.1	H6TCE0		7
endo-β-1,4-mannanase (Man1; LsMan1)	3.2.1.78	doi	Lactuca sativa	CAC51690.3	Q93X40		7
endo-β-1,4-mannanase (NCU08412)	3.2.1.78	pubmed	Neurospora crassa OR74A	EAA34048.2	Q7SC42		7
endo-β-1,4-mannanase (Man5; CsMan5) (partial)	3.2.1.78	pubmed	Neurospora sitophila DSM 16514	CCI55471.1		4AWE[A]	7
β-mannanase (ManA)	3.2.1.78	pubmed	Orpinomyces sp. PC-2	AAL01213.1	Q96V96		7
endo-β-mannanase (Ma;PoMan5A) (Man5A)	3.2.1.78	pubmed	Penicillium oxalicum GZ-2	AGW24296.1	U3N1Q2		7
β-mannanase (Man5C6;Man5)	3.2.1.78	doi	Penicillium sp. enrichment culture clone C6 / ACCC32495	AEV41143.1	G9BY18		7
endo-β-1,4-mannanase (Man5F63)	3.2.1.78	pubmed	Penicillium sp. F63 XC-2012 / CGMCC 1669	AFC38441.1	I3PML9		7
β-mannanase 5D (Man5D)	3.2.1.78	doi	Phanerochaete chrysosporium RP78	ABG79370.1	Q0PQY8		7
endo-β-1,4-mannanase (Man5AP13) (Man5A)	3.2.1.78	pubmed	Phialophora sp. CGMCC 3329 / P13	ADF28533.1	D5IF02		7
endo-β-1,4-mannanase (PaMan5A;Pa_6_490) (Man5A)	3.2.1.78	pubmed	Podospora anserina S mat+	CAP71606.1 ADO14134.1 CDP31001.1	B2B3C0	3ZIZ[A]	7
endo-β-1,4-mannanase (Man6;PtrMan6)	3.2.1.78	pubmed	Populus trichocarpa	AFX59322.1 EEF05441.1	K7WJ21		7
β-mannanase (RmMan5B) (Man5B)	3.2.1.78	pubmed	Rhizomucor miehei CAU432	AGV01048.1	A0A075C6T6	4LYP[A,B] 4LYQ[A] 4LYR[A] 4NRR[A,B] 4NRS[A,B]	7
β-mannanase (RmMan5A) (Man5A)	3.2.1.78	pubmed	Rhizomucor miehei CAU432 / CGMCC 4967	AGC24277.1	L7SVX1	4L3M[A] 4QP0[A]	7
endo-β-mannanase 4a / mannan transglycosylase/hydrolase (Man4; LeMan4; LeMAN4a; LeMAN4i; MTH)	3.2.1.78	pubmed	Solanum lycopersicum	AAK97760.1 AAK56557.1 AAK97759.2	Q8L5J1 Q8RVL3 Q93WT4	1RH9[A]	7
β-mannanase (Man1;LeMAN1)	3.2.1.78	pubmed	Solanum lycopersicum	AAB87859.2	O48540		7
endo-β-1,4-mannanase (Man5;LeMAN5)	3.2.1.78	pubmed	Solanum lycopersicum	AAM26920.1	Q6YM50		7
endo-β-1,4-mannanase (Man2;LeMAN2)	3.2.1.78	pubmed	Solanum lycopersicum	AAG00315.2 AAG00315.1	Q9FZ03		7
β-mannanase (Man5C1) (acidic)	3.2.1.78	pubmed	Talaromyces pinophilus C1	AEV40667.1	G9BRM6		7
β-mannanase	3.2.1.78	doi	Talaromyces trachyspermus ATCC 24792	BAP19029.1	A0A077JNB5 A0A087WNH1	3WFL[A]	7
β-mannanase (Man2;bMan2)	3.2.1.78	pubmed	Thermothelomyces thermophilus C1	AFJ59924.1	I2C091		7
β-mannanase (Man5;Man5XZ7)	3.2.1.78	pubmed	Thielavia arenaria XZ7	AGG69667.1	S4TZ32		7
β-mannanase (Man446; TaMan5)	3.2.1.78	pubmed	Trichoderma asperellum ND-1	UNE56028.1			7
β-mannanase (ThMan5A) (Man5A)	3.2.1.78	pubmed	Trichoderma harzianum MGQ2	AGH62580.1	M4T2Q5		7
β-mannanase (Man1)	3.2.1.78	doi	Trichoderma longibrachiatum DSM 63060	ADN93457.1	E2FZU3		7
β-mannanase (Man1; TrMan5A) (Man5A)	3.2.1.78	doi	Trichoderma reesei RUTC-30	AAA34208.1 ABJ41268.1	Q99036	1QNO[A] 1QNP[A] 1QNQ[A] 1QNR[A] 1QNS[A]	7
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