Activities in Sub Family	Endo-β-1,4-glucanase (EC 3.2.1.4);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (2130); Uniprot accession (61); PDB accession (35); 3D entries (9); cryst (0)

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Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
68921		Aspergillus wentii v1 (Aspwe1)				5
119809		Aspergillus wentii v1 (Aspwe1)				5
66384		Aspergillus zonatus v1 (Aspzo1)				5
422897		Astrocystis sublimbata CBS 130006 v1.0 (Astsub1)				5
62682		Astrocystis sublimbata CBS 130006 v1.0 (Astsub1)				5
50641		Astrocystis sublimbata CBS 130006 v1.0 (Astsub1)				5
391252		Aulographum hederae CBS 113979 version 2 (Aulhe2)				5
endo-β-1,4-glucanase (Egl;ApCel5A) (Cel5A)	3.2.1.4	Aureobasidium pullulans ATCC 62921 / NRRL Y-2311-1	AEM23896.1	H2B656		5
67830		Aureobasidium pullulans NBB 7.2.1 v1.0 (AurpulNBB1)				5
81870		Aureobasidium pullulans NBB 7.2.1 v1.0 (AurpulNBB1)				5
78415		Aureobasidium pullulans NBB 7.2.1 v1.0 (AurpulNBB1)				5
83954		Aureobasidium pullulans var. melanogenum (Aurpu_var_mel1)				5
64904		Aureobasidium pullulans var. melanogenum (Aurpu_var_mel1)				5
53433		Aureobasidium pullulans var. namibiae (Aurpu_var_nam1)				5
75001		Aureobasidium pullulans var. namibiae (Aurpu_var_nam1)				5
58431		Aureobasidium pullulans var. namibiae (Aurpu_var_nam1)				5
340167		Aureobasidium pullulans var. pullulans EXF-150 (Aurpu_var_pul1)				5
339990		Aureobasidium pullulans var. pullulans EXF-150 (Aurpu_var_pul1)				5
348317		Aureobasidium pullulans var. pullulans EXF-150 (Aurpu_var_pul1)				5
endoglucanase		Auricularia heimuer	QES86350.1			5
1234052		Auricularia subglabra (Aurde3_1)				5
138514		Auricularia subglabra (Aurde3_1)				5
124125		Auricularia subglabra (Aurde3_1)				5
1163753		Auricularia subglabra (Aurde3_1)				5
486307		Auriculariopsis ampla NL-1724 v1.0 (Auramp1)				5
491136		Auriculariopsis ampla NL-1724 v1.0 (Auramp1)				5
1558106		Auriscalpium vulgare FP105234-Sp v1 (Aurvu1)				5
1591331		Auriscalpium vulgare FP105234-Sp v1 (Aurvu1)				5
12183		Batrachochytrium salamandrivorans BS (Batsa1)				5
12184		Batrachochytrium salamandrivorans BS (Batsa1)				5
120036		Baudoinia compniacensis UAMH 10762 (Bauco1)				5
27601		Baudoinia compniacensis UAMH 10762 (Bauco1)				5
47		Beauveria bassiana ARSEF 2860 (Beaba1)				5
5764		Beauveria brongniartii RCEF 3172 (Corbr1)				5
418478		Biscogniauxia marginata CBS 124505 v1.0 (Bisma1)				5
172861		Biscogniauxia marginata CBS 124505 v1.0 (Bisma1)				5
418249		Biscogniauxia marginata CBS 124505 v1.0 (Bisma1)				5
398817		Biscogniauxia marginata CBS 124505 v1.0 (Bisma1)				5
412324		Biscogniauxia marginata CBS 124505 v1.0 (Bisma1)				5
9394		Biscogniauxia mediterranea AZ0048 v1.0 (Bisme1)				5
549612		Biscogniauxia mediterranea AZ0048 v1.0 (Bisme1)				5
472187		Biscogniauxia mediterranea AZ0048 v1.0 (Bisme1)				5
692970		Biscogniauxia mediterranea AZ0048 v1.0 (Bisme1)				5
107824		Biscogniauxia mediterranea CBS 129072 v1.0 (Bismed1)				5
642181		Biscogniauxia mediterranea CBS 129072 v1.0 (Bismed1)				5
173746		Biscogniauxia mediterranea CBS 129072 v1.0 (Bismed1)				5
643878		Biscogniauxia mediterranea CBS 129072 v1.0 (Bismed1)				5
194011		Biscogniauxia mediterranea CBS 129072 v1.0 (Bismed1)				5
549445		Biscogniauxia sp. genotype 304 FL1348 v1.0 (Biscog1)				5
60936		Biscogniauxia sp. genotype 304 FL1348 v1.0 (Biscog1)				5
244187		Biscogniauxia sp. genotype 304 FL1348 v1.0 (Biscog1)				5
592148		Biscogniauxia sp. genotype 304 FL1348 v1.0 (Biscog1)				5
424624		Biscogniauxia sp. genotype 304 FL1348 v1.0 (Biscog1)				5
endo-β-1,4-glucanase		Bispora antennata	AFY98622.1			5
47402		Bjerkandera adusta (Bjead1_1)				5
35099		Bjerkandera adusta (Bjead1_1)				5
311850		Bjerkandera adusta (Bjead1_1)				5
54893		Bjerkandera adusta (Bjead1_1)				5
49257		Blyttiomyces helicus v1.0 (Blyhe1)				5
48071		Blyttiomyces helicus v1.0 (Blyhe1)				5
76405		Boeremia exigua MPI-SDFR-AT-0100 v1.0 (Boeex1)				5
450028		Boeremia exigua MPI-SDFR-AT-0100 v1.0 (Boeex1)				5
3613774		Boletus edulis BED1 v4.0 (Boled5)				5
3650125		Boletus edulis BED1 v4.0 (Boled5)				5
862387		Boletus edulis BED1 v4.0 (Boled5)				5
3613831		Boletus edulis BED1 v4.0 (Boled5)				5
1184024		Boletus edulis Prilba v1.0 (Boledp1)				5
1533701		Boletus edulis Prilba v1.0 (Boledp1)				5
1182110		Boletus edulis Prilba v1.0 (Boledp1)				5
1455542		Boletus edulis Prilba v1.0 (Boledp1)				5
590835		Bombardia bombarda SMH3391-2 v1.0 (Bombom1)				5
589299		Bombardia bombarda SMH3391-2 v1.0 (Bombom1)				5
507907		Bombardia bombarda SMH3391-2 v1.0 (Bombom1)				5
617180		Bombardia bombarda SMH3391-2 v1.0 (Bombom1)				5
178228		Botryobasidium botryosum FD-172 SS1 (Botbo1)				5
115910		Botryobasidium botryosum FD-172 SS1 (Botbo1)				5
178227		Botryobasidium botryosum FD-172 SS1 (Botbo1)				5
294680		Botryosphaeria dothidea (Botdo1_1)				5
297142		Botryosphaeria dothidea (Botdo1_1)				5
294447		Botryosphaeria dothidea (Botdo1_1)				5
294986		Botryosphaeria dothidea (Botdo1_1)				5
BCIN_14g01690		Botrytis cinerea B05.10	ATZ56968.1			5
BCIN_16g03020		Botrytis cinerea B05.10	ATZ58546.1			5
BCIN_03g04010 (Bccel5A)		Botrytis cinerea B05.10	ATZ48155.1			5
endo-β-1,4-glucanase (Cel5A)		Botrytis cinerea SAS56	AAT40313.1			5
glycoside hydrolase family 5 protein (Bofut4_p059260.1)		Botrytis cinerea T4	CCD44346.1			5
glycoside hydrolase family 5 protein (Bofut4_p112910.1) (fragment)		Botrytis cinerea T4	CCD47981.1			5
cel5A, endo-β-1,4-glucanase precursor (Bofut4_p020810.1)		Botrytis cinerea T4	CCD51775.1			5
12920		Botrytis cinerea T4 (Botcin1)				5
4637		Botrytis cinerea T4 (Botcin1)				5
3165		Botrytis cinerea T4 (Botcin1)				5
10105		Butyriboletus roseoflavus v1.0 (Butyri1)				5
461016		Byssothecium circinans CBS 675.92 (Bysci1)				5
522002		Byssothecium circinans CBS 675.92 (Bysci1)				5
178833		Byssothecium circinans CBS 675.92 (Bysci1)				5
532593		Byssothecium circinans CBS 675.92 (Bysci1)				5
462989		Cadophora sp. DSE1049 v1 (Cadsp1)				5
655183		Cadophora sp. DSE1049 v1 (Cadsp1)				5
444576		Cadophora sp. DSE1049 v1 (Cadsp1)				5
622886		Cadophora sp. DSE1049 v1 (Cadsp1)				5
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