Glycoside Hydrolase Family 5 / Subf 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (3516); Uniprot accession (276); PDB accession (20); 3D entries (9); cryst (0)
All (3119) Bacteria (2943) Eukaryota (174) unclassified (2) Structure (9) Characterized (60)
| 1 | 2 |
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 glycoside hydrolase family 5 endoglucanase, partial (Glu-2) (fragment)   Penicillium sp. 0728-003 B PDA/MF07-022 CDL74341.1     5
 endoglucanase (Cel5A) 3.2.1.4 Pestalotiopsis sp. AN 7 BAI66446.1 D2KTU9   5
 endoglucanase (Cel5A) (Cel5A)   Phanerochaete chrysosporium AAU12275.2
AAU12275.1
Q66NB7   5
 endo-β-1,4-glucanase (EgG5) 3.2.1.4 Phialophora sp. G5 / CGMCC 3328 ADZ44606.1     5
 ORF (fragment)   Phoma sp. 0729-001 C PDA/MF07-028 CDL74342.1     5
 EgL (fragment)   Pluteus cervinus AEQ58913.1     5
 EgL (fragment)   Pluteus petasatus AEQ58915.1     5
 Pa_1_5990   Podospora anserina S mat+ CAP60294.1
CDP22932.1
B2AB32   5
 unnamed protein product   Podospora anserina S mat+ CAP61800.1
CDP28876.1
B2AED4   5
 unnamed protein product   Podospora anserina S mat+ CAP73319.1
CDP25722.1
B2B694   5
 endoglucanase III (Cel4;EGIII)   Polyporus arcularius 69B-8 BAF75943.1 A7M6Q1   5
 endo-β-1,4-glucanase (PpCel5A) (Cel5A) 3.2.1.4 Postia placenta Mad-698-R ADH51729.1 D7REW2   5
 endo-β-1,4-glucanase (PpCel5B) (Cel5B) 3.2.1.4 Postia placenta Mad-698-R XP_002475436.1
ADH51730.1
D7REW3   5
 broad specificity endo-β-glucanase (Egl5A;TeEgl5A) 3.2.1.4 Rasamsonia emersonii CBS 394.64 AHV83755.1
CAJ75961.1
    5
 endo-β-1,4-glucanase (Eg1) 3.2.1.4 Rasamsonia emersonii IMI 392299 AAL33639.2
AAL33630.1
AAL33639.1
Q8WZD7   5
 ORF (fragment)   Rhizoctonia solani 0628-006 1 A WA/MF06-181 CDL74343.1     5
 endoglucanase VII (EgVII)   Rhizopus stolonifer var. reflexus TP-02 AII80538.1     5
 endo-β-1,4-glucanase I (Eg1) 3.2.1.4 Robillarda sp. Y-20 BAA90480.1
JX0131
P23044
Q9P981
  5
 endo-β-1,4-glucanase 1 / carboxymethylcellulase 1 (Cmc1) 3.2.1.4 Saitozyma flava MUT-6 AAC60541.1
BAA03070.1
Q04469   5
 endo-1-4-β-cellulase   Saitozyma flava OO2 APB92618.1     5
 endo-β-1,4-glucanase I (EG1;EGI;EGII;SCHCODRAFT_40122) 3.2.1.4 Schizophyllum commune H4-8 EFI96731.1 P81190   5
 sscle_03g023660   Sclerotinia sclerotiorum 1980 UF-70 APA07596.1     5
 sscle_03g026960   Sclerotinia sclerotiorum 1980 UF-70 APA07926.1     5
 sscle_14g099920   Sclerotinia sclerotiorum 1980 UF-70 APA15222.1     5
 PIIN_01190   Serendipita indica DSM 11827 CCA67360.1     5
 PIIN_01192   Serendipita indica DSM 11827 CCA67361.1     5
 PIIN_08751 (fragment)   Serendipita indica DSM 11827 CCA74782.1     5
 PIIN_10600 (fragment)   Serendipita indica DSM 11827 CCA76609.1     5
 PIIN_10779 (fragment)   Serendipita indica DSM 11827 CCA76793.1     5
 cellulase   Stegonsporium opalus ARO48344.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Stereum rugosum 0629-045 2 D PDA/MF06-294 CDL74344.1     5
 endoglucanase (EG)   Taiwanofungus camphoratus B479 AIO10991.1     5
 endo-β-1,4-glucanase 5A (TCE0_013f01292) (Cel5A) 3.2.1.4 Talaromyces cellulolyticus Y-94 GAM33994.1     5
 endo-β-1,4-glucanase 5 (Eng5) 3.2.1.4 Talaromyces pinophilus KMJ601 ACN43345.1 C0L2S4   5
 endoglucanase 2 (EG2;EGIIa) (partial) (Cel5A) 3.2.1.4 Talaromyces verruculosus B221-151     5L9C[A,B,C,D]
5I6S[A]
5
 endo-β-1,4-glucanase (Eg1;Eng1;TaCel5A) (Cel5A) 3.2.1.4 Thermoascus aurantiacus IFO 9748 AAL88714.2
AAL16412.1
ACE10214.1
CAT02251.1
CAZ67882.1
Q8TG26
Q96UI5
1GZJ[A,B]
1H1N[A,B]
5
 endoglucanase   Thermoascus aurantiacus RCKK AFY52522.1     5
 endo-β-1,4-glucanase (Eg1)   Thermoascus aurantiacus var. levisporus AAX51678.1 Q2VRK9   5
 MYCTH_52068   Thermothelomyces thermophila ATCC 42464 AEO58455.1     5
 endo-β-1,4-glucanase (EG II;StCel5A;MYCTH_86753) (Cel5A) 3.2.1.4 Thermothelomyces thermophila ATCC 42464 AEO53769.1
AEM23898.1
    5
 THITE_2107758   Thielavia terrestris NRRL 8126 AEO62940.1     5
 THITE_118353   Thielavia terrestris NRRL 8126 AEO67179.1     5
 THITE_124883   Thielavia terrestris NRRL 8126 AEO68519.1     5
 THITE_123205   Thielavia terrestris NRRL 8126 AEO69910.1     5
 THITE_72629   Thielavia terrestris NRRL 8126 AEO70679.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Trametes cinnabarina 285/PB CDL74356.1     5
 endoglucanase (Eg-1) 3.2.1.4 Trametes hirsuta BAD01163.1
BAD01164.1
Q75UV6   5
 endoglucanase (TvEG) 3.2.1.4 Trametes versicolor       5
 endo-β-1,4-glucanase (Glu1)   Trichoderma asperellum PQ34 AHW57398.1     5
 endo-β-1,4-glucanase (Glu2)   Trichoderma asperellum PQ34 AHW57399.1     5
 endoglucanase II (EgII)   Trichoderma atroviride AJP16798.1     5
 endo-β-1,4-glucanase II (EG2;EGII;Egl2;EG-II;TrEGII;TrCel5A) (formerly EGIII) (Cel5A) 3.2.1.4 Trichoderma reesei AAA34213.1
AAQ24883.1
AAR60515.1
ABA64553.1
ABE22094.1
P07982 3QR3[A,B] 5
 Cel5b (Cel5B)   Trichoderma reesei QM6A AAP57754.1
ABH83954.1
ABH83956.1
Q7Z9M6   5
 endo-β-1,4-glucanase (C4endoII) 3.2.1.4 Trichoderma sp. C-4 AAR29981.1 Q6S4S0   5
 endoglucanase III (EgIII;EG III)   Trichoderma sp. SSL ACH92572.1 B5TYI3   5
 endoglucanase   Trichoderma viride ABQ95572.1 A5Z0S4   5
 endoglucanase III (EG3;EGIII) 3.2.1.4 Trichoderma viride AS 3.3711 AAQ21383.1 Q7Z7X2   5
 endoglucanase VIII (EgvIII) 3.2.1.4 Trichoderma viride AS 3.3711 ACD36972.1 B4YEW2   5
 endo-β-1,4-glucanase II (Egl2) 3.2.1.4 Trichoderma viride MC300-1 BAA36216.1 O93833   5
 endoglucanase (EG)   Trichoderma viride wdf1 ADJ10627.1 D9I7P5   5
 ORF (fragment)   Ulocladium sp. 0729-007 1 C PDA/MF07-034 CDL74345.1     5
 ORF (fragment)   uncultured fungus CCC18707.1     5
 ORF (fragment)   uncultured fungus CCC18708.1     5
 ORF (fragment)   uncultured fungus CCC18709.1     5
 ORF (fragment)   uncultured fungus CCC18710.1     5
 ORF (fragment)   uncultured fungus CCC18711.1     5
 ORF (fragment)   uncultured fungus CCC18712.1     5
 ORF (fragment)   uncultured fungus CCC18713.1     5
 ORF (fragment)   uncultured fungus CCC18714.1     5
 ORF (fragment)   uncultured fungus CCC18716.1     5
 ORF (fragment)   uncultured fungus CCC18718.1     5
 EgL (fragment)   Volvariella bombycina AEQ58920.1     5
 endoglucanase I (EG1;EGI) 3.2.1.4 Volvariella volvacea V14 AAG59832.1
AEQ58914.1
Q9C3Z8   5
 endoglucanase I (EgI;NCel5A) (Cel5A) 3.2.1.4 Volvariella volvacea WX32 ACE06751.1     5
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