Activities in Sub Family	Endo-β-1,4-glucanase (EC 3.2.1.4);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (2130); Uniprot accession (61); PDB accession (35); 3D entries (9); cryst (0)

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Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
3328		Colletotrichum tofieldiae 0861 (Colto1)				5
8448		Colletotrichum tofieldiae 0861 (Colto1)				5
1261		Colletotrichum tofieldiae 0861 (Colto1)				5
1396		Colletotrichum tofieldiae 0861 (Colto1)				5
glycoside hydrolase family 5 protein		Coniochaeta hoffmannii CBS 245.38	AUS45833.1			5
glycoside hydrolase family 5 protein		Coniochaeta hoffmannii CBS 245.38	AUS45836.1			5
glycoside hydrolase family 5 protein		Coniochaeta hoffmannii CBS 245.38	AUS45855.1			5
glycoside hydrolase family 5 protein (fragment)		Coniochaeta hoffmannii CBS 245.38	AUS45852.1			5
glycoside hydrolase family 5 protein		Coniochaeta hoffmannii CBS 245.38	AUS45863.1			5
215192		Coniochaeta ligniaria NRRL 30616 v1 (Conlig1)				5
681989		Coniochaeta ligniaria NRRL 30616 v1 (Conlig1)				5
212701		Coniochaeta ligniaria NRRL 30616 v1 (Conlig1)				5
551248		Coniochaeta ligniaria NRRL 30616 v1 (Conlig1)				5
632289		Coniochaeta ligniaria NRRL 30616 v1 (Conlig1)				5
113058		Coniochaeta ligniaria R110-5 v1.0 (ColoR110_1)				5
128453		Coniochaeta ligniaria R110-5 v1.0 (ColoR110_1)				5
59185		Coniochaeta ligniaria R110-5 v1.0 (ColoR110_1)				5
77719		Coniochaeta ligniaria R110-5 v1.0 (ColoR110_1)				5
1161798		Coniochaeta sp. 2T2.1 v1.0 (Conioc1)				5
978641		Coniochaeta sp. 2T2.1 v1.0 (Conioc1)				5
317816		Coniochaeta sp. 2T2.1 v1.0 (Conioc1)				5
592926		Coniochaeta sp. 2T2.1 v1.0 (Conioc1)				5
981662		Coniochaeta sp. 2T2.1 v1.0 (Conioc1)				5
501816		Coniochaeta sp. 2T2.1 v1.0 (Conioc1)				5
977302		Coniochaeta sp. 2T2.1 v1.0 (Conioc1)				5
362917		Coniochaeta sp. 2T2.1 v1.0 (Conioc1)				5
377435		Coniochaeta sp. 2T2.1 v1.0 (Conioc1)				5
964546		Coniochaeta sp. 2T2.1 v1.0 (Conioc1)				5
921565		Coniophora olivacea MUCL 20566 v1.0 (Conol1)				5
850539		Coniophora olivacea MUCL 20566 v1.0 (Conol1)				5
809434		Coprinellus angulatus DOB1924 v1.0 (Copang1)				5
1066150		Coprinellus angulatus DOB1924 v1.0 (Copang1)				5
5449		Coprinopsis cinerea (Copci1)				5
61145		Coprinopsis cinerea AmutBmut pab1-1 (Copci_AmutBmut1)				5
225314		Coprinus sp. MPI-PUGE-AT-0042 v1.0 (Copph3)				5
1476658		Coprinus sp. MPI-PUGE-AT-0042 v1.0 (Copph3)				5
A9K55_009287		Cordyceps militaris ATCC 34164	ATY62125.1			5
9157		Cordyceps militaris CM01 (Cormi1)				5
42807		Corynascella inaequalis CBS 284.82 v1.0 (Corin1)				5
33938		Corynascella inaequalis CBS 284.82 v1.0 (Corin1)				5
50190		Corynascella inaequalis CBS 284.82 v1.0 (Corin1)				5
45564		Corynascella inaequalis CBS 284.82 v1.0 (Corin1)				5
12950		Corynascus novoguineensis CBS 359.72 v1.0 (Corno1)				5
39462		Corynascus novoguineensis CBS 359.72 v1.0 (Corno1)				5
29118		Corynascus novoguineensis CBS 359.72 v1.0 (Corno1)				5
328185		Corynespora cassiicola CCP v1 (Corca1)				5
576773		Corynespora cassiicola CCP v1 (Corca1)				5
482795		Crassisporium funariophilum DOB1098 v1.0 (Crafun1)				5
798368		Crassisporium funariophilum DOB1098 v1.0 (Crafun1)				5
667012		Crassisporium funariophilum DOB1098 v1.0 (Crafun1)				5
657849		Crassisporium funariophilum DOB1098 v1.0 (Crafun1)				5
782029		Crassisporium funariophilum DOB1098 v1.0 (Crafun1)				5
890716		Crepidotus variabilis CBS 506.95 v1.0 (Crevar1)				5
806866		Crepidotus variabilis CBS 506.95 v1.0 (Crevar1)				5
728641		Crucibulum laeve CBS 166.37 v1.0 (Crula1)				5
720527		Crucibulum laeve CBS 166.37 v1.0 (Crula1)				5
721851		Crucibulum laeve CBS 166.37 v1.0 (Crula1)				5
705065		Crucibulum laeve CBS 166.37 v1.0 (Crula1)				5
256970		Cryphonectria parasitica EP155 v2 (Crypa2)				5
51565		Cryphonectria parasitica EP155 v2 (Crypa2)				5
108403		Cryphonectria parasitica EP155 v2 (Crypa2)				5
65165		Cryphonectria parasitica EP155 v2 (Crypa2)				5
27471		Cryphonectria parasitica EP155 v2 (Crypa2)				5
L203_102794		Cryptococcus depauperatus CBS 7841	WVN87611.1			5
L204_102778		Cryptococcus depauperatus CBS 7855	WVO15134.1			5
IAR50_001741		Cryptococcus sp. DSM 104548	WVQ72195.1			5
carboxymethylcellulase (CsCMCase)	3.2.1.4	Cryptococcus sp. S-2	ABP02069.1	A4UU22		5
yc1106_02137		Curvularia clavata yc1106	USP74863.1			5
yc1106_03965		Curvularia clavata yc1106	USP76691.1			5
CcaverHIS002_0306910 (fragment)		Cutaneotrichosporon cavernicola HIS002	BEI82823.1			5
CcaverHIS019_0306830		Cutaneotrichosporon cavernicola HIS019	BEI90613.1			5
CcaverHIS631_0306900		Cutaneotrichosporon cavernicola HIS631	BEI98391.1			5
CcaverHIS641_0306860		Cutaneotrichosporon cavernicola HIS641	BEJ06164.1			5
CspHIS471_0307890		Cutaneotrichosporon sp. HIS471	BEJ13615.1			5
470546		Cyathus striatus AH 40144 v2.0 (Cyastr2)				5
1241585		Cyathus striatus AH 40144 v2.0 (Cyastr2)				5
1428531		Cyathus striatus AH 40144 v2.0 (Cyastr2)				5
1501364		Cyathus striatus AH 40144 v2.0 (Cyastr2)				5
1418611		Cyathus striatus AH 40144 v2.0 (Cyastr2)				5
387118		Cylindrobasidium torrendii FP15055 ss-10 (Cylto1)				5
356083		Cylindrobasidium torrendii FP15055 ss-10 (Cylto1)				5
371797		Cylindrobasidium torrendii FP15055 ss-10 (Cylto1)				5
160777		Cylindrocarpon olidum MPI-CAGE-CH-0241 v1.0 (Cylol1)				5
439831		Cylindrocarpon olidum MPI-CAGE-CH-0241 v1.0 (Cylol1)				5
404547		Cylindrocarpon olidum MPI-CAGE-CH-0241 v1.0 (Cylol1)				5
ORF (fragment)		Cylindrocarpon sp. 0629-017 3 A WA/MF06-299	CDL74333.1			5
1296073		Cytidiella melzeri FP 102339 v1.0 (Cytmel1)				5
1262989		Cytidiella melzeri FP 102339 v1.0 (Cytmel1)				5
1407714		Cytidiella melzeri FP 102339 v1.0 (Cytmel1)				5
1415127		Cytidiella melzeri FP 102339 v1.0 (Cytmel1)				5
646494		Dactylonectria estremocensis MPI-CAGE-AT-0021 (Daces1)				5
47671		Dactylonectria estremocensis MPI-CAGE-AT-0021 (Daces1)				5
587224		Dactylonectria estremocensis MPI-CAGE-AT-0021 (Daces1)				5
59705		Dactylonectria macrodidyma MPI-CAGE-AT-0147 v1.0 (Dacma1)				5
924509		Dactylonectria macrodidyma MPI-CAGE-AT-0147 v1.0 (Dacma1)				5
248742		Dactylonectria macrodidyma MPI-CAGE-AT-0147 v1.0 (Dacma1)				5
504369		Daldinia bambusicola CBS 122872 v1.0 (Dalba1)				5
96477		Daldinia bambusicola CBS 122872 v1.0 (Dalba1)				5
209232		Daldinia bambusicola CBS 122872 v1.0 (Dalba1)				5
304316		Daldinia caldariorum CBS 122874 v1.0 (Dalcal1)				5
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