Glycoside Hydrolase Family 5 / Subf 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (3604); Uniprot accession (276); PDB accession (20); 3D entries (9); cryst (0)
All (3208) Bacteria (3032) Eukaryota (174) unclassified (2) Structure (9) Characterized (60)
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 endoglucanase (Egl;EglA;azo2236) 3.2.1.4 Azoarcus sp. BH72 ABB92850.1
CAL94853.1
A0S6A6   5
 endoglucanase (Cel5D) 3.2.1.4 Martelella mediterranea WP_018063499.1     5
 endoglucanase (CelX) (Cel5M) 3.2.1.4 Pseudomonas sp. MM15 AEM45646.1     5
 endo-β-1,4-glucanase (Egl) 3.2.1.4 Ralstonia solanacearum AW AAA61980.1 P17974   5
 RSp0162 (Egl) 3.2.1.4 Ralstonia solanacearum GMI1000 ABG46712.1
CAD17313.1
NP_521723.1
P58599   5
 endoglucanase S (EndS) 3.2.1.4 Sinorhizobium meliloti M5N1CS AAG44364.1 Q9F0G8   5
 endoglucanase (RBcel1) 3.2.1.4 uncultured bacterium ACO55737.1 C1JI15 4EE9[A]
4M24[A]
5LJF[A,B]
5
 endo-β-1,4-glucanase (UmCel5A) (Cel5A) 3.2.1.4 uncultured bacterium ABB51612.1 Q308B6   5
 endoglucanase (XF2708;EGL) 3.2.1.4 Xylella fastidiosa 9a5c AAF85505.1
NP_299985.1
Q9PA12   5
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 endoglucanase 2 (Cmc2;FII-CMCase;FII CM-cellulase) 3.2.1.4 Aspergillus aculeatus F-50 BAA29030.1 O74169   5
 endo-β-1,4-glucanase V (FV CM-cellulase;Cel1) 3.2.1.4 Aspergillus aculeatus WO 94/14953 AAC08587.1 O59951   5
 endoglucanase / cellulase (Egl2) 3.2.1.4 Aspergillus fumigatus Z5 ADX78144.1     5
 endoglucanase / cellulase (Egl3) 3.2.1.4 Aspergillus fumigatus Z5 ADX78145.1     5
 endo-β-1,4-glucanase C (EglC) (Cel5B) 3.2.1.4 Aspergillus kawachii BAB62319.1 Q96WQ8   5
 endo-β-1,4-glucanase A (EglA) (Cel5A) 3.2.1.4 Aspergillus kawachii BAB62317.1 Q96WR0   5
 endo-β-1,4-glucanase A (EglA; AN1285.2) 3.2.1.4 Aspergillus nidulans FGSC A4 EAA65878.1
ABF50848.1
BAA82592.1
Q5BDU5   5
 endo-β-1,4-glucanase (AN5214.2) 3.2.1.4 Aspergillus nidulans FGSC A4 ABF50872.1
EAA62395.1
Q1HFS8   5
 endoglucanase B (EglB) 3.2.1.4 Aspergillus niger BCRC 31494 ACT68011.1 O74706   5
 endo-β-1,4-glucanase B (EglB) 3.2.1.4 Aspergillus niger CBS 120.49 / N400 AAE60102.1
AAE84292.1
CAA03653.1
CAA03658.1
CAA11965.1
O74706   5
 endo-β-1,4-glucanase B (EglB;An07g08950) 3.2.1.4 Aspergillus niger CBS 513.88 CAK45103.1 A2QPC3   5
 endo-β-1,4-glucanase (Eng1;EgI;AnCel5A) 3.2.1.4 Aspergillus niger IFO31125 AAG50051.1 O74706
Q9C3Z7
5I77[A]
5I78[A,B]
5I79[A,B]
5
 endo-β-1,4-glucanase (CelE) 3.2.1.4 Aspergillus oryzae KBN616 BAD72778.1 Q2UPQ4
Q5TKT6
  5
 endo-β-1,4-glucanase (Egl;ApCel5A) (Cel5A) 3.2.1.4 Aureobasidium pullulans ATCC 62921 / NRRL Y-2311-1 AEM23896.1     5
 cellulase (CelA;CsCelA) 3.2.1.4 Ciboria shiraiana AIC79156.1     5
 carboxymethylcellulase (CsCMCase) 3.2.1.4 Cryptococcus sp. S-2 ABP02069.1 A4UU22   5
 β-1,4-endoglucanase (GlCel5A;GL28282) (Cel5A) 3.2.1.4 Ganoderma lucidum     5D8W[A,B]
5D8Z[A,B]
5
 endo-β-1,4-glucanase (GtCel5A) (Cel5A) 3.2.1.4 Gloeophyllum trabeum ATCC 11539 ADH51728.1 D7REW1
P84194
  5
 endo-β-1,4-glucanase 3 (CMC3;Egl2) 3.2.1.4 Humicola grisea var. thermoidea IFO9854 BAA12676.1     5
 endo-β-1,4-glucanase IV (CMC3) 3.2.1.4 Humicola insolens ATCC 16454 CAA53631.1 Q12624   5
 endoglucanase (Cen1;En-1) 3.2.1.4 Irpex lacteus MC-2 BAD67544.1 Q5W7K4   5
 endo-β-1,4-glucanase 1 (Egl1) 3.2.1.4 Macrophomina phaseolina AAB51451.1 Q12638   5
 endo-β-1,4-glucanase 2 (Egl2) 3.2.1.4 Macrophomina phaseolina AAB03889.1 Q12637   5
 endo-β-1,4-glucanase (GH5-1;EG2;NCU00762) 3.2.1.4 Neurospora crassa OR74A CAE81955.1
ABZ29259.1
XP_324942.1
Q7SDR1   5
 endo-β-1,4-glucanase (EGb1;EGb2) (Cel5C) 3.2.1.4 Penicillium brasilianum IBT 20888 ACB06750.1 B8Q961   5
 endoglucanase II / 5A (Eg2;Egl2) (Cel5A) 3.2.1.4 Penicillium decumbens 114-2 / JU-A10 ABY28340.1 A9Z054   5
 endoglucanase 1 (Egl1;Pe-Egl1) (partial) 3.2.1.4 Penicillium echinulatum 9A01S2 ACR82487.1 C5J4L7   5
 endo-β-1,4-glucanase II (Egl2) 3.2.1.4 Penicillium janthinellum Biourge IMET 43733 (C41) CAA61740.1 Q12665   5
 endoglucanase (Cel5A) 3.2.1.4 Pestalotiopsis sp. AN 7 BAI66446.1 D2KTU9   5
 endo-β-1,4-glucanase (EgG5) 3.2.1.4 Phialophora sp. G5 / CGMCC 3328 ADZ44606.1     5
 endo-β-1,4-glucanase (PpCel5A) (Cel5A) 3.2.1.4 Postia placenta Mad-698-R ADH51729.1 D7REW2   5
 endo-β-1,4-glucanase (PpCel5B) (Cel5B) 3.2.1.4 Postia placenta Mad-698-R XP_002475436.1
ADH51730.1
D7REW3   5
 broad specificity endo-β-glucanase (Egl5A;TeEgl5A) 3.2.1.4 Rasamsonia emersonii CBS 394.64 AHV83755.1
CAJ75961.1
    5
 endo-β-1,4-glucanase (Eg1) 3.2.1.4 Rasamsonia emersonii IMI 392299 AAL33639.2
AAL33630.1
AAL33639.1
Q8WZD7   5
 endo-β-1,4-glucanase I (Eg1) 3.2.1.4 Robillarda sp. Y-20 BAA90480.1
JX0131
P23044
Q9P981
  5
 endo-β-1,4-glucanase 1 / carboxymethylcellulase 1 (Cmc1) 3.2.1.4 Saitozyma flava MUT-6 AAC60541.1
BAA03070.1
Q04469   5
 endo-β-1,4-glucanase I (EG1;EGI;EGII;SCHCODRAFT_40122) 3.2.1.4 Schizophyllum commune H4-8 EFI96731.1 P81190   5
 endo-β-1,4-glucanase 5A (TCE0_013f01292) (Cel5A) 3.2.1.4 Talaromyces cellulolyticus Y-94 GAM33994.1     5
 endo-β-1,4-glucanase 5 (Eng5) 3.2.1.4 Talaromyces pinophilus KMJ601 ACN43345.1 C0L2S4   5
 endoglucanase 2 (EG2;EGIIa) (partial) (Cel5A) 3.2.1.4 Talaromyces verruculosus B221-151     5L9C[A,B,C,D]
5I6S[A]
5
 endo-β-1,4-glucanase (Eg1;Eng1;TaCel5A) (Cel5A) 3.2.1.4 Thermoascus aurantiacus IFO 9748 AAL88714.2
AAL16412.1
ACE10214.1
CAT02251.1
CAZ67882.1
Q8TG26
Q96UI5
1GZJ[A,B]
1H1N[A,B]
5
 endo-β-1,4-glucanase (EG II;StCel5A;MYCTH_86753) (Cel5A) 3.2.1.4 Thermothelomyces thermophila ATCC 42464 AEO53769.1
AEM23898.1
    5
 endoglucanase (Eg-1) 3.2.1.4 Trametes hirsuta BAD01163.1
BAD01164.1
Q75UV6   5
 endoglucanase (TvEG) 3.2.1.4 Trametes versicolor       5
 endo-β-1,4-glucanase II (EG2;EGII;Egl2;EG-II;TrEGII;TrCel5A) (formerly EGIII) (Cel5A) 3.2.1.4 Trichoderma reesei AAA34213.1
AAQ24883.1
AAR60515.1
ABA64553.1
ABE22094.1
P07982 3QR3[A,B] 5
 endo-β-1,4-glucanase (C4endoII) 3.2.1.4 Trichoderma sp. C-4 AAR29981.1 Q6S4S0   5
 endoglucanase III (EG3;EGIII) 3.2.1.4 Trichoderma viride AS 3.3711 AAQ21383.1 Q7Z7X2   5
 endoglucanase VIII (EgvIII) 3.2.1.4 Trichoderma viride AS 3.3711 ACD36972.1 B4YEW2   5
 endo-β-1,4-glucanase II (Egl2) 3.2.1.4 Trichoderma viride MC300-1 BAA36216.1 O93833   5
 endoglucanase I (EG1;EGI) 3.2.1.4 Volvariella volvacea V14 AAG59832.1
AEQ58914.1
Q9C3Z8   5
 endoglucanase I (EgI;NCel5A) (Cel5A) 3.2.1.4 Volvariella volvacea WX32 ACE06751.1     5
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