Glycoside Hydrolase Family 5 / Subf 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (3604); Uniprot accession (276); PDB accession (20); 3D entries (9); cryst (0)
All (3208) Bacteria (3032) Eukaryota (174) unclassified (2) Structure (9) Characterized (60)
| 1 | 2 |
Eukaryota
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Agaricus arvensis FB-AA-61 CDL74346.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Agaricus comtulus FB-AC-01 CDL74349.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Agaricus xanthodermus FB-AX-06 CDL74330.1     5
 ORF (fragment)   Alternaria sp. 0602-001 2B PDA/MF06-192 CDL74328.1     5
 EgL (fragment)   Amanita armillariiformis AEQ58924.1     5
 EgL (fragment)   Amanita manicata AEQ58922.1     5
 EgL (fragment)   Amanita prairiicola AEQ58918.1     5
 EgL (fragment)   Amanita prairiicola AEQ58919.1     5
 EgL (fragment)   Amanita sp. sp-Ridley-2 AEQ58916.1     5
 EgL (fragment)   Amanita subcaligata AEQ58923.1     5
 EgL (fragment)   Amanita thiersii AEQ58917.1     5
 EgL (fragment)   Amanita vittadinii AEQ58921.1     5
 EGX49988.1   Arthrobotrys oligospora ATCC 24927 EGX49988.1     5
 EGX49194.1   Arthrobotrys oligospora ATCC 24927 EGX49194.1     5
 EGX47949.1   Arthrobotrys oligospora ATCC 24927 EGX47949.1     5
 EGX45346.1   Arthrobotrys oligospora ATCC 24927 EGX45346.1     5
 EGX46126.1 (fragment)   Arthrobotrys oligospora ATCC 24927 EGX46126.1     5
 endoglucanase II   Aspergillus aculeatus AAN16396.1
AAN75019.1
Q8J0N5
Q8J135
  5
 endoglucanase 2 (Cmc2;FII-CMCase;FII CM-cellulase) 3.2.1.4 Aspergillus aculeatus F-50 BAA29030.1 O74169   5
 endo-β-1,4-glucanase V (FV CM-cellulase;Cel1) 3.2.1.4 Aspergillus aculeatus WO 94/14953 AAC08587.1 O59951   5
 endoglucanase (CenA)   Aspergillus fumigatus WL002 AOY41714.1     5
 endoglucanase / cellulase (Egl2) 3.2.1.4 Aspergillus fumigatus Z5 ADX78144.1     5
 endoglucanase / cellulase (Egl3) 3.2.1.4 Aspergillus fumigatus Z5 ADX78145.1     5
 endo-β-1,4-glucanase C (EglC) (Cel5B) 3.2.1.4 Aspergillus kawachii BAB62319.1 Q96WQ8   5
 endo-β-1,4-glucanase A (EglA) (Cel5A) 3.2.1.4 Aspergillus kawachii BAB62317.1 Q96WR0   5
 endo-β-1,4-glucanase A (EglA; AN1285.2) 3.2.1.4 Aspergillus nidulans FGSC A4 EAA65878.1
ABF50848.1
BAA82592.1
Q5BDU5   5
 endo-β-1,4-glucanase (AN5214.2) 3.2.1.4 Aspergillus nidulans FGSC A4 ABF50872.1
EAA62395.1
Q1HFS8   5
 endoglucanase B (EglB) 3.2.1.4 Aspergillus niger BCRC 31494 ACT68011.1 O74706   5
 endo-β-1,4-glucanase B (EglB) 3.2.1.4 Aspergillus niger CBS 120.49 / N400 AAE60102.1
AAE84292.1
CAA03653.1
CAA03658.1
CAA11965.1
O74706   5
 An01g11670   Aspergillus niger CBS 513.88 CAK44069.1 A2QAI8   5
 endo-β-1,4-glucanase B (EglB;An07g08950) 3.2.1.4 Aspergillus niger CBS 513.88 CAK45103.1 A2QPC3   5
 endo-β-1,4-glucanase (EglA;An16g06800)   Aspergillus niger CBS 513.88 CAK42930.1 A2R8E0   5
 endo-β-1,4-glucanase (Eg1)   Aspergillus niger DL08 AHY00945.1     5
 endo-β-1,4-glucanase (Eng1;EgI;AnCel5A) 3.2.1.4 Aspergillus niger IFO31125 AAG50051.1 O74706
Q9C3Z7
5I77[A]
5I78[A,B]
5I79[A,B]
5
 endo-β-1,4-glucanase (CelE) 3.2.1.4 Aspergillus oryzae KBN616 BAD72778.1 Q2UPQ4
Q5TKT6
  5
 AO090005001553 (EglA)   Aspergillus oryzae RIB40 BAE56461.1 Q2UPQ4   5
 AO090011000715   Aspergillus oryzae RIB40 BAE65168.1 Q2TZU7   5
 endoglucanase   Aspergillus terreus SUK-1 AAW68436.2
AAW68436.1
Q5G1M1   5
 endo-β-1,4-glucanase (AuCel5A) (Cel5A)   Aspergillus usamii E001 AEY76081.1     5
 endo-β-1,4-glucanase (Egl;ApCel5A) (Cel5A) 3.2.1.4 Aureobasidium pullulans ATCC 62921 / NRRL Y-2311-1 AEM23896.1     5
 endo-β-1,4-glucanase   Bispora antennata AFY98622.1     5
 endo-β-1,4-glucanase (Cel5A)   Botrytis cinerea SAS56 AAT40313.1 Q6IVV6   5
 glycoside hydrolase family 5 protein (Bofut4_p059260.1)   Botrytis cinerea T4 CCD44346.1     5
 glycoside hydrolase family 5 protein (Bofut4_p112910.1) (fragment)   Botrytis cinerea T4 CCD47981.1     5
 cel5A, endo-β-1,4-glucanase precursor (Bofut4_p020810.1)   Botrytis cinerea T4 CCD51775.1     5
 cellulase (CelA;CsCelA) 3.2.1.4 Ciboria shiraiana AIC79156.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Cladosporium sp. 0629-033 2 WA Aa/MF06-304 CDL74329.1     5
 ORF (fragment)   Clonostachys rosea 0628-013 3 PDA/MF06-095 CDL74338.1     5
 Eg8-20   Clonostachys rosea f. catenulata HL-1-1 AFK10489.1     5
 ORF (fragment)   Colletotrichum coccodes 0629-022 1 A PDA/MF06-283 CDL74331.1     5
 ORF (fragment)   Colletotrichum coccodes 0629-022 1 A PDA/MF06-283 CDL74332.1     5
 carboxymethylcellulase (CsCMCase) 3.2.1.4 Cryptococcus sp. S-2 ABP02069.1 A4UU22   5
 ORF (fragment)   Cylindrocarpon sp. 0629-017 3 A WA/MF06-299 CDL74333.1     5
 ORF (fragment)   Epicoccum nigrum 0629-002 J 4 A B PDA/MF06-217 CDL74335.1     5
 ORF   Flammulina velutipes KACC 42777 ADX07304.1     5
 FFUJ_01844   Fusarium fujikuroi IMI 58289 CCT61678.1     5
 FFUJ_14767   Fusarium fujikuroi IMI 58289 CCT67754.1     5
 FFUJ_11390   Fusarium fujikuroi IMI 58289 CCT75371.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Fusarium graminearum 0656-004 2 A WA/MF06-059 CDL74336.1     5
 unnamed protein product   Fusarium graminearum PH-1 CEF73786.1     5
 endo-β-1,4-glucanase (FgCel5A;FGSG_03795;FG03795) (Cel5A)   Fusarium graminearum PH-1 CEF78665.1     5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Fusarium solani 0610-001 2 A WA/MF06-071 CDL74337.1     5
 β-1,4-endoglucanase (GlCel5A;GL28282) (Cel5A) 3.2.1.4 Ganoderma lucidum     5D8W[A,B]
5D8Z[A,B]
5
 endo-β-1,4-glucanase (Cel5G) (Cel5G)   Gloeophyllum trabeum AEJ35166.1     5
 endo-β-1,4-glucanase (GtCel5A) (Cel5A) 3.2.1.4 Gloeophyllum trabeum ATCC 11539 ADH51728.1 D7REW1
P84194
  5
 ORF (fragment)   Gloeoporus dichrous 133/Gd CDL74355.1     5
 glycoside hydrolase family 5 endoglucanase, partial (Glu-1) (fragment)   Grifola frondosa 136 CDL74353.1
CDL74354.1
    5
 ORF (fragment)   Heterobasidion annosum FB-HA-37 CDL74347.1     5
 predicted protein   Hordeum vulgare subsp. vulgare BAK01092.1     5
 endo-β-1,4-glucanase 3 (CMC3;Egl2) 3.2.1.4 Humicola grisea var. thermoidea IFO9854 BAA12676.1     5
 endo-β-1,4-glucanase IV (CMC3) 3.2.1.4 Humicola insolens ATCC 16454 CAA53631.1 Q12624   5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Hypholoma sp. 150 150/K 107 CDL74350.1     5
 endoglucanase II (EgII)   Hypocrea orientalis EU7-22 AFD50195.1     5
 ORF   Hypocrella siamensis MTCC 10142 ANH56493.1     5
 cellulase   Inonotus hispidus Haeb08 AIY53679.1     5
 endoglucanase (EG)   Inonotus obliquus JL01 AMK37824.1     5
 endoglucanase (Cen1;En-1) 3.2.1.4 Irpex lacteus MC-2 BAD67544.1 Q5W7K4   5
 ORF   Leptosphaeria maculans JN3 v23.1.3 CBX91913.1 E5R4E5   5
 endocellulase (Cel5A)   Leucoagaricus gongylophorus Ae322 CDJ79817.1     5
 endocellulase (Cel5B)   Leucoagaricus gongylophorus Ae322 CDJ79818.1     5
 EgL (fragment)   Limacella glischra AEQ58911.1     5
 EgL (fragment)   Limacella illinita AEQ58912.1     5
 endo-β-1,4-glucanase 1 (Egl1) 3.2.1.4 Macrophomina phaseolina AAB51451.1 Q12638   5
 endo-β-1,4-glucanase 2 (Egl2) 3.2.1.4 Macrophomina phaseolina AAB03889.1 Q12637   5
 MG00319.4   Magnaporthe oryzae 70-15 XP_368925.1 G4NCZ5   5
 MG10083.4   Magnaporthe oryzae 70-15 XP_365863.1 G4N908   5
 glycoside hydrolase family 5 endoglucanase, partial (fragment)   Marasmius oreades FB-MO-71 CDL74348.1     5
 ORF (fragment)   Microdochium bolleyi 0629-022 2 WA/MF06-285 CDL74339.1     5
 endo-β-1,4-glucanase (GH5-1;EG2;NCU00762) 3.2.1.4 Neurospora crassa OR74A CAE81955.1
ABZ29259.1
XP_324942.1
Q7SDR1   5
 endo-β-1,4-glucanase (EGb1;EGb2) (Cel5C) 3.2.1.4 Penicillium brasilianum IBT 20888 ACB06750.1 B8Q961   5
 endo-β-1,4-glucanase (Egl1)   Penicillium crustosum 601 AHA15977.1     5
 endoglucanase II / 5A (Eg2;Egl2) (Cel5A) 3.2.1.4 Penicillium decumbens 114-2 / JU-A10 ABY28340.1 A9Z054   5
 endoglucanase/cellulase 1   Penicillium digitatum Pd01 AFV30215.1     5
 endoglucanase 1 (Egl1;Pe-Egl1) (partial) 3.2.1.4 Penicillium echinulatum 9A01S2 ACR82487.1 C5J4L7   5
 endo-β-1,4-glucanase II (Egl2) 3.2.1.4 Penicillium janthinellum Biourge IMET 43733 (C41) CAA61740.1 Q12665   5
 endo-β-1,4-glucanase 5   Penicillium oxalicum GZ-2 AIO06744.1     5
 Pc18g06080   Penicillium rubens Wisconsin 54-1255 CAP94832.1 B6HCI5   5
 Pc20g01940   Penicillium rubens Wisconsin 54-1255 CAP85523.1 B6HE68   5
 Pc22g19230   Penicillium rubens Wisconsin 54-1255 CAP99211.1 B6HVQ6   5
 glycoside hydrolase family 5 endoglucanase, partial (Glu-1) (fragment)   Penicillium sp. 0728-003 B PDA/MF07-022 CDL74340.1     5
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