Activities in Sub Family	Endo-β-1,4-glucanase (EC 3.2.1.4);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (2130); Uniprot accession (61); PDB accession (35); 3D entries (9); cryst (0)

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Eukaryota
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
142997		Exophiala xenobiotica CBS118157 (Exoxe1)				5
Glycosyl hydrolase family 5, partial (fragment)		Feramyces austinii WSF2c	AWI66944.1			5
Glycosyl hydrolase family 5, partial (fragment)		Feramyces austinii WSF2c	AWI66944.1			5
3096		Fibroporia radiculosa TFFH 294 (Fibra1)				5
3097		Fibroporia radiculosa TFFH 294 (Fibra1)				5
4239		Fibroporia radiculosa TFFH 294 (Fibra1)				5
833029		Fibulorhizoctonia sp. CBS 109695 (Fibsp1)				5
1054246		Fibulorhizoctonia sp. CBS 109695 (Fibsp1)				5
1037627		Fibulorhizoctonia sp. CBS 109695 (Fibsp1)				5
970429		Fibulorhizoctonia sp. CBS 109695 (Fibsp1)				5
1053206		Fibulorhizoctonia sp. CBS 109695 (Fibsp1)				5
921170		Fibulorhizoctonia sp. CBS 109695 (Fibsp1)				5
42918		Fibulorhizoctonia sp. CBS 109695 (Fibsp1)				5
1044681		Fibulorhizoctonia sp. CBS 109695 (Fibsp1)				5
883434		Fibulorhizoctonia sp. CBS 109695 (Fibsp1)				5
1048204		Fibulorhizoctonia sp. CBS 109695 (Fibsp1)				5
362269		Filobasidium floriforme CBS 6241 v1.0 (Filflo1)				5
358457		Filobasidium floriforme CBS 6241 v1.0 (Filflo1)				5
23928		Fistulina hepatica (Fishe1)				5
ORF		Flammulina velutipes KACC 42777	ADX07304.1			5
1315848		Fomes fomentarius CIRM-BRFM 1821 (Fomfom1)				5
1046328		Fomes fomentarius CIRM-BRFM 1821 (Fomfom1)				5
1364695		Fomes fomentarius CIRM-BRFM 1821 (Fomfom1)				5
118222		Fomitiporia mediterranea MF3/22 (Fomme1)				5
19081		Fomitiporia mediterranea MF3/22 (Fomme1)				5
165730		Fomitiporia mediterranea MF3/22 (Fomme1)				5
880312		Fomitopsis betulina (Piptoporus betulinus) CIRM-BRFM 1772 v1.1 (Pipbet1_1)				5
299825		Fomitopsis betulina (Piptoporus betulinus) CIRM-BRFM 1772 v1.1 (Pipbet1_1)				5
880315		Fomitopsis betulina (Piptoporus betulinus) CIRM-BRFM 1772 v1.1 (Pipbet1_1)				5
100175		Fomitopsis pinicola FP-58527 SS1 v3 (Fompi3)				5
142907		Fomitopsis pinicola FP-58527 SS1 v3 (Fompi3)				5
115275		Fomitopsis pinicola FP-58527 SS1 v3 (Fompi3)				5
CLAFUW4_05834		Fulvia fulva 2 4 5 9 11 IPO	WPV15282.1			5
CLAFUW4_02615		Fulvia fulva 2 4 5 9 11 IPO	WPV11595.1			5
CLAFUW7_02615		Fulvia fulva 2 4 9 11	WPV26116.1			5
CLAFUW7_05832		Fulvia fulva 2 4 9 11	WPV30315.1			5
CLAFUR5_02603		Fulvia fulva Race5_Kim	UJO13511.1			5
CLAFUR5_05976		Fulvia fulva Race5_Kim	UJO17226.1			5
QYS62_007888		Fusarium acuminatum	WZH46780.1			5
QYS62_000193		Fusarium acuminatum	WZH39284.1			5
615673		Fusarium tricinctum MPI-SDFR-AT-0044 (Fustri1)				5
544013		Fusarium tricinctum MPI-SDFR-AT-0044 (Fustri1)				5
633091		Fusarium tricinctum MPI-SDFR-AT-0044 (Fustri1)				5
564472		Fusarium commune MPI-SDFR-AT-0072 (Fusco1)				5
402729		Fusarium commune MPI-SDFR-AT-0072 (Fusco1)				5
68759		Fusarium commune MPI-SDFR-AT-0072 (Fusco1)				5
HYE67_002098		Fusarium culmorum Class2-1B	QPC59867.1			5
HYE67_009589		Fusarium culmorum Class2-1B	QPC67358.1			5
NCS54_01401100		Fusarium falciforme Fu3.1	WAO96341.1			5
NCS54_00325400		Fusarium falciforme Fu3.1	WAO86000.1			5
NCS54_00014800		Fusarium falciforme Fu3.1	WAO82969.1			5
CEK26_000218		Fusarium fujikuroi Augusto2	QGI89003.1			5
CEK26_007748		Fusarium fujikuroi Augusto2	QGI94679.1			5
CEK26_002998		Fusarium fujikuroi Augusto2	QGJ01554.1			5
CEK27_002993		Fusarium fujikuroi CSV1	QGI70664.1			5
CEK27_007768		Fusarium fujikuroi CSV1	QGI63797.1			5
CEK27_000215		Fusarium fujikuroi CSV1	QGI58090.1			5
CEK25_007798		Fusarium fujikuroi I1.3	QGI81069.1			5
CEK25_000214		Fusarium fujikuroi I1.3	QGI75308.1			5
CEK25_002964		Fusarium fujikuroi I1.3	QGI88008.1			5
FFUJ_01844		Fusarium fujikuroi IMI 58289	CCT61678.1			5
FFUJ_14767		Fusarium fujikuroi IMI 58289	CCT67754.1			5
FFUJ_11390		Fusarium fujikuroi IMI 58289	CCT75371.1			5
13917		Fusarium fujikuroi IMI 58289 (Fusfu1)				5
248		Fusarium fujikuroi IMI 58289 (Fusfu1)				5
6395		Fusarium fujikuroi IMI 58289 (Fusfu1)				5
FGRAMCML3066_01t13797.1		Fusarium graminearum	CZS81956.1			5
FGRAMCML3066_01t03989.1		Fusarium graminearum	CZS77052.1			5
glycoside hydrolase family 5 endoglucanase, partial (fragment)		Fusarium graminearum 0656-004 2 A WA/MF06-059	CDL74336.1			5
SNK03_006531 (Gh51)		Fusarium graminearum KSU23473	WXC60646.1			5
SNK03_001863 (fragment)		Fusarium graminearum KSU23473	WXC55919.1			5
QX201_001869 (fragment)		Fusarium graminearum KSU23522	WXC42084.1			5
QX201_006539 (Gh51)		Fusarium graminearum KSU23522	WXC46817.1			5
unnamed protein product		Fusarium graminearum PH-1	CEF73786.1			5
endo-β-1,4-glucanase (FgCel5A;FGSG_03795;FG03795) (Cel5A)		Fusarium graminearum PH-1	CEF78665.1			5
1874		Fusarium graminearum v1.0 (Fusgr1)				5
4305		Fusarium graminearum v1.0 (Fusgr1)				5
808202		Fusarium oxysporum f. sp. albedinis isolate 9 v1.0 (Fusoxalb1)				5
909552		Fusarium oxysporum f. sp. albedinis isolate 9 v1.0 (Fusoxalb1)				5
156493		Fusarium oxysporum f. sp. albedinis isolate 9 v1.0 (Fusoxalb1)				5
12558		Fusarium oxysporum f. sp. conglutinans race 2 54008 (PHW808) (Fusoxcon1)				5
2565		Fusarium oxysporum f. sp. conglutinans race 2 54008 (PHW808) (Fusoxcon1)				5
1157		Fusarium oxysporum f. sp. conglutinans race 2 54008 (PHW808) (Fusoxcon1)				5
9923		Fusarium oxysporum f. sp. cubense tropical race 4 54006 (II5) (Fusoxcub1)				5
189		Fusarium oxysporum f. sp. cubense tropical race 4 54006 (II5) (Fusoxcub1)				5
14273		Fusarium oxysporum f. sp. cubense tropical race 4 54006 (II5) (Fusoxcub1)				5
19470		Fusarium oxysporum f. sp. lycopersici 4287 v2 (Fusox2)				5
6908		Fusarium oxysporum f. sp. lycopersici 4287 v2 (Fusox2)				5
10513		Fusarium oxysporum f. sp. lycopersici 4287 v2 (Fusox2)				5
23021		Fusarium oxysporum f. sp. lycopersici MN25 (FoMN25) NRRL 54003 (Fusoxlyc1)				5
4504		Fusarium oxysporum f. sp. lycopersici MN25 (FoMN25) NRRL 54003 (Fusoxlyc1)				5
12529		Fusarium oxysporum f. sp. lycopersici MN25 (FoMN25) NRRL 54003 (Fusoxlyc1)				5
22187		Fusarium oxysporum f. sp. melonis (FoMelon) NRRL 26406 (Fusoxmel1)				5
8414		Fusarium oxysporum f. sp. melonis (FoMelon) NRRL 26406 (Fusoxmel1)				5
369		Fusarium oxysporum f. sp. melonis (FoMelon) NRRL 26406 (Fusoxmel1)				5
25799		Fusarium oxysporum f. sp. pisi HDV247 (Fusoxpis1)				5
5541		Fusarium oxysporum f. sp. pisi HDV247 (Fusoxpis1)				5
3125		Fusarium oxysporum f. sp. pisi HDV247 (Fusoxpis1)				5
4180		Fusarium oxysporum f. sp. radicis-lycopersici 26381 (CL57) (Fusoxrad1)				5
8638		Fusarium oxysporum f. sp. radicis-lycopersici 26381 (CL57) (Fusoxrad1)				5
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