Glycoside Hydrolase Family 5 / Subf 1

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (510); Uniprot accession (102); PDB accession (15); 3D entries (3); cryst (0)
| 1 | 2 | 3 | 4 | 5 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 B9T62_20790   Paenibacillus donghaensis KCTC 13049 ASA23029.1     1
 PGRAT_15895   Paenibacillus graminis DSM 15220 AIQ68937.1     1
 B4V02_07145   Paenibacillus kribbensis AM49 ASR46467.1     1
 ABE82_18415   Paenibacillus peoriae HS311 ALA43361.1     1
 endo-β-1,4-glucanase 3.2.1.4 Paenibacillus polymyxa AAA22631.1
AAY03292.1
P23548   1
 VK72_18980   Paenibacillus polymyxa ATCC 15970 APQ60649.1     1
 LK13_05715   Paenibacillus polymyxa CF05 AIY08118.1     1
 X809_19500   Paenibacillus polymyxa CR1 AHC21187.1
AIW41095.1
    1
 PPE_03461   Paenibacillus polymyxa E681 ADM71278.1 E0RKS1   1
 AOU00_05595   Paenibacillus polymyxa J AOK89338.1     1
 PPM_3722 (CelA3)   Paenibacillus polymyxa M1 CCI70531.1     1
 RE92_18740   Paenibacillus polymyxa Sb3-1 AJE52931.1     1
 PPSC2_c3966   Paenibacillus polymyxa SC2 ADO57917.1 E3E5P0   1
 PPSQR21_037080   Paenibacillus polymyxa SQR-21 SQR21 AHM67346.1     1
 PPYC1_07190   Paenibacillus polymyxa YC0136 APB70154.1     1
 PPYC2_07570   Paenibacillus polymyxa YC0573 APB74847.1     1
 PRIO_3446   Paenibacillus riograndensis SBR5 CQR55849.1     1
 BBD42_25070   Paenibacillus sp. BIHB4019 ANY69390.1     1
 P40081_04040   Paenibacillus sp. FSL P4-0081 AIQ27461.1     1
 R50912_03665   Paenibacillus sp. FSL R5-0912 AIQ39244.1     1
 endo-β-1,4-glucanase (Endo5A) 3.2.1.4 Paenibacillus sp. ICGEB2008 / MTCC 5639 AEB00655.1     1
 ASL14_19880   Paenibacillus sp. IHB B 3084 ALP38105.1     1
 endo-β-1,4-glucanase (Egl) 3.2.1.4 Paenibacillus sp. KCTC8848P AAL83749.1 Q8RPZ3   1
 HPL003_26960   Paenibacillus terrae HPL-003 AET62104.1     1
 SAMN04489860_0019   Paraoerskovia marina DSM 22126 SDR77692.1     1
 AAW51_2245   [Polyangium] brachysporum DSM 7029 AKJ28936.1     1
 Riv7116_4185   Rivularia sp. PCC 7116 AFY56617.1     1
 Riv7116_0722   Rivularia sp. PCC 7116 AFY53310.1     1
 RD2015_747   Roseateles depolymerans KCTC 42856 ALV05243.1     1
 RD2015_749   Roseateles depolymerans KCTC 42856 ALV05245.1     1
 RGI145_02340   Roseomonas gilardii U14-5 APT56123.1     1
 AD2_02839   Ruminiclostridium thermocellum AD2 ALX09817.1     1
 AD2_01719   Ruminiclostridium thermocellum AD2 ALX08709.1     1
 AD2_00416   Ruminiclostridium thermocellum AD2 ALX07424.1     1
 AD2_01837   Ruminiclostridium thermocellum AD2 ALX08827.1     1
 Cthe_0405 (CelL)   Ruminiclostridium thermocellum ATCC 27405 ABN51643.1 A3DCG4   1
 endo-β-1,4-glucanase B (CelB;EgB;Cthe_0536) (Cel5A) 3.2.1.4 Ruminiclostridium thermocellum ATCC 27405 ABN51772.1 P04956   1
 Cthe_2147 (CelO) (Cel5F)   Ruminiclostridium thermocellum ATCC 27405 ABN53350.1 A3DHC1   1
 endo-β-1,4-glucanase G (CelG;Cthe_2872) (Cel5D) 3.2.1.4 Ruminiclostridium thermocellum ATCC 27405 ABN54070.1 Q05332   1
 Clo1313_1701   Ruminiclostridium thermocellum DSM 1313 ADU74758.1     1
 Clo1313_1816   Ruminiclostridium thermocellum DSM 1313 ADU74872.1     1
 Clo1313_2805   Ruminiclostridium thermocellum DSM 1313 ADU75785.1     1
 Clo1313_0413   Ruminiclostridium thermocellum DSM 1313 ADU73502.1     1
 LQRI_1836   Ruminiclostridium thermocellum DSM 2360 LQRI ANV76577.1     1
 LQRI_1720   Ruminiclostridium thermocellum DSM 2360 LQRI ANV76461.1     1
 LQRI_2850   Ruminiclostridium thermocellum DSM 2360 LQRI ANV77591.1     1
 LQRI_0416   Ruminiclostridium thermocellum DSM 2360 LQRI ANV75163.1     1
 endo-1,4-β-glucanase (CelL)   Ruminiclostridium thermocellum F7 CAK18680.1 Q1JR84   1
 cellobiohydrolase (CelO) (Cel5F) 3.2.1.91 Ruminiclostridium thermocellum F7 CAB76938.1 Q9L3J2   1
 endo-β-1,4-glucanase B (CelB;EgB) (Cel5A) 3.2.1.4 Ruminiclostridium thermocellum NCIB 10682 CAA27266.1 P04956   1
 endo-β-1,4-glucanase G (CelG) (Cel5D) 3.2.1.4 Ruminiclostridium thermocellum NCIB 10682 CAA49187.1 Q05332   1
 Rumal_1049   Ruminococcus albus 7 = DSM 20455 ADU21575.1 E0L9A2   1
 Rumal_2017   Ruminococcus albus 7 = DSM 20455 ADU22510.1 E0LAT0   1
 Rumal_2777   Ruminococcus albus 7 = DSM 20455 ADU23246.1 E0L654   1
 cellulase (Cel5G)   Ruminococcus albus 8 AAT48117.1 Q6GVN1   1
 lichenase (Ra2830;CUS_5609) 3.2.1.73 Ruminococcus albus 8 EGC04285.1
ZP_08157835.1
    1
 RBI_I00497   Ruminococcus bicirculans 80/3 CCO04221.1     1
 endo-β-1,4-glucanase (GH5B;RUM_06330) (Cel5B) 3.2.1.4 Ruminococcus champanellensis 18P13 = JCM 17042 CBL16847.1 D4LB52   1
 Strop_2684   Salinispora tropica CNB-440 ABP55128.1 A4X8C8   1
 SAMD00079811_23510   Scytonema sp. HK-05 NIES-2130 BAY44749.1     1
 SAMD00079811_39570   Scytonema sp. HK-05 NIES-2130 BAY46348.1     1
 NIES4073_72930   Scytonema sp. NIES-4073 BAZ26387.1     1
 NIES4073_56600   Scytonema sp. NIES-4073 BAZ24761.1     1
 SVI_0875   Shewanella violacea DSS12 BAJ00846.1 D4ZGP7   1
 M5M_14915   Simiduia agarivorans SA1 = DSM 21679 AFV00118.1
AFV00107.2
    1
 STHERM_c20620 (StX;StCBM64A) 3.2.1.4 Spirochaeta thermophila DSM 6192 ADN02996.1 E0RQU0   1
 Spith_2109   Spirochaeta thermophila DSM 6578 AEJ62365.1     1
 BV401_21515   Streptomyces autolyticus CGMCC0516 AQA12639.1     1
 SBI_05889   Streptomyces bingchenggensis BCW-1 ADI09009.1 D7CGA5   1
 SHXM_05206   Streptomyces hygroscopicus XM201 AQW51743.1     1
 SIRAN5394   Streptomyces iranensis CDR08747.1     1
 SLINC_3798   Streptomyces lincolnensis NRRL 2936 ANS66022.1     1
 SMALA_3611   Streptomyces malaysiensis DSM 4137 ATL83845.1     1
 SNOD_15095   Streptomyces nodosus ATCC 14899 AJE41211.1     1
 Sfla_0913   Streptomyces pratensis ATCC 33331 ADW02371.1 C9NB23   1
 M271_26970   Streptomyces rapamycinicus NRRL 5491 AGP56864.1     1
 A4G23_00273   Streptomyces rubrolavendulae MJM4426 AOT57484.1     1
 SCAB_51081   Streptomyces scabiei 87.22 CBG72151.1 C9YTK2   1
 CGL27_22625   Streptomyces sp. 11-1-2 ASQ95494.1     1
 SAMN05444521_4982   Streptomyces sp. 3124.6 SHI18454.1     1
 AS200_25685   Streptomyces sp. CdTB01 ALV35061.1     1
 F750_5941   Streptomyces sp. PAMC 26508 AGJ58369.1     1
 A4E84_17785   Streptomyces sp. S10(2016) AMW11190.1     1
 Strvi_8930   Streptomyces violaceusniger Tu 4113 AEM88231.1     1
 SCL_1792   Sulfuricaulis limicola HA5 BAV34090.1     1
 TJEJU_3612   Tenacibaculum jejuense KCTC 22618 SNR17255.1     1
 TERTU_3565   Teredinibacter turnerae T7901 ACR11017.1 C5BRI4   1
 endoglucanase (EGtf2) (Cel5B) 3.2.1.4 Thermobifida fusca TM51 AAP56348.1 Q7X2N2   1
 endoglucanase 5B (Tfu_2712) (Cel5B) 3.2.1.4 Thermobifida fusca YX AAZ56745.1 Q47LC7   1
 multidomain cellulase   thermophilic anaerobe NA10 BAA22939.1 O24820   1
 endocellulase (CelA) (Cel5A) 3.2.1.4 Thermus caldophilus GK24 AAK60011.1 Q93Q07   1
 TCCBUS3UF1_1700   Thermus sp. CCB_US3_UF1 AEV15219.1     1
 Trad_1441   Truepera radiovictrix DSM 17093 ADI14563.1 D7CX55   1
 CelE2, partial   uncultured bacterium ANN44164.1     1
 VAB18032_22475   Verrucosispora maris AB-18-032 AEB45595.1     1
 XALc_2967   Xanthomonas albilineans GPE PC73 CBA17444.1     1
 XALc_2969   Xanthomonas albilineans GPE PC73 CBA17446.1     1
 AKJ12_08070   Xanthomonas arboricola pv. juglandis Xaj 417 AKU49746.1     1
 XAC0612 (EngXCA)   Xanthomonas axonopodis pv. citri str. 306 AAM35501.1
NP_640965.1
Q8PPS3   1
 XACM_0615 (EngxcA)   Xanthomonas axonopodis pv. citrumelo F1 AEO40920.1     1
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