Glycoside Hydrolase Family 5 / Subf 1

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (491); Uniprot accession (102); PDB accession (15); 3D entries (3); cryst (0)
Archaea
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 endo-β-1,4-glucanase (EglB;TCel4;PAB0632) 3.2.1.4 Pyrococcus abyssi GE5 CAB49854.1
AEG76944.1
NP_126623.1
Q9V052   1
 endo-β-1,4-glucanase (EGPh;EglB;TCel3;PH1171) 3.2.1.4 Pyrococcus horikoshii OT3 AAQ31833.1
AAQ31832.1
BAA30271.1
NP_143072.1
O58925 2ZUM[A]
2ZUN[A,B,C]
3AXX[A,B,C]
3QHM[A,B,C]
3QHN[A,B,C]
3QHO[A,B,C]
3VVG[A,B,C]
3W6L[A,B,C]
3W6M[A,B,C]
4DM1[A,B,C]
4DM2[A,B,C]
1
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 endo-β-1,4-glucanase E1 (EGAc;EGI;TcE1;Acel_0614) (Cel5A) 3.2.1.4 Acidothermus cellulolyticus 11B AAA75477.1
ABH84883.1
ABK52387.1
ACW33392.1
CAD42489.1
CAR96693.1
P54583 1C0D[A,B]
1ECE[A,B]
1VRX[A,B]
1
 endo-β-1,4-glucanase (Egl;AZC_1301) 3.2.1.4 Azorhizobium caulinodans ORS 571 BAF87299.1 A8I0V5   1
 endoglucanase (Cel17) (Cel5B) 3.2.1.4 bacterium enrichment culture clone FXVII-Cel5B AEL31247.1     1
 Athe_1866 (CelB;CbMan5C/Cel5A) (Man5C-Cel5A) 3.2.1.4 Caldicellulosiruptor bescii DSM 6725 ACM60954.1
CAB06784.1
B9MKU6
P96310
  1
 endo-β-1,4-glucanase / exo-β-1,4-glucanase (CelB;EgB) 3.2.1.4 Caldicellulosiruptor saccharolyticus CAA31936.1
A43802
P10474   1
 cellulase (CBH-B;CelB;Csac_1078) 3.2.1.4 Caldicellulosiruptor saccharolyticus DSM 8903 ABP66692.1 A4XIF7   1
 endo-β-1,4-glucanase D (CenD;Celf_1924) (Cel5A) 3.2.1.4 Cellulomonas fimi ATCC 484 AAA23089.1
AEE46054.1
P50400   1
 endo-β-1,4-glucanase B (CelB;CflB;CelCflB;SP18) 3.2.1.4 Cellulomonas flavigena CDBB-531 AAD48494.3
AAD48494.2
Q9S3V3   1
 bifunctional cellulase / expansin (CelA;pCM1_0020) 3.2.1.4 Clavibacter michiganensis subsp. michiganensis NCPPB 382 CAA44467.2
CAM98473.1
Q9K5C7   1
 cellulase (CelA;pCS0061) 3.2.1.4 Clavibacter michiganensis subsp. sepedonicus ATCC33113 AAK16222.1
CAQ03244.1
B0RJ54
Q9AF65
  1
 CMCase (P66;Ccel_2337) 3.2.1.4 [Clostridium] cellulolyticum H10 ACL76673.1 B8I5D7   1
 cellulase N (CelN; Ccel_0740) (Cel5N) 3.2.1.4 [Clostridium] cellulolyticum H10 ACL75118.1
AAG45162.1
B8I7W1
Q9EYQ0
  1
 endo-β-1,4-glucanase 5A (CpCel5A;Cphy_1163) (Cel5A) 3.2.1.4 Lachnoclostridium phytofermentans ISDg ABX41541.1 A9KN42   1
 endo-β-1,4-glucanase 3.2.1.4 Paenibacillus polymyxa AAA22631.1
AAY03292.1
P23548   1
 endo-β-1,4-glucanase (Endo5A) 3.2.1.4 Paenibacillus sp. ICGEB2008 / MTCC 5639 AEB00655.1     1
 endo-β-1,4-glucanase (Egl) 3.2.1.4 Paenibacillus sp. KCTC8848P AAL83749.1 Q8RPZ3   1
 endo-β-1,4-glucanase B (CelB;EgB;Cthe_0536) (Cel5A) 3.2.1.4 Ruminiclostridium thermocellum ATCC 27405 ABN51772.1 P04956   1
 endo-β-1,4-glucanase G (CelG;Cthe_2872) (Cel5D) 3.2.1.4 Ruminiclostridium thermocellum ATCC 27405 ABN54070.1 Q05332   1
 cellobiohydrolase (CelO) (Cel5F) 3.2.1.91 Ruminiclostridium thermocellum F7 CAB76938.1 Q9L3J2   1
 endo-β-1,4-glucanase B (CelB;EgB) (Cel5A) 3.2.1.4 Ruminiclostridium thermocellum NCIB 10682 CAA27266.1 P04956   1
 endo-β-1,4-glucanase G (CelG) (Cel5D) 3.2.1.4 Ruminiclostridium thermocellum NCIB 10682 CAA49187.1 Q05332   1
 lichenase (Ra2830;CUS_5609) 3.2.1.73 Ruminococcus albus 8 EGC04285.1
ZP_08157835.1
    1
 endo-β-1,4-glucanase (GH5B;RUM_06330) (Cel5B) 3.2.1.4 Ruminococcus champanellensis 18P13 = JCM 17042 CBL16847.1 D4LB52   1
 STHERM_c20620 (StX;StCBM64A) 3.2.1.4 Spirochaeta thermophila DSM 6192 ADN02996.1 E0RQU0   1
 endoglucanase (EGtf2) (Cel5B) 3.2.1.4 Thermobifida fusca TM51 AAP56348.1 Q7X2N2   1
 endoglucanase 5B (Tfu_2712) (Cel5B) 3.2.1.4 Thermobifida fusca YX AAZ56745.1 Q47LC7   1
 endocellulase (CelA) (Cel5A) 3.2.1.4 Thermus caldophilus GK24 AAK60011.1 Q93Q07   1
 endo-β-1,4-glucanase (EngXCA;EngA) (frameshift) 3.2.1.4 Xanthomonas campestris pv. campestris CAC18529.1
AAA27612.1
Q9EVR6 4TUF[A,B,C,D] 1
 endo-β-1,4-glucanase (EngXCA;XccEG;XCC3521) 3.2.1.4 Xanthomonas campestris pv. campestris str. ATCC 33913 AAM42791.1
NP_638867.1
P19487   1
 endo-β-1,4-glucanase 3.2.1.4 Xanthomonas sp. EC102 ACU30064.1 C7FFK1   1
 endoglucanase (XF0818) 3.2.1.4 Xylella fastidiosa 9a5c AAF83628.1
NP_298108.1
Q9PF60   1
unclassified
Protein Name EC#OrganismGenBank UniprotPDB/3DSubf
 β-glucanase 3.2.1.4 uncultured organism ADD61853.1 D9ZEU9   1
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