Activities in Sub Family	Endo-β-1,4-glucanase (EC 3.2.1.4); Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); Exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74);
Mechanism	Retaining e
Clan	GH-A
3D Structure Status	( β / α ) 8 barrel
Catalytic Nucleophile/Base	Glu (experimental)
Catalytic Proton Donor	Glu (experimental)
Note	Once known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resources	CAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)	MEGAZYME; NZYTech; PROZOMIX;
Statistics	GenBank accession (59); Uniprot accession (38); PDB accession (16); 3D entries (4); cryst (0)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
DMT42_17410		Streptomyces actuosus ATCC 25421	AWT43919.1			1
K1J60_24550		Streptomyces akebiae MG28	QYX79266.1			1
HCX60_17935		Streptomyces antibioticus DSM 41481	QIT45197.1			1
QR300_23345		Streptomyces antimycoticus FIM95-F1	WJD98674.1			1
G9272_20660		Streptomyces asoensis H2S5	QJT02436.1			1
O1Q96_41955		Streptomyces aurantiacus Qhu-M197	WAU85695.1			1
BV401_21515		Streptomyces autolyticus CGMCC0516	AQA12639.1			1
SBI_05889		Streptomyces bingchenggensis BCW-1	ADI09009.1			1
EJC51_22575		Streptomyces brunneus CR22	AZP18627.1			1
IHE65_25055		Streptomyces caniscabiei ID-03-3A	WEO26168.1			1
OG925_27830		Streptomyces canus NBC_01585	WSD87860.1			1
NRO40_02095		Streptomyces changanensis HL-66	UUS29741.1			1
CP983_23840		Streptomyces chartreusis ATCC 14922	QEV69388.1			1
HUT05_27190		Streptomyces chartreusis NA02069	QKZ20711.1			1
CP976_19730		Streptomyces coeruleorubidus ATCC 13740	QEV26146.1			1
PV963_20215		Streptomyces coeruleorubidus DM	WDV52531.1			1
R5U08_15985		Streptomyces coeruleorubidus WT-48	WOT35539.1			1
RFN52_17655		Streptomyces collinus CGMCC 4.1623	WMX65086.1			1
QU709_23665		Streptomyces coralus SX92	WLW54167.1			1
EJ357_20285		Streptomyces cyaneochromogenes MK-45	AZQ35546.1			1
L3078_20215		Streptomyces deccanensis KCTC 19241	ULR51437.1			1
NEH16_01035		Streptomyces drozdowiczii MDA8-470	UZK52885.1			1
GFH48_02005		Streptomyces fagopyri QMT-28	QFZ72191.1			1
IM697_03885		Streptomyces ferrugineus CCTCC AA2014009	QOV37582.1			1
CP974_01435		Streptomyces fradiae ATCC 10745 = DSM 40063	QEV15437.1			1
RYQ63_12495		Streptomyces fradiae FIMYZ-003	WOI60654.1			1
CP966_16165		Streptomyces galilaeus ATCC 14969	QEU66631.1			1
IAG43_25170		Streptomyces genisteinicus CRPJ-33	QNP65896.1			1
GCM10017557_36970		Streptomyces glomeroaurantiacus JCM 4677	BCL28838.1			1
test1122_03885		Streptomyces gobiensis 1_25	UGY90949.1			1
SGFS_055000		Streptomyces graminofaciens A-8890	BBC34206.1			1
V9K83_18540		Streptomyces griseoaurantiacus XQ-29	WWY86050.1			1
HEP81_00535		Streptomyces griseofuscus DSM 40191	QNT90871.1			1
DWG14_04720		Streptomyces griseorubiginosus 3E-1	AYC40455.1			1
ELQ87_21620		Streptomyces griseoviridis F1-27	AZS86563.1			1
DDJ31_17645		Streptomyces griseoviridis K61	QCN86574.1			1
CEB94_18200		Streptomyces hawaiiensis ATCC 12236	QCD56575.1			1
V8J11_18270		Streptomyces hygroscopicus subsp. hygroscopicus DSM 41954	WXA07514.1			1
SHXM_05206		Streptomyces hygroscopicus XM201	AQW51743.1			1
RFN58_19300		Streptomyces iakyrus CGMCC 4.1912	WVG03114.1			1
SIRAN5394		Streptomyces iranensis	CDR08747.1			1
RI060_23785		Streptomyces janthinus JCM 4387	WND20175.1			1
KJK29_21125		Streptomyces koelreuteriae MG62	QWB24882.1			1
J3S85_33045		Streptomyces lavenduligriseus Tu901	WDM15903.1			1
JEQ17_20825		Streptomyces liliifuscus ZYC-3	QQM41653.1			1
GJU35_25075		Streptomyces lincolnensis B48	QMV08590.1			1
SLCG_3059		Streptomyces lincolnensis LC-G	AXG54214.1			1
SLINC_3798		Streptomyces lincolnensis NRRL 2936	ANS66022.1			1
DNK48_25160		Streptomyces malaysiensis DSM 4137	QDL72111.1 ATL83845.1			1
R8789_25920		Streptomyces malaysiensis NA3722	WPB92375.1			1
POD33_13640		Streptomyces moderatus DT446	WCH93101.1			1
GO605_16705		Streptomyces murinus CR-43	UWW96027.1			1
CP978_15410		Streptomyces nodosus ATCC 14899	QEV39757.1			1
SNOD_15095		Streptomyces nodosus ATCC 14899	AJE41211.1			1
OHB35_23620		Streptomyces phaeochromogenes NBC 01752	WSD15997.1			1
OG931_22925		Streptomyces phaeochromogenes NBC_00186	WRZ30397.1			1
F9278_21055		Streptomyces phaeolivaceus GY16	QFQ98267.1			1
NFX46_19825		Streptomyces phaeoluteigriseus Qhu-M197	USQ85797.1			1
Sfla_0913		Streptomyces pratensis ATCC 33331	ADW02371.1			1
A4E84_17785		Streptomyces qaidamensis S10(2016)	AMW11190.1			1
LIV37_27430		Streptomyces rapamycinicus NRRL 5491	UTP32745.1			1
M271_26970		Streptomyces rapamycinicus NRRL 5491	AGP56864.1			1
LJB45_22305		Streptomyces rapamycinicus SRMK07	UTO64788.1			1
SRO_0552		Streptomyces rochei 7434AN4	BBC91728.1			1
IAG44_23080		Streptomyces roseirectus CRXT-G-22	QNP72012.1			1
A4G23_00273		Streptomyces rubrolavendulae MJM4426	AOT57484.1			1
SCAB_51081		Streptomyces scabiei 87.22	CBG72151.1			1
HUT11_19660		Streptomyces seoulensis A01	QKW28091.1			1
D0Z67_27285		Streptomyces seoulensis KCTC 9819	QBJ93613.1			1
I1A49_21830		Streptomyces solisilvae HNM0141	QPI57200.1			1
CGL27_22625		Streptomyces sp. 11-1-2	ASQ95494.1			1
SAMN05444521_4982		Streptomyces sp. 3214.6	SHI18454.1			1
IOD14_41350		Streptomyces sp. A2-16	QUC62699.1			1
N7U49_27700		Streptomyces sp. AD2-2	UXX94838.1			1
AS97_38095		Streptomyces sp. AgN23	QTI88820.1			1
P8A21_33865		Streptomyces sp. Alt1	WLQ52175.1			1
P8A19_06290		Streptomyces sp. Alt2	WLQ55073.1			1
P8A20_04885		Streptomyces sp. Alt3	WLQ62970.1			1
CVT30_24805		Streptomyces sp. AMCC400023	UJV42631.1			1
JIX56_26045		Streptomyces sp. CA-210063	UUU33054.1			1
AS200_25685		Streptomyces sp. CdTB01	ALV35061.1			1
RJD14_11615		Streptomyces sp. CGMCC 4.1456	WNF63198.1			1
VJ737_23480		Streptomyces sp. CGMCC 4.1772	WRU00459.1			1
NNW99_21245		Streptomyces sp. CRCS-T-1	UUA15527.1			1
NNW98_21250		Streptomyces sp. CRLD-Y-1	UUA07898.1			1
V8690_18650		Streptomyces sp. DG1A-41	WWT96274.1			1
JIX55_23525		Streptomyces sp. DSM 40750	UUU23020.1			1
HB370_18195		Streptomyces sp. DSM 40868	QIS71694.1			1
WJM95_02410		Streptomyces sp. f51	WYH81338.1			1
Q7C01_36185		Streptomyces sp. FXY-T5	WMD09479.1			1
C1703_17145		Streptomyces sp. Go-475	AXE86734.1			1
LUV23_21990		Streptomyces sp. HNM0561	UHH18744.1			1
MQE23_24980		Streptomyces sp. HP-A2021	UOB12113.1			1
N8I86_36445		Streptomyces sp. HUAS 14-6	UXY39721.1			1
O1G22_23430		Streptomyces sp. HUAS 2-6	WBO65560.1			1
PGH47_19175		Streptomyces sp. HUAS 31	WCD97677.1			1
RLT58_00840		Streptomyces sp. ITFR-16	WNI20547.1			1
RLT57_03945		Streptomyces sp. ITFR-21	WNI19533.1			1
KJK32_21050		Streptomyces sp. JCM17656	QWA22906.1			1
HUV60_018980		Streptomyces sp. KMM 9044	WAX79437.1			1
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