Glycoside Hydrolase Family 5 / Subf 1

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (610); Uniprot accession (102); PDB accession (15); 3D entries (3); cryst (0)
| 1 | 2 | 3 | 4 | 5 | 6 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 ACPOL_3660   Acidobacteriaceae bacterium SBC82 AXC12943.1     1
 endo-β-1,4-glucanase E1 (EGAc;EGI;TcE1;Acel_0614) (Cel5A) 3.2.1.4 Acidothermus cellulolyticus 11B AAA75477.1
ABH84883.1
ABK52387.1
ACW33392.1
CAD42489.1
CAR96693.1
P54583 1C0D[A,B]
1ECE[A,B]
1VRX[A,B]
1
 C8241_14745   Acidovorax avenae subsp. avenae AA78_5 AVS62769.1     1
 C8245_15080   Acidovorax avenae subsp. avenae AA81_1 AVS66833.1     1
 C8247_12870   Acidovorax avenae subsp. avenae AA99_2 AVS71229.1     1
 Acav_3053   Acidovorax avenae subsp. avenae ATCC 19860 ADX46955.1     1
 C8234_09605   Acidovorax avenae subsp. avenae COLB1 AVS78289.1     1
 C8237_12465   Acidovorax avenae subsp. avenae INDB2 AVS81814.1     1
 C8239_12870   Acidovorax avenae subsp. avenae INV AVS85530.1     1
 C8238_12970   Acidovorax avenae subsp. avenae KL3 AVS89032.1     1
 C8246_24010   Acidovorax avenae subsp. avenae MD5 AVS94289.1     1
 C8232_09065   Acidovorax avenae subsp. avenae MDB1 AVS96385.1     1
 C8236_12465   Acidovorax avenae subsp. avenae MOR AVS99540.1     1
 C8243_12495   Acidovorax avenae subsp. avenae NCT3 AVT03216.1     1
 C8248_11875   Acidovorax avenae subsp. avenae QH1 AVT06571.1     1
 C8242_12375   Acidovorax avenae subsp. avenae QHB1 AVT10187.1     1
 C8235_09970   Acidovorax avenae subsp. avenae Sa2 AVT13167.1     1
 C8240_13915   Acidovorax cattleyae CAT98_1 AVS74938.1     1
 Aave_2102   Acidovorax citrulli AAC00-1 ABM32683.1 A1TNZ5   1
 CQB05_04045   Acidovorax citrulli KACC17005 ATG93317.1     1
 endoglucanase, partial   Acidovorax citrulli xjgb-wy6 AKT09126.1     1
 SAMN04489716_1143   Actinoplanes derwentensis DSM 43941 SDS59746.1     1
 AFR_24740   Actinoplanes friuliensis DSM 7358 AGZ43214.1     1
 AMIS_38990   Actinoplanes missouriensis 431 BAL89119.1     1
 L083_3484   Actinoplanes sp. N902-109 AGL16994.1     1
 ACWT_3970   Actinoplanes sp. SE50 ATO83385.1     1
 ACPL_4099   Actinoplanes sp. SE50/110 AEV84994.1
SLM00792.1
    1
 SAMN04489717_2988   Actinopolymorpha singaporensis DSM 22024 SDS53076.1     1
 Amir_3216   Actinosynnema mirum DSM 43827 ACU37124.1 C6W8M5   1
 asmnew07   Actinosynnema pretiosum subsp. auranticum ATCC 31565 AEC53450.1     1
 APASM_3249   Actinosynnema pretiosum subsp. pretiosum ATCC 31280 AXX30614.1     1
 CNX65_16395   Actinosynnema pretiosum X47 ATE54663.1     1
 A4R43_06505   Amycolatopsis albispora WP1 AXB42227.1     1
 B737_5130   Amycolatopsis mediterranei RB AGT85794.1     1
 RAM_26450   Amycolatopsis mediterranei S699 AEK43767.1
AFO78666.1
    1
 AMED_5192   Amycolatopsis mediterranei U32 ADJ46955.1 D8I1M4   1
 SD37_21965   Amycolatopsis orientalis B-37 ANN21935.1     1
 D1815_18210   Aquimarina sp. AD1 AXT57588.1     1
 D1815_10490   Aquimarina sp. AD1 AXT56160.1     1
 D1816_19580   Aquimarina sp. AD10 AXT62469.1     1
 D1818_21420   Aquimarina sp. BL5 AXT53262.1     1
 D1818_12900   Aquimarina sp. BL5 AXT51693.1     1
 CFN17_10160 (fragment)   Arthrobacter sp. PM3 AXJ11793.1     1
 endo-β-1,4-glucanase (Egl;AZC_1301) 3.2.1.4 Azorhizobium caulinodans ORS 571 BAF87299.1 A8I0V5   1
 ABAZ39_32285   Azospirillum brasilense Az39 AIB16520.1     1
 ABAZ39_20660   Azospirillum brasilense Az39 AIB14334.1     1
 ABAZ39_04560   Azospirillum brasilense Az39 AIB11296.1     1
 AMK58_20535   Azospirillum brasilense Sp 7 ALJ37806.1     1
 AMK58_26700   Azospirillum brasilense Sp 7 ALJ39073.1     1
 AMK58_09480   Azospirillum brasilense Sp 7 ALJ35637.1     1
 AZOBR_150049   Azospirillum brasilense Sp245 CCC98631.1
AWJ89478.1
    1
 AZOBR_p1110164   Azospirillum brasilense Sp245 CCD00695.1
AWJ92203.1
    1
 AZOBR_p470008   Azospirillum brasilense Sp245 CCD03592.1
AWJ94529.1
    1
 A6A40_25970   Azospirillum humicireducens SgZ-5 AWB08461.1     1
 A6A40_20580   Azospirillum humicireducens SgZ-5 AWB07432.1     1
 AZOLI_p10561   Azospirillum lipoferum 4B CBS88800.1     1
 AZOLI_p40099   Azospirillum lipoferum 4B CBS90502.1     1
 AZL_a06890   Azospirillum sp. B510 BAI74220.1 D3P0P1   1
 AZL_d05040   Azospirillum sp. B510 BAI76330.1 D3P6Q1   1
 DEW08_22580   Azospirillum sp. CFH 70021 AWK88854.1     1
 DM194_23795   Azospirillum sp. M2T2B2 AWU97304.1     1
 DM194_13755   Azospirillum sp. M2T2B2 AWU95399.1     1
 TSH58p_16070   Azospirillum sp. TSH58 AWJ84900.1     1
 TSH58p_20605   Azospirillum sp. TSH58 AWJ85939.1     1
 TSH58p_24850   Azospirillum sp. TSH58 AWJ86697.1     1
 AL072_19540   Azospirillum thiophilum BV-S ALG73272.1     1
 AL072_23195   Azospirillum thiophilum BV-S ALG73945.1     1
 endoglucanase (Cel17) (Cel5B) 3.2.1.4 bacterium enrichment culture clone FXVII-Cel5B AEL31247.1     1
 CIY_21950   Butyrivibrio fibrisolvens 16/4 CBK74877.1 D4IVT4   1
 bpr_I1499   Butyrivibrio proteoclasticus B316 ADL34236.1 E0RWD8   1
 Athe_1866 (CelB;CbMan5C/Cel5A) (Man5C-Cel5A) 3.2.1.4 Caldicellulosiruptor bescii DSM 6725 ACM60954.1
CAB06784.1
B9MKU6
P96310
  1
 Calkro_0854   Caldicellulosiruptor kronotskyensis 2002 ADQ45730.1 E4SDC1   1
 COB47_1671   Caldicellulosiruptor obsidiansis OB47 ADL42951.1 D9TFI1   1
 endo-β-1,4-glucanase / exo-β-1,4-glucanase (CelB;EgB) 3.2.1.4 Caldicellulosiruptor saccharolyticus CAA31936.1
A43802
P10474   1
 cellulase (CBH-B;CelB;Csac_1078) 3.2.1.4 Caldicellulosiruptor saccharolyticus DSM 8903 ABP66692.1 A4XIF7   1
 multidomain endoglucanase (CelB)   Caldicellulosiruptor sp. Tok7B.1 AAD30364.1 Q9X3P6   1
 NIES22_60310   Calothrix brevissima NIES-22 BAY65919.1     1
 NIES267_13610   Calothrix parasitica NIES-267 BAY81883.1     1
 NIES267_49770   Calothrix parasitica NIES-267 BAY85477.1     1
 IJ00_21580   Calothrix sp. 336/3 AKG24782.1     1
 IJ00_14720   Calothrix sp. 336/3 AKG22350.1     1
 IJ00_24435   Calothrix sp. 336/3 AKG24820.1     1
 NIES2100_07100   Calothrix sp. NIES-2100 BAY20966.1     1
 NIES3974_19500   Calothrix sp. NIES-3974 BAZ05303.1     1
 NIES4071_47850   Calothrix sp. NIES-4071 BAZ12951.1     1
 NIES4071_04830   Calothrix sp. NIES-4071 BAZ08678.1     1
 NIES4101_40790   Calothrix sp. NIES-4101 BAZ38144.1     1
 NIES4101_46910   Calothrix sp. NIES-4101 BAZ38749.1     1
 NIES4105_04820   Calothrix sp. NIES-4105 BAZ54829.1     1
 NIES4105_47790   Calothrix sp. NIES-4105 BAZ59097.1     1
 Cal6303_3022   Calothrix sp. PCC 6303 AFZ01969.1     1
 Cal7507_3091   Calothrix sp. PCC 7507 AFY33503.1     1
 A7sIIA15_04770   Candidatus Planktophila vernalis ASY20173.1     1
 Caci_4214   Catenulispora acidiphila DSM 44928 ACU73078.1 C7QI33   1
 endo-β-1,4-glucanase D (CenD;Celf_1924) (Cel5A) 3.2.1.4 Cellulomonas fimi ATCC 484 AAA23089.1
AEE46054.1
P50400   1
 endo-β-1,4-glucanase B (CelB;CflB;CelCflB;SP18) 3.2.1.4 Cellulomonas flavigena CDBB-531 AAD48494.3
AAD48494.2
Q9S3V3   1
 Cfla_1897   Cellulomonas flavigena DSM 20109 ADG74794.1 D5UEY4   1
 Celgi_1696   Cellulomonas gilvus ATCC 13127 AEI12207.1     1
 CBP52_04725   Cellulomonas sp. PSBB021 ASR54546.1     1
 Clole_2598   Cellulosilyticum lentocellum DSM 5427 ADZ84301.1     1
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