Glycoside Hydrolase Family 5 / Subf 1

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Activities in Sub Family
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (491); Uniprot accession (102); PDB accession (15); 3D entries (3); cryst (0)
| 1 | 2 | 3 | 4 |
Bacteria
Protein Name EC#Organism GenBankUniprotPDB/3DSubf
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 08224 AHZ96481.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 09081 AHZ96482.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 09085 AHZ96483.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 09086 AHZ96484.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 11015 AHZ96485.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 12069 AHZ96486.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 12083 AHZ96487.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 13048 AHZ96488.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 13054 AHZ96489.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 13084 AHZ96490.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 13090 AHZ96491.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 13091 AHZ96492.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 13109 AHZ96493.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 13115 AHZ96494.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 13117 AHZ96495.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 13129 AHZ96496.1     1
 cellulase, partial (CelA) (fragment)   Clavibacter michiganensis subsp. michiganensis 13134 AHZ96497.1     1
 CelA   Clavibacter michiganensis subsp. michiganensis BT0505 AHN16207.1     1
 CelA (fragment)   Clavibacter michiganensis subsp. michiganensis Cmm_MKH AEM65927.1
AEM65928.1
    1
 CMM_2443 (CelB)   Clavibacter michiganensis subsp. michiganensis NCPPB 382 CAN02524.1 A5CTT9   1
 bifunctional cellulase / expansin (CelA;pCM1_0020) 3.2.1.4 Clavibacter michiganensis subsp. michiganensis NCPPB 382 CAA44467.2
CAM98473.1
Q9K5C7   1
 CMN_02390 (CeL)   Clavibacter michiganensis subsp. nebraskensis NCPPB 2581 type strain: NCPPB 2581 CCE76326.1     1
 cellulase (CelA;pCS0061) 3.2.1.4 Clavibacter michiganensis subsp. sepedonicus ATCC33113 AAK16222.1
CAQ03244.1
B0RJ54
Q9AF65
  1
 CAC0912   Clostridium acetobutylicum ATCC 824 AAK78888.1
NP_347548.1
Q97KK6   1
 SMB_G0929 (CelB)   Clostridium acetobutylicum DSM 1731 AEI33087.1     1
 CEA_G0924   Clostridium acetobutylicum EA 2018 ADZ19963.1     1
 CMCase (P66;Ccel_2337) 3.2.1.4 [Clostridium] cellulolyticum H10 ACL76673.1 B8I5D7   1
 cellulase N (CelN; Ccel_0740) (Cel5N) 3.2.1.4 [Clostridium] cellulolyticum H10 ACL75118.1
AAG45162.1
B8I7W1
Q9EYQ0
  1
 endoglucanase (Eng5A)   Clostridium cellulovorans BAV13030.1     1
 endoglucanase (Eng5E)   Clostridium cellulovorans BAV13035.1     1
 Clocel_0619   Clostridium cellulovorans 743B ADL50390.1 D9SRM3   1
 Clocel_0983   Clostridium cellulovorans 743B ADL50749.1 D9STD3   1
 Clocl_1981   [Clostridium] clariflavum DSM 19732 AEV68583.1     1
 Clocl_3932   [Clostridium] clariflavum DSM 19732 AEV70372.1     1
 Clocl_1122   [Clostridium] clariflavum DSM 19732 AEV67797.1     1
 Cel5B (Cel5B)   Clostridium josui BAI52933.1 D1MXA2   1
 Clole_2598   Clostridium lentocellum DSM 5427 ADZ84301.1     1
 Cspa_c18680 (Celb2)   Clostridium saccharoperbutylacetonicum N1-4(HMT) AGF55638.1     1
 Clo1100_1829   Clostridium sp. BNL1100 AEY66039.1     1
 Clo1100_2788   Clostridium sp. BNL1100 AEY66946.1     1
 B5808_07170   Cnuibacter physcomitrellae XA(T) ARJ05010.1     1
 Cwoe_0159   Conexibacter woesei DSM 14684 ADB48595.1 D3F517   1
 PA27867_1437   Cryobacterium arcticum PAMC 27867 ANP72394.1     1
 Cyan10605_2560   Cyanobacterium aponinum PCC 10605 AFZ54640.1     1
 CYFUS_005260   Cystobacter fuscus DSM 52655 ATB39812.1     1
 EUS_18130   [Eubacterium] siraeum 70/3 CBK96886.1 D4JUW7   1
 ES1_23790   [Eubacterium] siraeum V10Sc8a CBL35203.1 D4MN70   1
 SAMN04488543_1663   Friedmanniella luteola DSM 21741 SDS40102.1     1
 SAMN04488544_1121 (fragment)   Friedmanniella sagamiharensis DSM 21743 SDU86229.1     1
 GM3709_2278   Geminocystis sp. NIES-3709 BAQ65513.1     1
 Glo7428_3546   Gloeocapsa sp. PCC 7428 AFZ32015.1     1
 A9404_07265   Halothiobacillus sp. LS2 ANJ67208.1     1
 SD1D_0238 (Celb2)   Herbinix luporum SD1D CUH91791.1     1
 SD1D_0139 (CelB)   Herbinix luporum SD1D CUH91693.1     1
 cellulase (H4;Haur_2820)   Herpetosiphon aurantiacus DSM 785 ABX05458.1 A9B2K7   1
 BN2497_13425   Janthinobacterium sp. CG23_2 CUI24937.1     1
 Jden_0734   Jonesia denitrificans DSM 20603 ACV08398.1 C7R1T0   1
 CEP80_01495   Jonesia denitrificans FDAARGOS_301 ASE07953.1     1
 endoglucanase, partial (Cel5A)   Jonesia quinghaiensis Y2 API85532.1     1
 KSE_69000   Kitasatospora setae KM-6054 BAJ32658.1 E4N3C4   1
 endo-β-1,4-glucanase 5A (CpCel5A;Cphy_1163) (Cel5A) 3.2.1.4 Lachnoclostridium phytofermentans ISDg ABX41541.1 A9KN42   1
 Lxx22675 (CelA)   Leifsonia xyli subsp. xyli str. CTCB07 AAT89935.1 Q6ACF8   1
 LBDG_00070   Leptolyngbya boryana dg5 BAS60474.1     1
 LBWT_70 (fragment)   Leptolyngbya boryana IAM M-101 BAS54126.1     1
 NIES2135_06290   Leptolyngbya boryana NIES-2135 BAY53817.1     1
 LEP3755_40970   Leptolyngbya sp. NIES-3755 BAU13557.1     1
 O77CONTIG1_02914   Leptolyngbya sp. O-77 BAU43092.1     1
 Mahau_1116   Mahella australiensis 50-1 BON AEE96313.1     1
 AZF01_06880   Martelella sp. AD-3 AMM84112.1     1
 MEBOL_000684   Melittangium boletus DSM 14713 ATB27246.1     1
 SAMN04489810_3464   Microbacterium pygmaeum DSM 23142 SDH61822.1     1
 BJP65_02895   Microbacterium sp. BH-3-3-3 AOX44867.1     1
 SAMN05216488_1924   Microbacterium sp. LKL04 SCY46623.1     1
 MTES_0141   Microbacterium testaceum StLB037 BAJ73105.1     1
 Mic7113_4470   Microcoleus sp. PCC 7113 AFZ20162.1     1
 Micau_1546   Micromonospora aurantiaca ATCC 27029 ADL45104.1 D9SYR9   1
 GA0070611_6160   Micromonospora auratinigra DSM 44815 SBT53509.1     1
 GA0070612_5967   Micromonospora chokoriensis DSM 45160 SCF29189.1     1
 GA0070607_1055   Micromonospora coriariae DSM 44875 SCE74509.1     1
 GA0070614_4776   Micromonospora coxensis DSM 45161 SCG71042.1     1
 GA0070614_0384   Micromonospora coxensis DSM 45161 SCG37348.1     1
 GA0070610_4046   Micromonospora echinofusca DSM 43913 SCG17725.1     1
 GA0070618_0392   Micromonospora echinospora DSM 43816 SCE71858.1     1
 GA0070621_0342   Micromonospora narathiwatensis DSM 45248 SBT38231.1     1
 GA0070623_2127   Micromonospora rifamycinica DSM 44983 SCG53214.1     1
 GA0074704_2216   Micromonospora siamensis DSM 45097 SCG48664.1     1
 ML5_1807   Micromonospora sp. L5 ADU07338.1 D3C675   1
 GA0070619_0769   Micromonospora zamorensis DSM 45600 SCG39192.1     1
 Mflv_3001   Mycobacterium gilvum PYR-GCK ABP45478.1 A4TBD9   1
 Mspyr1_23340   Mycobacterium gilvum Spyr1 ADT98979.1     1
 Mvan_3505   Mycobacterium vanbaalenii PYR-1 ABM14300.1 A1TAV0   1
 BKM31_47890   Nonomuraea sp. ATCC 55076 AQZ68170.1     1
 BZZ01_24965   Nostocales cyanobacterium HT-58-2 ARV61444.1     1
 BZZ01_24160   Nostocales cyanobacterium HT-58-2 ARV61297.1     1
 PBOR_03685   Paenibacillus borealis DSM 13188 AIQ56159.1     1
 B9T62_20790   Paenibacillus donghaensis KCTC 13049 ASA23029.1     1
 PGRAT_15895   Paenibacillus graminis DSM 15220 AIQ68937.1     1
 B4V02_07145   Paenibacillus kribbensis AM49 ASR46467.1     1
 ABE82_18415   Paenibacillus peoriae HS311 ALA43361.1     1
 endo-β-1,4-glucanase 3.2.1.4 Paenibacillus polymyxa AAA22631.1
AAY03292.1
P23548   1
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