Polysaccharide Lyase Family 8

Activities in Family	Exo-β-1,4-glucuronan lyase (EC 4.2.2.-); Exo-hyaluronate lyase (EC 4.2.2.-); Hyaluronate lyase (EC 4.2.2.1); Xanthan lyase (EC 4.2.2.12); Chondroitinase B (EC 4.2.2.19); Poly(β-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3); Chondroitin AC lyase (EC 4.2.2.5); Heparin lyase / heparin lyase I (EC 4.2.2.7);
Mechanism	b-elimination
3D Structure Status	( α / α ) ₆ toroid + anti-parallel β-sheet
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX;
Statistics	GenBank accession (4807); Uniprot accession (30); PDB accession (54); 3D entries (13); cryst (1)

Summary

Download PL8 (5166) Taxonomic display Structure (13 - 1 cryst) Characterized (33)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
NCTC12090_01400 (HylB)		Streptococcus equi subsp. zooepidemicus NCTC12090	SQF05908.1			1
NCTC4675_01333 (HylB)		Streptococcus equi subsp. zooepidemicus NCTC4675	VTS30303.1			1
NCTC6176_01339 (HylB)		Streptococcus equi subsp. zooepidemicus NCTC6176	SQF81960.1			1
NCTC6180_00474 (HylB)		Streptococcus equi subsp. zooepidemicus NCTC6180	VEF05717.1			1
NCTC7022_01369 (HylB)		Streptococcus equi subsp. zooepidemicus NCTC7022	SQE96238.1			1
LJFMMFNO_01367 (HylB)		Streptococcus equi subsp. zooepidemicus SEZ13	QUQ80354.1			1
JDBNIEOD_00739 (HylB)		Streptococcus equi subsp. zooepidemicus SEZ14	QUQ77717.1			1
MCPGFBBE_01276 (HylB)		Streptococcus equi subsp. zooepidemicus SEZ18	QTZ59171.1			1
JFMEOBDD_00788 (HylB)		Streptococcus equi subsp. zooepidemicus SEZ25	QTZ56709.1			1
GDAKBCAL_01296 (HylB)		Streptococcus equi subsp. zooepidemicus SEZ28	QTZ29811.1			1
IEMOCGPF_00680 (HylB)		Streptococcus equi subsp. zooepidemicus SEZ33	QTR93604.1			1
HCFMJIKG_01364 (HylB)		Streptococcus equi subsp. zooepidemicus SEZ36	QTR96125.1			1
HIEAAJJG_01388 (HylB)		Streptococcus equi subsp. zooepidemicus SEZ46	QTC12631.1			1
KVP03_06035 (HylB) (fragment)		Streptococcus equi subsp. zooepidemicus SEZ_14-145	UFR17475.1			1
RIM62_03770 (HylB)		Streptococcus equi subsp. zooepidemicus ZHZ211	WOK53983.1			1
BMF34_01220		Streptococcus iniae 89353	APD31157.1			1
Q9317_01300		Streptococcus iniae BH15-2	WLR87982.1			1
Q9318_01370		Streptococcus iniae BH16-24	WLR89927.1			1
QYR56_09415		Streptococcus iniae CB Si-1	WNZ97379.1			1
QLH56_03925		Streptococcus iniae DFSM220524	WHL22333.1			1
CTW00_00807 (HylB)		Streptococcus iniae FP5228	ATX39008.1			1
D5R92_06735		Streptococcus iniae GX005	AYB02088.1			1
QLH62_01325 (fragment)		Streptococcus iniae GXAS200705	WHL24657.1			1
DQ08_01045		Streptococcus iniae ISET0901	AHY15097.1			1
DW64_01040		Streptococcus iniae ISNO	AHY16967.1			1
PQ615_07990		Streptococcus iniae LSSM211007SI	WKZ89311.1			1
QYR59_01170		Streptococcus iniae P3SAB	WNZ91749.1			1
QMA0248_0228 (HylB)		Streptococcus iniae QMA0248	ASL34076.1			1
K710_0217		Streptococcus iniae SF1	AGM98022.1			1
QYR55_01145		Streptococcus iniae Si 1-19	WNZ88539.1			1
QYR57_00910		Streptococcus iniae Si 4-21	WNZ90125.1			1
QYR58_00500		Streptococcus iniae Si 6-21	WNZ93180.1			1
QYR54_09410		Streptococcus iniae Si 7-21	WNZ94411.1			1
QYR60_01145		Streptococcus iniae Si 8-21	WNZ96178.1			1
D5R90_06770		Streptococcus iniae YM011	AYB03955.1			1
SI82_01295		Streptococcus iniae YSFST01-82	AJG25283.1			1
hyaluronate lyase	4.2.2.1	Streptococcus intermedius ATCC 27335	AAK67167.1	Q934I4		1
SIR_1547		Streptococcus intermedius B196	AGU76898.1			1
SII_1533		Streptococcus intermedius C270	AGU78697.1			1
A6J72_07395		Streptococcus intermedius FDAARGOS_233	ARC27012.1			1
FOC71_09605		Streptococcus intermedius FDAARGOS_769	QKH78711.1			1
SCIM_1362		Streptococcus intermedius JTH08	BAM24016.1			1
RN88_07180		Streptococcus intermedius KCOM 1545	ALF28283.1			1
NCTC11324_01543		Streptococcus intermedius NCTC11324	SQH52493.1			1
SITYG_16360		Streptococcus intermedius TYG1620	BAW17615.1			1
RYQ61_02015		Streptococcus intermedius XH2169	WOI91642.1			1
SAMEA4412692_01386 (HylA)		Streptococcus merionis NCTC13788	SNU89167.1			1
NCTC10708_01510 (fragment)		Streptococcus milleri NCTC10708	VEE83406.1
NCTC10708_01509 (fragment)		Streptococcus milleri NCTC10708	VEE83403.1
hyaluronate lyase (HyL)		Streptococcus oralis ASP0312-So	BCR37041.1			1
hyaluronate lyase (HyL)		Streptococcus oralis ASP0312-Sp	BCR37040.1			1
DG474_01710		Streptococcus oralis CCUG 53468	UTX65911.1			1
GOM47_01575		Streptococcus oralis SOT	UJD01484.1			1
hyaluronate lyase (HyL)		Streptococcus oralis SP2752	BCR37042.1			1
INT76_10670		Streptococcus oriscaviae HKU75	QUE54259.1			1
STP_1167		Streptococcus parauberis KCTC 11537	AEF25615.1			1
N2A96_07535		Streptococcus parauberis KSP10	UWM88423.1			1
N2A93_07540		Streptococcus parauberis KSP14	UWM86452.1			1
N2A94_06090		Streptococcus parauberis KSP20	UWM90076.1			1
P1T44_02330		Streptococcus parauberis SPOF19J15	WEM63631.1			1
P1T47_07275		Streptococcus parauberis SPOF21J2	WEM59236.1			1
BUM80_10710		Streptococcus pneumoniae 11A	AUC46739.1			1
CWI64_08655		Streptococcus pneumoniae 19F	AUB33652.1			1
SAMEA2146691_00305		Streptococcus pneumoniae 2245STDY5562278	VFH36008.1			1
SAMEA2148390_00319		Streptococcus pneumoniae 2245STDY5562351	VFH52701.1			1
SAMEA2147627_00349		Streptococcus pneumoniae 2245STDY5562369	VFH39652.1			1
SAMEA2150192_00280		Streptococcus pneumoniae 2245STDY5562412	VFH63301.1			1
SAMEA2145720_00259		Streptococcus pneumoniae 2245STDY5562562	VFH56913.1			1
SAMEA2162916_00336		Streptococcus pneumoniae 2245STDY5562600	VFH54667.1			1
SAMEA2157525_00322		Streptococcus pneumoniae 2245STDY5562629	VFH38729.1			1
SAMEA2203271_00394		Streptococcus pneumoniae 2245STDY5605535	VFH43289.1			1
SAMEA2203380_00301		Streptococcus pneumoniae 2245STDY5605669	VFH39829.1			1
SAMEA2203393_00420		Streptococcus pneumoniae 2245STDY5605682	VFH41045.1			1
SAMEA2204055_00313		Streptococcus pneumoniae 2245STDY5609197	VFH38267.1			1
SAMEA2204095_00301		Streptococcus pneumoniae 2245STDY5609237	VFH44106.1			1
SAMEA2336038_00432		Streptococcus pneumoniae 2245STDY5699131	VFH56851.1			1
SAMEA2341150_00372		Streptococcus pneumoniae 2245STDY5699394	VFH57270.1			1
SAMEA2341240_00373		Streptococcus pneumoniae 2245STDY5699475	VGM69976.1			1
SAMEA2434444_00324		Streptococcus pneumoniae 2245STDY5775485	VFH60204.1			1
SAMEA2434479_00391		Streptococcus pneumoniae 2245STDY5775520	VFH63924.1			1
SAMEA2434504_00356		Streptococcus pneumoniae 2245STDY5775545	VFH71583.1			1
SAMEA2434511_00394		Streptococcus pneumoniae 2245STDY5775553	VGM72086.1			1
SAMEA2434561_00300		Streptococcus pneumoniae 2245STDY5775603	VFH80899.1			1
SAMEA2434568_00359 (fragment)		Streptococcus pneumoniae 2245STDY5775610	VFH82377.1			1
SAMEA2434568_00358 (fragment)		Streptococcus pneumoniae 2245STDY5775610	VFH82368.1			1
SAMEA2434623_00342		Streptococcus pneumoniae 2245STDY5775666	VFH80195.1			1
SAMEA2434829_00293		Streptococcus pneumoniae 2245STDY5775874	VFH75298.1			1
SAMEA2627289_00334		Streptococcus pneumoniae 2245STDY5868782	VFH77767.1			1
SAMEA2796698_00285		Streptococcus pneumoniae 2245STDY5982722	VFH75739.1			1
SAMEA2797120_00278		Streptococcus pneumoniae 2245STDY5983173	VFH78257.1			1
SAMEA3175698_00327		Streptococcus pneumoniae 2245STDY6020210	VFH96377.1			1
SAMEA3175709_00287		Streptococcus pneumoniae 2245STDY6020221	VFI00432.1			1
SAMEA3175728_00357		Streptococcus pneumoniae 2245STDY6020240	VGM74205.1			1
SAMEA3233211_00350 (fragment)		Streptococcus pneumoniae 2245STDY6030848	VFH93871.1			1
SAMEA3233395_00365		Streptococcus pneumoniae 2245STDY6031034	VFI01133.1			1
SAMEA3233409_00345		Streptococcus pneumoniae 2245STDY6031048	VFH95894.1			1
SAMEA3354333_00395 (fragment)		Streptococcus pneumoniae 2245STDY6092581	VFH97728.1			1
SAMEA3354333_00394 (fragment)		Streptococcus pneumoniae 2245STDY6092581	VFH97722.1			1
SAMEA3354357_00441		Streptococcus pneumoniae 2245STDY6092613	VFI00818.1			1
SAMEA3381325_00327		Streptococcus pneumoniae 2245STDY6092834	VFI00133.1			1
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