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Polysaccharide Lyase Family 8

Activities in FamilyExo-β-1,4-glucuronan lyase (EC 4.2.2.-);
Exo-hyaluronate lyase (EC 4.2.2.-);
Hyaluronate lyase (EC 4.2.2.1);
Xanthan lyase (EC 4.2.2.12);
Chondroitinase B (EC 4.2.2.19);
Poly(β-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3);
Chondroitin AC lyase (EC 4.2.2.5);
Heparin lyase / heparin lyase I (EC 4.2.2.7);
Mechanism b-elimination
3D Structure Status( α / α ) 6 toroid + anti-parallel β-sheet
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (4807); Uniprot accession (30); PDB accession (54); 3D entries (13); cryst (1)
Summary
Download PL8 (5166) Taxonomic display Structure (13 - 1 cryst) Characterized (33)
| 1 | ... | 28 | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | ... | 47 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 CUGBS08_01230 (HylB)   Streptococcus agalactiae CU_GBS_08 AMQ14781.1     1
 CUGBS98_01167 (HylB)   Streptococcus agalactiae CU_GBS_98 AMQ16773.1     1
 A6J82_06845   Streptococcus agalactiae FDAARGOS_254 ARC45071.1     1
 EGX82_10455   Streptococcus agalactiae FDAARGOS_512 AYZ24217.1     1
 FOB77_08675   Streptococcus agalactiae FDAARGOS_669 QET35740.1     1
 FOB78_02465   Streptococcus agalactiae FDAARGOS_670 QET53184.1     1
 A9256_06185   Streptococcus agalactiae FWL1402 ANR97234.1     1
 AOY37_06410   Streptococcus agalactiae GBS ST-1 ALP87742.1     1
 DK41_06360   Streptococcus agalactiae GBS1-NY AIK71752.1     1
 DK42_06655   Streptococcus agalactiae GBS2-NM AIK73870.1     1
 DX05_06680   Streptococcus agalactiae GBS6 AIK75919.1     1
 GBS85147_1176   Streptococcus agalactiae GBS85147 AKI57601.1     1
 A964_1170   Streptococcus agalactiae GD201008-001 AFS45935.1     1
 GX026_05610   Streptococcus agalactiae GX026 AKU01911.1     1
 GX064_06035   Streptococcus agalactiae GX064 AKU00152.1     1
 SAH002_06140 (fragment)   Streptococcus agalactiae H002 AKU03714.1    
 SAHN016_06120   Streptococcus agalactiae HN016 AKT96278.1     1
 SAGS_1243 (Hylb_1) (fragment)   Streptococcus agalactiae HU-GS5823 BBG32927.1    
 SAGS_1245 (Hylb_2) (fragment)   Streptococcus agalactiae HU-GS5823 BBG32929.1    
 MSA_13200 (fragment)   Streptococcus agalactiae ILRI005 CCW40178.1     1
 SAIL_13150   Streptococcus agalactiae ILRI112 CCW42329.1     1
 BQ8897_BM110_01288 (HylB)   Streptococcus agalactiae isolate BM110 SIW57730.1     1
 SA111_01368 (HylB)   Streptococcus agalactiae isolate SA111 CZT39479.1     1
 NCTC11930_00904 (HylB)   Streptococcus agalactiae NCTC11930 SQF30737.1     1
 NCTC13947_00953 (HylB)   Streptococcus agalactiae NCTC13947 VEJ27661.1     1
 NCTC13949_01247 (HylB)   Streptococcus agalactiae NCTC13949 VEJ12998.1     1
 NCTC8184_01208 (HylB)   Streptococcus agalactiae NCTC8184 VED65165.1     1
 NCTC8187_01195 (HylB)   Streptococcus agalactiae NCTC8187 SQG26488.1     1
 hyaluronate lyase (HylB;SaHyl;Gbs1270) 4.2.2.1 Streptococcus agalactiae NEM316 CAD46929.1
AAA56749.1
NP_735714.1		 Q53591 1F1S[A]
1I8Q[A]
1LXM[A] 		1
 EN72_06630   Streptococcus agalactiae NGBS061 AIF86754.1     1
 AMM49_06240   Streptococcus agalactiae NGBS128 AMD32505.1     1
 AMR84_06675   Streptococcus agalactiae NGBS357 AOF51244.1     1
 EN73_06165   Streptococcus agalactiae NGBS572 AIF88771.1     1
 C2E56_06950   Streptococcus agalactiae NJ1606 QHO95713.1     1
 DLM82_06535   Streptococcus agalactiae PLGBS13 QDK30316.1     1
 CUZ18_05240   Streptococcus agalactiae QMA0271 AWQ29481.1     1
 BTH44_05635   Streptococcus agalactiae S13 APO41878.1     1
 A9J19_05590   Streptococcus agalactiae S25 ANI27449.1     1
 DSN71_06295   Streptococcus agalactiae S73 AXC17570.1     1
 SaSA1_1062 (HylB)   Streptococcus agalactiae SA1 AUO87086.1     1
 SaSA102_1060 (HylB)   Streptococcus agalactiae SA102 AUP03517.1     1
 SaSA132_1057 (HylB)   Streptococcus agalactiae SA132 AUP05100.1     1
 SaSA136_1056 (HylB)   Streptococcus agalactiae SA136 AUP06760.1     1
 SaSA159_1057 (HylB)   Streptococcus agalactiae SA159 AUP08310.1     1
 SaSA16_1053 (HylB)   Streptococcus agalactiae SA16 AUO92047.1     1
 SaSA191_1059 (HylB)   Streptococcus agalactiae SA191 AUP11473.1     1
 SaSA195_1062 (HylB)   Streptococcus agalactiae SA195 AUP13072.1     1
 SaSA20_1016 (HylB)   Streptococcus agalactiae SA20 AFV72474.1     1
 SaSA201_1058 (HylB)   Streptococcus agalactiae SA201 AUP14720.1     1
 SaSA209_1058 (HylB)   Streptococcus agalactiae SA209 AUP16403.1     1
 SaSA212_1056 (HylB)   Streptococcus agalactiae SA212 AUP18080.1     1
 SaSA218_1057 (HylB)   Streptococcus agalactiae SA218 AUP19769.1     1
 SaSA220_1055 (HylB)   Streptococcus agalactiae SA220 AUP21466.1     1
 SaSA245_1053 (HylB)   Streptococcus agalactiae SA245 AUP23144.1     1
 SaSA256_1055 (HylB)   Streptococcus agalactiae SA256 AUP24829.1     1
 SaSA289_1057 (HylB)   Streptococcus agalactiae SA289 AUP26522.1     1
 SaSA30_1059 (HylB)   Streptococcus agalactiae SA30 AUO80582.1     1
 SaSA33_1058 (HylB)   Streptococcus agalactiae SA33 AUO82174.1     1
 SaSA330_1059 (HylB)   Streptococcus agalactiae SA330 AUP28218.1     1
 SaSA333_1056 (HylB)   Streptococcus agalactiae SA333 AUP29916.1     1
 SaSA341_1058 (HylB)   Streptococcus agalactiae SA341 AUP31611.1     1
 SaSA343_1053 (HylB)   Streptococcus agalactiae SA343 AUP33314.1     1
 SaSA346_1051 (HylB)   Streptococcus agalactiae SA346 AUP35019.1     1
 SaSA374_1057 (HylB)   Streptococcus agalactiae SA374 AUP36682.1     1
 SaSA375_1057 (HylB)   Streptococcus agalactiae SA375 AUP38342.1     1
 SaSA5_1060 (HylB)   Streptococcus agalactiae SA5 AUO88741.1     1
 SaSA53_1053 (HylB)   Streptococcus agalactiae SA53 AUO83823.1     1
 SaSA623_1057 (HylB)   Streptococcus agalactiae SA623 AUP40066.1     1
 SaSA627_1057 (HylB)   Streptococcus agalactiae SA627 AUP41795.1     1
 SaSA73_1060 (HylB)   Streptococcus agalactiae SA73 AUO85460.1     1
 SaSA75_1059 (HylB)   Streptococcus agalactiae SA75 AUO93726.1     1
 SaSA79_1061 (HylB)   Streptococcus agalactiae SA79 AUO95388.1     1
 SaSA81_1052 (HylB)   Streptococcus agalactiae SA81 AUO97055.1     1
 SaSA85_1063 (HylB)   Streptococcus agalactiae SA85 AUO98700.1     1
 SaSA9_1061 (HylB)   Streptococcus agalactiae SA9 AUO90388.1     1
 SaSA95_1059 (HylB)   Streptococcus agalactiae SA95 AUP00345.1     1
 SaSA97_1061 (HylB)   Streptococcus agalactiae SA97 AUP01974.1     1
 EXA24_06830   Streptococcus agalactiae Sag153 QIW49448.1     1
 B2G84_06620 (fragment)   Streptococcus agalactiae Sag158 AQY26557.1    
 B1H24_06860   Streptococcus agalactiae Sag37 AQY24485.1     1
 AMD29_06425   Streptococcus agalactiae SG-M1 ALB16210.1     1
 BB194_06520   Streptococcus agalactiae SG-M158 ASA84053.1     1
 BB197_06520   Streptococcus agalactiae SG-M163 ASA82000.1     1
 BB164_07095 (fragment)   Streptococcus agalactiae SG-M25 ASA90294.1    
 BB268_06520   Streptococcus agalactiae SG-M29 ASA88157.1     1
 BB165_06145   Streptococcus agalactiae SG-M4 ASA99110.1     1
 BB313_06515   Streptococcus agalactiae SG-M50 ASA86103.1     1
 BB162_06165   Streptococcus agalactiae SG-M6 ASA94416.1     1
 hyaluronate liase, partial (HylB) (fragment)   Streptococcus agalactiae SGB221 QIP75519.1    
 CWQ22_06060   Streptococcus agalactiae SGEHI2015-107 ATZ83062.1     1
 CWQ23_06060   Streptococcus agalactiae SGEHI2015-113 ATZ89517.1     1
 CWQ20_06325   Streptococcus agalactiae SGEHI2015-25 ATZ85066.1     1
 CWQ21_06595   Streptococcus agalactiae SGEHI2015-95 ATZ91585.1     1
 RDF_1194   Streptococcus agalactiae SS1 AKI95609.1     1
 hyaluronate lyase (fragment)   Streptococcus agalactiae SU12 BBB87118.1    
 hyaluronate lyase (fragment)   Streptococcus agalactiae SU12 BBB87116.1    
 hyaluronate lyase (fragment)   Streptococcus agalactiae SU97 BBB87173.1     1
 hyaluronate lyase (fragment)   Streptococcus agalactiae SU97 BBB87174.1     1
 DNK17_09455   Streptococcus agalactiae TFJ0901 AZL56540.1     1
 hyaluronate lyase (Hyl) (fragment)   Streptococcus agalactiae VMC-57 AEV45786.1     1
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