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Polysaccharide Lyase Family 8

Activities in FamilyExo-β-1,4-glucuronan lyase (EC 4.2.2.-);
Exo-hyaluronate lyase (EC 4.2.2.-);
Hyaluronate lyase (EC 4.2.2.1);
Xanthan lyase (EC 4.2.2.12);
Chondroitinase B (EC 4.2.2.19);
Poly(β-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3);
Chondroitin AC lyase (EC 4.2.2.5);
Heparin lyase / heparin lyase I (EC 4.2.2.7);
Mechanism b-elimination
3D Structure Status( α / α ) 6 toroid + anti-parallel β-sheet
Commercial Enzyme Provider(s)MEGAZYME; PROZOMIX;
Statistics GenBank accession (4807); Uniprot accession (30); PDB accession (54); 3D entries (13); cryst (1)
Summary
Download PL8 (5166) Taxonomic display Structure (13 - 1 cryst) Characterized (33)
| 1 | ... | 29 | 30 | 31 | 32 | 33 | 34 | 35 | 36 | 37 | ... | 47 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 hyaluronate lyase, partial (HylB) (fragment)   Streptococcus agalactiae VMC17 AEV45782.1     1
 hyaluronate lyase (Hyl) (fragment)   Streptococcus agalactiae VMC31 AEV45787.1     1
 hyaluronate lyase (HylB) (fragment)   Streptococcus agalactiae VMC55 AEK20863.1     1
 hyaluronate lyase (HylB) (fragment)   Streptococcus agalactiae VMC90 AEL88241.1     1
 BBP08_02765   Streptococcus agalactiae WC1535 AOQ20231.1     1
 YM001_06060   Streptococcus agalactiae YM001 AKT98224.1     1
 C2E46_06835   Streptococcus agalactiae YZ1605 QHO93537.1     1
 G9U50_06155   Streptococcus agalactiae ZQ0910 QIM31382.1     1
 SANR_1718   Streptococcus anginosus C238 AGU84133.1     1
 ORF   Streptococcus anginosus MAS624 AAQ73521.1     1
 ANG_0558   Streptococcus anginosus subsp. whileyi MAS624 BAN61028.1     1
 hyaluronate lyase 4.2.2.1 Streptococcus constellatus subsp. constellatus ATCC 27823 AAK67165.1 Q934I5   1
 ORF (partial)   Streptococcus constellatus subsp. constellatus C-19 AAQ73520.1    
 SCSC_1573   Streptococcus constellatus subsp. constellatus CCUG 24889 BBD23232.1     1
 SCI_1642   Streptococcus constellatus subsp. pharyngis C1050 AGU80540.1     1
 SCRE_1598   Streptococcus constellatus subsp. pharyngis C232 AGU73395.1     1
 SCR2_1598   Streptococcus constellatus subsp. pharyngis C818 AGU75149.1     1
 ORF   Streptococcus constellatus subsp. pharyngis MM9889A AAQ73523.1     1
 DEH83_06130   Streptococcus constellatus TCV107 UTX64866.1     1
 K6973_03990 (fragment)   Streptococcus dysgalactiae DY107 QZT28270.1     1
 I6I44_06520 (fragment)   Streptococcus dysgalactiae FDAARGOS_1087 QQY18308.1     1
 FOB62_01555   Streptococcus dysgalactiae FDAARGOS_654 QET82080.1     1
 FGCSD_1433 (HylB)   Streptococcus dysgalactiae Kdys0611 BBE40658.1     1
 NCTC6403_00745 (HylB)   Streptococcus dysgalactiae NCTC6403 VTS99804.1     1
 EBL83_03135   Streptococcus dysgalactiae SCDR-SD1 QFZ09303.1     1
 EA456_04480   Streptococcus dysgalactiae subsp. dysgalactiae DB31752-13 QGG99800.1     1
 NCTC4669_00818 (HylB)   Streptococcus dysgalactiae subsp. dysgalactiae NCTC4669 VDZ40044.1     1
 EA458_01415   Streptococcus dysgalactiae subsp. dysgalactiae STREP97-15 QGH03286.1     1
 SDSE159_06390   Streptococcus dysgalactiae subsp. equisimilis 159 BCK49382.1     1
 SDSE167_0713 (HylB)   Streptococcus dysgalactiae subsp. equisimilis 167 BAN93105.1     1
 SDSE89_06420   Streptococcus dysgalactiae subsp. equisimilis 89 BCK47310.1     1
 SDSE_0694 (HylB)   Streptococcus dysgalactiae subsp. equisimilis AC-2713 CCI62192.1     1
 SDE12394_03510   Streptococcus dysgalactiae subsp. equisimilis ATCC 12394 ADX24222.1     1
 SDEG_0654 (HylB)   Streptococcus dysgalactiae subsp. equisimilis GGS_124 BAH81156.1     1
 ML603_03055 (fragment)   Streptococcus dysgalactiae subsp. equisimilis Karl UMY69070.1     1
 MGCS35823_01422 (HylB)   Streptococcus dysgalactiae subsp. equisimilis MGCS35823 WEQ88243.1     1
 MGCS35922_01424 (HylB)   Streptococcus dysgalactiae subsp. equisimilis MGCS35922 WEQ86151.1     1
 MGCS35957_01396 (HylB)   Streptococcus dysgalactiae subsp. equisimilis MGCS35957 WEQ84032.1     1
 MGCS36044_01410 (HylB)   Streptococcus dysgalactiae subsp. equisimilis MGCS36044 WEQ82070.1     1
 MGCS36083_01426 (HylB)   Streptococcus dysgalactiae subsp. equisimilis MGCS36083 WEQ78012.1     1
 MGCS36089_01398 (HylB)   Streptococcus dysgalactiae subsp. equisimilis MGCS36089 WEQ75604.1     1
 MGGS36055_01516 (HylB)   Streptococcus dysgalactiae subsp. equisimilis MGGS36055 WEQ80112.1     1
 NCTC11554_00787 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC11554 VTT14358.1     1
 NCTC11556_00722 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC11556 VTT20590.1     1
 NCTC5370_00706 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC5370 SQE85503.1     1
 NCTC5371_00739 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC5371 SQF77647.1     1
 NCTC6179_00813 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC6179 SQF66648.1     1
 NCTC6181_02151 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC6181 VEF08302.1     1
 NCTC7136_00741 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC7136 SQG92562.1     1
 NCTC8546_00701 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC8546 VTS21365.1     1
 NCTC9413_00701 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC9413 VTT00236.1     1
 NCTC9414_01622 (HylB)   Streptococcus dysgalactiae subsp. equisimilis NCTC9414 SQF69583.1     1
 QWH96_03385   Streptococcus dysgalactiae subsp. equisimilis NS3396 WWE33338.1     1
 GGS_0628 (HylB)   Streptococcus dysgalactiae subsp. equisimilis RE378 BAM60784.1     1
 WJ054_03580   Streptococcus dysgalactiae subsp. equisimilis STG643 WYB66559.1     1
 HG697_03665   Streptococcus dysgalactiae subsp. equisimilis TPCH-A19 QJD61596.1     1
 HHM65_03695   Streptococcus dysgalactiae subsp. equisimilis TPCH-A74 QJD63506.1     1
 HHM66_03360   Streptococcus dysgalactiae subsp. equisimilis TPCH-A88 QJR38909.1     1
 QRS93_03340   Streptococcus dysgalactiae subsp. equisimilis TPCH-F37 WJD52852.1     1
 OPT60_03515   Streptococcus dysgalactiae subsp. equisimilis UT_10236 WHM88192.1     1
 OPT59_03710   Streptococcus dysgalactiae subsp. equisimilis UT_120444 WHM79817.1     1
 PMN45_11335   Streptococcus dysgalactiae USDA-20A WCE85890.1     1
 PP188_11340   Streptococcus dysgalactiae USDA_20B WCN25888.1     1
 MP619_07880 (fragment)   Streptococcus dysgalactiae WJ001 WAI94194.1     1
 P1X07_07235 (HylB)   Streptococcus equi Kargaly-22 WGS34635.1     1
 hyaluronidase (fragment)   Streptococcus equi SM001 AIS41026.1     1
 JZI44_07855 (HylB)   Streptococcus equi subsp. equi 470_001 QWB42342.1     1
 JZI56_07065 (HylB)   Streptococcus equi subsp. equi 470_003 QWB40255.1     1
 JZI50_02915 (HylB)   Streptococcus equi subsp. equi 470_006 QWB39317.1     1
 JZI48_08700 (HylB)   Streptococcus equi subsp. equi 470_007 QWB36469.1     1
 JZI59_02175 (HylB)   Streptococcus equi subsp. equi 470_008 QWB35259.1     1
 JZI66_07840 (HylB)   Streptococcus equi subsp. equi 489_002 QWB32417.1     1
 JZI57_07070 (HylB)   Streptococcus equi subsp. equi 489_004 QWB19358.1     1
 JZI54_02670 (HylB)   Streptococcus equi subsp. equi 489_005 QWB18558.1     1
 JZI51_06070 (HylB)   Streptococcus equi subsp. equi 489_010 QWB15304.1     1
 SE071780_01513   Streptococcus equi subsp. equi ATCC 39506 ASB97104.1     1
 NCTC12091_01309 (HylB)   Streptococcus equi subsp. equi NCTC12091 VED85854.1     1
 NCTC9682_01572 (Hylb_1)   Streptococcus equi subsp. equi NCTC9682 VEH34209.1     1
 hyaluronidase (Hyl)   Streptococcus equi subsp. zooepidemicus ACT33447.1     1
 HylC   Streptococcus equi subsp. zooepidemicus 542 AHI46574.1     1
 HylC   Streptococcus equi subsp. zooepidemicus 8 AHI46573.1     1
 hyaluronidase   Streptococcus equi subsp. zooepidemicus ATCC 35246 ACH78324.1     1
 hyaluronate lyase (HylB)   Streptococcus equi subsp. zooepidemicus ATCC 39920 AHJ09603.1     1
 GJS33_06510   Streptococcus equi subsp. zooepidemicus AZ-45470 QGM23791.1     1
 K3L73_06210 (HylB) (fragment)   Streptococcus equi subsp. zooepidemicus B630793 QZA21954.1     1
 QYM01_06505 (HylB)   Streptococcus equi subsp. zooepidemicus BJ-1 WKF65881.1     1
 hyaluronidase (Hyl) 4.2.2.1 Streptococcus equi subsp. zooepidemicus CVCC23362 ABV69920.1 A8HJR5   1
 Q426_02630   Streptococcus equi subsp. zooepidemicus CY AIA68655.1     1
 hyaluronidase (HylB)   Streptococcus equi subsp. zooepidemicus E69 AFK73249.1     1
 SZO_06680   Streptococcus equi subsp. zooepidemicus H70 CAW98747.1     1
 RIM63_06590 (HylB)   Streptococcus equi subsp. zooepidemicus HT321 WOK56553.1     1
 KCL43_06615 (HylB)   Streptococcus equi subsp. zooepidemicus IN-6992 QUF63522.1     1
 GJ622_06365 (HylB)   Streptococcus equi subsp. zooepidemicus ISU38408 QWN62109.1     1
 RIM64_03770 (HylB)   Streptococcus equi subsp. zooepidemicus JMC111 WOK55928.1     1
 hyaluronidase   Streptococcus equi subsp. zooepidemicus MF002 AKM20831.1     1
 Sez_1299   Streptococcus equi subsp. zooepidemicus MGCS10565 ACG62635.1     1
 hyaluronidase (HylB)   Streptococcus equi subsp. zooepidemicus NC88 AFK73248.1     1
 NCTC11606_01304 (HylB)   Streptococcus equi subsp. zooepidemicus NCTC11606 SQF54316.1     1
 NCTC11824_01293 (HylB)   Streptococcus equi subsp. zooepidemicus NCTC11824 SQG17479.1     1
 NCTC11854_02014 (HylB)   Streptococcus equi subsp. zooepidemicus NCTC11854 VTP94435.1     1
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