Polysaccharide Lyase Family 8

Activities in Family	Exo-β-1,4-glucuronan lyase (EC 4.2.2.-); Exo-hyaluronate lyase (EC 4.2.2.-); Hyaluronate lyase (EC 4.2.2.1); Xanthan lyase (EC 4.2.2.12); Chondroitinase B (EC 4.2.2.19); Poly(β-mannuronate) lyase / M-specific alginate lyase (EC 4.2.2.3); Chondroitin AC lyase (EC 4.2.2.5); Heparin lyase / heparin lyase I (EC 4.2.2.7);
Mechanism	b-elimination
3D Structure Status	( α / α ) ₆ toroid + anti-parallel β-sheet
Commercial Enzyme Provider(s)	MEGAZYME; PROZOMIX;
Statistics	GenBank accession (4807); Uniprot accession (30); PDB accession (54); 3D entries (13); cryst (1)

Summary

Download PL8 (5166) Taxonomic display Structure (13 - 1 cryst) Characterized (33)

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
EWF18_14015		Staphylococcus aureus subsp. aureus VB9352	QBB16950.1			1
SAVC_09900		Staphylococcus aureus subsp. aureus VC40	AEZ38132.1			1
E5491_12430		Staphylococcus aureus subsp. aureus WCUH29	QBZ86505.1			1
SAZ172_2305 (HysA)		Staphylococcus aureus subsp. aureus Z172	AGY90405.1			1
DD555_12545		Staphylococcus aureus SVH7513	AWI94352.1			1
RK63_002165		Staphylococcus aureus TCH 959	AUU72006.1			1
CPC18_13190		Staphylococcus aureus TF3198	AVT86180.1			1
TMSFP480_17140 (Hysa_1)		Staphylococcus aureus Tokyo12480	BBK65283.1			1
TMSFP480_20810 (Hysa_2)		Staphylococcus aureus Tokyo12480	BBK65650.1			1
TMSFP482_20850 (Hysa_2)		Staphylococcus aureus Tokyo12482	BBK68229.1			1
TMSFP482_17170 (Hysa_1)		Staphylococcus aureus Tokyo12482	BBK67861.1			1
USA300LVJ_21450		Staphylococcus aureus TPS3156	BCD44365.1			1
EX97_11340		Staphylococcus aureus UA-S391_USA300	AIA28693.1			1
BSG38_12410		Staphylococcus aureus UCI62	APZ38202.1			1
DKK89_00740		Staphylococcus aureus USA 100	AZR69393.1			1
AZ30_11650		Staphylococcus aureus USA300-ISMMS1	AHJ08020.1			1
AYM13_12230		Staphylococcus aureus USA300-SUR1	AQQ84907.1			1
AYM23_12290		Staphylococcus aureus USA300-SUR10	AQR11379.1			1
AYM24_12290		Staphylococcus aureus USA300-SUR11	AQR14318.1			1
AYM25_11970		Staphylococcus aureus USA300-SUR12	AQR17195.1			1
AYM26_12300		Staphylococcus aureus USA300-SUR13	AQR20142.1			1
AYM27_12305		Staphylococcus aureus USA300-SUR14	AQR23082.1			1
AYM28_12305		Staphylococcus aureus USA300-SUR15	AQR26024.1			1
AYM29_12305		Staphylococcus aureus USA300-SUR16	AQR29012.1			1
AYM30_12310		Staphylococcus aureus USA300-SUR17	AQR31960.1			1
AYM31_12305		Staphylococcus aureus USA300-SUR18	AQR34904.1			1
AYM32_12305		Staphylococcus aureus USA300-SUR19	AQR37853.1			1
AYM14_12230		Staphylococcus aureus USA300-SUR2	AQQ87834.1			1
AYM33_12280		Staphylococcus aureus USA300-SUR20	AQR40789.1			1
AYM34_12295		Staphylococcus aureus USA300-SUR21	AQR43727.1			1
AYM35_12270		Staphylococcus aureus USA300-SUR22	AQR46665.1			1
AYM36_12270		Staphylococcus aureus USA300-SUR23	AQR49601.1			1
AYM37_12305		Staphylococcus aureus USA300-SUR24	AQR52543.1			1
AYM15_12300		Staphylococcus aureus USA300-SUR3	AQQ90776.1			1
AYM16_12290		Staphylococcus aureus USA300-SUR4	AQQ93711.1			1
AYM18_12290		Staphylococcus aureus USA300-SUR5	AQQ96650.1			1
AYM19_12295		Staphylococcus aureus USA300-SUR6	AQQ99593.1			1
AYM20_12300		Staphylococcus aureus USA300-SUR7	AQR02557.1			1
AYM21_12290		Staphylococcus aureus USA300-SUR8	AQR05494.1			1
AYM22_12290		Staphylococcus aureus USA300-SUR9	AQR08440.1			1
AC807_2333		Staphylococcus aureus USA300_2014.C01	AKR52372.1			1
ACO02_1429		Staphylococcus aureus USA300_2014.C02	AKR46169.1			1
EP20_011105		Staphylococcus aureus V2200	ALK42585.1			1
ASL17_13125		Staphylococcus aureus V521	AND37019.1			1
ASL18_13125		Staphylococcus aureus V605	AND45683.1			1
E8M03_11690		Staphylococcus aureus VGC1	QEM86339.1			1
LR49_05405		Staphylococcus aureus WCH-SK2	AXN67690.1			1
EAX85_11005		Staphylococcus aureus WH3018	QHG77120.1			1
D7B62_05935		Staphylococcus aureus WH9628	QHG78899.1			1
SAXN108_2455		Staphylococcus aureus XN108	AID40896.1			1
AB179_11745		Staphylococcus aureus ZJ5499	AND03453.1			1
GAY69_10470		Staphylococcus aureus ZY05	QGM76062.1			1
SHYC_11715 (HysA)		Staphylococcus hyicus ATCC 11249	AJC97044.1			1
NZD48_11850		Staphylococcus hyicus MM2101	UWF56691.1			1
NCTC10350_02359		Staphylococcus hyicus NCTC10350	SQE49429.1			1
LN051_02175		Staphylococcus ratti CCM 9025	UEX90496.1			1
ML437_10590		Staphylococcus roterodami BDS-54	UMT80244.1			1
ML436_11195		Staphylococcus roterodami Zoo-28	UMT77685.1			1
ML436_08865		Staphylococcus roterodami Zoo-28	UMT77305.1			1
DMB76_000430		Staphylococcus saccharolyticus 13T0028	QRJ66737.1			1
DMB75_000385		Staphylococcus saccharolyticus DVP5-16-4677	QRJ68476.1			1
I6I31_03920		Staphylococcus saccharolyticus FDAARGOS_1074	QQB99049.1			1
NCTC13712_02147 (HylB)		Staphylococcus schweitzeri NCTC13712	VEE66651.1			1
KI229_10980		Staphylococcus sp. MZ1	QWC04102.1			1
KI230_11100		Staphylococcus sp. MZ3	QWC01546.1			1
KI234_11310		Staphylococcus sp. MZ7	QWC12659.1			1
KI239_11240		Staphylococcus sp. MZ8	QWB97440.1			1
KI244_08570		Staphylococcus sp. MZ9	QWC06248.1			1
JQN76_12795		Staphylococcus sp. SM3655	QRX76581.1			1
JQN76_06330		Staphylococcus sp. SM3655	QRX77920.1			1
JQN77_12780		Staphylococcus sp. SM9054	QRX79241.1			1
JQN77_06310		Staphylococcus sp. SM9054	QRX80581.1			1
JG553_08195 (HysA)		Staphylococcus sp. T93	QQV82571.1			1
GXP74_30850		Streptacidiphilus sp. P02-A3a	QMU71979.1
SCAT_4363		Streptantibioticus cattleyicolor NRRL 8057 = DSM 46488	CCB77059.1
SCATT_43510		Streptantibioticus cattleyicolor NRRL 8057 = DSM 46488	AEW96722.1
KX935_06200 (fragment)		Streptobacillus moniliformis BK14232	QXW65384.1
KX935_06160 (fragment)		Streptobacillus moniliformis BK14232	QXW65378.1
Smon_0125		Streptobacillus moniliformis DSM 12112	ACZ00618.1
Smon_0117 (fragment)		Streptobacillus moniliformis DSM 12112	ACZ00610.1
CEP89_03605		Streptobacillus moniliformis FDAARGOS_310	AVL42971.1
CEP89_03645 (fragment)		Streptobacillus moniliformis FDAARGOS_310	AVL42978.1
HKK59_06245		Streptococcus agalactiae 01173	QJQ92957.1			1
BSA_12760		Streptococcus agalactiae 09mas018883	CCW38045.1			1
V193_05585		Streptococcus agalactiae 138P	AHN30604.1			1
DN94_05585		Streptococcus agalactiae 138spar	AHX75150.1			1
GBS222_1026 (HylB)		Streptococcus agalactiae 2-22	CCO74748.1			1
SAG1197		Streptococcus agalactiae 2603V/R	AAN00079.1 NP_688206.1			1
DKY66_06695		Streptococcus agalactiae 32790-3A	QDI66339.1			1
hyaluronate lyase (HylB)	4.2.2.1	Streptococcus agalactiae 4755	CAA75865.1	O86478		1
GRB95_06050		Streptococcus agalactiae 515	QJC65326.1			1
CHF17_01286		Streptococcus agalactiae 874391	ASZ01543.1			1
SAK_1284 (HylB)		Streptococcus agalactiae A909	ABA45106.1			1
CCZ24_03895		Streptococcus agalactiae B105	AWZ35997.1			1
CDH84_05075		Streptococcus agalactiae B507	AWZ32146.1			1
CDH83_05005 (fragment)		Streptococcus agalactiae B508	AWZ30048.1
CDH85_07240		Streptococcus agalactiae B509	AWZ28445.1			1
GT95_06720		Streptococcus agalactiae C001	ASI66297.1			1
GBSCOH1_1103		Streptococcus agalactiae COH1	CDN66569.1			1
BB161_06890		Streptococcus agalactiae CUGBS591	ASA79900.1			1
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