Activities in Family	Hyaluronate lyase (EC 4.2.2.1); Gellan lyase (EC 4.2.2.25); Chondroitin AC lyase (EC 4.2.2.5);
Mechanism	b-elimination
Note	This family groups together polysaccharide lyases active on hyaluronan, gellan and chondroitin sulfate (Helbert et al., PNAS (2019) [PMID=30850540])
Statistics	GenBank accession (1068); Uniprot accession (5);

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
PPYC2_15205		Paenibacillus polymyxa YC0573	APB78419.1			2
FGY93_22440		Paenibacillus polymyxa ZF129	QDA29487.1			2
FQU75_02665		Paenibacillus polymyxa ZF197	QDY82398.1			2
MJ749_10415		Paenibacillus polymyxa ZJ-9	UMR37804.1			2
ET464_18140		Paenibacillus protaetiae FW100M-2	QAY68007.1			2
EHS13_26260 (fragment)		Paenibacillus psychroresistens ML311-T8	QGQ98141.1			1
EHS13_26265 (fragment)		Paenibacillus psychroresistens ML311-T8	QGQ98142.1			1
GZH47_09715		Paenibacillus rhizovicinus 14171R-81	QHW31104.1			1
GZH47_26450		Paenibacillus rhizovicinus 14171R-81	QHW33984.1			2
GZH47_20150		Paenibacillus rhizovicinus 14171R-81	QHW32894.1			1
PRIO_1667		Paenibacillus riograndensis SBR5	CQR53997.1			2
JI735_16460		Paenibacillus sonchi LMG 24727	QQZ63874.1			2
H1230_10950		Paenibacillus sp. 19GGS1-52	ULO09239.1			2
IJ21_46570		Paenibacillus sp. 32O-W	ALS30020.1			2
WG8_2240		Paenibacillus sp. Aloe-11	EHS57767.1			2
GE073_17180		Paenibacillus sp. B01	QGG57147.1			2
BBD42_14495 (fragment)		Paenibacillus sp. BIHB 4019 BIHB4019	ANY67548.1			2
P0X86_04645 (fragment)		Paenibacillus sp. BR1-192	WFB59537.1			2
DCC85_03115		Paenibacillus sp. CAA11	AWB43315.1			2
N6H13_14965		Paenibacillus sp. CC-CFT742	WJH31697.1			2
N6H14_04945 (fragment)		Paenibacillus sp. CC-CFT747	WJH35390.1			1
B9D94_24150 (fragment)		Paenibacillus sp. Cedars	AWP29512.1			2
K5K90_09830		Paenibacillus sp. DR312	QZN77446.1			2
HW560_03500		Paenibacillus sp. E222	QLG37313.1			2
H70357_24070 (fragment)		Paenibacillus sp. FSL H7-0357	AIQ19448.1			2
H70357_25695		Paenibacillus sp. FSL H7-0357	AIQ19729.1			2
H70737_10690		Paenibacillus sp. FSL H7-0737	AIQ23275.1			2
P40081_25895		Paenibacillus sp. FSL P4-0081	AIQ31214.1			2
R50345_11240		Paenibacillus sp. FSL R5-0345	AIQ35129.1			2
R50912_23860		Paenibacillus sp. FSL R5-0912	AIQ42741.1			2
R70723_23405		Paenibacillus sp. FSL R7-0273	AIQ48533.1			2
R70331_22435		Paenibacillus sp. FSL R7-0331	AIQ54020.1			2
QNH28_10740		Paenibacillus sp. G2S3	WHY21420.1			2
DVH26_16465		Paenibacillus sp. H1-7	ULL15895.1			2
DVH26_17785		Paenibacillus sp. H1-7	ULL16140.1			2
DVH26_27080		Paenibacillus sp. H1-7	ULL17800.1			1
DVH26_33095		Paenibacillus sp. H1-7	ULL18850.1			1
LOZ80_30690		Paenibacillus sp. HWE-109	UKS25886.1			2
ASL14_00365		Paenibacillus sp. IHB B 3084	ALP38910.1			2
Pjdr2_4038		Paenibacillus sp. JDR-2	ACT02668.1			2
JNUCC31_16515		Paenibacillus sp. JNUCC-31	QOS76467.1			2
JNUCC32_20480 (fragment)		Paenibacillus sp. JNUCC32	QOT08528.1			2
PQ460_08715		Paenibacillus sp. KACC 21273	WDF52473.1			2
T3H97_11025		halophilic eubacterium NRCC 41227 LX16	WVD78491.1			2
C0638_22205		Paenibacillus sp. lzh-N1	AUO09044.1			2
EGM68_11160		Paenibacillus sp. M-152	AZH29285.1			2
MJB10_08720		Paenibacillus sp. MBLB1832	WNR46161.1			1
MJB10_17960		Paenibacillus sp. MBLB1832	WNR42993.1			1
MJB10_22560		Paenibacillus sp. MBLB1832	WNR43851.1			1
MJB10_16190		Paenibacillus sp. MBLB1832	WNR42655.1			2
MJB10_16810 (fragment)		Paenibacillus sp. MBLB1832	WNR42776.1			1
MJB10_07575 (fragment)		Paenibacillus sp. MBLB1832	WNR45948.1			1
MJB10_18160		Paenibacillus sp. MBLB1832	WNR43031.1			1
MJB10_03685		Paenibacillus sp. MBLB1832	WNR45248.1			2
MJB10_16815 (fragment)		Paenibacillus sp. MBLB1832	WNR42777.1			1
MJB10_23190		Paenibacillus sp. MBLB1832	WNR43967.1			2
MJB10_07570 (fragment)		Paenibacillus sp. MBLB1832	WNR45947.1			1
LOS79_02400		Paenibacillus sp. MMS20-IR301	WNS44138.1			2
POTG_03719		Paenibacillus sp. oral taxon 786 str. D14	EES71610.1			2
MT997_05290		Paenibacillus sp. OVF10	UOK64014.1			2
QNO02_01900		Paenibacillus sp. PK1-4R	WJM08727.1			2
C2I18_03535		Paenibacillus sp. PK3_47	UQZ32710.1			2
PO903_19675		Paenibacillus sp. PK4536	WIM38847.1			2
K2F33_09410		Paenibacillus sp. PSB04	UYO07548.1			2
K2F33_22565		Paenibacillus sp. PSB04	UYO02520.1			1
KAI36_02245		Paenibacillus sp. S02	QYK67098.1			2
KAI37_02232		Paenibacillus sp. S25	QYK61908.1			2
KZ483_08140		Paenibacillus sp. sptzw28	QYR22889.1			2
GYMC10_0963 (fragment)		Paenibacillus sp. Y412MC10	ACX63261.1			2
V6669_01910		Paenibacillus sp. Y5S-9	WWP27274.1			2
L0M14_03900 (fragment)		Paenibacillus sp. YPD9-1	UJF34362.1			2
L0M14_03905 (fragment)		Paenibacillus sp. YPD9-1	UJF36251.1			2
L1F29_19880		Paenibacillus spongiae PHS-Z3	UVI27722.1			1
HPL003_19350		Paenibacillus terrae HPL-003	AET60610.1			2
FLT15_03585		Paenibacillus thiaminolyticus Mbale	QDM48157.1			1
L3476_20095		Paenibacillus thiaminolyticus Mbale2	WCR25618.1			1
FLT43_18080		Paenibacillus thiaminolyticus NRRL B-4156	QDM45168.1			1
JRJ22_21285		Paenibacillus tianjinensis TB2019	QSF43766.1			2
JRJ22_18845 (fragment)		Paenibacillus tianjinensis TB2019	QSF43326.1			2
KDC22_22500		Paenibacillus tritici PH55-1	QUL53173.1			2
V6W81_01750		Paenibacillus tundrae MLY93	WWM61780.1			2
PUW25_01495		Paenibacillus urinalis 2022CK-00829	WDI02692.1			2
PUW23_01495		Paenibacillus urinalis 2022CK-00830	WDH82948.1			2
PUW24_09040		Paenibacillus urinalis 2022CK-00833	WDH98998.1			2
BS614_05340		Paenibacillus xylanexedens PAMC 22703	APO43490.1			2
IRI77_29835		Paludibaculum fermentans P105	QOY86942.1			1
P3L47_09750		Parabacteroides chongii YMC B3181	WFE86843.1			1
P3L47_02240		Parabacteroides chongii YMC B3181	WFE85438.1			2
HHO38_02670		Parabacteroides distasonis CBBP	QJE31007.1			1
P8F78_19550		Parabacteroides distasonis PC19	WRY45771.1			1
NXY11_17005		Parabacteroides faecis BFG-489	UVQ49398.1			1
K6V26_17980		Parabacteroides goldsteinii BFG-241	UBD73042.1			1
NQ564_18535		Parabacteroides johnsonii DSM 18315	UWP42865.1			1
NQ542_17105		Parabacteroides merdae ATCC 43184	UWP46413.1			1
K6V24_13945		Parabacteroides merdae BFG-280	UBD60536.1			1
INE87_02046		Parabacteroides merdae CL06T03C08	QUT49571.1			1
D3H65_32560		Paraflavitalea soli 5GH32-13	AXY78436.1			1
D3H65_05370		Paraflavitalea soli 5GH32-13	AXY73440.1			1
GCM10025865_07740		Paraoerskovia sediminicola NBRC 108565	BDZ41475.1			1
Spico_1742		Parasphaerochaeta coccoides DSM 17374	AEC02940.1			1
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