Activities in Family	Hyaluronate lyase (EC 4.2.2.1); Gellan lyase (EC 4.2.2.25); Chondroitin AC lyase (EC 4.2.2.5);
Mechanism	b-elimination
Note	This family groups together polysaccharide lyases active on hyaluronan, gellan and chondroitin sulfate (Helbert et al., PNAS (2019) [PMID=30850540])
Statistics	GenBank accession (1068); Uniprot accession (5);

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
Cfast33896_07430		Coprobacter fastidiosus JCM 33896	BEG61788.1			1
Cop2CBH44_00610		Coprobacter secundus subsp. similis 2CBH44	BCI61708.1			2
Cop2CBH44_13470		Coprobacter secundus subsp. similis 2CBH44	BCI62994.1			1
Cop2CBH44_09180		Coprobacter secundus subsp. similis 2CBH44	BCI62565.1			2
SH580_00340 (fragment)		Coraliomargarita sp. J2-16	WPJ96147.1			2
SH580_12660		Coraliomargarita sp. J2-16	WPJ94287.1			2
QPJ90_12565		Curtobacterium sp. 458	WJX99151.1			1
BJK06_00825		Curtobacterium sp. BH-2-1-1	AOX64548.1			1
Csp_E34580		Curvibacter putative symbiont of Hydra magnipapillata	CBA26370.1			2
AEP_00573		Curvibacter sp. AEP1-3	ARV17533.1			2
CyaNS01_02120 (fragment)		Cyanobium sp. NS01	QNI71244.1			2
CyaNS01_02124 (fragment)		Cyanobium sp. NS01	QNI71248.1
CA2015_3427		Cyclobacterium amurskyense KCTC 12363	AKP52816.1			1
CA2015_3297		Cyclobacterium amurskyense KCTC 12363	AKP52689.1			1
Cycma_3558		Cyclobacterium marinum DSM 745	AEL27278.1			1
Cycma_3430		Cyclobacterium marinum DSM 745	AEL27153.1			1
Dmats_34195		Dactylosporangium matsuzakiense NRRL B-16293	UWZ42587.1			1
Dvina_39280		Dactylosporangium vinaceum NRRL B-16297	UAB94179.1			1
N8A98_13550 (fragment)		Devosia neptuniae A18/4-1	UXN68296.1			2
JI749_06635		Devosia oryziradicis G19	QQR37281.1			2
K1X15_01685		Devosia salina SCS-3	QYO77319.1			2
FPZ08_11705		Devosia sp. Gsoil 520	QDZ11368.1			1
PSC71_01730		Devosia sp. J2-20	WDQ99561.1			2
QOV41_12550		Devosia sp. RR2S18	WIJ23881.1			2
IM737_08120		Devosia sp. SL43	UJW87194.1			2
V8Z65_02030		Devosia sp. XK-2	WWZ46168.1			2
Dfer_4959		Dyadobacter fermentans DSM 18053	ACT96159.1			1
ON006_18780		Dyadobacter pollutisoli U1	WAC09795.1			1
HWI92_13220		Dyadobacter sandarakinus Q3-56	QRR01801.1			1
JS578_14145		Dysgonomonadaceae bacterium zrk40	QRX65188.1			1
G7050_11225		Dysgonomonas sp. HDW5A	QIK60365.1			1
G7051_11520		Dysgonomonas sp. HDW5B	QIK54932.1			1
FKX85_10310		Echinicola soli LN3S3	QDH79405.1			1
DN752_23080		Echinicola strongylocentroti MEBiC08714	AWW32793.1			2
DN752_16520		Echinicola strongylocentroti MEBiC08714	AWW31597.1			1
Echvi_2166		Echinicola vietnamensis DSM 17526	AGA78417.1			1
H7846_00555		Edaphobacter sp. 4G125	QNI36871.1			1
AFK01568		Emticicia oligotrophica DSM 17448	AFK01568.1			1
MB380_11975		Emticicia sp. 21SJ11W-3	UTA66321.1			1
PZY29_14435		Enterococcus casseliflavus ASE2	WEI91911.1			2
P0G38_14810		Enterococcus casseliflavus ASE4	WEL47032.1			2
PEZ80_02315		Enterococcus casseliflavus CQFYY22-063	WBY92563.1			2
U8771_02270		Enterococcus casseliflavus Dec0527	WRO94844.1			2
D8N35_01435		Enterococcus casseliflavus EC-369	AYJ43821.1			2
GFU50_02275		Enterococcus casseliflavus EC291	QGN28417.1			2
LLW22_02400		Enterococcus casseliflavus ECB140	UOO46065.1			2
ECKB_04910		Enterococcus casseliflavus KB1733	BFI77525.1			2
EFE1002_907		Enterococcus faecium isolate EFE10021	CUX98385.1			2
ENLAB_23260		Enterococcus innesii DB-1	BDG68762.1			2
EM151A_2689		Enterococcus mundtii 15-1A	BBM15850.1			2
EM4838_04485		Enterococcus mundtii DSM 4838	AUB52270.1			2
K9N66_03040		Enterococcus mundtii P6	UBM06143.1			2
DDJ96_04920		Enterococcus mundtii Pe103	QCJ55985.1			2
CYK55_05045		Enterococcus mundtii Pe161	AZP92506.1			2
EMQU_1017		Enterococcus mundtii QU 25 QU25	BAO06574.1			2
A5888_000551		Enterococcus sp. 9E7_DIV0242	WYJ88832.1			2
CXM95_02570		Enterococcus sp. CR-Ec1	AUJ84390.1			2
DOK79_002240		Enterococcus sp. DIV1094	WYJ80657.1			2
CK496_05375		Enterococcus thailandicus a523	ASZ07363.1			2
C4Q21_10200		Faecalibacterium prausnitzii APC918/95b	AXB29264.1			1
FP2_29880		Faecalibacterium prausnitzii L2-6 L2/6	CBL00243.1			1
FPR_25260		Faecalibacterium prausnitzii SL3/3	CBL02665.1			1
PXW01_13475		Faecalibacterium sp. BCRC 81399	WWE30097.1			1
MTP38_11145		Faecalibacterium sp. I3-3-89	UQK42633.1			1
MTP36_13785		Faecalibacterium sp. I4-1-79	UQK39847.1			1
MTP41_12120		Faecalibacterium sp. I4-3-84	UQK36595.1			1
MTP43_05205		Faecalibacterium sp. IP-1-18	UQK54918.1			1
FAES_3044		Fibrella aestuarina BUZ 2	CCH01053.1			1
A6C57_20500		Fibrella sp. ES10-3-2-2	ARK12524.1			1
FLA_4343		Filimonas lacunae NBRC 104114	BAV08307.1			1
R9C00_26195		Flammeovirgaceae bacterium SG7u.111	WPO35190.1			1
R9C00_19340		Flammeovirgaceae bacterium SG7u.111	WPO33856.1			2
BN863_10330		Formosa agariphila KMM 3901	CDF78745.1			2
FNB79_10000		Formosa sediminum PS13	QDO94285.1			2
FUAX_20430		Fulvitalea axinellae DSM 100852	BDD09611.1			1
MF406_12155		Georgenia sp. TF02-10	UNX53735.1			1
LB888_01550		Globicatella sp. PHS-GS-PNBC-21-1553	WPC08957.1			2
GCM10025732_18690		Glycomyces mayteni JCM 16217	BFF23904.1			2
K3N28_04955		Glycomyces sp. TRM65418	QZD56470.1			2
MUN88_20710		Gracilibacillus caseinilyticus SSWR10-1	UOQ48423.1			2
MUN87_20830		Gracilibacillus salinarum SSPM10-3	UOQ85057.1			2
GI584_07675		Gracilibacillus salitolerans SCU50	QGH33906.1			2
D7I44_01250		Gryllotalpicola protaetiae 2DFW10M-5	AYG02290.1			1
YC6258_05947		Gynuella sunshinyii YC6258	AJQ97971.1			2
AEE51428.1		Haliscomenobacter hydrossis DSM 1100	AEE51428.1			1
AS203_11720		Hoylesella enoeca F0113	ALO50006.1			1
FPZ11_16980		Humibacter ginsenosidimutans WJ7-1	QDZ16226.1			1
DVJ78_16450		Humibacter sp. BT305	AXH36791.1			1
NQ487_18445		Hungatella hathewayi DSM 13479	UWO82858.1			1
SD425_12630		Hymenobacter sp. GOD-10R	WRQ31104.1			1
EJN90_01870		Jeotgalibaca ciconiae H21T32	AZP03519.1			2
LZ578_00335 (fragment)		Jeotgalibaca sp. MA1X17-3	UJF15695.1			2
LZ578_00340 (fragment)		Jeotgalibaca sp. MA1X17-3	UJF15696.1			2
SAMN04488563_5347		Jiangella alkaliphila DSM 45079	SDU76882.1			1
RBB56_15315		Kineothrix sp. MB12-C1	WMC92202.1			1
L21SP4_01402		Kiritimatiella glycovorans L21-Fru-AB	AKJ64649.1			2
OX958_16425		Kribbella sp. CA-293567	WBQ08352.1			1
CE91St56_47590		Lachnospiraceae bacterium CE91-St56	BDF47636.1			2
CE91St56_11830		Lachnospiraceae bacterium CE91-St56	BDF44060.1			2
C3V36_08740		Lachnospiraceae bacterium oral taxon 500 W11650	AVM70490.1			1
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