Activities in Family	Hyaluronate lyase (EC 4.2.2.1); Gellan lyase (EC 4.2.2.25); Chondroitin AC lyase (EC 4.2.2.5);
Mechanism	b-elimination
Note	This family groups together polysaccharide lyases active on hyaluronan, gellan and chondroitin sulfate (Helbert et al., PNAS (2019) [PMID=30850540])
Statistics	GenBank accession (1051); Uniprot accession (5);

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
FE838_12025		Bacteroides thetaiotaomicron DSM 2079	QMW86743.1			1
BatF92_42350		Bacteroides thetaiotaomicron F9-2	BCA52293.1			2
BatF92_08910		Bacteroides thetaiotaomicron F9-2	BCA48949.1			1
I6G92_18855		Bacteroides thetaiotaomicron FDAARGOS_935	QQA07483.1			1
I6G92_02550		Bacteroides thetaiotaomicron FDAARGOS_935	QQA08833.1			2
RJT07_13085		Bacteroides thetaiotaomicron H-2209	WOG18108.1			2
RJT07_20130		Bacteroides thetaiotaomicron H-2209	WOG19441.1			1
RJT03_06410		Bacteroides thetaiotaomicron H-2622	WOG44039.1			2
RJT03_01745		Bacteroides thetaiotaomicron H-2622	WOG43172.1			1
MJ393_11365		Bacteroides thetaiotaomicron VPI 5482	UML63643.1			1
MJ393_04145		Bacteroides thetaiotaomicron VPI 5482	UML62273.1			2
KQP69_10425		Bacteroides thetaiotaomicron VPI-2808B	UYV02639.1			1
KQP69_17865		Bacteroides thetaiotaomicron VPI-2808B	UYU99472.1			2
KQP56_21585		Bacteroides thetaiotaomicron VPI-3164	UYU95197.1			1
KQP56_14960		Bacteroides thetaiotaomicron VPI-3164	UYU93935.1			2
KQP74_18920		Bacteroides thetaiotaomicron VPI-3443	UYU89992.1			2
KQP74_02230		Bacteroides thetaiotaomicron VPI-3443	UYU91472.1			1
BT2963		Bacteroides thetaiotaomicron VPI-5482	AAO78069.1			2
chondroitin-sulfate lyase (BT4410)	4.2.2.5	Bacteroides thetaiotaomicron VPI-5482	AAO79515.1			1
KP721_02730		Bacteroides thetaiotaomicron VPI-5482A	UYU86725.1			1
KP721_23110		Bacteroides thetaiotaomicron VPI-5482A	UYU86027.1			2
KQP77_02450		Bacteroides thetaiotaomicron VPI-BT7853	UYU82028.1			1
KQP77_06570		Bacteroides thetaiotaomicron VPI-BT7853	UYU82798.1			2
KQP72_23360		Bacteroides thetaiotaomicron VPI-BT8702	UYU75968.1			2
KQP72_01030		Bacteroides thetaiotaomicron VPI-BT8702	UYU76701.1			1
KQP59_11395		Bacteroides thetaiotaomicron VPI-BTDOT2	UYU73676.1			2
KQP59_02335		Bacteroides thetaiotaomicron VPI-BTDOT2	UYU71975.1			1
KQP68_18725		Bacteroides thetaiotaomicron WAL8669	UYU65594.1			1
KQP68_16535		Bacteroides thetaiotaomicron WAL8669	UYU65177.1			2
KQP65_23480		Bacteroides thetaiotaomicron WAL8713	UYU61345.1			1
KQP65_01435		Bacteroides thetaiotaomicron WAL8713	UYU62066.1			2
FQN58_01375		Bacteroides xylanisolvens APCS1/XY	QUR41976.1			1
P2T61_03660		Bacteroides xylanisolvens AY11-1	WET86775.1			1
NXW81_11660		Bacteroides xylanisolvens BFG-319	UVQ13321.1			1
NXX95_12385		Bacteroides xylanisolvens BFG-514	UVP21912.1			1
INE92_00060		Bacteroides xylanisolvens CL11T00C03	QUT28079.1			1
INE93_05112		Bacteroides xylanisolvens CL11T00C41	QUT27616.1			1
GFH35_06090		Bacteroides xylanisolvens funn3	QRM98275.1			1
FKZ68_11100		Bacteroides xylanisolvens H207	QDH54743.1			1
BXY_35320		Bacteroides xylanisolvens XB1A	CBK68523.1			1
DQQ01_15480		Blautia argi KCTC 15426	AWY99291.1			2
INP51_05190		Blautia liquoris LZLJ-3	QOV20344.1			1
Bfae_29060		Brachybacterium faecium DSM 4810	ACU86667.1			1
CFK41_14340		Brachybacterium ginsengisoli DCY80	ATG55823.1			1
NLU66_10820		Brachybacterium rhamnosum NBEC-018	UVY82723.1			1
DWV08_12185		Brachybacterium saurashtrense DSM 23186	AXK46293.1			1
C1N80_10020		Brachybacterium sp. SGAir0954	QCR53878.1			1
JFL75_08010		Breznakiella homolactica RmG30	QQO10847.1			2
bhn_I0696		Butyrivibrio hungatei MB2003	AOZ95730.1			1
bpr_I2146		Butyrivibrio proteoclasticus B316	ADL34879.1			1
U14_03457		Candidatus Moduliflexus flocculans	GAK52206.1			1
CS0771_32720		Catellatospora sp. IY07-71	BCJ73728.1			2
Caci_0131		Catenulispora acidiphila DSM 44928	ACU69086.1			2
KG102_14065		Cellulomonas fengjieae zg-ZUI188	QVI65236.1			1
M666_00045		Cellulophaga baltica 18	AIZ43603.1			2
M601_019925		Cellulophaga baltica 4	WFO15941.1			2
M667_00045		Cellulophaga baltica NN016038	AIY11744.1			2
H0I23_04935		Cellulophaga sp. HaHaR_3_176	QWX84985.1			2
H0I24_08150		Cellulophaga sp. HaHa_2_1	QXP53886.1			2
H0I25_07035		Cellulophaga sp. HaHa_2_95	QXP57529.1			2
FIC82_011530		Cellulosimicrobium protaetiae BI34	QJW36727.1			1
PVE73_03900		Chelativorans sp. AA-79	WEX10119.1			2
GWR21_02400		Chitinophaga agri H33E-04	QHS58484.1			1
GWR21_09530		Chitinophaga agri H33E-04	QHS59822.1			1
COR50_04215		Chitinophaga caeni 13	ATL46443.1			1
MYF79_25340		Chitinophaga filiformis YT5	UPK68286.1			1
MYF79_17100		Chitinophaga filiformis YT5	UPK66658.1			1
MKQ68_02980		Chitinophaga horti R8	UYQ94054.1			1
MKQ68_14255		Chitinophaga horti R8	UYQ91253.1			1
HF324_30580		Chitinophaga oryzae 1303	QJB41958.1			1
Cpin_4527		Chitinophaga pinensis DSM 2588	ACU61969.1			1
644968008		Chitinophaga pinensis DSM 2588	ACU63288.1			1
HF329_30595		Chitinophaga sp. 1310	QJB35422.1			1
FW415_20935		Chitinophaga sp. XS-30	QEH43196.1			1
PIECOFPK_00535		Chitinophagaceae bacterium C216	WWC82825.1			1
QNM32_05795		Chitinophagaceae bacterium DXS	WJK48699.1			1
OQ292_07560		Chondrinema litorale WSW3-B12	UZR95665.1			1
JS518_09280		Clostridiales bacterium FE2010	QTE73128.1			1
JRC49_04795		Clostridiales bacterium FE2011	QTE72141.1			1
JYE49_00375		Clostridiales bacterium R-7	QUC67210.1			1
JYE50_15215		Clostridiales bacterium WTE2008	QUA53013.1			1
JNO48_09935		Clostridiales bacterium XBB3002	QTE67518.1			1
Clocel_1515		Clostridium cellulovorans 743B	ADL51264.1			2
LL033_08075		Clostridium estertheticum CF002	WAG57178.1			2
LL037_04980		Clostridium estertheticum CF003	WAG66504.1			2
LL038_17495		Clostridium estertheticum CF009	WAG59418.1			2
LL065_22070		Clostridium estertheticum CF016	WAG40903.1			2
LL127_03890		Clostridium estertheticum CM034	WAG46702.1			2
Closa_1714		[Clostridium] saccharolyticum WM1	ADL04310.1			1
SAMN02745906_1109		[Clostridium] sphenoides JCM 1415 ATCC 19403	SET68569.1			1
B5808_04450		Cnuibacter physcomitrellae XA(T)	ARJ04557.1			1
SAMN04515647_0370		Cohaesibacter sp. ES.047	SNY90223.1			1
HH215_12780		Cohnella herbarum MFER-1	QJD83970.1			1
HH215_33460		Cohnella herbarum MFER-1	QJD87610.1			1
HH215_34675		Cohnella herbarum MFER-1	QJD87835.1			1
Cfast33896_07430		Coprobacter fastidiosus JCM 33896	BEG61788.1			1
Cop2CBH44_00610		Coprobacter secundus subsp. similis 2CBH44	BCI61708.1			2
Cop2CBH44_13470		Coprobacter secundus subsp. similis 2CBH44	BCI62994.1			1
Cop2CBH44_09180		Coprobacter secundus subsp. similis 2CBH44	BCI62565.1			2
SH580_00340 (fragment)		Coraliomargarita sp. J2-16	WPJ96147.1			2
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