Activities in Family	Hyaluronate lyase (EC 4.2.2.1); Gellan lyase (EC 4.2.2.25); Chondroitin AC lyase (EC 4.2.2.5);
Mechanism	b-elimination
Note	This family groups together polysaccharide lyases active on hyaluronan, gellan and chondroitin sulfate (Helbert et al., PNAS (2019) [PMID=30850540])
Statistics	GenBank accession (1068); Uniprot accession (5);

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
H4075_11030		Lacibacter sediminis S13-6-22	QNA42641.1			1
I6K70_08195		Lacrimispora saccharolytica FDAARGOS_1340	QRV21417.1			1
OW255_12315		Lacrimispora xylanolytica sy1	WAJ22360.1			1
Verru16b_01398		Lacunisphaera limnophila IG16b	AOS44337.1			2
NCTC4824_03628		Lederbergia lenta NCTC4824	SQI62159.1			2
SAMN04515683_2790		Leifsonia sp. 157MF	SDK24270.1			1
SAMN04515690_3828		Leifsonia sp. 197AMF	SDH71808.1			1
SAMN04515680_0150		Leifsonia sp. 21MFCrub1.1	SEA36878.1			1
SAMN04515684_3975		Leifsonia sp. 466MF	SDJ50192.1			1
SAMN04515685_2774		Leifsonia sp. 467MF	SEN38149.1			1
SAMN04515686_2162		Leifsonia sp. 509MF	SDN70083.1			1
SAMN04515691_0192		Leifsonia sp. 98AMF	SFL64730.1			1
IT072_17155		Leifsonia sp. ZF2019	UAJ78923.1			1
heparinase II/III family protein		Maribacter forsetii	WP_209435194.1			2
YQ22_02145		Maribacter sp. 1_2014MBL_MicDiv	APA63229.1			2
SAMN05192545_0701		Maribacter sp. MAR_2009_60	SDS06077.1			2
GM418_02615		Maribellus comscasis WC007	QGY42581.1			1
L1P08_14920		Mariluticola halotolerans LMO-2	UJQ94234.1			1
BKP56_10790		Marinilactibacillus sp. 15R	API89715.1			2
TM49_06940		Martelella endophytica YC6887	AJY48000.1			1
JET14_18320		Martelella lutilitoris ZRK001	QQM30201.1			1
JET14_22555		Martelella lutilitoris ZRK001	QQM33034.1			1
AZF01_16115		Martelella sp. AD-3	AMM86910.1			1
AZF01_21345		Martelella sp. AD-3	AMM87090.1			1
MPTP_0399		Melissococcus plutonius ATCC 35311	BAK20881.1			2
DAT1033_1578		Melissococcus plutonius DAT1033	BBP08017.1			2
DAT561_1490		Melissococcus plutonius DAT561	BBC61587.1			2
MPD5_1501 (fragment)		Melissococcus plutonius DAT561	BAL62704.1			2
MPD5_1500 (fragment)		Melissococcus plutonius DAT561	BAL62703.1
DAT585_0360		Melissococcus plutonius DAT585	BBD14766.1			2
DAT606_1578		Melissococcus plutonius DAT606	BBD17461.1			2
MEPL_c003570		Melissococcus plutonius S1	AIM24546.1			2
MVE64_19950		Metabacillus endolithicus KCTC 33579	UPG62703.1			2
KDJ21_025065		Metabacillus litoralis NCTR108	UHA59950.1			2
LPC09_06010		Metabacillus sp. B2-18	UGB32028.1			2
WCV66_08655		Metabacillus sp. FJAT-53654	WXB90249.1			2
HUW50_03945		Metabacillus sp. KUDC1714	QNF26766.1			2
QUC20_02830		Microbacterium arborescens SSF12	WJM16268.1			1
HCR76_00995		Microbacterium chengjingii HY60	QPZ38717.1			1
L2X98_02070		Microbacterium elymi KUDC0405	UJP13497.1			1
DXT68_14565		Microbacterium foliorum NRRL B-24224	AXL13220.1			1
GCM10017544_27950		Microbacterium imperiale JCM 1378	BFE41839.1			1
KV395_01705		Microbacterium luteolum KACC 14465	WDM45438.1			1
HW566_11770		Microbacterium oleivorans I46	QLD12390.1			1
BO218_07975		Microbacterium paludicola CC3	APF34127.1			1
IZR02_14540		Microbacterium paraoxydans 70447	QXE29558.1			1
SAMN04489809_1595		Microbacterium paraoxydans DSM 15019	SDS31984.1			1
VC184_02685		Microbacterium plantarum CoE-159-22	WRK17941.1			1
ET475_09775		Microbacterium protaetiae DFW100M-13	QAY60247.1			1
SM116_04085		Microbacterium rhizosphaerae KEMB 7306-513	WPR90479.1			1
G5T42_03640		Microbacterium sp. 4R-513	QIG38689.1			1
N8K70_01650		Microbacterium sp. AB	WOF23405.1			1
P6897_02930		Microbacterium sp. BDGP8	WHE36696.1			1
BJP65_11180		Microbacterium sp. BH-3-3-3	AOX46307.1			1
V8Z62_03570		Microbacterium sp. GJ_SRA_44_2022	WWS85311.1			1
GC092_01880		Microbacterium sp. JZ37	WRH16388.1			1
PU630_02460		Microbacterium sp. KACC 23027	WEG09450.1			1
L2X99_17340		Microbacterium sp. KUDC0406	UJP10089.1			1
LMS4_002074		Microbacterium sp. LMS4	WXK54417.1			1
LTA6_001777		Microbacterium sp. LTA6	WXH16360.1			1
OED01_15600		Microbacterium sp. M28	UYO97004.1			2
AXH82_04090		Microbacterium sp. PAMC 28756	AMG82656.1			1
C1N74_02985		Microbacterium sp. SGAir0570	QCR39495.1			1
C6C15_14760		Microbacterium sp. str. China	AVL98258.1			1
AB663_000363		Microbacterium sp. XT11	ALX65699.1			1
CSX12_16200		Microbacterium sp. Y-01	AZH79874.1			1
QNO11_14080		Microbacterium sp. zg-B96	WIM15648.1			1
GCM10025863_30490		Microbacterium suwonense NBRC 106310	BDZ40435.1			1
MTES_2088		Microbacterium testaceum StLB037	BAJ75052.1			1
FOE78_08345		Microlunatus elymi KUDC0627	QDP95904.1			1
SAMN04489812_5869		Microlunatus soli DSM 21800	SDT44276.1			1
HZU44_14405		Micromonospora carbonacea africana	QLK01421.1			1
ID554_25850		Micromonospora craniellae LHW63014	QOC91369.1			1
HQ865_09560		Mucilaginibacter mali G2-14	QKJ29992.1			1
Mucpa_5256		Mucilaginibacter paludis DSM 18603	EHQ29331.1			2
MTO98_22820		Mucilaginibacter sp. SMC90	UOE47242.1			1
Pan265_04120 (fragment)		Mucisphaera calidilacus Pan265	QDU70584.1
L1999_02605		Neobacillus drentensis JC05	ULT57493.1			2
QNH29_02880		Neobacillus sp. DY30	WHY01224.1			2
QNH48_03015		Neobacillus sp. YX16	WHZ03674.1			2
LZK81_25095		Neorhizobium galegae 7g	UIK08764.1			1
RG1141_PA13830		Neorhizobium galegae bv. officinalis bv. officinalis str. HAMBI 1141	CDN58215.1			1
RG540_PA15560		Neorhizobium galegae bv. orientalis str. HAMBI 540	CDN52232.1			1
QEO92_21085		Neorhizobium petrolearium OS53	WGI67460.1			1
A8C56_05760		Niabella ginsenosidivorans BS26	ANH80559.1			1
A8C56_08215		Niabella ginsenosidivorans BS26	ANH83792.1			1
A8C56_12430		Niabella ginsenosidivorans BS26	ANH81682.1			2
NIASO_03145		Niabella soli DSM 19437	AHF14452.1			1
NIASO_06935		Niabella soli DSM 19437	AHF14963.1			1
U0035_13370		Niabella yanshanensis HAMBI_3031	WQD36658.1			1
FOC77_09345		Niallia circulans FDAARGOS_783	QKH60832.1			2
HLK66_08345		Niallia circulans GN03	QJX61657.1			2
C2I06_02125		Niallia circulans PK3_109	AYV65762.1			2
C2H98_07410		Niallia circulans PK3_138	AYV71428.1			2
C2I17_03965		Niallia circulans PK3_15	UQZ73793.1			2
Niako_5247		Niastella koreensis GR20-10	AEW01484.1			1
NTH_01072		Nitratireductor thuwali 1536	UUP16625.1			2
OIE67_17695		Nonomuraea fuscirosea NBC 01801	WSA56370.1			2
BN4615_P5870		Nonomuraea gerenzanensis ATCC 39727	SBO96354.1			2
LCN96_26890		Nonomuraea gerenzanensis L70	UBU18515.1			2
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