Activities in Family	Hyaluronate lyase (EC 4.2.2.1); Gellan lyase (EC 4.2.2.25); Chondroitin AC lyase (EC 4.2.2.5);
Mechanism	b-elimination
Note	This family groups together polysaccharide lyases active on hyaluronan, gellan and chondroitin sulfate (Helbert et al., PNAS (2019) [PMID=30850540])
Statistics	GenBank accession (1068); Uniprot accession (5);

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Bacteria
Protein Name	EC#	Organism	GenBank	Uniprot	PDB/3D	Subf
GBF35_39770		Nonomuraea nitratireducens WYY166	QFY11896.1			2
WBK31_17670		Nonomuraea sp. N2-4H	WXK68227.1			2
B0W44_10410		Novibacillus thermophilus SG-1	AQS56119.1			2
H8S90_23120		Olivibacter sp. SDN3	QNL49580.1			1
OpiT1DRAFT_02401		Opitutaceae bacterium TAV1	EIP97951.1			1
OpiT1DRAFT_03330		Opitutaceae bacterium TAV1	EIP98854.1			2
OpiT1DRAFT_04322		Opitutaceae bacterium TAV1	EIP99792.1			2
OpiT1DRAFT_05506		Opitutaceae bacterium TAV1	EIQ00947.1			2
OpiT1DRAFT_04330		Opitutaceae bacterium TAV1	EIP99799.1			2
OpiT1DRAFT_03028		Opitutaceae bacterium TAV1	EIP98570.1			2
OpiT1DRAFT_02671		Opitutaceae bacterium TAV1	EIP98219.1			2
OPIT5_05215		Opitutaceae bacterium TAV5	AHF89716.1			2
OPIT5_08640 (fragment)		Opitutaceae bacterium TAV5	AHF90263.1			2
endo-gellan lyase (OPIT5_09595)	4.2.2.25	Opitutaceae bacterium TAV5	AHF90411.1	W0J0V6		2
OPIT5_09555		Opitutaceae bacterium TAV5	AHF90404.1			2
endo-chondroitin sulfate lyase (OPIT5_11155)	4.2.2.5	Opitutaceae bacterium TAV5	AHF90672.1	W0IWV0		2
OPIT5_11335		Opitutaceae bacterium TAV5	AHF90704.1			2
endo-gellan lyase (OPIT5_12920)	4.2.2.25	Opitutaceae bacterium TAV5	AHF90976.1	W0J2L2		2
OPIT5_15710		Opitutaceae bacterium TAV5	AHF91451.1			2
QEH68_18190		Paenarthrobacter sp. OM7	WGM19930.1			1
EJC50_03300		Paenibacillus albus 18JY67-1	AZN38808.1			1
P9222_03315 (fragment)		Paenibacillus amylolyticus Sample9_7	WFR63427.1			2
P9222_03320 (fragment)		Paenibacillus amylolyticus Sample9_7	WFR63428.1			2
OGI70_22775		Paenibacillus amylolyticus SQR-21	WFA83813.1			2
V6668_01895		Paenibacillus amylolyticus Y5S-7	WWP20967.1			2
MJA45_23995		Paenibacillus aurantius MBLB1776	WNQ10648.1			1
HUB98_18975		Paenibacillus barcinonensis KACC11450	QKS58120.1			2
PBOR_25735		Paenibacillus borealis DSM 13188	AIQ59974.1			2
AR543_16875		Paenibacillus bovis BD3526	ANF97516.1			2
HUB94_09080		Paenibacillus cellulosilyticus KACC 14175	QKS44548.1			2
LPB68_13855		Paenibacillus crassostreae LPB0068	AOZ93188.1			2
QJQ58_21550		Paenibacillus dendritiformis 2022CK-00834	WGU93125.1			1
PsJ27TS7_00460		Paenibacillus dendritiformis J27TS7	BFH66046.1			1
B9T62_20665		Paenibacillus donghaensis KCTC 13049	ASA26402.1			2
A3958_13920 (fragment)		Paenibacillus glucanolyticus 5162	ANA81003.1			2
WDY75_26120 (fragment)		Paenibacillus glucanolyticus GlSt238	WXG81824.1			2
C7121_01585 (fragment)		Paenibacillus glucanolyticus W10507	AVV54925.1			2
PGRAT_07885		Paenibacillus graminis DSM 15220	AIQ67567.1			2
SK066_08965		Paenibacillus hunanensis Y9	WPP43048.1			2
BBD41_10130		Paenibacillus ihbetae IHBB 9852	ANY72916.1			2
SK3146_06148		Paenibacillus konkukensis SK3146	UQZ86855.1			1
SK3146_06103		Paenibacillus konkukensis SK3146	UQZ86810.1			1
SK3146_00620		Paenibacillus konkukensis SK3146	UQZ81464.1			2
SK3146_00341		Paenibacillus konkukensis SK3146	UQZ81185.1			2
SK3146_03002		Paenibacillus konkukensis SK3146	UQZ83795.1			1
B4V02_14305		Paenibacillus kribbensis AM49	ASR47766.1			2
PQ456_14455		Paenibacillus kyungheensis KACC 18744	WCT54400.1			2
D5F53_24765 (fragment)		Paenibacillus lautus E7593-69	AYB46311.1			2
EIM92_01905		Paenibacillus lentus DSM 25539	AZK48829.1			2
GXP70_21110		Paenibacillus lycopersici 12200R-189	QHT62232.1			2
GXP70_26525		Paenibacillus lycopersici 12200R-189	QHT63168.1			1
LMZ02_05530		Paenibacillus macerans I6	UMV48851.1			2
PTQ21_07080		Paenibacillus marchantiae BMpBG1	WDQ34001.1			2
PM3016_785		Paenibacillus mucilaginosus 3016	AFC27739.1			2
B2K_04005		Paenibacillus mucilaginosus K02	AFH59895.1			2
ERY13_04190		Paenibacillus mucilaginosus KN-18	WFA16616.1			2
KNP414_00892		Paenibacillus mucilaginosus KNP414	AEI39482.1			2
KCX80_04175		Paenibacillus mucilaginosus PM12	WDM28448.1			2
AASFL403_04630		Paenibacillus nuruki AASFL403	CAJ1314468.1			2
CD191_06830		Paenibacillus odorifer CBA7130	AWV32349.1			2
PODO_06850		Paenibacillus odorifer DSM 15391	AIQ72994.1			2
KET34_01890		Paenibacillus pabuli E1	UPK44322.1			2
ABE82_11165		Paenibacillus peoriae HS311	ALA44820.1			2
RBB83_11100		Paenibacillus peoriae JJ21	WVX13093.1			2
MLD56_11005		Paenibacillus peoriae ZBSF16	UMY56932.1			2
IAQ67_10780		Paenibacillus peoriae ZF390	QNR69454.1			2
QPK24_01620		Paenibacillus polygoni C31	WIV19479.1			2
G7L40_24035		Paenibacillus polymyxa 2020	QPK60571.1			2
QNH38_10995		Paenibacillus polymyxa ACCC03434	WHX37947.1			2
VK72_11055		Paenibacillus polymyxa ATCC 15970	APQ62108.1			2
CUU60_00820		Paenibacillus polymyxa ATCC 842	UOD83809.1			2
CPY53_25430		Paenibacillus polymyxa C12	UNL96700.1			2
SKN87_11185		Paenibacillus polymyxa C2	WPQ58986.1			2
LK13_23380		Paenibacillus polymyxa CF05	AIY11322.1			2
DI243_10630		Paenibacillus polymyxa CJX518	QOH61841.1			2
X809_11335		Paenibacillus polymyxa CR1	AHC19798.1			2
G7035_24120		Paenibacillus polymyxa DSM 36	QPK55482.1			2
U3G77_16980		Paenibacillus polymyxa DSM 365	WRL59827.1			2
PPE_02099		Paenibacillus polymyxa E681	ADM69935.2			2
LAZ93_10525		Paenibacillus polymyxa EB4 G3	UBS89257.1			2
C1A50_2233		Paenibacillus polymyxa HY96-2	AUS26406.1			2
AOU00_23675		Paenibacillus polymyxa J	AOK92562.1			2
MF622_002211		Paenibacillus polymyxa K 1.14	URJ62372.1			2
ERJ71_11260		Paenibacillus polymyxa KN-03	WEK64942.1			2
PPM_2107 (M1_2391)		Paenibacillus polymyxa M1	CCC85044.1			2
LMH85_10855		Paenibacillus polymyxa MEZ6	UQQ37380.1			2
MF623_004772		Paenibacillus polymyxa O 1.27	URJ55344.1 WEC94912.1			2
MF624_004752		Paenibacillus polymyxa O 2.11	URJ69860.1			2
OYT09_11045		Paenibacillus polymyxa P3	WCM63437.1			2
RQP19_10730		Paenibacillus polymyxa PJH16	WOZ40481.1			2
MF625_003108		Paenibacillus polymyxa R 3.13	URJ33878.1 WDZ57134.1			2
MF627_001208		Paenibacillus polymyxa R 4.24	URJ41619.1 WGV33444.1			2
MF626_001678		Paenibacillus polymyxa R 4.5	URJ52179.1 WDZ59826.1			2
MF628_000206		Paenibacillus polymyxa R 5.31	URJ45738.1 URJ45738.3			2
MF620_002118		Paenibacillus polymyxa R 6.14	URJ67179.1 WDZ62103.1			2
RE92_01360		Paenibacillus polymyxa Sb3-1	AJE49784.1			2
PPSC2_10995		Paenibacillus polymyxa SC2	ADO56310.2			2
J4I02_11405		Paenibacillus polymyxa SF05	WDM24044.1			2
PPSQR21_021870		Paenibacillus polymyxa SQR-21 SQR21	AHM65835.1			2
PPYC1_13280		Paenibacillus polymyxa YC0136	APB73399.1			2
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