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Glycoside Hydrolase Family 5

Activities in Family[retaining] arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-);
β-1,3-mannanase (EC 3.2.1.-);
β-rutinosidase /α-L-rhamnose-(1,6)-β-D-glucosidase (EC 3.2.1.-);
Glucomannan-specific endo-β-1,4-glucanase (EC 3.2.1.-);
Mannan exo-β-1,4-mannosidase (EC 3.2.1.-);
Steryl β-glucosidase (EC 3.2.1.104);
Endoglycosylceramidase (EC 3.2.1.123);
Chitosanase (EC 3.2.1.132);
β-D-galactofuranosidase (EC 3.2.1.146);
β-primeverosidase (EC 3.2.1.149);
Oligoxyloglucan reducing-end-specific cellobiohydrolase (EC 3.2.1.150);
Xyloglucan-specific endo-β-1,4-glucanase / endo-xyloglucanase (EC 3.2.1.151);
Endo-β-1,6-galactanase (EC 3.2.1.164);
Hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168);
β-glucosidase (EC 3.2.1.21);
β-galactosidase (EC 3.2.1.23);
β-mannosidase (EC 3.2.1.25);
Xylan β-1,4-xylosidase (EC 3.2.1.37);
Endo-β-1,3-glucanase / laminarinase (EC 3.2.1.39);
Endo-β-1,4-glucanase (EC 3.2.1.4);
β-glucosylceramidase (EC 3.2.1.45);
β-galactosylceramidase (EC 3.2.1.46);
β-N-acetylhexosaminidase (EC 3.2.1.52);
α-L-arabinofuranosidase (EC 3.2.1.55);
Exo-β-1,3-glucanase (EC 3.2.1.58);
Endo-β-1,3(4)-glucanase / lichenase-laminarinase (EC 3.2.1.6);
Lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73);
Exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74);
Endo-β-1,6-glucanase (EC 3.2.1.75);
Endo-β-1,4-mannanase (EC 3.2.1.78);
Endo-β-1,4-xylanase (EC 3.2.1.8);
Cellobiohydrolase (EC 3.2.1.91);
Mechanism Retaining e
ClanGH-A
3D Structure Status( β / α ) 8 barrel
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (31227); Uniprot accession (673); PDB accession (296); 3D entries (110); cryst (0)
Summary
Download GH5 (44486) Taxonomic display Structure (110) Characterized (624)
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
Eukaryota
Protein Name EC#ReferenceOrganismGenBank UniprotPDB/3D Subf
 exo-β-1,3-glucanase (Exg1;ExgA) 3.2.1.58 pubmed
 Aspergillus oryzae CBS 12559 CAC07551.1
AHH92832.1
CAD97460.1		 Q7Z9L3   9
 exo-β-1,3-glucanase (Exg1;AO090003000990) 3.2.1.58 pubmed
 Aspergillus oryzae RIB40 BAE58099.1 Q7Z9L3   9
 xyloglucan-specific endo-β-1,4-glucanase (Xeg5A; AO090003001590) (Xeg5A) 3.2.1.151 pubmed
 Aspergillus oryzae RIB40 EIT83526.1
BAE58401.1
BAE58402.1		 I8IVP5
Q2UJ63
Q2UJ64		   4
 rutinosidase / 6-O-α-L-rhamnosyl-β-glucosidase (AoRut; AO090012000917) 3.2.1.- pubmed
 Aspergillus oryzae RIB40 BAE61018.1 A0A1S9DRB1
Q2UBP7		 6LA0[A,B] 23
 endo-β-1,4-mannanase 3.2.1.78 pubmed
 Aspergillus sp. T16 AHA38074.1 A0A0B4KYG3   7
 β-mannanase (MANN) 3.2.1.78 pubmed
 Aspergillus sulphureus ABC59553.1 Q2LE69   7
 β-mannanase 3.2.1.78 pubmed
 Aspergillus sulphureus 138284 ABE73149.1     7
 β-mannanase (AuMan5A) (Man5A) 3.2.1.78 pubmed
 Aspergillus usamii E001 / YL-01-78 ADZ99027.1 F2XJJ2   7
 cellulase / CMCase (Cmc1) 3.2.1.4 doi
 Aureobasidium pullulans 98 ACH69873.1
ACH63253.1		 B5M499
B5M6A4		   22
 endo-β-1,4-glucanase (Egl;ApCel5A) (Cel5A) 3.2.1.4 pubmed
 Aureobasidium pullulans ATCC 62921 / NRRL Y-2311-1 AEM23896.1 H2B656   5
 exo-β-1,3-glucanase (Exg2) 3.2.1.58 pubmed
 Bipolaris zeicola AAF65310.1 Q9P8N7   9
 endo-β-1,4-mannanase (Man5) 3.2.1.78 pubmed
 Bispora antennata CBS 126.38 AFJ68087.1 I2CMF4   7
 endo-β-1,4-mannanase 5A (Man5A) 3.2.1.78 pubmed
 Bispora sp. MEY-1 ACH56965.1 B5LXD7   7
 β-mannanase (CMA3; CmacGH5-3; GH5-3) 3.2.1.78 pubmed
 Callosobruchus maculatus ADU33273.1 E7CIR1   10
 endo-β-1,4-xylanase (CMA2; CmacGH5-2; GH5-2) 3.2.1.37 pubmed
 Callosobruchus maculatus ADU33272.1 E7CIR0   10
 β-glucosidase 1 GH5 family (GH5BG1; CsGH5BG1) 3.2.1.21 pubmed
 Camellia sinensis ARU79086.1 A0A1Y0K2D4   14
 exo-β-1,3-glucanase (Xog; XOG1; Exg; Ca49c10.05) 3.2.1.58 pubmed
 Candida albicans CAA39908.1
AAV05307.1
CAA21969.1		 P29717 1CZ1[A]
1EQC[A]
1EQP[A]
2PB1[A]
2PBO[A]
2PC8[A]
2PF0[A]
3N9K[A]
3O6A[A]
4M80[A]
4M81[A]
4M82[A] 		9
 exo-β-1,3-glucanase (Exg1) 3.2.1.58 pubmed
 Candida oleophila AAM21469.1 Q8NKF9   9
 β-mannanase (CsMan5A) (Man5A) 3.2.1.78 doi
 Chaetomium sp. CQ31 ADW82104.1 G9BZJ2   7
 cellulase (CelA;CsCelA) 3.2.1.4 pubmed
 Ciboria shiraiana AIC79156.1 A0A068B5I5   5
 endo-β-1,4-mannanase (ManA;CaMANA) 3.2.1.78 pubmed
 Coffea arabica CAC08208.1
AAX01860.1		 Q9FT02   7
 endo-β-1-4-mannanase (ManB;CaMANB) 3.2.1.78 pubmed
 Coffea arabica CAC08442.1 Q9FT03   7
 β-1,3-glucosidase (Bgl1; BGL1; CC1G_06564) 3.2.1.58 pubmed
 Coprinopsis cinerea okayama7#130 EAU92553.1     9
 mannanase (CC1G_09314; CcMan5C) (Man5C) 3.2.1.78 pubmed
 Coprinopsis cinerea okayama7#130 XP_001830154.1     7
 β-glucocerebrosidase (EGCrP1;CNAG_00623) 3.2.1.45 pubmed
 Cryptococcus neoformans var. grubii H99 BAL46040.1
AFR92751.1
AFR92751.2		 H1AE12   12
 steryl β-glucosidase (EGCrP2;CNAG_05607) (vacuolar) 3.2.1.104 pubmed
 Cryptococcus neoformans var. grubii H99 AFR99035.1 J9W473 7LPO[A,B,C,D]
7LPP[A,B,C,D]
7LPQ[A,B,C,D] 		12
 carboxymethylcellulase (CsCMCase) 3.2.1.4 pubmed
 Cryptococcus sp. S-2 ABP02069.1 A4UU22   5
 endo-β-1,4-mannanase (Man;CaMan) 3.2.1.78 pubmed
 Cryptopygus antarcticus ABV68808.1 B4XC07 4OOU[A,B]
4OOZ[A,B] 		10
 endoglycoceramidase (EGCase) 3.2.1.123 pubmed
 Cyanea nozakii BAB16369.1
BAB16370.1		 Q9GV15
Q9GV16		   27
 endo-β-mannanase (DcMan1) 3.2.1.78 doi
 Daucus carota AAN34823.1 Q8H6B4   7
 endo-1,4-β-mannanase 3.2.1.78 pubmed
 Eisenia fetida BBB35836.1 A0A2Z5VGG0 5Y6T[A] 10
 β-1,6-glucanase (GcnA) 3.2.1.75 pubmed
 Epichloe festucae FL1 ABK27195.1 A0FJV0   15
 β-1,6-glucanase (GcnA) 3.2.1.75 pubmed
 Epichloe festucae var. lolii LP19 ABK27199.1 A0FJV4   15
 circular permutation of xylanase/cellulase (CelA) (fragment) 3.2.1.4 doi
 Epidinium caudatum BAC57895.1 Q86S90  
 endoglucanase (Epi2) 3.2.1.4 doi
 Epidinium caudatum BAC57893.1 Q86S92   4
 endo-β-1,4-glucanase (Epi3) (probable fragment) 3.2.1.4 doi
 Epidinium caudatum BAA76394.1 Q9XXV3   4
 CMCase (Cmc-06) (Cel5A) 3.2.1.4 pubmed
 Epidinium ecaudatum CAH69214.1
CAL91975.1		 Q5F324   4
 β-mannanase (Man5A) 3.2.1.78 pubmed
 Evansstolkia leycettana JCM12802 AJF11663.1 A0A0B5FP75   7
 β-1,6-galactanase (Gal1;FoGal1) 3.2.1.164 pubmed
 Fusarium oxysporum 12S BAF42338.1 A0ZSY6   16
 endo-β-1,4-glucanase (GlCel5A; GL28282) (Cel5A) 3.2.1.4 pubmed
 Ganoderma lucidum QDK64599.1 A0A1A9TAJ1 5D8W[A,B]
5D8Z[A,B] 		5
 β-mannanase (GVI1; GH5-1) 3.2.1.78 pubmed
 Gastrophysa viridula ADU33333.1 E7CIX1   10
 β-1,4-endoglucanase (Eng-3) 3.2.1.4 pubmed
 Globodera rostochiensis RO-1 AAN03645.1
AAN03646.1		 Q8MM42   2
 β-1,4-endoglucanase (Eng-4) 3.2.1.4 pubmed
 Globodera rostochiensis RO-1 AAN03647.1
AAN03648.1		 Q8MM50   2
 endoglucanase 1 (Eng1;Eng-1;Gr-eng1;Gr-eng-1) 3.2.1.4 pubmed
 Globodera rostochiensis RO-1 AAC63988.1
AAC48325.1		 O16028
Q7KQF7		   2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 pubmed
 Globodera rostochiensis RO-1 AAC48341.1
AAC63989.1		 O44078
O77094		   2
 endo-β-1,4-glucanase (GtCel5A) (Cel5A) 3.2.1.4 pubmed
 Gloeophyllum trabeum ATCC 11539 ADH51728.1 D7REW1
P84194		   5
 β-mannanase (GLOTRDRAFT_110405) (Man5A) 3.2.1.78 pubmed
 Gloeophyllum trabeum ATCC 11539 / CBS900.73 EPQ57046.1 S7QAW1   7
 endo-β-1,4-mannanase (GmMan1; Glyma19g41090.1) 3.2.1.78 pubmed
 Glycine max ABG88068.1 Q0PKY2   7
 GpGH5 / M427DRAFT_29612 3.2.1.- pubmed
 Gonapodya prolifera JEL478 KXS18720.1 A0A139APP3   34
 endo-β-1,4-mannanase (Man1;HdMan) 3.2.1.78 pubmed
 Haliotis discus hannai BAE78456.1 Q2MH89   10
 endo-β-1,4-glucanase 1a (Eng1A;Eng-1A;Hα-eng-1a) 3.2.1.4 doi
 Heterodera avenae ACO55952.1
AFQ55438.1
AGH32769.1		 D5FQ93
M4QVR5		   2
 endoglucanase 1 (Eng1;Eng-1) 3.2.1.4 pubmed
 Heterodera glycines AAC15707.1
AAC48327.1
CAB42450.1
CAB59144.1		 O18453   2
 endoglucanase 2 (Eng2;Eng-2) 3.2.1.4 pubmed
 Heterodera glycines AAC48326.1
AAC15708.1
CAB42449.1
CAB59143.1		 O18454
O61595		   2
 endoglucanase 3 (Eng3;Eng-3) 3.2.1.4 pubmed
 Heterodera glycines AAC33848.1
AAC33860.1		 O77449   2
 endo-β-1,4-mannanase (Man1;HvMAN1) 3.2.1.78 pubmed
 Hordeum vulgare subsp. vulgare BAK05001.1
ABC87082.1		 F2ECC9
Q2I011		   7
 endo-β-1,4-glucanase 3 (CMC3;Egl2) 3.2.1.4 pubmed
pubmed
 Humicola grisea var. thermoidea IFO9854 BAA12676.1 Q12624   5
 endo-β-1,4-glucanase IV (CMC3) 3.2.1.4 pubmed
 Humicola insolens ATCC 16454 CAA53631.1 Q12624   5
 β-mannanase (alkali-tolerant) (Man5A) 3.2.1.78 pubmed
 Humicola insolens Y1 ADZ99301.1 H6TCE0   7
 endoglycoceramidase (EGCase) 3.2.1.123 pubmed
 Hydra magnipapillata BAD20464.1 Q6L6S1   27
 β-mannanase (Man1;HhMAN1) 3.2.1.78 pubmed
 Hypothenemus hampei ACU52526.1
ACU52527.1
ADF22325.1		 C8CAP6   8
 endoglucanase (Cen1;En-1) 3.2.1.4 pubmed
 Irpex lacteus MC-2 BAD67544.1 Q5W7K4   5
 exo-β-1,3-glucanase (Eg;Exg1) 3.2.1.58 pubmed
 Komagataella pastoris X-33 AAY28969.1 Q2TCV2   9
 endoglucanase LbGH5-CBM1 3.2.1.4 pubmed
 Laccaria bicolor XP_001879429.1 B0D5M7   5
 endo-β-1,4-mannanase (Man1; LsMan1) 3.2.1.78 doi
 Lactuca sativa CAC51690.3 Q93X40   7
 exo-β-1,3-glucanase (Exg1; EXG1) 3.2.1.58 pubmed
 Lentinula edodes H600 BAD97445.1
BAD97446.1		 Q53UH0   9
 endo-β-1,4-mannanase (LpsGH5_8) 3.2.1.78 pubmed
 Lyrodus pedicellatus VAX65844.1 A0A8K1XLY2   8
 endo-β-1,4-glucanase 1 (Egl1) 3.2.1.4 pubmed
 Macrophomina phaseolina AAB51451.1 Q12638   5
 endo-β-1,4-glucanase 2 (Egl2) 3.2.1.4 pubmed
 Macrophomina phaseolina AAB03889.1 Q12637   5
 endo-β-1,4-glucanase 1 (Eng-1) 3.2.1.4 pubmed
 Meloidogyne incognita AAD45868.1 Q9UA57   2
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 pubmed
 Meloidogyne incognita AAK21883.2 Q9BJZ0   2
 endo-β-1,4-glucanase (Eng-1A;Mi-eng-1) 3.2.1.4 pubmed
 Meloidogyne incognita AAK21882.1 Q9BJZ1   2
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 pubmed
 Meloidogyne incognita AAK21881.1 Q9BJZ2   2
 endo-β-1,4-mannanase (Man5A) 3.2.1.78 pubmed
 Mytilus edulis CAC81056.1 Q8WPJ2 2C0H[A] 10
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 pubmed
 Neocallimastix frontalis AAC63094.1 Q01409   4
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 pubmed
 Neocallimastix patriciarum AAE59927.1
CAA83238.1		 Q12647   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.8		 pubmed
pubmed
pubmed
pubmed
pubmed
pubmed
 Neocallimastix patriciarum W5 AAC06321.1
AEX92707.1		 O59943   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.8		 pubmed
pubmed
pubmed
pubmed
pubmed
pubmed
 Neocallimastix patriciarum W5 AAC06321.1 H2BPT1
O59943		   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.8		 pubmed
pubmed
pubmed
pubmed
pubmed
pubmed
 Neocallimastix patriciarum W5 AAC06321.1 H2BPT1
O59943		   4
 β-1,6-glucanase 3.2.1.75 pubmed
 Neotyphodium sp. FCB-2002 AAN04103.1 Q8NJN4   15
 endo-β-1,4-glucanase (GH5-1;EG2;NCU00762) 3.2.1.4 pubmed
 Neurospora crassa OR74A CAE81955.1
ABZ29259.1
XP_324942.1		 Q6MGI3
Q7SDR1		   5
 endo-β-1,4-mannanase (NCU08412) 3.2.1.78 pubmed
 Neurospora crassa OR74A EAA34048.2 Q7SC42   7
 endo-β-1,4-mannanase (Man5; CsMan5) (partial) 3.2.1.78 pubmed
 Neurospora sitophila DSM 16514 CCI55471.1   4AWE[A] 7
 endo-β-1,4-glucanase (CelA) 3.2.1.4 pubmed
 Orpinomyces joyonii 19-2 AAC49731.1 P87211   2
 endo-β-1,4-glucanase (CelB2) (fragment) 3.2.1.4 pubmed
 Orpinomyces joyonii SG4 AAB69348.1 O13334   4
 endo-β-1,4-glucanase (CelB29) 3.2.1.4 pubmed
 Orpinomyces joyonii SG4 AAB69347.1 O13333   4
 β-mannanase (ManA) 3.2.1.78 pubmed
 Orpinomyces sp. PC-2 AAL01213.1 Q96V96   7
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 pubmed
 Orpinomyces sp. PC-2 AAD04193.1
AAE59925.1		 P78719   4
 endo-β-1,4-glucanase E (CelE) 3.2.1.4 pubmed
 Orpinomyces sp. PC-2 AAC05164.1 Q9HFE0   4
 exo-β-1,4-glucosidase / exo-β-1,3-glucosidase (GH5BG; Os10g0370500) 3.2.1.58
3.2.1.74		 pubmed
pubmed
 Oryza sativa Japonica Group AAM08614.1
AAM08821.1
AAP53379.1
BAF26372.1
BAG89316.1
BAT10560.1		 Q0IY43
Q8RU06		   14
 endo-β-1,4-glucanase (EGb1;EGb2) (Cel5C) 3.2.1.4 doi
 Penicillium brasilianum IBT 20888 ACB06750.1 B8Q961   5
 endoglucanase 5C (PdCel5C) (Cel5C) 3.2.1.4 pubmed
 Penicillium decumbens 114-2 AFG25592.1 H9TUB0   4
 endoglucanase II / 5A (Eg2;Egl2) (Cel5A) 3.2.1.4 pubmed
 Penicillium decumbens 114-2 / JU-A10 ABY28340.1 A9Z054   5
 endoglucanase 1 (Egl1;Pe-Egl1) 3.2.1.4 pubmed
 Penicillium echinulatum (nom. illeg.) 9A01S2 ACR82487.1 C5J4L7   5
 endo-β-1,4-glucanase II (Egl2) 3.2.1.4 pubmed
 Penicillium janthinellum Biourge IMET 43733 (C41) CAA61740.1 Q12665   5
 β-primeverosidase (Bgl2) 3.2.1.149 pubmed
 Penicillium multicolor TS-5 / IAM7153 BAG70961.1 B5MEI8   23
 endo-β-mannanase (Ma;PoMan5A) (Man5A) 3.2.1.78 pubmed
 Penicillium oxalicum GZ-2 AGW24296.1 U3N1Q2   7
 β-mannanase (Man5C6;Man5) 3.2.1.78 doi
 Penicillium sp. enrichment culture clone C6 / ACCC32495 AEV41143.1 G9BY18   7
 endo-β-1,4-mannanase (Man5F63) 3.2.1.78 pubmed
 Penicillium sp. F63 XC-2012 / CGMCC 1669 AFC38441.1 I3PML9   7
 β-xylosidase (Xyl5;PcXyl5;PcGH5) 3.2.1.37 pubmed
 Phanerochaete chrysosporium AHL69750.2
AIA81045.1		 W8QRE4   22
 β-mannanase 5D (Man5D) 3.2.1.78 doi
 Phanerochaete chrysosporium RP78 ABG79370.1 Q0PQY8   7
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