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Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-); lichenase / endo-β-1,3-1,4-glucanase (EC 3.2.1.73); β-glycosidase (EC 3.2.1.-); endo-β-1,3-glucanase / laminarinase (EC 3.2.1.39); β-N-acetylhexosaminidase (EC 3.2.1.52); chitosanase (EC 3.2.1.132)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (15391); Uniprot accession (1921); PDB accession (224); 3D entries (78); cryst (0)
Summary
All (13983) Archaea (95) Bacteria (11450) Eukaryota (2242) Viruses (8) unclassified (188) Structure (78) Characterized (563)
| 1 | 2 | 3 | 4 | 5 | 6 |
Eukaryota
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 endo-β-1,4-glucanase IV (CMC3) 3.2.1.4 Humicola insolens ATCC 16454 CAA53631.1 Q12624   5
 β-mannanase (alkali-tolerant) (Man5A) 3.2.1.78 Humicola insolens Y1 ADZ99301.1     7
 endoglycoceramidase (EGCase) 3.2.1.123 Hydra magnipapillata BAD20464.1 Q6L6S1   27
 β-mannanase (Man1;HhMAN1) 3.2.1.78 Hypothenemus hampei ACU52526.1
ACU52527.1		 C8CAP6   8
 endoglucanase (Cen1;En-1) 3.2.1.4 Irpex lacteus MC-2 BAD67544.1 Q5W7K4   5
 exo-β-1,3-glucanase (Eg;Exg1) 3.2.1.58 Komagataella pastoris X-33 AAY28969.1 Q2TCV2   9
 PAS_chr2-1_0454 (Exg;Exg1) 3.2.1.58 Komagataella phaffii GS115 CAY69081.1
AOA67579.1		 C4R0Q7   9
 endoglucanase LbGH5-CBM1 3.2.1.4 Laccaria bicolor XP_001879429.1     5
 endo-β-1,4-mannanase (Man1) 3.2.1.78 Lactuca sativa CAC51690.3 Q93X40   7
 exo-β-1,3-glucanase (Exg1) 3.2.1.58 Lentinula edodes H600 BAD97445.1
BAD97446.1		 Q53UH0   9
 endo-β-1,4-glucanase 1 (Egl1) 3.2.1.4 Macrophomina phaseolina AAB51451.1 Q12638   5
 endo-β-1,4-glucanase 2 (Egl2) 3.2.1.4 Macrophomina phaseolina AAB03889.1 Q12637   5
 endo-β-1,4-glucanase 1 (Eng-1) 3.2.1.4 Meloidogyne incognita AAD45868.1 Q9UA57   2
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 Meloidogyne incognita AAK21883.2 Q9BJZ0   2
 endo-β-1,4-glucanase (Eng-1A;Mi-eng-1) 3.2.1.4 Meloidogyne incognita AAK21882.1 Q9BJZ1   2
 β-1,4-endoglucanase (Eng-2) 3.2.1.4 Meloidogyne incognita AAK21881.1 Q9BJZ2   2
 endo-β-1,4-mannanase (Man5A) 3.2.1.78 Mytilus edulis CAC81056.1 Q8WPJ2 2C0H[A] 10
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Neocallimastix frontalis AAC63094.1 Q01409   4
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Neocallimastix patriciarum AAE59927.1
CAA83238.1		 Q12647   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73		 Neocallimastix patriciarum W5 AAC06321.1
AEX92707.1		 O59943   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73		 Neocallimastix patriciarum W5 AAC06321.1 O59943   4
 endo-β-1,4-glucanase D (CelD;W5-CelD;W5C-P) (Cel5D) 3.2.1.4
3.2.1.4
3.2.1.73
3.2.1.73		 Neocallimastix patriciarum W5 AAC06321.1 O59943   4
 β-1,6-glucanase 3.2.1.75 Neotyphodium sp. FCB-2002 AAN04103.1 Q8NJN4   15
 endo-β-1,4-glucanase (GH5-1;EG2;NCU00762) 3.2.1.4 Neurospora crassa OR74A CAE81955.1
ABZ29259.1
XP_324942.1		 Q7SDR1   5
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Orpinomyces joyonii 19-2 AAC49731.1 P87211   2
 endo-β-1,4-glucanase (CelB2) (fragment) 3.2.1.4 Orpinomyces joyonii SG4 AAB69348.1 O13334   4
 endo-β-1,4-glucanase (CelB29) 3.2.1.4 Orpinomyces joyonii SG4 AAB69347.1 O13333   4
 β-mannanase (ManA) 3.2.1.78 Orpinomyces sp. PC-2 AAL01213.1 Q96V96   7
 endo-β-1,4-glucanase B (CelB) 3.2.1.4 Orpinomyces sp. PC-2 AAD04193.1
AAE59925.1		 P78719   4
 endo-β-1,4-glucanase E (CelE) 3.2.1.4 Orpinomyces sp. PC-2 AAC05164.1 Q9HFE0   4
 exo-β-1,3-glucosidase (GH5BG;Os10g0370500) 3.2.1.58 Oryza sativa Japonica Group AAM08614.1
AAM08821.1
AAP53379.1
BAF26372.1
BAG89316.1
BAT10560.1		 Q8RU06   14
 endo-β-1,4-glucanase (EGb1;EGb2) (Cel5C) 3.2.1.4 Penicillium brasilianum IBT 20888 ACB06750.1 B8Q961   5
 endoglucanase 5C (PdCel5C) (Cel5C) 3.2.1.4 Penicillium decumbens 114-2 AFG25592.1     4
 endoglucanase II / 5A (Eg2;Egl2) (Cel5A) 3.2.1.4 Penicillium decumbens 114-2 / JU-A10 ABY28340.1 A9Z054   5
 endoglucanase 1 (Egl1;Pe-Egl1) (partial) 3.2.1.4 Penicillium echinulatum 9A01S2 ACR82487.1 C5J4L7   5
 endo-β-1,4-glucanase II (Egl2) 3.2.1.4 Penicillium janthinellum Biourge IMET 43733 (C41) CAA61740.1 Q12665   5
 β-primeverosidase (Bgl2) 3.2.1.149 Penicillium multicolor TS-5 / IAM7153 BAG70961.1 B5MEI8   23
 endo-β-mannanase (Ma;PoMan5A) (Man5A) 3.2.1.78 Penicillium oxalicum GZ-2 AGW24296.1     7
 β-mannanase (Man5C6;Man5) 3.2.1.78 Penicillium sp. enrichment culture clone C6 / ACCC32495 AEV41143.1     7
 endo-β-1,4-mannanase (Man5F63) 3.2.1.78 Penicillium sp. F63 XC-2012 / CGMCC 1669 AFC38441.1     7
 endoglucanase (Cel5A) 3.2.1.4 Pestalotiopsis sp. AN 7 BAI66446.1 D2KTU9   5
 β-xylosidase (Xyl5;PcXyl5;PcGH5) (partial) 3.2.1.37 Phanerochaete chrysosporium AHL69750.2
AIA81045.1		     22
 β-mannanase 5D (Man5D) 3.2.1.78 Phanerochaete chrysosporium RP78 ABG79370.1 Q0PQY8   7
 endo-β-1,4-mannanase (Man5AP13) (Man5A) 3.2.1.78 Phialophora sp. CGMCC 3329 / P13 ADF28533.1 D5IF02   7
 endo-β-1,4-glucanase (EgG5) 3.2.1.4 Phialophora sp. G5 / CGMCC 3328 ADZ44606.1     5
 exo-1,3-glucanase (Exg1) 3.2.1.58 Pichia angusta ATCC 14754 CAA86948.1 Q12626   9
 endoglucanase 5A (Cel5A) (Cel5A) 3.2.1.4 Piromyces equi CAB92326.1 Q9P867   4
 endoglucanase 5A (Cel5A) (Cel5A) 3.2.1.4 Piromyces equi CAB92326.1 Q9P867   4
 endoglucanase 5A (Cel5A) (Cel5A) 3.2.1.4 Piromyces equi CAB92326.1 Q9P867   4
 endoglucanase 5A (Cel5A) (Cel5A) 3.2.1.4 Piromyces equi CAB92326.1 Q9P867   4
 endoglucanase A (CelA;EglA) (partial) 3.2.1.4 Piromyces rhizinflatus 2301 AAF00074.2   3AYR[A]
3AYS[A] 		4
 endoglucanase (Egl-1) (Cel5B) 3.2.1.4 Piromyces rhizinflatus 2301 AAD43818.1 Q9Y870   4
 endo-β-1,4-mannanase (PaMan5A;Pa_6_490) (Man5A) 3.2.1.78 Podospora anserina S mat+ CAP71606.1
ADO14134.1
CDP31001.1		 B2B3C0 3ZIZ[A] 7
 endo-β-1,4-mannanase (Man6;PtrMan6) 3.2.1.78 Populus trichocarpa AFX59322.1
EEF05441.1		     7
 endo-β-1,4-glucanase (PpCel5A) (Cel5A) 3.2.1.4 Postia placenta Mad-698-R ADH51729.1 D7REW2   5
 endo-β-1,4-glucanase (PpCel5B) (Cel5B) 3.2.1.4 Postia placenta Mad-698-R XP_002475436.1
ADH51730.1		 D7REW3   5
 endoglucanase / cellulase (PhEG) 3.2.1.4 Psacothea hilaris BAB86867.1 Q8T890   2
 β-1,3-mannanase / β-1,3-glucomannanase (Man5C) 3.2.1.- Purpureocillium lilacinum ATCC 36010 BAD06516.1 Q76G11   31
 exo-β-1,3-glucanase (Glu1;GLU1;PTRG_04560) 3.2.1.58 Pyrenophora tritici-repentis Alg3-24 EDU47467.1     9
 broad specificity endo-β-glucanase (Egl5A;TeEgl5A) 3.2.1.4 Rasamsonia emersonii CBS 394.64 AHV83755.1
CAJ75961.1		     5
 endo-β-1,4-glucanase (Eg1) 3.2.1.4 Rasamsonia emersonii IMI 392299 AAL33639.2
AAL33630.1
AAL33639.1		 Q8WZD7   5
 β-mannanase (RmMan5B) (Man5B) 3.2.1.78 Rhizomucor miehei CAU432 AGV01048.1   4LYP[A,B]
4LYQ[A]
4LYR[A]
4NRR[A,B]
4NRS[A,B] 		7
 β-mannanase (RmMan5A) (Man5A) 3.2.1.78 Rhizomucor miehei CAU432 / CGMCC 4967 AGC24277.1   4L3M[A]
4QP0[A] 		7
 β-glucosylceramidase (EGCrP1;RO3G_04172) 3.2.1.45 Rhizopus delemar RA 99-880 EIE79467.1     12
 endo-β-1,4-glucanase I (Eg1) 3.2.1.4 Robillarda sp. Y-20 BAA90480.1
JX0131		 P23044
Q9P981		   5
 exo-β-1,3-glucanase (sporulation) (Spr1;Ssg1) 3.2.1.58 Saccharomyces cerevisiae GRF88 AAB24895.1
CAA41952.1
CAA99399.1		 P32603   9
 exo-β-1,3-glucanase / flavonoid β-glucosidase (sporulation) (Ssg1;Spr1;YOR190W) 3.2.1.21
3.2.1.58		 Saccharomyces cerevisiae S288c AAU09785.1
NP_014833.1		 P32603   9
 exo-β-1,3-glucanase 1 / flavonoid β-glucosidase (Exg1;Bgl1;Scw6;YLR300W) 3.2.1.21
3.2.1.58		 Saccharomyces cerevisiae S288c AAA34599.1
AAB67345.1
AAT93088.1
NP_013403.1		 P23776 1H4P[A,B] 9
 exo-1,3-glucanase 2 (Exg2;YDR261c) 3.2.1.58 Saccharomyces cerevisiae S288c CAA86950.1
CAA92719.1
CAA94100.1
NP_010547.1		 P52911   9
 flavonoid β-glucosidase (YIR007W;YIB7W) 3.2.1.21 Saccharomyces cerevisiae S288c NP_012272.1
CAA86077.1
CAA86209.1		 P40566   12
 endo-β-1,4-glucanase 1 / carboxymethylcellulase 1 (Cmc1) 3.2.1.4 Saitozyma flava MUT-6 AAC60541.1
BAA03070.1		 Q04469   5
 endo-β-1,4-glucanase I (EG1;EGI;EGII;SCHCODRAFT_40122) 3.2.1.4 Schizophyllum commune H4-8 EFI96731.1 P81190   5
 endo-β-1,6-glucanase (Exg3;SPBC2D10.05) 3.2.1.75 Schizosaccharomyces pombe 972h- CAA21163.1
NP_596224.1		 O74799  
 endo-β-1,6-glucanase (Exg1;SPBC1105.05) 3.2.1.75 Schizosaccharomyces pombe 972h- CAB50968.1
NP_596461.1		 Q9URU6   9
 exo-β-1,3-glucanase (Exg1) 3.2.1.58 Schwanniomyces occidentalis ATCC 26077 CAA86951.1 Q12700   9
 endo-β-mannanase 4a / mannan transglycosylase/hydrolase (Man4;LeMan4;LeMAN4a;LeMAN4i;MTH) 3.2.1.78
2.4.1.-		 Solanum lycopersicum AAK97760.1
AAK56557.1
AAK97759.2		 Q8L5J1
Q8RVL3
Q93WT4		 1RH9[A] 7
 β-mannanase (Man1;LeMAN1) 3.2.1.78 Solanum lycopersicum AAB87859.2 O48540   7
 endo-β-1,4-mannanase (Man5;LeMAN5) 3.2.1.78 Solanum lycopersicum AAM26920.1 Q6YM50   7
 endo-β-1,4-mannanase (Man2;LeMAN2) 3.2.1.78 Solanum lycopersicum AAG00315.2
AAG00315.1		 Q9FZ03   7
 cellulase (CFP-EG1) 3.2.1.4 Spirotrichonympha leidyi BAD90558.1 Q5DWF1   2
 endo-β-1,4-glucanase 5A (TCE0_013f01292) (Cel5A) 3.2.1.4 Talaromyces cellulolyticus Y-94 GAM33994.1     5
 β-mannanase (Man5A) 3.2.1.78 Talaromyces leycettanus JCM12802 AJF11663.1     7
 β-mannanase (Man5C1) (acidic) 3.2.1.78 Talaromyces pinophilus C1 AEV40667.1     7
 endo-β-1,4-glucanase 5 (Eng5) 3.2.1.4 Talaromyces pinophilus KMJ601 ACN43345.1 C0L2S4   5
 β-mannanase 3.2.1.78 Talaromyces trachyspermus ATCC 24792 BAP19029.1   3WFL[A] 7
 endoglucanase 2 (EG2;EGIIa) (partial) (Cel5A) 3.2.1.4 Talaromyces verruculosus B221-151     5L9C[A,B,C,D]
5I6S[A] 		5
 endo-β-1,4-glucanase (Eg1;Eng1;TaCel5A) (Cel5A) 3.2.1.4 Thermoascus aurantiacus IFO 9748 AAL88714.2
AAL16412.1
ACE10214.1
CAT02251.1
CAZ67882.1		 Q8TG26
Q96UI5		 1GZJ[A,B]
1H1N[A,B] 		5
 endo-β-1,4-glucanase (EG II;StCel5A;MYCTH_86753) (Cel5A) 3.2.1.4 Thermothelomyces thermophilus ATCC 42464 AEO53769.1
AEM23898.1		     5
 β-mannanase (Man2;bMan2) 3.2.1.78 Thermothelomyces thermophilus C1 AFJ59924.1     7
 β-mannanase (Man5;Man5XZ7) 3.2.1.78 Thielavia arenaria XZ7 AGG69667.1     7
 endoglucanase (Eg-1) 3.2.1.4 Trametes hirsuta BAD01163.1
BAD01164.1		 Q75UV6   5
 endoglucanase (TvEG) 3.2.1.4 Trametes versicolor       5
 endo-β-1,6-glucanase (Bgn16.2;B16-2) 3.2.1.75 Trichoderma harzianum CAA55789.1
ACM42428.1
CAA55788.1		 Q12711
Q12712		   15
 β-mannanase (ThMan5A) (Man5A) 3.2.1.78 Trichoderma harzianum MGQ2 AGH62580.1     7
 β-mannanase (Man1) 3.2.1.78 Trichoderma longibrachiatum DSM 63060 ADN93457.1 E2FZU3   7
 endo-β-1,4-glucanase II (EG2;EGII;Egl2;EG-II;TrEGII;TrCel5A) (formerly EGIII) (Cel5A) 3.2.1.4 Trichoderma reesei AAA34213.1
AAQ24883.1
AAR60515.1
ABA64553.1
ABE22094.1		 P07982 3QR3[A,B] 5
 β-mannanase (TrMan5A) (Man5A) 3.2.1.78 Trichoderma reesei RUTC-30 AAA34208.1
ABJ41268.1		 Q99036 1QNO[A]
1QNP[A]
1QNQ[A]
1QNR[A]
1QNS[A] 		7
 endo-β-1,4-glucanase (C4endoII) 3.2.1.4 Trichoderma sp. C-4 AAR29981.1 Q6S4S0   5
 β-1,6-glucanase (Bgn3) 3.2.1.75 Trichoderma virens AAL84696.1
ABV71387.1		 Q8TG97   15
 endoglucanase III (EG3;EGIII) 3.2.1.4 Trichoderma viride AS 3.3711 AAQ21383.1 Q7Z7X2   5
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