Glycoside Hydrolase Family 5

Activities in Familyendo-β-1,4-glucanase / cellulase (EC 3.2.1.4); endo-β-1,4-xylanase (EC 3.2.1.8); β-glucosidase (EC 3.2.1.21); β-mannosidase (EC 3.2.1.25); β-glucosylceramidase (EC 3.2.1.45); glucan β-1,3-glucosidase (EC 3.2.1.58); licheninase (EC 3.2.1.73); exo-β-1,4-glucanase / cellodextrinase (EC 3.2.1.74); glucan endo-1,6-β-glucosidase (EC 3.2.1.75); mannan endo-β-1,4-mannosidase (EC 3.2.1.78); cellulose β-1,4-cellobiosidase (EC 3.2.1.91); steryl β-glucosidase (EC 3.2.1.104); endoglycoceramidase (EC 3.2.1.123); chitosanase (EC 3.2.1.132); β-primeverosidase (EC 3.2.1.149); xyloglucan-specific endo-β-1,4-glucanase (EC 3.2.1.151); endo-β-1,6-galactanase (EC 3.2.1.164); hesperidin 6-O-α-L-rhamnosyl-β-glucosidase (EC 3.2.1.168); β-1,3-mannanase (EC 3.2.1.-); arabinoxylan-specific endo-β-1,4-xylanase (EC 3.2.1.-); mannan transglycosylase (EC 2.4.1.-)
Mechanism Retaining
ClanGH-A
3D Structure Status( β / α ) 8
Catalytic Nucleophile/BaseGlu (experimental)
Catalytic Proton DonorGlu (experimental)
NoteOnce known as cellulase family A; many members have been assigned to subfamilies as described by Aspeborg et al. (2012) BMC Evol Biol. 12(1):186 (PMID: 22992189).
External resourcesCAZypedia; HOMSTRAD; PROSITE;
Commercial Enzyme Provider(s)MEGAZYME; NZYTech; PROZOMIX;
Statistics GenBank accession (11690); Uniprot accession (1922); PDB accession (209); 3D entries (74); cryst (0)
All (10313) Archaea (67) Bacteria (8119) Eukaryota (2005) Viruses (5) unclassified (117) Structure (74) Characterized (547)
| 1 | 2 | 3 | 4 | 5 | 6 |
Bacteria
Protein Name EC#OrganismGenBank UniprotPDB/3D Subf
 endo-β-1,4-glucanase D (CelD;CelCCD;EGCCD;Ccel_0840) (Cel5D) 3.2.1.4 [Clostridium] cellulolyticum H10 ACL75216.1
BAA14354.1
P25472.1
P25472   25
 CMCase (P66;Ccel_2337) 3.2.1.4 [Clostridium] cellulolyticum H10 ACL76673.1 B8I5D7   1
 endo-β-1,4-glucanase A (CelA;Cca;CelCcaCcel_1099) (Cel5A) 3.2.1.4 [Clostridium] cellulolyticum H10 AAA23221.1
AAA51444.1
ACL75458.1
P17901 1EDG[A] 4
 cellulase N (CelN; Ccel_0740) (Cel5N) 3.2.1.4 [Clostridium] cellulolyticum H10 ACL75118.1
AAG45162.1
B8I7W1
Q9EYQ0
  1
 mannanase K (ManK;Ccel_0736) (Man5K) 3.2.1.78 [Clostridium] cellulolyticum H10 ACL75115.1
AAG45159.1
B8I7V8
Q9EYQ3
  17
 endo-β-1,4-glucanase 5A (EngF) (Cel5A) 3.2.1.4 Clostridium cellulovorans AAB40891.1 P94622   2
 endo-β-1,4-glucanase / xylanase B (EngB;Clocel_1150) 3.2.1.4
3.2.1.73
3.2.1.8
Clostridium cellulovorans 743B AAA23231.1
ADL50906.1
C5RHC3
P28621
  4
 endoglucanase G (EngG;Clocel_2600) 3.2.1.- Clostridium cellulovorans 743B ADL52309.1 D9SQV3   55
 Clocel_3099 (Man5B) 3.2.1.78 Clostridium cellulovorans 743B ADL52789.1 D9STQ5   7
 Clocel_3099 (Man5B) 3.2.1.78 Clostridium cellulovorans 743B ADL52789.1 D9STQ5   7
 β-mannanase A (ManA;Clocel_2818) 3.2.1.78 Clostridium cellulovorans 743B AAF06110.2
ADL52514.1
C5RQ36
D9SS67
Q9LAJ3
  17
 endo-β-1,4-glucanase / xylanase D (EngD) 3.2.1.4
3.2.1.73
3.2.1.8
Clostridium cellulovorans ATCC 35269 AAA23233.1 P28623 3ICG[A,B,C,D]
3NDY[A,B,C,D]
3NDZ[A,B,C,D]
4
 endo-β-1,4-glucanase E (EngE) 3.2.1.4 Clostridium cellulovorans ATCC 35269 AAD39739.1 Q9XD99   4
 endo-β-1,4-glucanase 5A (CelA) (Cel5A) 3.2.1.4 Clostridium josui BAA12826.1
BAA12826.2
Q59290   2
 mannanase 5A (Man5A) 3.2.1.78 Clostridium josui BAI52931.1 D1MXA0   17
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Clostridium longisporum AAC37035.1 P54937   4
 endo-β-1,4-glucanase (EglA) 3.2.1.4 Clostridium saccharobutylicum P262 AAA23230.1 P15704   2
 endo-β-1,4-glucanase C307 (CelC307) 3.2.1.4 Clostridium sp. F1 BAA00793.1 P23340   37
 endoglucanase 5A (ChCel5A;CHU_1107) (Cel5A) 3.2.1.4 Cytophaga hutchinsonii ATCC 33406 ABG58383.1 Q11W33   2
 periplasmic endoglucanase 5B (CHU_2103) (Cel5B) 3.2.1.4 Cytophaga hutchinsonii ATCC 33406 ABG59366.1 Q11T98 5IHS[A] 2
 endo-β-1,4-glucanase (Cel5Z) 3.2.1.4 Dickeya chrysanthemi PY35 AAF18152.1 Q9REW0   2
 endo-β-1,4-glucanase Z (CelZ;EgZ;Dda3937_02793) (Cel5A=Cel5Z) 3.2.1.4 Dickeya dadantii 3937 ADM99099.1
CAA68604.1
P07103 1EGZ[A,B,C] 2
 DICTH_0008 (Cel5A) 3.2.1.4 Dictyoglomus thermophilum H-6-12 ACI18520.1 B5YAS2   25
 endoglucanase (LC1;CelA;Dtur_0670) (Cel5B) 3.2.1.4 Dictyoglomus turgidum DSM 6724 ACK41955.1 B8DZM2   25
 endoglucanase (Dtur_0671) 3.2.1.- Dictyoglomus turgidum DSM 6724 ACK41956.1 B8DZM3   36
 endoglucanase (EcCel5A) (Cel5A) 3.2.1.4 Eubacterium cellulosolvens 5 BAE46390.1 Q3LHN3   4
 endoglucanase (EcCel5A) (Cel5A) 3.2.1.4 Eubacterium cellulosolvens 5 BAE46390.1 Q3LHN3   4
 endoglucanase (FgCel5A;Cel14.1) (Cel5A) 3.2.1.4 Fervidobacterium gondwanense AB39 AFY97404.1     25
 endo-β-1,4-glucanase (FnCel5A;Fnod_1560) (Cel5A) 3.2.1.4 Fervidobacterium nodosum Rt17-B1 ABS61403.1
ADD73709.1
A7HNC0 3NCO[A,B]
3RJX[A]
3RJY[A]
25
 Fisuc_0728 / FSU_1166 3.2.1.78 Fibrobacter succinogenes subsp. succinogenes S85 ACX74338.1 C9RMW0   10
 Fisuc_0786 / FSU_1228 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 ACX74396.1
ADL25822.1
C9RNF0   4
 Fisuc_1224 / FSU_1685 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 ACX74827.1
ADL26286.1
C9RQJ1   2
 Fisuc_2933 / FSU_0196 3.2.1.78 Fibrobacter succinogenes subsp. succinogenes S85 ACX76513.1
ADL26912.1
C9RP45  
 Fisuc_1523 / FSU_2005 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 ACX75120.1
ADL26743.1
C9RRD4  
 Fisuc_3081 / FSU_0347 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 ACX76661.1
ADL25927.1
C9RQB4   4
 endo-β-1,4-glucanase 3 (Cel3;Cel-3;Eg3;Fisuc_2230;FSU_2772) (Cel5G) 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 AAA24893.1
ACX75816.1
ADL25000.1
P14250  
 endo-β-1,4-glucanase G (CelG;Fisuc_0897;FSU_1346) 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 AAB38548.1
ACX74504.1
ADL25356.1
Q47916   4
 cellodextrinase A (CedA;Fisuc_1584;FSU_2070) (Cel5C) 3.2.1.74 Fibrobacter succinogenes subsp. succinogenes S85 AAA50210.1
ACX75179.1
ADL26975.1
C9RRJ3
Q59441
  52
 endoglucanase (partial) 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 AAC06197.1 O66065   2
 cellulase (Fisuc_2364;FSU_2914) (Cel5H) 3.2.1.4 Fibrobacter succinogenes subsp. succinogenes S85 ABU45500.1
ACX75950.1
ADL27061.1
A7UG69   2
 endo-β-1,4-glucanase (CelA;GsCelA) 3.2.1.4 Geobacillus sp. 70PC53 ACJ60856.1 C5H6X3 4XZB[A]
4XZW[A]
2
 β-mannanase (ManF) 3.2.1.78 Geobacillus stearothermophilus MCA2184 AAC71692.1 Q9ZI87   7
 endoglucanase (Cel5;HCH_03914) 3.2.1.4 Hahella chejuensis KCTC 2396 ABC30636.1 Q2SFD8   2
 endo-β-1,4-glucanase 5A (CpCel5A;Cphy_1163) (Cel5A) 3.2.1.4 Lachnoclostridium phytofermentans ISDg ABX41541.1 A9KN42   1
 endo-β-1,4-glucanase (CpCel5C;Cphy_2058) (Cel5C) 3.2.1.4 Lachnoclostridium phytofermentans ISDg ABX42426.1 A9KIH4   4
 endoglucanase (CelA;lpg1918) 3.2.1.4 Legionella pneumophila subsp. pneumophila str. Philadelphia 1 AAU27988.1
AGH53362.1
Q5ZU89  
 endoglucanase (Cel5D) 3.2.1.4 Martelella mediterranea WP_018063499.1     5
 endo-β-1,4-glucanase A (CelA) 3.2.1.4 Paenibacillus barcinonensis BP-23 CAA73113.1 O08342   4
 endo-β-1,4-glucanase B (CelB;EG-B) 3.2.1.4 Paenibacillus lautus PL236 AAA22408.1
CAA01934.1
P23550   4
 xyloglucanase (XG5;PpXG5) 3.2.1.151 Paenibacillus pabuli AAR65335.1 H9KVH3 2JEP[A,B]
2JEQ[A]
4
 endo-β-1,4-glucanase 3.2.1.4 Paenibacillus polymyxa AAA22631.1
AAY03292.1
P23548   1
 cellulase 5A (Cel5A) 3.2.1.4 Paenibacillus polymyxa GS01 ABV08875.1 A9Q741   2
 cellulase 5B (Cel5B) 3.2.1.4 Paenibacillus polymyxa GS01 ABV08876.1 A9Q742   4
 Sequence 4 from patent US 6630340 3.2.1.151 Paenibacillus sp. AAR65336.1     4
 endo-β-1,4-glucanase (Endo5A) 3.2.1.4 Paenibacillus sp. ICGEB2008 / MTCC 5639 AEB00655.1     1
 endo-β-1,4-glucanase (Egl) 3.2.1.4 Paenibacillus sp. KCTC8848P AAL83749.1 Q8RPZ3   1
 xyloglucanase (XEG5) (Xeg5) 3.2.1.151 Paenibacillus sp. KM21 BAE44526.1 Q3MUH8   4
 endo-β-1,4-glucanase (Cel5A) 3.2.1.4 Paenibacillus xylanilyticus KJ-03 AFC68970.1     4
 endo-β-1,4-glucanase N (CelN) (fragment) 3.2.1.4 Pectobacterium carotovorum ATROSEPTICA AAC37033.1 Q59394   2
 endo-β-1,4-glucanase V1 3.2.1.4 Pectobacterium carotovorum SCC3193 CAA55823.1 Q59395   2
 endo-β-1,4-glucanase V 3.2.1.4 Pectobacterium carotovorum SCRI193 CAA53592.1 Q47096   2
 endo-β-1,4-glucanase (CelA) 3.2.1.4 Pectobacterium carotovorum subsp. carotovorum LY34 AAC02964.2
AAC02964.1
O31029   2
 cellulase (fragment) 3.2.1.4 Photobacterium panuliri LBS5T ALC76666.1    
 xylanase (ORF0336) (Xyn5B) 3.2.1.8 Prevotella bryantii B14 ADI70667.1 D7SFG3   21
 xylanase (ORF0150) (Xyn5A) 3.2.1.8 Prevotella bryantii B14 ADI70668.1 D7SFG4   21
 mixed-linkage β-glucanase/xyloglucanase (Orf4;CMCase;PBR_0368) (Cel5A) 3.2.1.151
3.2.1.73
Prevotella bryantii B14 AAC97596.1
AAA22909.1
O06842
Q44878
3L55[A,B]
3VDH[A,B]
5D9M[A,B]
5D9N[A,B]
5D9O[A,B]
5D9P[A,B]
4
 endo-β-1,4-glucanase (PRU_1856) 3.2.1.4 Prevotella ruminicola 23 ADE83057.1
BAA74515.1
D5EU37
Q9ZN63
  38
 xylanase / endoglucanase (PRU_2231) 3.2.1.4
3.2.1.8
Prevotella ruminicola 23 AAC36862.1
ADE83418.1
D5EV54
Q45397
  4
 endoglucanase (CelA;BrEND) 3.2.1.4 Prevotella ruminicola AR20 1814455A     4
 endoglucanase (CelG) (Cel5G) 3.2.1.4 Pseudoalteromonas haloplanktis A23 CAA76775.1 O86099 1TVN[A,B]
1TVP[A,B]
2
 endoglucanase (CelA) 3.2.1.4 Pseudoalteromonas sp. MB-1 AAS58467.1 Q6QA02   2
 cellulase (CelY) 3.2.1.4 Pseudoalteromonas sp. NO3 ACN62172.1 C0KZC4   2
 bifunctional β-N-acetylglucosaminidase / chitosan-active enzyme (fragment) 3.2.1.52
3.2.1.-
Pseudomonas putida P3(4) ADG43125.1 D6R436   48
 endoglucanase (CelX) (Cel5M) 3.2.1.4 Pseudomonas sp. MM15 AEM45646.1     5
 β-mannosidase (Tth Man5;Theth_0949) 3.2.1.25 Pseudothermotoga thermarum DSM 5069 AEH51033.1     19
 endo-β-1,4-glucanase (CelX) 3.2.1.4 psychrophilic marine bacterium DY3 AAP04424.1 Q841J5   2
 endo-β-1,4-glucanase (Egl) 3.2.1.4 Ralstonia solanacearum AW AAA61980.1 P17974   5
 RSp0162 (Egl) 3.2.1.4 Ralstonia solanacearum GMI1000 ABG46712.1
CAD17313.1
NP_521723.1
P58599   5
 oligogalactosyl-N-acylsphingosine 1,1-β-galactohydrolase / endogalactosylceramidase / endoglycoceramidase III (EGalC;EGCase III) 3.2.1.123 Rhodococcus hoagii M-750 BAF56440.1 A4PCI3   29
 endoglycoceramidase I (EGCase I) 3.2.1.123 Rhodococcus sp. C9 BAB17317.1 Q9FAC7   28
 endoglycoceramidase II (EGCase II) 3.2.1.123 Rhodococcus sp. M-777 AAB67050.1 O33853 2OSW[A,B]
2OSX[A]
2OSY[A,B]
2OYK[A,B]
2OYL[A,B]
2OYM[A,B]
28
 endoglycosylceramidase I (EGCase I;G419_15918) 3.2.1.123 Rhodococcus triatomae BKS 15-14 EME18930.1    
 endo-β-1,4-glucanase E (CelE;EgE) (Cel5C) 3.1.1.72
3.2.1.4
Ruminiclostridium thermocellum AAA23224.1 P10477 4IM4[A,B,C,D,E,F] 4
 endo-β-1,4-glucanase B (CelB;EgB;Cthe_0536) (Cel5A) 3.2.1.4 Ruminiclostridium thermocellum ATCC 27405 ABN51772.1 P04956   1
 acetylxylan esterase / 6-O-glycoside deacetylase (CelE;CtCE2;Cthe_0797) (Cel5C) 3.1.1.72
3.1.1.-
Ruminiclostridium thermocellum ATCC 27405 ABN52032.1 A3DDK3   4
 β-mannanase (CtMan5A;Cthe_0821) (Man5A) 3.2.1.78 Ruminiclostridium thermocellum ATCC 27405 ABN52056.1 A3DDM7   55
 bifunctional endo-β-1,4-glucanase / β-1,4-xylanase H (CelH;EgH;CtCelH;CtCel5E;Cthe_1472) (Lic26A;Cel5E) 3.2.1.4
3.2.1.8
Ruminiclostridium thermocellum ATCC 27405 ABN52701.1
CCF82162.1
P16218 4U3A[A,B]
4U5I[A,B]
4U5K[A,B]
5BYW[A,B,C,D,E]
25
 xylanase (M6;CtM6;CtXyl5A;Cthe_2193) (arabinoxylan-specific) (Xyl5A) 3.2.1.- Ruminiclostridium thermocellum ATCC 27405 ABN53395.1 A3DHG6 2Y8K[A]
5AK1[A]
5G56[A]
5LA0[A]
5LA1[A]
5LA2[A,B]
34
 endo-β-1,4-glucanase G (CelG;Cthe_2872) (Cel5D) 3.2.1.4 Ruminiclostridium thermocellum ATCC 27405 ABN54070.1 Q05332   1
 cellobiohydrolase (CelO) (Cel5F) 3.2.1.91 Ruminiclostridium thermocellum F7 CAB76938.1 Q9L3J2   1
 endo-β-1,4-glucanase C (CelC) 3.2.1.4 Ruminiclostridium thermocellum F7 CAC27410.1 Q9AL36   37
 endo-β-1,4-glucanase B (CelB;EgB) (Cel5A) 3.2.1.4 Ruminiclostridium thermocellum NCIB 10682 CAA27266.1 P04956   1
 endo-β-1,4-glucanase G (CelG) (Cel5D) 3.2.1.4 Ruminiclostridium thermocellum NCIB 10682 CAA49187.1 Q05332   1
 endo-β-1,4-glucanase / β-1,3:1,4-glucanase H (CelH) (Lic26A;Cel5E) 3.2.1.4
3.2.1.73
Ruminiclostridium thermocellum NCIB 10682 AAA23225.1 H6SHY4
P16218
  25
 endo-β-1,4-glucanase C (LC2;CelC;EgC) (Cel5B) 3.2.1.4 Ruminiclostridium thermocellum NCIB 10682EL AAA23220.1 P07985
P0C2S3
1CEC[A]
1CEN[A]
1CEO[A]
37
 endo-1,4-glucanase 4 (EGIV) 3.2.1.4 Ruminococcus albus BAA32286.1 Q07940   2
 Rumal_1082 (Cel5D) 3.2.1.4 Ruminococcus albus 7 = DSM 20455 ADU21608.1 E0L8I8   4
 lichenase (Ra0453;CUS_6741) (β-1,3-specific;cellobiose releasing) 3.2.1.73 Ruminococcus albus 8 ZP_08159266.1
EGC02962.1
    37
 lichenase (Ra2830;CUS_5609) 3.2.1.73 Ruminococcus albus 8 EGC04285.1
ZP_08157835.1
    1
 endo-1,4-glucanase I (EGI) 3.2.1.4 Ruminococcus albus F-40 AAA26469.1 P16216   4
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